DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and ATR

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_011511226.1 Gene:ATR / 545 HGNCID:882 Length:2646 Species:Homo sapiens


Alignment Length:2877 Identity:595/2877 - (20%)
Similarity:1039/2877 - (36%) Gaps:786/2877 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 TTSVVQQFVNGLKSRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIFTMVNATDINE 67
            |..::|.|.:.:....|||...|.:..:.             :::|..:.|.|:..:.:|     
Human   146 TKELLQLFEDLVYLHRRNVMGHAVEWPVV-------------MSRFLSQLDEHMGYLQSA----- 192

  Fly    68 KKGGALAMKCLINCEG-----SLTARKGISPYLNRLRDLLL---------INDVSVMEIAARSLV 118
                .|.:..:.|.|.     .:...:.|:....|.::|||         .....:..:|...|.
Human   193 ----PLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLT 253

  Fly   119 KLANM------PTSKGADSF----------DFDIKKAFE---------VLRGERQEYRRHSAVF- 157
            :|..:      |.|....||          |.|..|.:|         :...|.:.||....|: 
Human   254 ELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYL 318

  Fly   158 --------------ILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIR--------------- 193
                          :|..|...|......|:|.:|.....|.::....:|               
Human   319 NMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVL 383

  Fly   194 --ESAGEALRAALIVTAQRESTKQSSEPQWYRICY-DEANGSFNADLGSSKDQKGVTRDDRIHGG 255
              |...|.|...|....:.||.:...|.|    |. .:.|.|.|:| |.|..::      |:...
Human   384 GIEVDAEYLLGPLYAALKMESMEIIEEIQ----CQTQQENLSSNSD-GISPKRR------RLSSS 437

  Fly   256 LVVFNELFRCANATWERRYTSLKTLFPKTQHNKFLEASSSSSMGSQLNTLVPRLKVPFIDKLGST 320
            |   |...|....|.|.::..:      .|.:....|....:...|::.....||.|.|:.|   
Human   438 L---NPSKRAPKQTEEIKHVDM------NQKSILWSALKQKAESLQISLEYSGLKNPVIEML--- 490

  Fly   321 QTHLGEGEHHKGVAKFASQHNVLESAYAQEILQEHYTSICDNV--LEQRTSKSPYVQQALLQILP 383
                      :|:|.      ||:......:...|....|...  .:.::.|.|.|         
Human   491 ----------EGIAV------VLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSV--------- 530

  Fly   384 RLAAFNRAVFVEKYLQTCVSHLMQILRGKEKDRTV-----AYITIGYMAVAVQSAIEVHLSSIMT 443
             :..:....|..|.|::|.| |::.::..:.:.|:     .|..:.||  .|.|:.|.|:...:.
Human   531 -VITWMSLDFYTKVLKSCRS-LLESVQKLDLEATIDKVVKIYDALIYM--QVNSSFEDHILEDLC 591

  Fly   444 SVKVALP-----SKDLTSKRKVPVDPAVFACITLLAHA-----VKSEIADDVKDILEQ--MFYTG 496
            .: ::||     |.|              .|:.|...|     :...|:|......:.  :|...
Human   592 GM-LSLPWIYSHSDD--------------GCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLT 641

  Fly   497 LSP-------ALTVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYTALPTIAIDGSLMQ 554
            |.|       ...|....|..:...::::...|...:|.|  .|....:|...:..:..|..:::
Human   642 LFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQ--QNSCNRVPKILIDKVKDDSDIVK 704

  Fly   555 NGDGATTVLALKTL-GTF--------NFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTCTR--- 607
            ....:.....:.|| |.|        .|.|...:|...|.......||....:|:| ..|..   
Human   705 KEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKA-SVCKPFLF 768

  Fly   608 LLKLAVQSSESMENSKTLSDTVSHVIERL---------------LMVAITDMDCNVRI------- 650
            |||..:.|...:    ...|.:.|:.:.|               |:..:.|.|.:||:       
Human   769 LLKKKIPSPVKL----AFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIK 829

