DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and prkdc

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	XP_009301676.1	Gene:	prkdc / 562283	ZFINID:	ZDB-GENE-030131-9008	Length:	4119	Species:	Danio rerio

Alignment Length:	3243	Identity:	638/3243 - (19%)
Similarity:	1124/3243 - (34%)	Gaps:	1033/3243 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TTSVVQQFVNGLKSRNRNVQNKA----------------------TQDLLFYV-------KTELR 38
            :...|||..:.|....|.:::||                      ..:::.::       :||.|
Zfish  1134 SVGTVQQCCSSLDHLKRIIKHKADSLNINSKRRIPRGFPADQSVCLSNVVLWLLTQCGRPQTECR 1198

  Fly    39 EMSQEELAQFFDEFDHHIFTMVNATDINEKKGGALAMKCLINCEG-----SLTARKGISPYLNR- 97
            ..|.|...:|......:....:...:..:::|....:.||   ||     ..|.|:..:|:..|
Zfish  1199 HKSMELFFEFVPLLPGNSSPAMWLDEQLKQRGPGFLISCL---EGGGLLSQPTLREIEAPFSIRG 1260

  Fly    98 ---LRDLLL------------------------------------INDVSVMEI-AARSLVKLAN 122
               ..||||                                    :.::|:.:| |||:..:|.|
Zfish  1261 TLQWMDLLLAALDCYNTFTNLRCLQLQRILGTCEKSSFLPAVHFFLTELSMQDIQAARACFRLGN 1325

  Fly   123 MPTS----KGADSFDFD----IKKAFE----VLRGERQEYRR-------HSAVFILRELAIALPT 168
            ...|    :..:.:::.    |.:..|    ||:...|:..:       :|::|.|..||:..|:
Zfish  1326 AGQSHFSPRETEQYNYSKCSIIVRMLEFSTMVLQKCPQDLWKLMEKDVFNSSLFTLVVLAVCEPS 1390

  Fly   169 YF-----YQHILTFF-EVIFNAIFDPKPAIRESAGEALRAALIVTAQRESTKQSSEPQWYRIC-- 225
            ..     ...::|.. ||.|       |.::..|....|..|....:...||||.|    .:|
Zfish  1391 SIGFNMADLEVMTHLPEVCF-------PLLKALASAPYRTQLESCIRMRITKQSVE----ELCAI 1444

  Fly   226 --YD----EANGSFNADLGSSKDQKGVTRDDRIH-GGLVVFNELFRCANATW-----ERRYTSL- 277
              |:    .::.|.|..|.:.:         ::| .||:  |.:....:|::     .:..||:
Zfish  1445 DLYETDTRNSHASMNLLLSACR---------QLHQSGLL--NSVLHSQDASYGCSLGSKLLTSVY 1498

  Fly   278 KTLFPKTQHNKF--------------------LEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQT 322
            |::.|.|.....                    |...|..::|..|||:.  |.||....|.....
Zfish  1499 KSIAPGTDRKSLPSMDVGSRKLADRLVQLSFCLGDQSEQTVGLLLNTIT--LSVPLSGSLNPHFL 1561

  Fly   323 HLGEGEHHKGVAKFASQHNVLESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQALLQILPRLAA 387
            ....||:.         :::.:::...|:|:....|:  .:|....:::|.:...||..:...:.
Zfish  1562 SFSHGEYF---------YSLFQTSLNTELLRSVDRSV--PLLLSSANQNPSMVSVLLNGMLDHSF 1615

  Fly   388 FNRAV-------FVEKYLQ--------------------TCVSHLMQILRGKEKDRTVAYIT--- 422
            ..|:|       ..|:.|:                    :.:|.|.::|   :.|.:|...|
Zfish  1616 RERSVRKSQGSQLAEQVLKGWDLLRPWWDGPAATPESKTSVLSLLAKVL---QIDSSVCSNTSHP 1677

  Fly   423 ------IGYMAVAVQSAIEVHLSS---IMTSVKVALPSKDLTSKRKV---------PVDPAVFA- 468
                  ..:.|:....::.::|.|   ||.....||||..|...|:.         |:....|.
Zfish  1678 AFNAVFTTFTALLTDVSMPLNLKSQALIMLPFFTALPSMPLEELRRALESLVATHFPMQSDEFPR 1742

