DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and smg1

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_009297728.1 Gene:smg1 / 569810 ZFINID:ZDB-GENE-061013-767 Length:3641 Species:Danio rerio


Alignment Length:2602 Identity:519/2602 - (19%)
Similarity:899/2602 - (34%) Gaps:888/2602 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   549 DGSLMQNGDGATTVLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTCTRLLKLAV 613
            ||.|.:|..|      .|:||                         ||:|:..|.|.....:...
Zfish    84 DGGLSENAYG------WKSLG-------------------------QELRINDVTTDITTFQHGN 117

  Fly   614 QSSESMENSKTLSDTVSHVIE----RLLMVAITDMDCNVRIRILRSLDETF---DGKLAQPESLN 671
            ::..:.:..|:....::|..|    .||..|..:.|...|:..::.:.|..   :.|:...:.|:
Zfish   118 RALATKDMRKSQDRPLAHSEESRLANLLRRASREDDRERRLATMKQMKEFIVHSENKVVLVKQLD 182

  Fly   672 SLFITLHD-------EIFEIRELAMVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQ 729
            |:..||:|       .:.|:|:.|...:|.|.:. .:|...::...|.     ||:|..::::  
Zfish   183 SILSTLNDILNESSKLLQELRQEAAWCLGLLCAA-LSYEAERIFKWMF-----LKFSVSTKDE-- 239

  Fly   730 SAKML----DHLVIST---PRLISSYMNPI---LKALVPKLHEPE---SNPGVILNVLR------ 775
             .|:|    .|..:.|   .:..|:.|..:   |::::..|..||   .:...||.|.|      
Zfish   240 -VKLLYLVAVHKALETAGEKKAFSAVMQLVMSNLQSILENLDTPELLCQSVKCILLVARCYPHIF 303

  Fly   776 ------TIGDLA--------------EVNG--------------------GS--DEMELWADDLL 798
                  |:..|.              :|:|                    |.  ::||.:|:||.
Zfish   304 STNFRDTVDILVGWHIDHTQKHSLTQQVSGWLQSLEQFWVADLAFSTTLLGQFLEDMEAYAEDLS 368

  Fly   799 SILLEMLGDAGSP------DKRGVALWTLGQLISATGRVVTPYHKYPV----LIDILINFLK--T 851
            .::....||...|      .|....|.....::.:.|....|....|:    :.|:|...|.  |
Zfish   369 HVVSGESGDEDIPPPTVSLPKLAALLRVFSTVVHSIGERFNPIRGPPITEAYVTDVLNRVLACVT 433

  Fly   852 EQRRSIRRETIRVLG------LLGAMDPYKHKMNKGLIDSQKDNVLIAYSDGKVDESQD------ 904
            ..::....|.:...|      ||.::|     :...|||:     :|:|...:::..|:      
Zfish   434 TAKQVFFSEAVLTAGNECVCVLLVSID-----LGGQLIDA-----VISYGLDQLNCCQNCGPEYS 488

  Fly   905 ISTAELLVNMGNALDEYYPAVAIAAL---------MRILRDPTLSTRHTSVVQAVTFIFQSLGIK 960
            :|...||..:.:.::...||..:..|         :|..|:..:......|..||      |.:|
Zfish   489 LSVLTLLTLVVDQINTKLPASFVEKLLAPKSHLLELRFHREREVMAAAHGVYHAV------LSLK 547

  Fly   961 CVPYLAQVLPNLLDNVRTADNNLREFL-------------FQQL------AILVAFVKLHIISYM 1006
            .:|.|......:|..:..|.|:|...|             |.||      |..|....|..::.:
Zfish   548 NIPILEAAYKLVLGEMGCALNSLLSPLGLPDACPHIQHPAFSQLNFSPERAEFVLIFNLSALTTI 612

  Fly  1007 GDIFKLIKEFWTINTPLQNTLINLIEQIAVALGCEFRDYLAELIPQILRVL-----QHDN----- 1061
            |:....:...|.    |..|:..|:.|..|.:..:...:...:...:|..|     :||:     
Zfish   613 GNTKNSLIGMWA----LSPTVFALLSQNLVIVHSDLAVHHPAVQYAVLYTLYSHCTRHDHFISSS 673

