DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and Atr

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_003750609.1 Gene:Atr / 685055 RGDID:1305796 Length:2636 Species:Rattus norvegicus


Alignment Length:2695 Identity:552/2695 - (20%)
Similarity:970/2695 - (35%) Gaps:862/2695 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   277 LKTLFPKTQHNKFLEASSSSSMGS-QLNTLVPRLKVPF--------------------------- 313
            :|||||       .||.:..::.. .||.|:.:|:|.|                           
  Rat   302 VKTLFP-------FEAEAYRNIEPVYLNVLLEKLRVMFEDRVLMRLKSDLLKAALCHLLQYFLTF 359

  Fly   314 -----------------------IDKLGSTQTHLGE--GEHHKGVAKFASQHNVLESAYAQEILQ 353
                                   :|.|| .|||:|.  |..:..:...:::  ::|....| ..|
  Rat   360 VPAGYESALQVRKVYVTDICRALVDVLG-VQTHVGYLLGPFYAALKMESTE--IIERIQCQ-AQQ 420

  Fly   354 EHYTSICDNVLEQR----TSKSPYVQQALLQILPRLAAFNRAVFVEKYLQTCVSHLMQILRGKEK 414
            |:.....|.|..:|    :|.|.|.:.:      |.:.....|.::|     .|.|..:|:.|.:
  Rat   421 ENLRGSNDGVSPKRRRLSSSLSSYKRPS------RQSEEINHVDMDK-----KSILWNVLKQKAE 474

  Fly   415 DRTVAYITIGYMAVAVQSAIE-----VHLSSIMTSVKVALPSKDLTS----------KRKVPV-- 462
            ...:: :..|.:..:|..|:|     :.|:::.|   |....:|:..          |:|.||  
  Rat   475 SLQIS-LECGTLKNSVAEALEGITIVLQLTALCT---VHCSHQDMDGHNAKDCQHKYKKKPPVVI 535

  Fly   463 --------DPAVFACITLLAHAVKSE---IADDVKDILEQMFYTGLSPALTVCLRELSENVPQLK 516
                    ...:.:|.:||....|.|   :.|.|..|.:.:.|.                  |:|
  Rat   536 TWMSLDFYTKVLKSCKSLLESVQKHELELVIDSVVRIYDALMYI------------------QVK 582

  Fly   517 SA----ITEGLIGILSQVLMNKAAILPYTALPTIAIDGSLMQNGDGATTVLALK----------- 566
            |:    :.|.|.|:||         ||:  :.:.:.|.||... ..||.:|.|.           
  Rat   583 SSFQDHVLEELCGMLS---------LPW--IYSYSDDNSLKMT-TFATNLLRLSQRVWESYSPQA 635

  Fly   567 --------TLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQ----------TCTRLLKLAV 613
                    ||    |.::..||:.....::.:....:.||...|:          :|.::.|:.:
  Rat   636 QSQCVFLLTL----FPKRIFLDWRTTVYNWALKSSHEVIRTSCVKGFFILLQQENSCNQIPKMLI 696

  Fly   614 Q------------------------------SSESME-----------NSKTLS----------- 626
            .                              :|.|:|           |.|..|           
  Rat   697 DRVKDDSHVVKKEFASVLGQLVCTLHGMFYLTSSSVEPFFGPVDLFCKNLKATSQHECSSSQVKA 761

  Fly   627 -----------------------DTVSHVIERL---------------LMVAITDMDCNVRIRIL 653
                                   |.:.|:.:.|               |:..:.|.|.:|||   
  Rat   762 SVCKPFLFLLTKNTPSPVKLAFIDNLHHLCKHLDFQEDETEVKAVLGTLLNLMEDPDKDVRI--- 823

  Fly   654 RSLDETFDGKLAQ-PESLNSL--FITLHDEIFEIRELAMVTIGRLSSINPAYVMPKLRTTMIELI 715
                 .|.|.:.. .|||||.  ||   .|:|.:|.....|..::|..|      :|:.|:|...
  Rat   824 -----AFSGNIKYILESLNSEDGFI---KELFVLRMKEAYTHAQISRSN------ELKDTLILTT 874