  Fly   469 ----------CI------------TLLAHAVKSEIADDVKDILEQMFYTGLSPALTVCLRE---- 507
                      ||            .||...:...:..|.|.|:|::|        ..|.::
Zfish  1743 GSLQCNNYMDCIRKFLEALQLSQSPLLLKLMARVLCRDKKHIMEELF--------QACFQKIAHQ 1799

  Fly   508 --LSENVPQLKSAITE----------GLIGILSQVLMNKAAILPYTALPTIAIDGSLMQNGDGAT 560
              |.:.|..|.|....          .|:|::.:||:..|:.....||....|...       |.
Zfish  1800 SYLGKQVLLLSSTYQSFQAKEVPSNFMLMGLIDRVLLPLASHCSPQALSQFFISNI-------AD 1857

  Fly   561 TVLALKTLGTFN----FEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTCTRLLKLAVQS------ 615
            .:..|:|..|.:    ||.|.|:..  .|...          ||.:.  :||.|..|.|
Zfish  1858 IMTTLQTRFTKSVESVFESQIMMKI--GCCKL----------LEVLY--SRLPKEEVYSKNSAIN 1908

  Fly   616 --------SESMENSKTL------SDTVSHVIERLLMVAITDMDC---NVRIRILR-SLDET--F 660
                    :|..|.||.|      :.|.:...|.:|:.......|   |..|.::. |.:||  :
Zfish  1909 QAFCGTGCAEGNELSKNLLKSCFEAFTENMTGEMVLLELRRQFHCAAYNCAIALISCSFNETKFY 1973

  Fly   661 DGKL--AQPESLNSLFITLHD---------EI---FEIRELAMVTIGRLSSIN---PAYVMPK-- 706
            .|.|  .:|:....:|..|.|         ||   .|.::..::....:|..|   |.|:..:
Zfish  1974 QGFLFTEKPDKNQFIFDNLIDSQRVYNFPIEIDVPIERKKKYVMIRKEVSGENGDAPVYLSSQSY 2038

  Fly   707 -LRTTMIELITDLKYS----GMSRNKE------QSAKMLDHL-VISTPRLISSYMNPILKALVPK 759
             ..:::.|.::...:|    ..|.|.:      .|::|.:.. |:|....:...|:.:      .
Zfish  2039 MADSSLSEEMSQFDFSTGVQSFSYNSQNPSGVSSSSRMRERKEVLSQDETVELEMDEL------N 2097

  Fly   760 LHEPESNPGVILNVLRTIGDLAEVNGGSDEMEL--WADDLLSILLEMLGDAGSPDKRGVALWTLG 822
            .||..:|...:|..::......:|..|....:|  |    :..|...|.:..:|  ..:.|: :.
Zfish  2098 QHECMANMTALLRHMQRNNITPKVEEGVRPSDLPPW----MKFLQGKLDNPSTP--LNIRLF-IA 2155

  Fly   823 QLISATGRVVTPYHKY---PVL-----------------IDILINFLK----TEQRRSIRRETI- 862
            :||..|..:..||.|:   |::                 :||::..|.    ...:.:.|.|.:
Zfish  2156 KLIINTEEIFRPYAKHWLGPLMQLVVSSSNGGEGIHFMVVDIVVTVLSWASVASPKGNTRDEVLV 2220

  Fly   863 -RVLGLL------GAMDPYKHKMN--KGLIDSQKDNVLIAYS------DGKVDESQDISTA-ELL 911
             |:||.|      .....::|.:.  :.:::..||.:.|.|.      .|....|:|.|.. :||
Zfish  2221 NRLLGFLFKNCFHSKRAVFRHNLEIIRTVVECWKDCLTIPYDLIYERFAGTDPNSKDNSVGIQLL 2285

  Fly   912 -VNMGNALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSL--GIKCVPY------LAQ 967
             :.|.|.|..|              |......|..       .||||  .:..:.|      .|:
Zfish  2286 GIVMANNLPPY--------------DAACGIEHDR-------YFQSLANNLSFIRYKEVYSAAAE 2329

