DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and Mtor

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_064393.2	Gene:	Mtor / 56717	MGIID:	1928394	Length:	2549	Species:	Mus musculus

Alignment Length:	2597	Identity:	1390/2597 - (53%)
Similarity:	1795/2597 - (69%)	Gaps:	191/2597 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STTSVVQQFVNGLKSRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIFTMVNATDIN 66
            |..||:|||.:||||||...:.||.::|..||..|||||||||..:|:|:.:||||.:|:::|.|
Mouse    17 SNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDAN 81

  Fly    67 EKKGGALAMKCLINCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARSLVKLANMPTSKGADS 131
            |:|||.||:..||..||..:.|  |..:.|.||:||..:|..|||:|::::.:||....:..|:.
Mouse    82 ERKGGILAIASLIGVEGGNSTR--IGRFANYLRNLLPSSDPVVMEMASKAIGRLAMAGDTFTAEY 144

  Fly   132 FDFDIKKAFEVLRGERQEYRRHSAVFILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESA 196
            .:|::|:|.|.|..:|.|.|||:||.:||||||::||:|:|.:..||:.||.|::|||.||||.|
Mouse   145 VEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGA 209

  Fly   197 GEALRAALIVTAQRESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNE 261
            ..||||.||:|.||| .|:..:|||||..::||...|:..|..   :||:.|||||||.|::.||
Mouse   210 VAALRACLILTTQRE-PKEMQKPQWYRHTFEEAEKGFDETLAK---EKGMNRDDRIHGALLILNE 270

  Fly   262 LFRCANATWERRYTSLKTLFPKTQ----HNKFLEASSSSSMGSQLNTLVPRLKVPF--------- 313
            |.|.::...||....::.:   ||    |:|:  .......|::     ||...||
Mouse   271 LVRISSMEGERLREEMEEI---TQQQLVHDKY--CKDLMGFGTK-----PRHITPFTSFQAVQPQ 325

  Fly   314 -----IDKLG--STQTHLGEGEHHKGVAKFASQHNVLESAYAQEILQEHYTSICDNVLEQRTSKS 371
                 :..||  |.|..:|     .|.:...::..::||...:::::|.:..:|..||:.|:||:
Mouse   326 QPNALVGLLGYSSPQGLMG-----FGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRSSKN 385

  Fly   372 PYVQQALLQILPRLAAFNRAVFVE-KYLQTCVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIE 435
            ..:|..:|.:|||||||..:.|.: :|||..::|::..:: |||:||.|:..:|.::|||:|..:
Mouse   386 SLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVK-KEKERTAAFQALGLLSVAVRSEFK 449

  Fly   436 VHLSSIMTSVKVALPSKDLTSKRK--VPVDPAVFACITLLAHAVKSEIADDVKDILEQMFYTGLS 498
            |:|..::..::.|||.||...||:  |.||..||.||::||.|:...|..|:|::||.|...|||
Mouse   450 VYLPRVLDIIRAALPPKDFAHKRQKTVQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLS 514

  Fly   499 PALTVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYTALP-----TIAIDG--SLMQNG 556
            ||||..|.:||..:||||..|.:||:.:||.|||:|.  |.:..:|     .:|..|  :|.:..
Mouse   515 PALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKP--LRHPGMPKGLAHQLASPGLTTLPEAS 577

  Fly   557 DGATTVLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTCTRLLKLAVQ--SSESM 619
            |.|:..|||:|||:|.||..::..||:.|||:|:..|.:|||:||.:||:|||..::.  |..:.
Mouse   578 DVASITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAH 642

  Fly   620 ENSKTLSDTVSHVIERLLMVAITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEI 684
            ..|:|....|:.|:.:||:|.|||.|.::|..:|.||||.||..|||.|:|.:||:.|:|::|||
Mouse   643 VVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEI 707

  Fly   685 RELAMVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYM 749
            ||||:.|:|||||:|||:|||.||..:|:::|:|::||:.|.|||||:||.|||.:.||||..||
Mouse   708 RELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYM 772