  Fly   716 TDLKYSGMSRNKEQSAKMLDHLV--------------------------ISTPRLISSYMNPILK 754
            .|:   |.:...:.....|.||:                          :......|.|..||.:
  Rat   875 GDI---GRAAKGDLIPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQNFFSQYKKPICQ 936

  Fly   755 ALVPKLHEPE-----SNPGVILNV------------LRTIGDLAEVNGGSDEMELWADDLLSILL 802
            .||..||..:     |.|.....:            |.|:.::|.|....| :..:....|.:||
  Rat   937 FLVESLHSSQMTALPSTPCQTAEMRKQHVAHHREMALNTLSEIANVFDFPD-LNRFLTRTLQVLL 1000

  Fly   803 EMLGDAGSPDKRGVALWTLGQLISATGR-VVTPYHKYPVLIDILINFLKTEQRRS---IRRETIR 863
            ..|....|| .....:.|||:.::...| ::....|| :...::.:..|.|..|:   ::.||..
  Rat  1001 PDLAAKASP-AASALIRTLGKQLNVNRREILINNFKY-IFSHLVCSCSKDELERALHYLKNETEI 1063

  Fly   864 VLG--------------LLGAMDPYKHKMNKGLIDSQKDNVLIAY--SDGKVDESQDISTAELLV 912
            .||              ||...:.|:...| ||      ::|.::  ||......:||::.||:.
  Rat  1064 ELGSLLRQDFQGLHNELLLRIGEHYQQVFN-GL------SILASFASSDDPYQGPRDITSPELMA 1121

  Fly   913 N-----------------MGNALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLG-- 958
            :                 :.:::......:|:.:||.:::  .:..:|.|.|:.........|  
  Rat  1122 DYLQPKLLGILAFFNMQLLSSSVGIEDKKMALTSLMSLMK--LMGPKHVSSVRVKMMTTLRTGLR 1184

  Fly   959 ----------------IKCV------PYLAQVLPNLLDNVRTADNNLREFLFQQLAI--LVAFVK 999
                            ::|:      |.|:.|:..||..::........ :|..|.|  .||...
  Rat  1185 FKDDFPELCCRAWDCFVRCLDHAYLGPLLSHVIVALLPLIQMQPKETAA-IFHYLIIENRVAVQD 1248

  Fly  1000 -LHIISYMGD------IFKLIKEF---WTINTPLQNTLINLIEQIAVALGCEFRDYLAELIPQIL 1054
             ||.|.::.|      |..:::|:   .:.:|.||.||     |::                  :
  Rat  1249 FLHEIYFLPDHPELEKIKAVLQEYRKETSESTDLQTTL-----QLS------------------M 1290

  Fly  1055 RVLQHDNSKDRM-VTRRLLQALQKFGSTLGYYLPLILPPIVKLFDS----PYVPQQVSMV--ALE 1112
            :.:||:|...|: ....|.:.|.|....|..|..          ||    |.:.|.|:::  ..:
  Rat  1291 KAIQHENVDVRIHALTSLKETLYKNQEKLIKYAT----------DSETVEPVISQLVTVILKGCQ 1345

  Fly  1113 TINN---LAC-------------QLDFTDFSSRIIHPLVRVLDAEPELRDQAMTT-------LRS 1154
            ..|:   |.|             :|||:              ..|.:.:|....|       ...
  Rat  1346 DANSQARLLCGECLGELGAIDPGRLDFS--------------TTETQGKDFTFVTGVEDLSFAYG 1396

  Fly  1155 LAKQLGKKYLVFVPMVQRTLNKHRIVDP---EYEELLSKIKSCSTLADSYGAGESELRPSRFKNN 1216
            |..:|.:.||.:.       :..|..|.   ..:|||| |..|..: .|.|.|....:  ||..:
  Rat  1397 LLMELTRAYLAYA-------DNSRAQDSAAYAIQELLS-IYDCREM-QSNGPGHQLWK--RFPEH 1450