  Fly  1062 ------------------------------------SKDRM--VTRRLL-------QALQKFGST 1081
                                                |||.:  ..||||       ..:.|...|
Zfish   674 LSSSSPSLFDGAVISTVTTATKRHFSTLLNLLGMLLSKDHLNPEARRLLLTWSLEVALMMKKSET 738

  Fly  1082 LGYYLPLI-LPPIVK-----LFDSPYVPQQVSMVALETINNL-----------------ACQLDF 1123
               |.||. ||..:|     |.:|   ..:.:.:.|:..|:|                 .|::  
Zfish   739 ---YAPLFSLPSFLKFCKGLLANS---LNEDTTICLQACNSLQVLSSSLTMELLQRCVDVCRV-- 795

  Fly  1124 TDFSSRIIHPLVRVLDA-------------------EPELRDQAMTTLRSLAK------------ 1157
                 :::|..|||..|                   ..|:::.::...|.::|            
Zfish   796 -----QLVHSAVRVRQAFGKLLRSVPMHVALSSAHSHSEIKEISLAIRRHMSKVPSNTFHPQDFS 855

  Fly  1158 ----------------------------QLGKKYLVFVPMVQRTLNKHRIV-------DPEYEEL 1187
                                        :|.||....||   |.|.|...|       :.....:
Zfish   856 DLIGFILYGTVHRGGKEPWLERLYHSCQRLEKKDSAMVP---RALLKTEAVLWQWAVWEAAQFTV 917

  Fly  1188 LSKIKS-CSTLADSYGAGESELR--PSRFKNNEPFVTDRNSNNKNLQVTTNELRTA--------- 1240
            |||::: .....|::...|..:|  .:...|.|..::..:....:....||:||.|         
Zfish   918 LSKLRTPLGRAQDTFQTIEGMIRSLAAHSLNTEQELSQWSGGESDEGHHTNQLRLALLLQFLENL 982

  Fly  1241 ------------------------WQVTRRVSKDDWVEWLK--RLSIGLLKESPSHALRACRSLA 1279
                                    :..|.|.:..||:..::  .:.:|||...|:..:|      
Zfish   983 EKLMYNAYEGCASALTAPPKGIRTFFYTNRQTCQDWLTRIRLALMRVGLLSGQPAVTVR------ 1041

  Fly  1280 QEYDTLLRDLFNAAFISCWTELSPDLKNELTQSLIQALQVTDMPEITQTIL--NLAEFMEHCDRD 1342
            ..:| ||.::.|::     |: .|:::..:|. |::||.....||..|.:.  :||.        
Zfish  1042 HGFD-LLTEIKNSS-----TQ-GPEMEVPVTM-LVEALCELRCPEAIQGLAAWSLAN-------- 1090

  Fly  1343 PIPIETKLLG-TRAMACRAYAK----ALRYKEEEFLLRE---DSQVFE-SLILINNK-------- 1390
                ..|.:| ..::|.:|..|    ||.|:|:...:..   ..:||: ||:.:...        
Zfish  1091 ----TGKSMGWLSSVALQAEGKFEKAALEYQEQLCAVTGMDCSIKVFDRSLLKLTGTNTSSPKHT 1151

  Fly  1391 ----------LQQREAAEGLLTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLKTDSSDLEAR 1445
                      |:..|.:..:|....|.|.|..|....:|.:..|..::.:.::|..:.|.:|:..
Zfish  1152 SSGEGRKTVLLKSSECSPEVLNFLANKACECYVALSDWESVQEWQASMMNLKKNSSSSSVNLKTD 1216

  Fly  1446 LGHMRCLEAL--GDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPED- 1507
            ..::|.:...  ||::|                                    .|..:..:|.| 
Zfish  1217 FNYIRAMSRFEEGDFTE------------------------------------CRAQLELLPGDD 1245

  Fly  1508 -------TQDGSYYRAVL-AVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQML 1564
                   |:|....:.:| ||...|....|:.|:.  .||.:.:.:::..::|:.       |.:
Zfish  1246 YGLLNSTTKDKIDLKRLLPAVLSPDPSELQKAIEV--QLLRSAVGAISATNHEQD-------QKV 1301