  Fly   750 NPILKALVPKLH--EPESNPGVILNVLRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGSPD 812
            .||||||:.||.  :|:.|||||.|||.|||:||:|:|  .||..|.|:|..|:::||.|:....
Mouse   773 EPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSG--LEMRKWVDELFIIIMDMLQDSSLLA 835

  Fly   813 KRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIRRETIRVLGLLGAMDPYKHK 877
            ||.|||||||||:::||.||.||.|||.|:::|:|||||||.:..|||.|||||||||:||||||
Mouse   836 KRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK 900

  Fly   878 MNKGLIDSQKDNVLIAYSDGK-VDESQDISTAELLVNMGN-ALDEYYPAVAIAALMRILRDPTLS 940
            :|.|:||..:|...::.|:.| ..:|.|.||:|:|||||| .|||:||||::.|||||.||.:||
Mouse   901 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLS 965

  Fly   941 TRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADNNLREFLFQQLAILVAFVKLHIISY 1005
            ..||.||||:||||:|||:|||.:|.||:|..|:.:|..|..:||||||||.:||:|||.||..|
Mouse   966 HHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPY 1030

  Fly  1006 MGDIFKLIKEFWTINTPLQNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRMVTRR 1070
            |.:|..|::|||.:||.:|:|:|.|||||.||||.||:.||.:|||.:|||..||||:.|:|:.:
Mouse  1031 MDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSQGRIVSIK 1095

  Fly  1071 LLQALQKFGSTLGYYLPLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLV 1135
            ||.|:|.||:.|..||.|:|||||||||:|.||......||||::.|...|||||::||||||:|
Mouse  1096 LLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVDRLTESLDFTDYASRIIHPIV 1160

  Fly  1136 RVLDAEPELRDQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADS 1200
            |.||..||||..||.||.||..||||||.:|:|||.:.|.:|||....|:.|:.:|....||||
Mouse  1161 RTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLAD- 1224

  Fly  1201 YGAGESELRPSRFKNNEPFVTD----RNSNN-------------KNLQVTTNELRTAWQVTRRVS 1248
                         :..:|.:..    |:|..             |.|.|:|..|:.||...||||
Mouse  1225 -------------EEEDPLIYQHRMLRSSQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVS 1276

  Fly  1249 KDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISCWTELSPDLKNELTQSL 1313
            ||||:|||:|||:.|||:|.|.:||:|.:|||.|:.:.||||||||:|||:||:.|.::||.:|:
Mouse  1277 KDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSI 1341

  Fly  1314 IQALQVTDMPEITQTILNLAEFMEHCDRDPIPIETK----LLGTRAMACRAYAKALRYKEEEFLL 1374
            ..||...|:.|:|||:|||||||||.|:.|:|:...    |||.||..||||||||.|||.||..
Mouse  1342 ELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQK 1406

  Fly  1375 REDSQVFESLILINNKLQQREAAEGLLTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLKTDS 1439
            .....:.||||.|||||||.|||.|:|........||.:|..||||||.|::||..|::.:.|:.
Mouse  1407 GPTPAILESLISINNKLQQPEAASGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNK 1471

  Fly  1440 SDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCI 1504
            .|.|..||.||||||||:|.:|......:|.....|.:::...:||.|||||..|::|.||...|
Mouse  1472 EDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMI 1536

  Fly  1505 PEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEE 1569
            |.||.||::||||||:|.|.|..||:.||:.|||||.|||:||||||.|||||||...||:||||
Mouse  1537 PRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEE 1601

  Fly  1570 VIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGSL 1634
            ||||||:|||||.::.:||:||||.||:||||::|:.|.||||.||||:.|||||||||.|||.|
Mouse  1602 VIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRL 1666

  Fly  1635 HLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCL 1699
            .|:|||||:|||.||....:.|||...|||||||.|.|..:.:..:|::.:.|||.|..|:..
Mouse  1667 ALAHKTLVLLLGVDPSRQLDHPLPTAHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQ-- 1729