  Fly   651 RILRSLDETFDGKLAQPESLNSLFITLHDEIF---------EIRELAMVTIGRLSSINPAYVMPK 706
            .||.|||.. ||      .:..||:....|.:         |:::..::|.|.:.......::|.
Human   830 HILESLDSE-DG------FIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPF 887

  Fly   707 LRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHE--------- 762
            ....::..:.....|.......:...::....:......|.|..||.:.||..||.         
Human   888 ALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNT 952

  Fly   763 PESNPGVILN--------VLRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGSPDKRGVALW 819
            |..|..|...        .|.|:.::|.|....| :..:....|.:||..|....|| .....:.
Human   953 PCQNADVRKQDVAHQREMALNTLSEIANVFDFPD-LNRFLTRTLQVLLPDLAAKASP-AASALIR 1015

  Fly   820 TLGQLISATGR-VVTPYHKYPVLIDILINFLKTEQRRS---IRRETIRVLG-------------- 866
            |||:.::...| ::....|| :...::.:..|.|..|:   ::.||...||              
Human  1016 TLGKQLNVNRREILINNFKY-IFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNEL 1079

  Fly   867 LLGAMDPYKHKMNKGLIDSQKDNVLIAY--SDGKVDESQDISTAELLVN---------------- 913
            ||...:.|:...| ||      ::|.::  ||......:||.:.||:.:                
Human  1080 LLRIGEHYQQVFN-GL------SILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQ 1137

  Fly   914 -MGNALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLG------------------I 959
             :.:::......:|:.:||.:::  .:..:|.|.|:.........|                  :
Human  1138 LLSSSVGIEDKKMALNSLMSLMK--LMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFV 1200

  Fly   960 KCVPYLAQVLPNLLDNVRTADNNLREFLFQQLAILVAFV----------KLHIISYMGD------ 1008
            :|:.:..  |.:||.:|..|...|.....::.|.:..::          .||.|.::.|      
Human  1201 RCLDHAC--LGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELKK 1263

  Fly  1009 IFKLIKEF---WTINTPLQNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRM-VTR 1069
            |..:::|:   .:.:|.||.||     |::                  ::.:||:|...|: ...
Human  1264 IKAVLQEYRKETSESTDLQTTL-----QLS------------------MKAIQHENVDVRIHALT 1305

  Fly  1070 RLLQALQKFGSTLGYYL-------PLILPPI-VKLFDSPYVPQQVSMVALETINNLAC----QLD 1122
            .|.:.|.|....|..|.       |:|...: |.|........|..::..|.:..|..    :||
Human  1306 SLKETLYKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLD 1370

  Fly  1123 FT-------DFSSRIIHPLVRVLDAEPELRDQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIV 1180
            |:       ||:..|          |..:.|.:..  ..|..:|.:.||.:.       :..|..
Human  1371 FSTTETQGKDFTFVI----------ETGVEDSSFA--YGLLMELTRAYLAYA-------DNSRAQ 1416

  Fly  1181 DP---EYEELLSKIKSCSTLADSYGAGESELRPSRFKNN-----EPFVTDRNSNNKNLQVTTNEL 1237
            |.   ..:|||| |..|..: ::.|.|....|  ||..:     ||.:   |:..|:.|.:|:  
Human  1417 DSAAYAIQELLS-IYDCREM-ETNGPGHQLWR--RFPEHVREILEPHL---NTRYKSSQKSTD-- 1472

  Fly  1238 RTAWQVTRR---VSK--DDWVEWLKRLSIGLLKESPSHALRA----CRSLAQEYD-----TLLRD 1288
               |...::   :||  .::.||....: |.|.....|.|.:    |.|:..::|     .||..
Human  1473 ---WSGVKKPIYLSKLGSNFAEWSASWA-GYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPH 1533