  Fly   968 VLPNLLDNVRTADNNLREFLF----------------QQLAILVAFVKLH----IISYMGDIFKL 1012
            |:..:|:.:...:|.:...||                .:..:.::.|..|    :..::..:|.|
Zfish  2330 VIGLILNYMTERENQIEGTLFNITVTKLMDLRKKEVDDKFIVCLSKVSKHFPPLVDRFINPVFYL 2394

  Fly  1013 IKE-----------------------FWTINTP------------LQNTLINLIEQIAVALGCEF 1042
            :.:                       |..:.|.            .|...:::|.:|   |.|..
Zfish  2395 LPKLHGMLKTHCLECVLSRADVIPEIFLHLKTKGLSQIMSHKDEGRQRVCLDIIHKI---LACLK 2456

  Fly  1043 RDYLAELIPQILRVLQH-----------------DNSKD-------------RMVTRRLLQALQK 1077
            .:.|.|::..:.....|                 ||..|             .:....|||.|..
Zfish  2457 PEELKEILGAVTAFASHPSPVCRERMYDILMWIQDNYSDSESREDSTSVEVLSVARETLLQGLTD 2521

  Fly  1078 FGSTLGYYLPLI------LPP--------IVKLFDSPYVPQQVSMVALETINNLACQLDFT---- 1124
            ....|..|:...      |||        ::|...|..:.:|...:|.:.:      |:.|
Zfish  2522 ENYGLQLYVRNFWSHESRLPPETLERMLVVLKSLYSSRIEEQFLSLATDLL------LEMTSHSP 2580

  Fly  1125 DFSSRIIH-PLVR------VLDAEPELRDQAMTTL------------------------------ 1152
            ||:..:.. ||..      .:|:...:|...:|.:
Zfish  2581 DFTRNMFEFPLSECKFQDYTIDSNWRMRSTVLTPMFMETQATQGAEAAGSQAATVRGQIRATQTS 2645

  Fly  1153 ----RSLAKQLGKK--YLVFVPMVQRTLNKHRIVDPEYEELL----------------------- 1188
                ::||...|::  |.........||..:.:.......||
Zfish  2646 LEFSQTLAPGAGRRSAYNWLTGSSVDTLADYSLSSDSLSSLLVFDKKRSERPQAAWRAVGAGFGS 2710

  Fly  1189 SKIKSCSTLADSYGAGESELRPSRFKNNEPFVTDRNSNNKNLQVTTNELRTAWQVTRR------- 1246
            .::.:.|...||..|.|.|.|....:....|:.|:  ..::::....|:.:  |.|.|
Zfish  2711 KRLTATSDDTDSRTAAERERRADILRLRRRFLKDK--EKESIKFAKKEIHS--QRTERERRADLK 2771

  Fly  1247 VSKDDWVEWLKRLSIGLLKESP---SHALRACRSLAQEYDTLLRDLFNAAFISCWTELSPDLKNE 1308
            :.:|..|...:...:|.|.:..   |..:...::|||...||.:.||::.|.....|:.....|:
Zfish  2772 IRQDAQVTLYRSYRVGDLPDIQIQFSSLIAPLQALAQRDATLAKQLFSSLFAGVLVEMERLKSNK 2836

  Fly  1309 LTQSLIQALQVTDMPEITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRAYAKALRYKEEEFL 1373
            .|..:::.|..|....:.::.:....|:. |.:|.......|||.......|...|...:....|
Zfish  2837 ETADILKELVQTLNAFLNKSTVYFPPFIS-CIQDMSYHHKALLGVEPSLVSATCLASLQQPMGIL 2900

  Fly  1374 LREDSQVFESLILINNKLQQREAAEGLLTRYRNAANELNVQGRW------YEKLHNWDEALEHYE 1432
            |.|:|       |::......|..   |.|.|..........||      |..|.::|.....:.
Zfish  2901 LLEES-------LLHGAGASEEPP---LKRARGKRELPPDTERWIHLAKLYRSLGDYDVVRGIFS 2955

  Fly  1433 RNLKTDS---SDLEARLGHMRCLEALGDWSE---LSN--VTKHEWENFG--TEAKSRAGPLAAVA 1487
            ..:.|.|   :.|:|        ||..|::|   |.|  :.|.:|:: |  |..:.....:||:.
Zfish  2956 GKIGTKSITFTALQA--------EAKSDYAEAVKLYNEALNKEDWDD-GEPTITEKDFWEIAALE 3011

