DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and Pik3c3

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_075247.1 Gene:Pik3c3 / 65052 RGDID:620899 Length:887 Species:Rattus norvegicus


Alignment Length:1097 Identity:227/1097 - (20%)
Similarity:378/1097 - (34%) Gaps:368/1097 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1335 FMEHCDRDPIPIETK---LLGTRAMACRAYAKALR---------YKEEEFLLREDSQVFESLILI 1387
            ::..||.| |.::.|   |.|.|..  ::|...|.         |:|....|....|||      
  Rat     9 YIYSCDLD-INVQLKIGSLEGKREQ--KSYKAVLEDPMLKFSGLYQETCSDLYVTCQVF------ 64

  Fly  1388 NNKLQQREAAEG------LLTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLKTDSSDLEARL 1446
                     |||      :.|.|:..:.      ||     ||:|.|:     |.....||... 
  Rat    65 ---------AEGKPLALPVRTSYKPFST------RW-----NWNEWLK-----LPVKYPDLPRN- 103

  Fly  1447 GHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPL--AAVAAWG-----------LQDWEAMR 1498
                           :.|....|:.:|   ..||.|:  ..|:.:|           |:.|    
  Rat   104 ---------------AQVALTIWDVYG---PGRAVPVGGTTVSLFGKYGMFRQGMHDLKVW---- 146

  Fly  1499 EYVRCIPEDTQDGSY-----YRAVLAVHHDDFETAQRLIDETR-------DLLDTELT----SMA 1547
                  |....|||.     .|....:..|......:|....|       |.|| .||    .|.
  Rat   147 ------PNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLD-RLTFREIEMI 204

  Fly  1548 GESYERAYGAMV------CVQMLAELEEVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQ 1606
            .||.:|:...|.      ||:...:...::.|:...:...|:.|.:        .||:.....:.
  Rat   205 NESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSF--------ELVKVPDPQMS 261

  Fly  1607 VHSLVVKPHEDIHTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLN------PNQPLPCNQPQVT 1665
            :.:||...|.      |.|...|...|.|    .|.....|..:||      |.:.|...:..:.
  Rat   262 MENLVESKHH------KLARSLRSGPSDH----DLKPNATTRDQLNIIVSYPPTKQLTYEEQDLV 316

  Fly  1666 YAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQRLMARCYLRMATWQNKLQDSI 1730
            :.:..|:  .||    .:.||.|:...:.:   ||.||  :|...|:.:       |        
  Rat   317 WKFRYYL--TNQ----EKALTKFLKCVNWD---LPQEA--KQALELLGK-------W-------- 355

  Fly  1731 RPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSD 1795
            :|..::.:||....            |   |.|..|.:...:.|.:..              |.|
  Rat   356 KPMDVEDSLELLSS------------H---YTNPTVRRYAVARLRQAD--------------DED 391

  Fly  1796 LMIIQRYAVPAVQGF-FRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEAL-LSGMKLIEINTWL 1858
            |::   |.:..||.. :.:...|| |.|:.|.:        .:.|.|.|:| .||:...:|::  
  Rat   392 LLM---YLLQLVQALKYENFDDIK-NGLEPTKK--------DSQASVSESLSSSGVSSADIDS-- 442

  Fly  1859 QVIPQLIARIDTHRQLVGQLIHQLLMDI--------------GKNHPQAL-VYPLTVASKSASLA 1908
                             .|:|...|..:              |:|..|.| .:.::.|.|:::||
  Rat   443 -----------------SQIITNPLPPVASPPPASKSKEVSDGENLEQDLCTFLISRACKNSTLA 490

  Fly  1909 RRNAAFKIL-----DSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASR-LYFGDRNVK 1967
            .....:.|:     |:.::...|                   ||.:...:...|: |..||::|:
  Rat   491 NYLYWYVIVECEDQDTQQRDPKT-------------------HEMYLNVMRRFSQALLKGDKSVR 536

  Fly  1968 GMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQK 2032
            .|..:|......::|....:|      |..||.....:.::|.:  |::.|.::           
  Rat   537 VMRSLLAAQQTFVDRLVHLMK------AVQRESGNRKKKNERLQ--ALLGDNEK----------- 582

  Fly  2033 ISRQLPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIR 2097
                                |...|:|| :|....| |..|| .||.....:..|...|.:|..:
  Rat   583 --------------------MNLSDVEL-IPLPLEP-QVKIR-GIIPETATLFKSALMPAQLFFK 624

  Fly  2098 GSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGW- 2161
            ..:|..|..:.|..:|||||:.::|:.||::.||..:    ..:|.:..|.|:..||..|.:.: 
  Rat   625 TEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKE----NLDLKLTPYKVLATSTKHGFMQFI 685

  Fly  2162 --VPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKL 2224
              ||..:.|.|                ..::.||...|              |..:|..:.::. 
  Rat   686 QSVPVAEVLDT----------------EGSIQNFFRKY--------------APSETGPNGISA- 719

  Fly  2225 LWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMT 2289
                        |..:.|.:|.|...::.||||:||||..||:|.: :||:.|||||    ..:.
  Rat   720 ------------EVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTK-TGKLFHIDFG----YILG 767

  Fly  2290 REKFPEKIPFRLTRMLIKAMEVTGIE--GTYRRTCESVMLVLRRNKDSLMAVLEAFV 2344
            |:..|...|.:|.:.:::.|..|..|  ..:|:.|.:..|.|||..:.::.:....|
  Rat   768 RDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMV 824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 227/1097 (21%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 17/97 (18%)
PIKKc_TOR 2075..2353 CDD:270713 69/275 (25%)
FATC 2440..2471 CDD:280430
Pik3c3NP_075247.1 C2_PI3K_class_III 26..186 CDD:176042 43/221 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..170 4/20 (20%)
PI3Ka_III 283..503 CDD:238442 58/309 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 416..467 11/77 (14%)
PI3Kc_III 539..883 CDD:270628 87/380 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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