  Fly  1289 LFNAAFISC--------WTELSPDLKNELTQSLIQALQV-TDMPEI-TQTILNLAEFM------- 1336
            :.....:.|        :.|:...||:: .|..|....: :|:.:: |||:.::.:.:       
Human  1534 ILVYVLLGCNQEDQQEVYAEIMAVLKHD-DQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHK 1597

  Fly  1337 ------EHCDR---------------------------DPIPIETKLLGTRAMACRAYAKALRYK 1368
                  |.|..                           |.||.:|  |...:...:||.:|:.: 
Human  1598 FQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFLDLIPQDT--LAVASFRSKAYTRAVMH- 1659

  Fly  1369 EEEFLLREDSQVFESLILINNKLQQREAAEGL--LTRYRNAANELNVQGRWYEKLHNWDEALEHY 1431
            .|.|:..:...:.|.|..:..........:|:  ::..|.|...|..|...:|.|....:|...|
Human  1660 FESFITEKKQNIQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACY 1724

  Fly  1432 ERNLKTDSSDLEARLGHMRCLEALGDWSELSNV---------TKHEWENFGTEAKSRAGPLAAVA 1487
            :|.::.:...:....|.::.:..||   :||.|         .:.||.:       ........|
Human  1725 DRAIQLEPDQIIHYHGVVKSMLGLG---QLSTVITQVNGVHANRSEWTD-------ELNTYRVEA 1779

  Fly  1488 AWGLQDWEAMREYVRCIPEDTQDGS-------YYRAVLAVHHDD---FETAQRLIDETRDLLDTE 1542
            ||.|..|:.:..|:      ..||.       ..:.:|:....|   |..:.:|: ....::...
Human  1780 AWKLSQWDLVENYL------AADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLV-RAEQIVPLS 1837

  Fly  1543 LTSMAGESYERAYGAMVCVQMLAELEEVIQ--YKLIP---ERREPLKTMWWKRLQGGQRLVEDWR 1602
            ..|....||:|.|..:|.:.||.|||..|:  ::..|   .:.:.|.  |..||:..|.......
Human  1838 AASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLN--WVARLEMTQNSYRAKE 1900

  Fly  1603 RIIQVH----SLVVKP--HEDI-HTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCN 1660
            .|:.:.    ||..:|  :|.: ..||:.|.:.||:|    .|:|..           |..|...
Human  1901 PILALRRALLSLNKRPDYNEMVGECWLQSARVARKAG----HHQTAY-----------NALLNAG 1950

  Fly  1661 QPQVTYAY---TKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQRLM--ARCYLRMA 1720
            :.::...|   .|::.:...:.:|...|...|     || |.|......:.:.::  .|..|.:.
Human  1951 ESRLAELYVERAKWLWSKGDVHQALIVLQKGV-----EL-CFPENETPPEGKNMLIHGRAMLLVG 2009

  Fly  1721 TWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKA-WHLWAYMNFKVVQAQKSALDKQQPPGASM 1784
            .:..:.. :...:||   ::.::..|:..|.|... ::|..|.:..:.....:.::||       
Human  2010 RFMEETA-NFESNAI---MKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQ------- 2063

  Fly  1785 GMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSL--QDTLRLLTLWFDYGNHAEVYEALLS 1847
                     .||:   ||   .|..|.||:..  ||..  |...|:||||.|||..|  ||...:
Human  2064 ---------GDLI---RY---IVLHFGRSLQY--GNQFIYQSMPRMLTLWLDYGTKA--YEWEKA 2109

  Fly  1848 GM--------------KLIEINT-------WLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHP 1891
            |.              |:|..:|       :|....|||:||......|..::.:::..:...:|
Human  2110 GRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYP 2174

  Fly  1892 QALVYPLTVASKSASLARRNAAFKILDS---MRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGL 1953
            |..::.:|..|||:...|.|...:||:.   |:|.....|..|...:::|              |
Human  2175 QQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKL--------------L 2225