  Fly  1700 PPEALKQQDQ-------RLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWH 1757
              .|:..:||       :|||||:|::..||..|| .|....|...|:.:..||.:|.:||||||
Mouse  1730 --HAIATEDQQHKQELHKLMARCFLKLGEWQLNLQ-GINESTIPKVLQYYSAATEHDRSWYKAWH 1791

  Fly  1758 LWAYMNFKVV---QAQKSALDKQQ--------------------PPGASMGMTMGSGLDSD---- 1795
            .||.|||:.|   :.|..|.|:::                    ...|:...|.||..:|:
Mouse  1792 AWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAASAAAATSTEGSNSESEAESN 1856

  Fly  1796 --------------------LMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAE 1840
                                |::   |.|||||||||||||.:||:||||||:||||||||:..:
Mouse  1857 ENSPTPSPLQKKVTEDLSKTLLL---YTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPD 1918

  Fly  1841 VYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSA 1905
            |.|||:.|:|.|:|:|||||||||||||||.|.|||:||||||.|||:.|||||:|||||||||.
Mouse  1919 VNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKST 1983

  Fly  1906 SLARRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMF 1970
            :.||.|||.|||.:|.:||.|||:||:|.|||||||||||||.||||||||||||||:|||||||
Mouse  1984 TTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMF 2048

  Fly  1971 EILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISR 2035
            |:|||||||:||||||||||||:|||||:|.||.||.::|..|..|.||.:|||:|||||::||:
Mouse  2049 EVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISK 2113

  Fly  2036 QLPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSN 2100
            ||||||||||.||||||:.|:||||||||:|:|.|.:|||..|..:|||||||||||||.:.|||
Mouse  2114 QLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSN 2178

  Fly  2101 GKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHC 2165
            |.::::||||||||||||||||||.||||||.:||.:.|:||:||||||||||||||||||||||
Mouse  2179 GHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHC 2243

  Fly  2166 DTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSP 2230
            ||||.||||||:|||:.||.|||.||..|||||||||||||||||||:..|.|||||||||||||
Mouse  2244 DTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSP 2308

  Fly  2231 SSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPE 2295
            |||:||:||.||||||||||||||||||||||||||||||:||||||||||||||||||||||||
Mouse  2309 SSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPE 2373

  Fly  2296 KIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKG 2360
            ||||||||||..||||||::|.||.||.:||.|||.:|||:|||||||||||||||||:|.:.||
Mouse  2374 KIPFRLTRMLTNAMEVTGLDGNYRTTCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKG 2438

  Fly  2361 NDAVAGAGAPGGRGGSGMQDSLS--NSVE--DSLPMAKSKPYDPTLQQGG------LHNNVAD-- 2413
            |           :......||.|  .|||  |.:.:.     :|..::.|      :|:.:.|
Mouse  2439 N-----------KRSRTRTDSYSAGQSVEILDGVELG-----EPAHKKAGTTVPESIHSFIGDGL 2487