  Fly  1217 -----EPFVTDRNSNNKNLQVTTNELRTAWQ-VTRRV--SK--DDWVEWLKRLS---IGLLKESP 1268
                 ||.:   |:..|:.|.:|:     |. ||:.:  ||  :::.||....:   |..::::.
  Rat  1451 VREILEPHL---NTRYKSSQKSTD-----WSGVTKPIYLSKLGNNFAEWSSSWAGYLITKVRDNL 1507

  Fly  1269 SHALRACRSLAQEYD-----TLLRDLFNAAFISC--------WTELSPDLKNELTQSLIQALQVT 1320
            :..:..|.|:..::|     .||..:.....:.|        :.|:...||::...::......:
  Rat  1508 ASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCSQEDQQEVYAEIMAVLKHDDQHAISTQDSAS 1572

  Fly  1321 DMPEI-TQTILNLAEFMEHCDR----------------------------------DPIPIETKL 1350
            |:.:: |||:.::.:.:....|                                  |.||.:|  
  Rat  1573 DLCQLSTQTVFSMLDHLTQWARHKFQALNAEKLAQNKPKGVSSVNFEDYQSVTRFLDLIPQDT-- 1635

  Fly  1351 LGTRAMACRAYAKALRYKEEEFLLREDSQVFESLILINNKLQQREAAEGL--LTRYRNAANELNV 1413
            |...:...:||.:|:.: .|.|:..:...:.:.|..:..........:|:  ::..|.|...|..
  Rat  1636 LAVASFRSKAYTRAVMH-FESFITEKKQNIQKHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKE 1699

  Fly  1414 QGRWYEKLHNWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNV---------TKHEW 1469
            |...:|.:....:|...|:|.::.:...:....|.::.:..||   :||.|         .:.||
  Rat  1700 QILEHESIGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLG---QLSTVITQVNGVHANRSEW 1761

  Fly  1470 ENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDGS-------YYRAVLAVHHDD--- 1524
            .:       ........|||.|..|:.:..|:      ..||.       ..:.:|:....|   
  Rat  1762 TD-------ELNTYRVEAAWKLSQWDLVENYL------AADGKSTTWSVRLGQLLLSAKKRDTTA 1813

  Fly  1525 FETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQ---YKLIPERREPLKTM 1586
            |....:|: ....::.....|....||:|.|..:|.:.||.|||..::   :|...:........
  Rat  1814 FYDTLKLV-RAEQIVPLSAASFERGSYQRGYEFIVRLHMLCELEHSLKPLFHKFPGDSCNEDSLN 1877

  Fly  1587 WWKRLQGGQRLVEDWRRIIQVH----SLVVKP--HEDI-HTWLKYASLCRKSGSLHLSHKTLVML 1644
            |..||:..|........|:.:.    ||..:|  :|.: ..||:.|.:.||:|    .|:|..  
  Rat  1878 WAARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAG----HHQTAY-- 1936

  Fly  1645 LGTDPKLNPNQPLPCNQPQVTYAY---TKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQ 1706
                     |..|...:.::...|   .|::.:...:.:|...|...|     || |.|......
  Rat  1937 ---------NALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGV-----EL-CFPENKSPT 1986

  Fly  1707 QDQRLM--ARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKA-WHLWAYMNFKVVQ 1768
            :.:.::  .|..|.:..:..:.. :...:||   ::.::..|.:.|.|... ::|..|.:..:..
  Rat  1987 ESKHMLIHGRATLLVGRFMEETA-NFESNAI---MKKYKDVTLFLPEWEDGHFYLAKYYDKLMPM 2047

  Fly  1769 AQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSL--QDTLRLLTL 1831
            ...:.::||                .||:   ||   .|..|.||:..  ||..  |...|:|:|
  Rat  2048 VTDNKMEKQ----------------GDLI---RY---IVLHFGRSLQY--GNQFIYQSMPRMLSL 2088

  Fly  1832 WFDYGNHAEVYEALLSGMK--------LIEINT-------------WLQVIPQLIARIDTHRQLV 1875
            |.|:|  |:.||....|..        |.:||:             :|....|||:||......|
  Rat  2089 WLDFG--AKAYEWEKGGRSDRLQMRNDLAKINSVLTEHTNRLAPYQFLTAFSQLISRICHSHDEV 2151

