DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tor and pik3c2a

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_005159362.2 Gene:pik3c2a / 571356 ZFINID:ZDB-GENE-030328-39 Length:1691 Species:Danio rerio


Alignment Length:1654 Identity:300/1654 - (18%)
Similarity:530/1654 - (32%) Gaps:597/1654 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1080 STLGYYLPLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRV------- 1137
            :.|.|..|.:.|.:.||||      :::..:....|..:..::....|.:.:.||.:.       
Zfish   200 AALVYSQPAVTPEMAKLFD------KIASTSEYLKNGRSSSMETESASVKSLEPLPQPSEPPNIS 258

  Fly  1138 ----LDAEP-------ELRDQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVD---PEYEELL 1188
                ||.:|       |:.:....:.....::.||....:..::|   ::|..||   |:.||  
Zfish   259 RFEWLDLDPLNKRKEVEVEETPAVSSCPFIEESGKAKDPWDAVLQ---DEHETVDNGSPKAEE-- 318

  Fly  1189 SKIKSCSTLADSYGAGESELRPSRFKNNEPFVTDRNSNNK------------------NLQVTT- 1234
             |.|:......|.||..::.:.....:|....:.....||                  ||:|.. 
Zfish   319 -KCKATQPRRASTGAAVTKSQSLSISSNSTNQSTGKQVNKGSTNVLSKYSALQEKEAQNLEVVAF 382

  Fly  1235 ----NELRTAWQ---------------VTRRVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQ 1280
                ::||:.:.               :|:|.:..|....:| :||. :.:|.......| .:..
Zfish   383 CEDISKLRSKFPHDDLSTNPGYVLSPVITQRDAGGDNGGSVK-VSIE-ISDSQQPVTFTC-DVTS 444

  Fly  1281 EYDTLLRDLFNAAFISCWTELSPDLKNELTQSLIQA--LQVTDMPEITQTILNLA--EFMEHCDR 1341
            ..|.|:....      ||      :.::|.|..|.:  |:|....|:.|...:|.  |::::|.:
Zfish   445 PVDLLIMQAL------CW------VHDDLNQVDINSYVLKVCGQEEVLQNKHSLGSHEYVQNCRK 497

  Fly  1342 DPIPIETKLLGTRAMACRAYAKALRYKEEEFLLREDSQVFESLILINNKLQQREAAEGLLTRYRN 1406
            ....|:.:||....|     .:.|....|:.:...|.:.:  |.|:....::....|||.     
Zfish   498 WESEIKLQLLFLSTM-----RRDLARTAEDDISPIDLEKY--LGLVERPFKEAVTREGLA----- 550

  Fly  1407 AANELNVQGRWYEKLHNWDEALE--HYERNLKTDSSDLEARLGHMRCLE-ALGDWSELSNVTKHE 1468
                               |.||  |.:.||               ||: ....:..:.||.:  
Zfish   551 -------------------EYLEGFHKQVNL---------------CLQNENNQYKTVDNVVQ-- 579

  Fly  1469 WENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCI--PEDTQDGSYYRAVLAVHHDDFETAQRL 1531
                  ..|:....|..|....:.|  |::...|.:  |. |:...:|..               
Zfish   580 ------SVKNLCCALDEVETPAITD--AVKRLKRSVNLPR-TRSPEHYAE--------------- 620

  Fly  1532 IDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQYKL----------------IPERR 1580
                   |....||..|.:  ..|.:.| .:.||.|.:.: |:|                |.|.:
Zfish   621 -------LQAGATSSGGSA--NGYSSPV-EESLAVLTDAV-YELAKLYLQSFCPISPGFMIEEHK 674

  Fly  1581 EPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWL----KYASLCRKSGSLHLSHKTL 1641
            |..:..  |...|....::  ..:..||.:..       ||:    ||..:|.      |:|.  
Zfish   675 EDERDS--KEASGTTEHLQ--FTLFAVHGIPA-------TWVSSFEKYYLMCA------LTHN-- 720

  Fly  1642 VMLLGTDPKLNPNQPLPCNQPQV-TYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEAL- 1704
                      |.|...|....:| ||....|       ...:::|.:|..:    :|.||.||: 
Zfish   721 ----------NRNLFKPVQSKKVGTYKSFFY-------HIKWDELINFPIS----VSLLPLEAML 764

  Fly  1705 -------------------KQQD---------------QRLMARCYLRMATWQNKLQDSIRPDAI 1735
                               ||:.               :|:::|....::.|.:  ..:::|.|.
Zfish   765 SLSLYGVLSQNANNSPDSNKQRKGPELLGKVSMPLFDFRRVLSRGSKLLSLWTS--PQALQPGAA 827

  Fly  1736 QGALECFEK--------------------------ATSYDPNWYKAWHLWAYMNFKVVQAQKSAL 1774
            .......||                          ..|.||               :.|..:|.:
Zfish   828 GKGRNPTEKIILQVDFPSPAVDVLYVGPQENGCPNPQSLDP---------------LDQDDRSEI 877

