DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and atr

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_696163.5 Gene:atr / 567770 ZFINID:ZDB-GENE-070912-458 Length:2633 Species:Danio rerio


Alignment Length:2748 Identity:556/2748 - (20%)
Similarity:978/2748 - (35%) Gaps:795/2748 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 SAVFILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESAGEALRAALIVTAQRESTKQSSE 218
            |.|.:.|  .:.|..:...|...||.. |..:.|..||..||.        :....||..:.|  
Zfish   249 SMVLLTR--IVTLGGFPEDHSQPFFSA-FLHVLDSLPAFDESE--------LGVFSREFQQLS-- 300

  Fly   219 PQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIH--------GGLVVFNEL------------- 262
                |..:....|:.             :|.:|:|        ..|||...|             
Zfish   301 ----RCIFQHEEGAH-------------SRFERVHLNMLMERLEKLVVIGALEHLKVKEVKATLC 348

  Fly   263 -------------FRCANATWERRYTS-----LKTLFPKTQHNKFLE------------ASSSSS 297
                         :.||....:.|..:     :||:..|.||.:.||            |:....
Zfish   349 EVFCFILGFVPPGYECALQIRKERVAAICKALIKTIGTKDQHEQSLEGYLYAALKTDAIAAMQDV 413

  Fly   298 MGSQLNTLVPRLKVPFIDKLGSTQTHLGEGEHHKGVAK-------FASQHNV-------LESAYA 348
            ..|..:...||:   :.::|.:.:.:|......:...|       ..|:..|       ||....
Zfish   414 QASVSDPADPRM---YEEELPAKRPNLSLPTQLRSRDKTQPMQVDMKSRSEVWAAVDCRLEELLT 475

  Fly   349 QEILQEHYTSICDNVLE-----------------------QRTSKSPYVQQALL---QILPRLAA 387
            |  ::.|..|.|.:.::                       :::|:|..|.|.:.   |:|.::..
Zfish   476 Q--MRNHTVSQCVSAVQGLAVIFHLAALCSEHSLKGPQRGEKSSESSVVAQLIWLKPQMLAQVVE 538

  Fly   388 FNRAVFVEKYLQTCVSHLMQ-ILR----------GKEKDRT-----VAYITIGYMAVAVQSAIEV 436
            ..|.|....|.:..:.||:: |:|          ..|.|::     .|.:::.:  |...|:..|
Zfish   539 SCRTVLANNYNEEHLEHLVEGIVRILDAVLYLSTNSESDKSFHRNICALLSVPW--VLEHSSQSV 601

  Fly   437 HLSSIMTSVKVALPSKDLTSKRKVPVDPAVFA--CITLLAHAVKS-------------------- 479
            :.::...:..:||      |::..||..|...  |:.|||...||                    
Zfish   602 YQTASFPASLIAL------SQKLAPVYNAQTRAHCVFLLAPLSKSVCGDWRSSVYRWALQSKSEA 660

  Fly   480 EIADDVKD---ILEQMFYTGLSPALTVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAI-LPY 540
            |.|..|:.   :|.|:.....|......|..|.::..::|:.:. |:.|.|:..|...:.: .|.
Zfish   661 ERASAVRGFPILLHQLGVKSNSLIHEALLNRLQDSSTEVKTELA-GITGQLACCLSESSQLQFPQ 724

  Fly   541 TALPT--IAIDGSLMQNGDGATTVLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQ 603
            ..:|:  :...|..:.:...:.|    .::||     ..:..|:|.....    |..:::...::
Zfish   725 ETMPSHQLLCSGLSISDFHSSQT----SSIGT-----SILTPFLQLLKPV----EDMKVKQAFIK 776

  Fly   604 TCTRLLKLAVQSSESMENSKTLSDTVSHVIERLLMVAITDMDCNVRIRI---LRSLDETFDG--- 662
            ....|.| .|....:..::|.|.:.:.::||        |.|..|||..   :::|.|.::|   
Zfish   777 NIRHLFK-HVDLGNTDPDTKALVNALVNLIE--------DPDQEVRIMFGQNIKNLLEFWNGNGF 832

  Fly   663 ----------------KLAQPESLNSLFITLHDEIFEIRELAMVTIG-------RLSSINPAYVM 704
                            |.::...|.:..|....||....|..:|:..       .||..||..|.
Zfish   833 LKELLVSRLKEAYTNAKTSRNNELKNTLILTTGEIGRAAEGNLVSFALLRLLHCLLSKSNPVSVA 897