  Fly  1488 AWG-LQDWEAMREY-------------------------------VRCIPEDTQDGSYYRAVLAV 1520
            |:. |.:|::: ||                               :|.:.:..|.|...:.:|:.
Zfish  3012 AYNHLTEWKSL-EYCATVNIDDSSPIRLDRMWTETFYVETYLQYMMRSMLKQLQMGETNQDLLSF 3075

  Fly  1521 HHDDFETAQ-RLIDETRDLLDTELTSMAGESYERA-YGAMVC----------------------- 1560
            .....:|.: ::|.||....:..|..:..|.|:|| |.|..|
Zfish  3076 VDAAMKTEEHKIIMETHYSQELSLLYILQEDYDRAKYYANNCMQVFMQNYSSIDPLLNRSRLTVL 3140

  Fly  1561 --VQMLAELEEVIQY----------KLI--------PERREPLKTMW--------------WKRL 1591
              ||.|.|:::.:.|          |.:        |:.:.....:|              .|||
Zfish  3141 QSVQALTEIQDFLNYITGDVSVNSLKFMIRRWTSHYPDAKLDPMNVWDDIITSRCFFLDKILKRL 3205

  Fly  1592 --------------QG-GQRL--------------VED--WRR-IIQVHSLVVKPHEDIHTWLKY 1624
                          || |:.|              :.|  |:: ...|.|.::|   ::|...|.
Zfish  3206 KSTPENSMEVDGADQGSGEELGVLVKTCKFNMKLQMADSAWKQNNFPVASKLLK---ELHRHAKI 3267

  Fly  1625 --ASLCRKSGSL-HLSHKTLVMLLGTDPKLN---PNQPLPCNQPQVTYAYTKYMAANNQLQEAYE 1683
              |.|.|...|. ..:||.:.. ||...|:|   ...||                    |::|..
Zfish  3268 DDARLLRWVHSFSRFTHKRIAR-LGPSEKINALLKTVPL--------------------LKDAER 3311

  Fly  1684 QLTHFVSTYSQELSCLPPEALKQQDQR-LMARCYLRMA------------TWQNKLQDSIR---- 1731
            |        |:.||     |...:||| |:...|..||            ..:.|:|..::
Zfish  3312 Q--------SEALS-----ARMLRDQRILLGTTYDLMAGAADRSPFALETLGEEKVQKILQLSQA 3363

  Fly  1732 ---PDAIQG----ALECFEKA---TSYDPNWYKAWH------LWAYM---NFKVVQAQKSALDKQ 1777
               ...::|    |||....|   ...:...:...|      :.|||   ||    ..:...:.:
Zfish  3364 SSIAQVVEGLQIQALELLRSAACKAEEEEQSFSQQHVNTHGIVEAYMTMANF----CDRRLRESE 3424

  Fly  1778 QPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTL---RLLTLWFDYGNHA 1839
            |...|         :.|.|..:..:.|..:      :..:|.:|.:..|   |||.|       .
Zfish  3425 QKEEA---------ISSKLQSLPEHVVKMM------LKALKLSSEEARLKFPRLLQL-------V 3467

  Fly  1840 EVYEAL---LSGMKLIEINTWLQV--IPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLT 1899
            |||.|.   |...:::.:..||.:  |.|::|.:|..:   ...:..::.:|.:.:||||:||..
Zfish  3468 EVYPAETLDLMVREVVSVPCWLLIGWISQMMALLDKPQ---ATAVQHVIEEIAECYPQALIYPYM 3529

  Fly  1900 VAS------KSASLARRNAAF-----KILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGL 1953
            ::|      :||| .:||..|     .:||     ...:::..|...::|....:|:.:.|.|..
Zfish  3530 ISSENYTFEESAS-GQRNREFVEKLESLLD-----KGGVIQGFVDALQQLSNPEMLFKDWWDEVK 3588

  Fly  1954 EEASRLYFGDRNVK--GMFEIL----EPLHAMLERGPQTLKETSFSQAYGREL--------TEAY 2004
            .:..:.....:.:|  .|.|:|    .|......|        .|.|.:.:|:        ::.|
Zfish  3589 NQLDKPNLDKKKMKLQYMTELLGDAKSPRFGSYRR--------KFIQKFSKEVEKLLGAGGSKLY 3645