  Fly  1775 DKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHA 1839
            :|.....::.|:   |..|..|:..|||       :.|....    ||...|.....| |:|:..
Zfish   878 EKLCARASTFGL---SRADRQLLWDQRY-------YCREYEY----SLPKILASAPSW-DWGSMG 927

  Fly  1840 EVYEAL--------LSGMKLIEIN-----------TWLQ---------VIPQLIARIDTHRQLVG 1876
            |::..|        :|.::|:|..           :|:|         .:|||:..:.....|  
Zfish   928 EIHALLHHWPALSPVSALELLESKFADTEVRKVAVSWIQSSSDDELADYLPQLVQAVKFECHL-- 990

  Fly  1877 QLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILDSMRKHSPTLVEQAVMCSEELIRV 1941
                                             :||..|.|                .|..|..|
Zfish   991 ---------------------------------KNALVKFL----------------LSRALGNV 1006

  Fly  1942 AILWHEQW--HEGLEEASRLYFGDRNVKGMFEIL----EPLHAMLERGPQTLKETSFSQAYGREL 2000
            .|..:..|  .:.:::.:   ||.|..:.:..:|    ..|.|.||      |:|...|..|...
Zfish  1007 NIAHYLYWLLRDAVQDPA---FGQRYERILCVLLCLCGTGLRAELE------KQTRLVQLLGALA 1062

  Fly  2001 TEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPGS 2065
            .:..:.|...:...::..|:|....    |||.|.:||         :||.|: .|:|.:.|...
Zfish  1063 EKVRQASSSTRQVVLLEGLERVQSF----FQKNSCRLP---------ISPSLV-AKELNIKVCSF 1113

  Fly  2066 YNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTL 2130
            :|.....::|:::..:                 ..|.:...:.|..||||||...:|:..:::.:
Zfish  1114 FNSNAVPLKIALVNAD-----------------PLGDEINVMFKVGEDLRQDMLALQMIRIMDRI 1161

  Fly  2131 LLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAP 2195
            .|.:    ..:|.|..:..|....:.|::..||..:||                           
Zfish  1162 WLQE----GLDLRIVNFKCISTGKDKGMVELVPSSETL--------------------------- 1195

  Fly  2196 DYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLK--SPSSELWFERRNNYTRSLAVMSMVGYILGL 2258
                    :|::|.....|..:...||:  ||:  :|:.:.:.:...|:..:.|...:..||||:
Zfish  1196 --------RKIQVEYGVTGSFKDKPLAE--WLRKYNPAEDEYEKASENFIYTCAGCCVATYILGI 1250

  Fly  2259 GDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFP-EKIPFRLTRMLIKAMEVTGIEGTYRR-- 2320
            .|||..|:|| |.:|.:.|||||.....|.....|. ::.||.||..:  |..:.|.|....|  
Zfish  1251 CDRHNDNIML-RSTGHMFHIDFGKFLGHAQMIGSFKRDRAPFVLTSDM--AYVINGGERPTSRFQ 1312

  Fly  2321 ----TCESVMLVLRRNKDSLMAVLE----------------AFVYDPL-----------LNWRLL 2354
                .|.....::|::.:..:.:|.                .:|||.|           ...||:
Zfish  1313 LFVDLCSQAYNLIRKHSNLFLNLLSLMTQSGLPELTGVQDLKYVYDALQPQTTDAEATIFFTRLI 1377

  Fly  2355 D-----VDKKGNDAVAG------AGAPGG---------RGGSGMQDSLSNSVEDSLPMAKSKPYD 2399
            :     |..|.|..:..      :|.|..         |..:..||   ..:.|:...:..|.|:
Zfish  1378 ESSLGSVATKFNFFIHNLAQLRFSGLPSNDEPILSFAPRTYTMKQD---GKIRDASVFSYQKRYN 1439

  Fly  2400 P---------TLQQG---------------GLHNNVA------DETNSKASQVIKRVKCKLTGTD 2434
            |         .|::|               .|||.:.      ......:..|:.|...|    |
Zfish  1440 PDKHYTYVIRILREGQSEPQFVFRTFDEFQELHNKLTILFQLWKLPGFPSKMVLGRTHIK----D 1500

  Fly  2435 FQTEKSVNEQSQVELLIQQATNNENLCQC 2463
            ..:::.|...|.|..|::.:|   .:.||
Zfish  1501 VASKRKVELNSYVHNLMRSST---EVAQC 1526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 300/1654 (18%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 22/102 (22%)
PIKKc_TOR 2075..2353 CDD:270713 63/313 (20%)
FATC 2440..2471 CDD:280430 7/24 (29%)
pik3c2aXP_005159362.2 Amelogenin <137..207 CDD:330537 2/6 (33%)
PI3K_rbd 420..507 CDD:307097 20/101 (20%)
C2A_PI3K_class_II 681..852 CDD:175979 34/210 (16%)
PI3Ka 872..1038 CDD:320871 39/234 (17%)
PKc_like 1045..1397 CDD:328722 91/432 (21%)
PX_PI3K_C2_alpha 1428..1536 CDD:132822 20/106 (19%)
C2B_PI3K_class_II 1565..1686 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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