  Fly  1565 AELEEVIQYK-------LIPER------REPLKTMWWKRLQGGQRL--------VEDWRRIIQVH 1608
            |..:.:::|.       |.|.|      .:.|.|:...:|.....|        .||....:...
Zfish  1302 ASSDTLVKYLKQTGRICLGPLRLSTLTLSDSLPTLSTLQLHCANSLENSLCNQHPEDCLIPLFSE 1366

  Fly  1609 SLVVKPHEDIHTW---LKYAS----------------------LC-------RKSGSLHLSHKTL 1641
            :|.....:|:..|   |:|.:                      ||       ||.|::.|:  |.
Zfish  1367 ALTTCKQQDVQPWLHALRYTTFQREFFQKLKGSSSPVDSHLMELCLTAVKFARKQGNIALA--TR 1429

  Fly  1642 VMLLGTDPKLNPNQPLPCNQ----------------PQVTYAYTKYMAANNQLQEAYEQLTHFVS 1690
            ::.|.:.|.::..:.....|                |::.....|.:.|..|...|.|.|:....
Zfish  1430 LLSLCSKPAMSDTEGQDLVQSFRQLSLEGTVGEKWGPELEIEKAKVLFAAGQSVSAMEMLSSCAL 1494

  Fly  1691 TYSQELSCLPPEALKQQDQRLMARCYLRMATWQN------------------------------- 1724
            :|.....|.....     :.::..|...:|.|::                               
Zfish  1495 SYCHSGKCELAAC-----RSVLTLCKWLLADWKDLTPQLKMVVKKNSGSTSLSTLSKNISGLLEL 1554

  Fly  1725 KLQD------------SI---RPDAIQGALECFEKATSYDPNWYKAWHL---WAY-MNFKVVQ-- 1768
            .|:|            |:   .||.:.|.|  ::.:|:..|...|:|..   ||| ...|||.  
Zfish  1555 PLEDQGMPHITTETTVSVGVGEPDFVLGQL--YQLSTTQAPEVAKSWAALASWAYRWGRKVVDNA 1617

  Fly  1769 ----------AQKSALDKQQPPGAS----------MGMTM--GSGLDSDLMIIQR---------- 1801
                      .:|..:::..|.|.|          :|..|  .:|:..:.|.:|.          
Zfish  1618 SQGEGVPLLLGEKKEIEELLPAGTSDEDKETIFGILGQAMCRPAGIQDEDMALQNEEDDEDDMVD 1682

  Fly  1802 --------------------------------------YAVPAVQGFFRSISLIKG--------- 1819
                                                  |.| :.:.:|..:.|..|         
Zfish  1683 VIGRQLLGACPWLSDVEDTVTDGLIGVWRRVVDRIFSLYRV-SCRAYFTFLKLNAGQVPIDEDDP 1746

  Fly  1820 -------NSLQD--------TLRLLTLWFDYGNHA-EVYEALLSGMKLIEINTWLQVIPQLIARI 1868
                   ||.|.        |||||.|..   .|| |:.|.|..|:.......|..:||||.:|:
Zfish  1747 KLLLNNQNSKQSSDDVIVMATLRLLRLLV---KHAGELREGLEHGLASTPTAPWRGIIPQLFSRL 1808

  Fly  1869 DTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAA-------------------- 1913
            :.....:.|.|..||..:.::.|..::||..|.|.|.....:.|.                    
Zfish  1809 NHPEAYIRQSICSLLCRVAQDSPHLILYPAIVGSISLGGEAQTAGNKLPSSLPTLLGNMQGEGLC 1873

  Fly  1914 ------------------------------------FKILDSMRKHSPTLVEQAVMCSEELIRVA 1942
                                                .||:|.:...:||:|.|..|...||.||.
Zfish  1874 GGESETGSGPTSQESSRGEEMVMYSSEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVGELRRVT 1938

  Fly  1943 ILWHEQW-----HEGLEEASRLYFGDRNVK-----GMFEILEPLHAMLERGPQTLKETSFSQAYG 1997
            :||.|.|     .:.:....|:...:..||     ......|.:..|.|:....:|...|:..:.
Zfish  1939 LLWDELWLGVLQQQHMHVLRRIQQLEDEVKRVQNNNTLRKDEKVAIMREKHSALMKPVVFALDHV 2003