  Fly  1954 EEASRLYFGDRNVKGM---FEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAV 2015
            |..::...|..:...|   |::|:.|          ::|.:||:                    :
Human  2226 ELCNKPVDGSSSTLSMSTHFKMLKKL----------VEEATFSE--------------------I 2260

  Fly  2016 VMDLDRAWDIYYHVFQKISRQLPQLTSL---------ELPYVSPKLMTCKDLELAVPGSYNPGQE 2071
            ::.|.             |..:|.|.|:         ..|:               ||.:     
Human  2261 LIPLQ-------------SVMIPTLPSILGTHANHASHEPF---------------PGHW----- 2292

  Fly  2072 LIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPD 2136
             ..|:.....::::.|.|:|:|:.::||:||.|:.:.|..:|||:|.|:|:..||:|..|..|.:
Human  2293 -AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAE 2356

  Fly  2137 TFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLI-RDYRDKKKVPLNQEHRTMLNFAPDYDHL 2200
            :.||.|.|:.||||||:...|:|.||.:...|..:: :.|::|......:|.|..:  .|  ...
Human  2357 SRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCM--LP--KSA 2417

  Fly  2201 TLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSN 2265
            .|.:|::||...|.........:......|....|:..|:.|.||.||||||||||||||||..|
Human  2418 ALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGEN 2482

  Fly  2266 LMLDRMSGKILHIDF------GDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCES 2324
            ::.|.::|:.:|:||      |:.|||       ||.:|||||..::..|...|.||.:||.||.
Human  2483 ILFDSLTGECVHVDFNCLFNKGETFEV-------PEIVPFRLTHNMVNGMGPMGTEGLFRRACEV 2540

  Fly  2325 VMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAG-AGAPGGRGGSGMQDSLSNSVED 2388
            .|.::|..::.||:||:.|::|||:.|         :..|.| :.||....|..:.:        
Human  2541 TMRLMRDQREPLMSVLKTFLHDPLVEW---------SKPVKGHSKAPLNETGEVVNE-------- 2588

  Fly  2389 SLPMAKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTGTDFQTEKSVNEQSQVELLIQQ 2453
                 |:|.:...::|             :...||| .:.::||.....|      ..|..|||:
Human  2589 -----KAKTHVLDIEQ-------------RLQGVIK-TRNRVTGLPLSIE------GHVHYLIQE 2628

  Fly  2454 ATNNENLCQCYIGWCPF 2470
            ||:...|||.|:||.|:
Human  2629 ATDENLLCQMYLGWTPY 2645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 529/2500 (21%)
HEAT repeat 632..658 CDD:293787 10/47 (21%)
HEAT repeat 668..698 CDD:293787 6/38 (16%)
HEAT repeat 706..736 CDD:293787 1/29 (3%)
HEAT repeat 749..780 CDD:293787 11/47 (23%)
HEAT repeat 798..823 CDD:293787 8/24 (33%)
DUF3385 831..999 CDD:288698 37/231 (16%)
HEAT repeat 841..870 CDD:293787 9/45 (20%)
HEAT repeat 880..917 CDD:293787 9/55 (16%)
HEAT repeat 925..954 CDD:293787 6/28 (21%)
Rapamycin_bind 1937..2034 CDD:285924 12/99 (12%)
PIKKc_TOR 2075..2353 CDD:270713 105/284 (37%)
FATC 2440..2471 CDD:280430 13/31 (42%)
ATRXP_011511226.1 UME 1119..1224 CDD:214825 14/108 (13%)
FAT 1773..2094 CDD:280429 77/378 (20%)
TEL1 <2135..2646 CDD:227365 172/642 (27%)
PIKKc_ATR 2295..2569 CDD:270625 105/293 (36%)
FATC 2615..2646 CDD:280430 14/37 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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