  Fly   705 PKLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHE------- 762
            .......:....|||...                     ..|.|.|||.:.||..||.       
Zfish   898 AYTEIQALATCRDLKLQS---------------------FFSQYRNPICQFLVESLHSRHVTALR 941

  Fly   763 --PESNPGVI-----------LNVLRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGSPDKR 814
              |:.:...:           |::|..:..:.:.    .::..:.:..|.:||..|....||...
Zfish   942 CTPDQSSEALQEEAAHQRELALDILSHVAHVFDF----PDLNRFLNRTLQVLLPFLAAKASPTAS 1002

  Fly   815 GVALWTLGQLISATGR-VVTPYHKYPVLIDILINFLKTEQRRS---IRRETIRVLGLLGAMDPYK 875
            .: :.|:.:.::...| ::....|| :...::.:..|.|..|:   ::.||...||.|...|   
Zfish  1003 AL-IRTIAKQLNVNRREMLINNFKY-IFSHLVCSCSKEELERAFHYLKNETEIELGSLLRQD--- 1062

  Fly   876 HKMNKGLIDSQKDNVLIAYSDGKVDESQDISTAELLVNMGNALDEYYPAVAIAALMRILRDPTLS 940
               .:||.:                        |||:.:|....:.:..:||.|......||...
Zfish  1063 ---FQGLHN------------------------ELLLRLGEHYQQVFNGLAILASFASSDDPYQG 1100

  Fly   941 TRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADNNLREFLFQQLAI--LVAFVKL--- 1000
            .|..:....:....|       |.|..:|  ...|::...::..|...:::|:  |::.:||   
Zfish  1101 PREITTPGCMADYLQ-------PKLLGIL--AFFNMQLLSSSAGEKEKKKMALNSLMSLMKLMGP 1156

  Fly  1001 -HIIS--------------YMGDIFKLIKEFWT----------INTPLQNTLINLI-------EQ 1033
             ||.|              |..|..:|....|.          :...|.:.::.|:       ::
Zfish  1157 KHISSVRVKMMTTLRTGLRYKDDFPELCCRTWDCFVRCLDPSYLGPLLSHVIVALLPLISIQPKE 1221

  Fly  1034 IAVALGC-------EFRDYLAELI-----PQI---------------------------LRVLQH 1059
            .||.:..       |.:|:|.|:.     |::                           :|.:||
Zfish  1222 TAVIMHYLIVENREEVQDFLHEIYFLPDHPELKIIHKVLQDYRKQTSKSTDMQAALQLSMRAIQH 1286

  Fly  1060 DNSKDRM-VTRRLLQALQKFGSTLGYYLPLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDF 1123
            :|...|: ....|.:.:.|....|          :..:.||..|...:|.  |.|:....||...
Zfish  1287 ENVDVRIHALTSLKEMIYKNQDAL----------LKHVLDSEMVEPVISQ--LVTVLLRGCQDVN 1339

  Fly  1124 TD---FSSRIIHPLVRV----LDAEPELRDQAMTTLRS----------LAKQLGKKYLVFVPMVQ 1171
            |:   .....:..|..:    ||..|.......:|..|          |..:|.:.:|.:...| 
Zfish  1340 TEARLLCGECLGELGAIDPGRLDLSPADTQGTGSTFVSGIDDPNFAYELLTELTRAFLAYADDV- 1403

  Fly  1172 RTLNKHRIVDP---EYEELLSKIKSCSTLADSYGAGESELRPSRFKN-NEPFVTDRNSNNKNLQV 1232
                  |..|.   ..:||||..:......||.|.......|.:.:. .||.:..|..:::.: |
Zfish  1404 ------RAQDAAAYAMQELLSLFECREGRTDSSGRRLWRRFPEQVQEILEPHLNTRYKSSQKV-V 1461

  Fly  1233 TTNELRTAWQVTRRVSK-DDW-VEWLKRLSIGLLKESPSHALRA----CRSLAQEYD-----TLL 1286
            ..::|:....::.|.|| .|| ..|     .|.|.....|.|..    |.|...::|     .||
Zfish  1462 NWSKLKKPIYLSSRGSKFSDWSATW-----AGYLISKVRHELAGKVFNCCSFIIKHDYKVTIYLL 1521

