DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tor and pik3c2b

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_003199535.1 Gene:pik3c2b / 567938 ZFINID:ZDB-GENE-050309-145 Length:1587 Species:Danio rerio


Alignment Length:1297 Identity:247/1297 - (19%)
Similarity:410/1297 - (31%) Gaps:488/1297 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1165 VFVPMVQR-------TLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELRPSRFKNNEPFVTD 1222
            :|.|.|.:       |||...:.|.     ||||.     .|....|.|. |.:..|:.:...  
Zfish   174 LFTPEVDQPKLSFGETLNYDNLNDS-----LSKIN-----GDWLSPGRSR-RANGDKSGKAVA-- 225

  Fly  1223 RNSNNKNLQV-------TTNELRTAWQVTRRVSKDDWVEWLKRLSIG------------LLKESP 1268
             .||....|:       |....|:    .||||.|.       :|:|            :.:|..
Zfish   226 -RSNTLPPQIPPRTYLPTPKSTRS----QRRVSVDP-------VSLGSRPNGFGYELFQVSEERD 278

  Fly  1269 SHALRACRSLAQEYDTLLRDLF-------NAAFISCWTELSPDL-KNELTQSLIQALQVTDMPE- 1324
            ......|..|     .|||..:       |:.|:  |   ||.: ::||.|.|..:::||...: 
Zfish   279 EEVAAFCHVL-----DLLRSAYPCNDYSKNSGFV--W---SPCVAQDELQQGLGVSIKVTVYSDH 333

  Fly  1325 ------------------ITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRAYAKALRYKEEE 1371
                              |.||:.     ..|.|.|.|.::..||...:.|             |
Zfish   334 FREPLTFSCDGSSTIDLLIYQTLC-----YAHDDLDMIDVDDYLLKICSQA-------------E 380

  Fly  1372 FLLREDSQVFESLILINNKLQQREAAEGLLTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLK 1436
            ||  :::|...|...|...|:.......:||: |::.|                     .|....
Zfish   381 FL--KNTQTLASFEYIQQCLKFDWDIRLILTK-RSSVN---------------------MELART 421

  Fly  1437 TDSSDLEARLGHMRCL-----------EALGDWSELSNVTKHEWENF--------------GTEA 1476
            |:..|..:.:.|...|           |||   :.|.:...:|.|:|              ....
Zfish   422 TEDDDTPSTMNHSILLQERPIKQTVTKEAL---TLLLDTFHNEAESFLLSEVELPLHVERLVQSV 483

  Fly  1477 KSRAGPLAAVAAWGLQDWEAMREYVRC----IPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRD 1537
            |:....||||....:.  .|:.:...|    .|:..:|.|    |||...:.....::|.....|
Zfish   484 KALCTSLAAVETPDIT--AALNQLPACPCRLQPKVQKDVS----VLAKKENRVAIVEKLTAAILD 542

  Fly  1538 LLDTELTSMAGESYERAYG--AMVCVQMLAELEEVIQYKLIPERREPLKTMWW-----------K 1589
            |::...::.....:...:.  :...:|....:..|:.:.:....|.|:.   |           .
Zfish   543 LVELYCSTFNANFHTMPHSSRSTAPIQEAGMVTNVLSFSVYAAHRVPIT---WAASYENFFLSCS 604

  Fly  1590 RLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPN 1654
            ...||..|              ..|.   ||       .::|.|.:|.|     |:..|.::   
Zfish   605 LTHGGVEL--------------CAPQ---HT-------SKQSVSKYLFH-----LVVWDQRV--- 637

  Fly  1655 QPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQRLMARCYLRM 1719
                |...|:           |||... .|||  |:.|:..|.  ||...:::.:          
Zfish   638 ----CFPVQI-----------NQLPRE-SQLT--VTLYATPLP--PPGGAEEKSK---------- 672

  Fly  1720 ATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASM 1784
               |.:..:|:                        .|......||:.|......|         :
Zfish   673 ---QKRSIESL------------------------GWVTMPLFNFRHVLTCGRKL---------L 701

  Fly  1785 GM---TMGSG---------LDSDLMIIQ----------RYAVPAVQGF-----FRSISLIKGNSL 1822
            |:   |.|||         ...|.:|:|          |::.||...|     |..:..:....|
Zfish   702 GLWPSTPGSGNARSSTPNFSQPDSVILQVDFPTSSFEVRFSTPAPAEFSPQYEFSHLDQVSQRQL 766

  Fly  1823 QDTLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIG 1887
            .|.|...:|:                        ||.  |:       .|:|:.:..:..     
Zfish   767 HDVLHKKSLF------------------------WLS--PE-------DRRLLWEKRYFC----- 793

  Fly  1888 KNHPQALVYPLTVASKSA----------SLARRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVA 1942
              |.:|...||.:||..:          :|.|:......||::...:.|..:|      |..|.|
Zfish   794 --HVEASRLPLVLASAPSWEWACLPDIYALLRQWGCMNHLDALGLLNATFPDQ------ECRRTA 850

  Fly  1943 ILWHEQWHEGLEEASRLYFGDRNVKGM-FEILEPLHA---MLERG--------------PQTLKE 1989
            :    ||.:.:.:...|.|..:.|:.: :|.....|.   :|.|.              ..||::
Zfish   851 V----QWMDSISDPELLDFLPQLVQALKYECYLDSHLVRFLLRRAIGDVRIAHYLFWLLKDTLQD 911

  Fly  1990 TSFSQAY-----------GRELTEAYEWSQRYKTSAVVMDLDRAW--DIYYHVFQKI------SR 2035
            :.||..|           ||.|.|.::              .:.|  ::...|.|::      ||
Zfish   912 SQFSVRYQYLLAALLCCSGRGLREEFD--------------RQCWLVNVLAKVAQRVREASPSSR 962

  Fly  2036 Q---------LPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRP 2091
            |         :.|..|:.        .:|:     :|  .|||..:..|:|  .:.....|...|
Zfish   963 QAILREGLDDVKQFFSIN--------SSCR-----LP--LNPGLLVKGINI--QSCSYFNSNAVP 1010

  Fly  2092 RKLCIRGSN--GKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLST 2154
            .||..:..:  |.:...:.|..:|||||...:|:..::|.:.:.:....|..:    :.......
Zfish  1011 LKLSFQNQDHLGDNINVIFKAGDDLRQDMLTLQIIRIMNKIWVQEGLDMRMVI----FRCFSTGR 1071

  Fly  2155 NSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGD 2219
            ..|::..:|..:||                                   :|::|.....|..:..
Zfish  1072 GRGMVEMIPSAETL-----------------------------------RKIQVEHGVTGSFKDR 1101

  Fly  2220 DLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFG 2281
            .||..|...:|:.|.:.:...|:..|.|...:..||||:.|||..|:|| :.||.:.|||||
Zfish  1102 PLADWLQKHNPTEEEYEKAVENFIYSCAGCCVATYILGICDRHNDNIML-KTSGHMFHIDFG 1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 247/1297 (19%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 24/133 (18%)
PIKKc_TOR 2075..2353 CDD:270713 48/209 (23%)
FATC 2440..2471 CDD:280430
pik3c2bXP_003199535.1 PI3K_rbd 322..413 CDD:295323 22/111 (20%)
C2A_PI3K_class_II 569..741 CDD:175979 45/272 (17%)
PI3Ka 763..928 CDD:294194 38/214 (18%)
PI3Kc_C2_beta 934..1287 CDD:119421 62/300 (21%)
PX_domain 1317..1425 CDD:295365
C2B_PI3K_class_II 1458..1579 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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