  Fly  2414 ----ETNSKASQVIKRVKCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPFW 2471
                ..|.||.|:|.||:.||||.||..:.:::..:||||||:|||::||||||||||||||
Mouse  2488 VKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW 2549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	1251/2285 (55%)
		HEAT repeat	632..658	CDD:293787	12/25 (48%)
		HEAT repeat	668..698	CDD:293787	18/29 (62%)
		HEAT repeat	706..736	CDD:293787	15/29 (52%)
		HEAT repeat	749..780	CDD:293787	21/32 (66%)
		HEAT repeat	798..823	CDD:293787	12/24 (50%)
		DUF3385	831..999	CDD:288698	102/169 (60%)
		HEAT repeat	841..870	CDD:293787	19/28 (68%)
		HEAT repeat	880..917	CDD:293787	17/38 (45%)
		HEAT repeat	925..954	CDD:293787	18/28 (64%)
		Rapamycin_bind	1937..2034	CDD:285924	75/96 (78%)
		PIKKc_TOR	2075..2353	CDD:270713	228/277 (82%)
		FATC	2440..2471	CDD:280430	21/30 (70%)
Mtor	NP_064393.2	Interaction with NBN. /evidence=ECO:0000250	1..651		264/657 (40%)
		TEL1	363..2549	CDD:227365	1240/2228 (56%)
		HEAT 16	637..683		18/45 (40%)
		HEAT repeat	655..681	CDD:293787	12/25 (48%)
		HEAT 17	686..724		23/37 (62%)
		HEAT repeat	691..721	CDD:293787	18/29 (62%)
		HEAT 18	727..766		20/38 (53%)
		HEAT repeat	729..759	CDD:293787	15/29 (52%)
		HEAT 19	769..811		26/43 (60%)
		HEAT repeat	772..805	CDD:293787	21/32 (66%)
		HEAT 20	814..853		19/38 (50%)
		HEAT repeat	817..847	CDD:293787	15/29 (52%)
		DUF3385	854..1024	CDD:288698	102/169 (60%)
		HEAT 21	857..893		24/35 (69%)
		HEAT 22	894..942		24/47 (51%)
		HEAT 23	943..988		31/44 (70%)
		HEAT repeat	955..981	CDD:293787	18/25 (72%)
		HEAT 24	989..1027		20/37 (54%)
		HEAT repeat	993..1021	CDD:293787	14/27 (52%)
		HEAT 25	1029..1068		22/38 (58%)
		HEAT repeat	1033..1062	CDD:293787	15/28 (54%)
		HEAT 26	1069..1105		19/35 (54%)
		HEAT repeat	1073..1099	CDD:293787	14/25 (56%)
		HEAT 27	1106..1144		21/37 (57%)
		HEAT repeat	1111..1142	CDD:293787	18/30 (60%)
		HEAT 28	1145..1188		29/42 (69%)
		HEAT repeat	1154..1180	CDD:293787	17/25 (68%)
		HEAT 29	1189..1225		15/49 (31%)
		HEAT 30	1226..1273		10/46 (22%)
		HEAT 31	1274..1311		24/36 (67%)
		HEAT 32	1312..1345		17/32 (53%)
		TPR 1	1346..1382		17/35 (49%)
		TPR 2	1383..1408		17/24 (71%)
		TPR 3	1409..1442		16/32 (50%)
		TPR 4	1443..1473		13/29 (45%)
		TPR 5	1474..1507		14/32 (44%)
		TPR 6	1508..1541		14/32 (44%)
		TPR 7	1542..1574		20/31 (65%)
		TPR 8	1575..1614		31/38 (82%)
		TPR 9	1615..1649		20/33 (61%)
		TPR 10	1650..1693		27/42 (64%)
		TPR 11	1694..1731		15/40 (38%)
		TPR 12	1732..1786		18/54 (33%)
		TPR 13	1787..1846		16/58 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1825..1867		5/41 (12%)
		TPR 14	1898..1930		21/31 (68%)
		TPR 15	1931..1970		30/38 (79%)
		TPR 16	1971..2005		22/33 (67%)
		Sufficient for interaction with the FKBP1A/rapamycin complex	2012..2144		104/131 (79%)
		Rapamycin_bind	2015..2112	CDD:285924	75/96 (78%)
		PIKKc_TOR	2153..2431	CDD:270713	228/277 (82%)
		Interaction with MLST8. /evidence=ECO:0000250	2258..2296		28/37 (76%)
		FATC	2518..2549	CDD:280430	21/30 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849821
Domainoid	1	1.000	646	1.000	Domainoid score	I162
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3637
Inparanoid	1	1.050	2542	1.000	Inparanoid score	I30
Isobase	1	0.950	-	0.896241	Normalized mean entropy	S1632
OMA	1	1.010	-	-		QHG53650
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003052
OrthoInspector	1	1.000	-	-		oto93833
orthoMCL	1	0.900	-	-		OOG6_100794
Panther	1	1.100	-	-	LDO	PTHR11139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1538
SonicParanoid	1	1.000	-	-		X2407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740