  Fly  1287 RDLFNAAFISCWTELSPDLKNELTQSLIQALQVTDMPEI--------------TQTILNLAEFME 1337
            ..:.....|.|    :.:.:.|:|:.::..|:..| |.:              |||:.::.:.:.
Zfish  1522 PHILVYVLIGC----TQEEQREVTEEIMAVLKEGD-PRLVRLQENASSLSQLSTQTVFSMLDHLT 1581

  Fly  1338 HCDRDPI-----------------------------------PIETKLLGTRAMACRAYAKALRY 1367
            ...|..:                                   .|...:|...:...|||.:|:.:
Zfish  1582 QWSRHKLQTLSTNKRTGKNAREQPPATGPENSEYQSVVAFLNSIPQDVLAKASFRSRAYTRAVMH 1646

  Fly  1368 KEEEFLLREDSQVFESLILINNKLQQREAAEGL--LTRYRNAANELNVQGRWYEKLHNWDEALEH 1430
             .|.|:..:...:.:.|..:..........:|:  :...|.....|..|...:|.:....|:...
Zfish  1647 -FESFIREKKQNIQDHLSFLQTLYAAMHEPDGVRGVNALRKEEPSLREQILEHESIGLLRESTAC 1710

  Fly  1431 YERNLKTDSSDLEARLGHMRCLEALGDWSELSNV---------TKHEWENFGTEAKSRAGPLAAV 1486
            |:|.::.:...|....|.|..:..||   :||.|         ::..|       ||........
Zfish  1711 YDRAIQLEPDQLAHYHGVMNSMLGLG---QLSTVITQVNGVLASRPRW-------KSDLNAYRVE 1765

  Fly  1487 AAWGLQDWEAMREYVRCIPEDTQDGSY----YRAVLAVHHDDFETAQRLIDETRDLLDTELTSMA 1547
            |||.|..|:.:.:|   :..|.:..::    .:.:||....|.|.....:...|......|::.:
Zfish  1766 AAWKLSKWDLVEDY---LASDCKSSTWGVRLGQMLLAAKKQDSEAFYEKLKIARKEQVVPLSAAS 1827

  Fly  1548 GE--SYERAYGAMVCVQMLAELEEVIQYKLIPE--------RREPLKTMWWKRL---QGGQRLVE 1599
            .|  :|:|.|..:|.:.||.|||.|.. :|..|        :.|| |..|...|   |...|..|
Zfish  1828 FECGTYQRGYEYIVRLHMLCELEHVFT-ELQKESSEAGRSKKPEP-KLNWDAHLLMTQNSFRAKE 1890

  Fly  1600 D---WRRIIQVHSLVVKPHEDI-HTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCN 1660
            .   .||.:...|......|.: ..||:.|.:.|::|    .|:|....|     ||...   .:
Zfish  1891 PVLALRRALLSLSKGSSCEEQVGECWLQSARVARRAG----HHQTAFNAL-----LNAEN---SH 1943

  Fly  1661 QPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQRLMAR--CYLRMATWQ 1723
            ..::.....|::.:...:.:|...|...|.      .|.|.:......:|:..:  ..|.:..:.
Zfish  1944 LSELFIEKAKWLWSKGDVHQALIVLQKGVQ------QCFPDDQTLTDPKRIQVKGNAMLLVGRYM 2002

  Fly  1724 NKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTM 1788
            .:.. :...:||   ::.::..|:..|.|...       ||.:.:    ..||..|      |..
Zfish  2003 EETA-NFESNAI---MKTYKDVTTLLPEWEDG-------NFYLAK----YYDKVMP------MVT 2046

  Fly  1789 GSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNS--LQDTLRLLTLWFDYGNHAEVYEALLSG--- 1848
            .:.|:....:| ||.|.    :|.. :|..||.  .|...|:||||.|:|  |:|||...:|   
Zfish  2047 DNKLERQGNLI-RYIVT----YFGK-ALQFGNQYIYQAMPRMLTLWLDFG--AKVYEFEKAGRSD 2103

  Fly  1849 -----MKLIEINT-------------WLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALV 1895
                 .:|.:||:             :|....|||:||......|..::.:::..:...:||..:
Zfish  2104 RVQMRTELTKINSVISDHTSNLSPYQFLTAFSQLISRICHSSNEVFAVLMEIVAKVFLAYPQQAM 2168

  Fly  1896 YPLTVASKSASLARRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLY 1960
            :.:|..|||:...|.|..                      :|:::.||..::.:.:.:.:|:|| 
Zfish  2169 WMMTAVSKSSYPTRMNRC----------------------KEILKKAISLNDSFMKFIGDANRL- 2210