  Fly  1876 GQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILDS---MRKHSPTLVEQAVMCSEE 1937
            ..::.:::..:...:||..::.:|..|||:...|.|...:||..   |:|.....|..|...:::
  Rat  2152 FVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILTKAIHMKKSLEKFVGDATRLTDK 2216

  Fly  1938 LIRVAILWHEQWHEGLEEASRLYFGDRNVKGM---FEILEPLHAMLERGPQTLKETSFSQAYGRE 1999
            |              ||..::...|..:...|   |::|:.|          :::.:||:.    
  Rat  2217 L--------------LELCNKSVDGSNSTLSMSTHFKMLKKL----------VEDPTFSEI---- 2253

  Fly  2000 LTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPG 2064
                                                 |..|.|:.:|.: |.::.........||
  Rat  2254 -------------------------------------LIPLQSVMIPTL-PSILGAHANHDPFPG 2280

  Fly  2065 --SYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLV 2127
              :|..|.:.:        :::::|.|:|:|:.::||:||.|:.:.|..:|||:|.|:|:..||:
  Rat  2281 HWAYLAGFDDV--------VEILSSLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLI 2337

  Fly  2128 NTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLI-RDYRDKKKVPLNQEHRTML 2191
            |..|..|.::.||.|.|:.||||||:...|:|.||.:...|..:: :.|::|......:|.|..:
  Rat  2338 NKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCM 2402

  Fly  2192 NFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYIL 2256
              .|  ....|.:|::||:..|.........:......|....|:..|:.|.||.||||||||||
  Rat  2403 --LP--KSAALSEKLKVFQEILLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYIL 2463

  Fly  2257 GLGDRHPSNLMLDRMSGKILHIDF------GDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIE 2315
            ||||||..|::.|..:|:.:|:||      |:.|||       ||.:|||||..::..|...|.|
  Rat  2464 GLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEV-------PEIVPFRLTHNMVNGMGPMGTE 2521

  Fly  2316 GTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQD 2380
            |.:||.||..:.::|..::.||:||:.|::|||:.|   ....||:                   
  Rat  2522 GLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVEW---SKPVKGH------------------- 2564

  Fly  2381 SLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTGTDFQTEKSV---- 2441
                        :|:.|           |...:..|.||...:..::.:|.|. .:|...|    
  Rat  2565 ------------SKAPP-----------NETGEVVNEKAKTHVLDIEQRLQGV-IKTRNRVTGLP 2605

  Fly  2442 -NEQSQVELLIQQATNNENLCQCYIGWCPF 2470
             :.:..|..|||:||:...|||.|:||.|:
  Rat  2606 LSIEGHVHYLIQEATDENLLCQMYLGWTPY 2635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 542/2663 (20%)
HEAT repeat 632..658 CDD:293787 7/40 (18%)
HEAT repeat 668..698 CDD:293787 12/31 (39%)
HEAT repeat 706..736 CDD:293787 6/29 (21%)
HEAT repeat 749..780 CDD:293787 10/47 (21%)
HEAT repeat 798..823 CDD:293787 8/24 (33%)
DUF3385 831..999 CDD:288698 40/229 (17%)
HEAT repeat 841..870 CDD:293787 9/45 (20%)
HEAT repeat 880..917 CDD:293787 9/55 (16%)
HEAT repeat 925..954 CDD:293787 6/28 (21%)
Rapamycin_bind 1937..2034 CDD:285924 10/99 (10%)
PIKKc_TOR 2075..2353 CDD:270713 103/284 (36%)
FATC 2440..2471 CDD:280430 14/36 (39%)
AtrXP_003750609.1 UME 1120..1226 CDD:214825 13/107 (12%)
FAT 1766..2087 CDD:280429 75/376 (20%)
TEL1 <2118..2636 CDD:227365 169/649 (26%)
PIKKc_ATR 2285..2559 CDD:270625 104/295 (35%)
FATC 2605..2636 CDD:280430 13/31 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.