  Fly  2005 EWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSP-KLMTCKDLELAVPGSYNP 2068
            |   |.|....:..:||... ....|||....:.:.:    |::|. |..|.|: ||.|||.|:.
Zfish  3646 E---RRKDKDFLQQVDRMVQ-SMRGFQKEPGNMKEYS----PWLSSFKAETLKN-ELEVPGQYDG 3701

  Fly  2069 GQELI-----RISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVN 2128
            ..:.:     :|:.....::|:||.:||:::.|||.:.:||.:|:||.||||||:|:.|||.::|
Zfish  3702 KSKPLPEYHAKITGFDERVKVMTSIRRPKRIIIRGDDERDYPFLVKGGEDLRQDQRIEQLFGVMN 3766

  Fly  2129 TLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNF 2193
            .:|..|....:|:||::.|.|||:::..|||.|:.:..||    :|:...::.  .||.:|:...
Zfish  3767 MILSQDTACSQRSLALRTYQVIPITSRIGLIEWMENTCTL----KDFLSSRRT--EQEQKTITRP 3825

  Fly  2194 APDYDHLT---------LMQKVEVFEHA-----------LGQTQGDDLAKLLWLK-SPSSELWFE 2237
            ...||...         :.:..|:::.|           :.|...|||.|..::: |.:.|.:..
Zfish  3826 NEFYDEWISKVAGKVEGIRRYAELYKKAKRVDTVNNFRRIEQMVPDDLLKRAFVRMSTTPEAFLS 3890

  Fly  2238 RRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLT 2302
            .|::::.|.||:.:..:|||:||||.||.|::..:|.::.||||..|..|......||.:|||||
Zfish  3891 LRSHFSSSHAVLCISHWILGIGDRHLSNFMINTETGGMIGIDFGHAFGSATQFLPVPELMPFRLT 3955

  Fly  2303 RMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVD--KKGNDAVA 2365
            |..|..|......|..:......:...|...|.|:..::.||.:|.|:|:..::.  |||.....
Zfish  3956 RQFINLMRPLAESGLIQSVMVHSLRAFRAEPDLLLNTMDVFVKEPSLDWKNFELKQLKKGGTWTE 4020

  Fly  2366 GAGAP------------GGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTL------QQGGLHNNVA 2412
            .....            ..|...|...|:..|.|..|...|...|...|      :|..:...:|
Zfish  4021 SVNTKEINWFPLQKVNFARRKLEGTNPSVITSEELCLGFEKMPEYKGLLAVARGEEQHNIRARLA 4085

  Fly  2413 DETNSKASQVIKRVKCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPF 2470
            |                         |.:..:.||:.|:.|||:...|.:.:|||.|:
Zfish  4086 D-------------------------KDLTVEDQVDCLLDQATDPNILGRVWIGWEPW 4118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	559/2803 (20%)
		HEAT repeat	632..658	CDD:293787	6/29 (21%)
		HEAT repeat	668..698	CDD:293787	7/41 (17%)
		HEAT repeat	706..736	CDD:293787	6/42 (14%)
		HEAT repeat	749..780	CDD:293787	5/30 (17%)
		HEAT repeat	798..823	CDD:293787	4/24 (17%)
		DUF3385	831..999	CDD:288698	41/233 (18%)
		HEAT repeat	841..870	CDD:293787	9/57 (16%)
		HEAT repeat	880..917	CDD:293787	11/44 (25%)
		HEAT repeat	925..954	CDD:293787	2/28 (7%)
		Rapamycin_bind	1937..2034	CDD:285924	22/110 (20%)
		PIKKc_TOR	2075..2353	CDD:270713	95/298 (32%)
		FATC	2440..2471	CDD:280430	11/31 (35%)
prkdc	XP_009301676.1	NUC194	1830..2211	CDD:285387	80/414 (19%)
		FAT	3070..3465	CDD:280429	84/450 (19%)
		PIKKc_DNA-PK	3713..4006	CDD:270716	95/298 (32%)
		FATC	4089..4119	CDD:280430	11/30 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26975at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820