  Fly  1961 FGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDI 2025
                           ...:||.|.:.:...|                     |.:.|      .:
Zfish  2211 ---------------TDKLLELGNKPVDGNS---------------------STLSM------SV 2233

  Fly  2026 YYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQEL-----IRISIIKTNLQVI 2085
            ::.:.:|:..: |..:.:.:|..|..:.|     |...|..||..:.     :.:|.....::::
Zfish  2234 HFKMLKKLVEE-PTFSQILIPLQSVLIPT-----LPSTGGANPKHDAFPGHWVYLSGFDDTVEIL 2292

  Fly  2086 TSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVI 2150
            .|.|:|:|:.::||:||.|..:.|..:|||:|.|:|:...|:|..|..|.::.||:|.|:.||||
Zfish  2293 ASLQKPKKISLKGSDGKFYTMMCKPKDDLRKDCRLMEFNCLINKSLRKDAESRRRDLRIRTYAVI 2357

  Fly  2151 PLSTNSGLIGWVPHCDTL-HTLIRDYRDKKKVPLNQEHRTML--NFAPDYDHLTLMQKV------ 2206
            ||:...|:|.||.....| |.|.:.|::|.......|.:.::  ..||..:.|.|.:.|      
Zfish  2358 PLNEECGIIEWVNKTAGLRHILTKLYKEKGIYVSGTELKKLILPKTAPFQEKLKLHKDVLCARHP 2422

  Fly  2207 EVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRM 2271
            .||.....:|..|          |:|  |:..|:.|.||.||||||||||||||||..|::.|..
Zfish  2423 PVFHEWFLRTFPD----------PTS--WYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSF 2475

  Fly  2272 SGKILHIDF------GDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLR 2330
            :|:.:|:||      |:.|:|       ||.:|||||:.::.||...|.||.:|:.||.::.::|
Zfish  2476 TGECVHVDFNCLFNKGETFDV-------PEVVPFRLTQNMVHAMGPMGTEGLFRQACEVILRLMR 2533

  Fly  2331 RNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLSNSVEDSLPMAKS 2395
            ..::.||:||:.|::|||:.|                                           |
Zfish  2534 DQREPLMSVLKTFLHDPLVEW-------------------------------------------S 2555

  Fly  2396 KPYDPTLQQGGLHNNVADET----NSKASQVIKRVKCKLTGTDFQTEK----SVNEQSQVELLIQ 2452
            ||..      |......:|:    |.||...:..::.:|.|......|    .::.:..|..|||
Zfish  2556 KPVK------GFSKTQVNESGEILNEKAKTHVLDIEQRLQGVIKNRNKVMGLPLSIEGHVHYLIQ 2614

  Fly  2453 QATNNENLCQCYIGWCPF 2470
            :||::..||..|:||.|:
Zfish  2615 EATDDNLLCMMYLGWGPY 2632

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 518/2543 (20%)
HEAT repeat 632..658 CDD:293787 8/28 (29%)
HEAT repeat 668..698 CDD:293787 8/36 (22%)
HEAT repeat 706..736 CDD:293787 3/29 (10%)
HEAT repeat 749..780 CDD:293787 10/50 (20%)
HEAT repeat 798..823 CDD:293787 7/24 (29%)
DUF3385 831..999 CDD:288698 31/172 (18%)
HEAT repeat 841..870 CDD:293787 8/31 (26%)
HEAT repeat 880..917 CDD:293787 6/36 (17%)
HEAT repeat 925..954 CDD:293787 6/28 (21%)
Rapamycin_bind 1937..2034 CDD:285924 13/96 (14%)
PIKKc_TOR 2075..2353 CDD:270713 107/292 (37%)
FATC 2440..2471 CDD:280430 12/31 (39%)
atrXP_696163.5 HEAT repeat 683..715 CDD:293787 6/32 (19%)
HEAT repeat 753..780 CDD:293787 3/30 (10%)
HEAT repeat 794..823 CDD:293787 9/36 (25%)
UME 1110..1216 CDD:214825 19/114 (17%)
HEAT repeat 1275..1301 CDD:293787 6/25 (24%)
HEAT repeat 1324..1353 CDD:293787 6/30 (20%)
FAT 1760..2084 CDD:280429 78/373 (21%)
TEL1 <2125..2633 CDD:227365 166/647 (26%)
PIKKc_ATR 2282..2556 CDD:270625 107/335 (32%)
FATC 2602..2633 CDD:280430 12/31 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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