  Fly  1998 RELTEA------YEWSQRYKTSAVVMDLDR------------AWDIYYHVFQKISRQLPQLTS-- 2042
            |.:|.|      .||.|.....|:...|:|            :|..:..:...:.::..:..|  
Zfish  2004 RSITAAPAETPHEEWFQETYGDAIHNALERLRSPLNPANPASSWVPFKQIMLSLQQRAQKRASYL 2068

  Fly  2043 LELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYL 2107
            |.|..:||:|....:.|:|:||..: ..:.:.|..:...:.::.:|.:|:||...||:|::|.||
Zfish  2069 LRLDEISPRLTAMANTEMALPGEVS-ATDAVTIQSVGNTITILPTKTKPKKLYFLGSDGRNYPYL 2132

  Fly  2108 LKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLI 2172
            .||.|||..|||:||..|:|||:..............:.|:|.||.|.||||.||.....|..|.
Zfish  2133 FKGLEDLHLDERIMQFLSIVNTMFTKVNQQESPRFQARHYSVTPLGTRSGLIQWVDGATPLFGLY 2197

  Fly  2173 RDYRDKKKVPLNQEHRTM------LNFAP--------------------------DYDHLTLMQK 2205
            :.::.::.|...|:.:..      |...|                          |:. |::|: 
Zfish  2198 KRWQQREAVVQAQKAQDSFQQPQNLPMVPRPSELYYSKISPALKAVGLSLDVSRRDWP-LSVMR- 2260

  Fly  2206 VEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDR 2270
             :|....:..|..:.|||.||....:...|:.....|.||.|||||||||:||||||..|:::|.
Zfish  2261 -DVLRELMEATPPNLLAKELWCSCTTPSEWWSVTQTYARSTAVMSMVGYIIGLGDRHLDNVLIDM 2324

  Fly  2271 MSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDS 2335
            .:|:::|||:..|||...:. :.|||:|||:|..:..|:.|||:||.:|.:||.|:.::||.:::
Zfish  2325 TTGEVVHIDYNVCFEKGKSL-RVPEKVPFRMTHNIETALGVTGVEGIFRLSCEQVVQIMRRGRET 2388

  Fly  2336 LMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLSNSVEDSLPMAKSKPYDP 2400
            |:.:|||||||||::|       .....|..|||..|.||.               .|::|....
Zfish  2389 LLTLLEAFVYDPLVDW-------TAGGEVGFAGAVYGGGGQ---------------QAENKQSKR 2431

  Fly  2401 TLQQGGLHNNVADETNSKASQVIKRVKC-------KLTGTDFQTEKSVNEQSQVELLIQQATNNE 2458
            .:::        |.|.|..|..:..:|.       ::||...|.|::|:|...::   :|.|..|
Zfish  2432 EMER--------DITRSLFSSRVAEIKVNWFKNRDEMTGVLPQLEEAVDEYLNLQ---EQLTQVE 2485

  Fly  2459 NL 2460
            .:
Zfish  2486 KV 2487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 519/2602 (20%)
HEAT repeat 632..658 CDD:293787 6/29 (21%)
HEAT repeat 668..698 CDD:293787 10/36 (28%)
HEAT repeat 706..736 CDD:293787 6/33 (18%)
HEAT repeat 749..780 CDD:293787 10/48 (21%)
HEAT repeat 798..823 CDD:293787 5/30 (17%)
DUF3385 831..999 CDD:288698 42/213 (20%)
HEAT repeat 841..870 CDD:293787 8/36 (22%)
HEAT repeat 880..917 CDD:293787 9/42 (21%)
HEAT repeat 925..954 CDD:293787 6/37 (16%)
Rapamycin_bind 1937..2034 CDD:285924 26/124 (21%)
PIKKc_TOR 2075..2353 CDD:270713 110/309 (36%)
FATC 2440..2471 CDD:280430 5/21 (24%)
smg1XP_009297728.1 HEAT repeat 143..173 CDD:293787 6/29 (21%)
HEAT repeat 183..216 CDD:293787 9/32 (28%)
HEAT repeat 223..254 CDD:293787 7/38 (18%)
SMG1 622..1231 CDD:292413 112/654 (17%)
PIKKc_SMG1 2100..2406 CDD:270714 110/316 (35%)
FATC 3611..3640 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D26975at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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