DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tor and PI4KB

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_011507936.1 Gene:PI4KB / 5298 HGNCID:8984 Length:849 Species:Homo sapiens


Alignment Length:325 Identity:70/325 - (21%)
Similarity:128/325 - (39%) Gaps:94/325 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  2031 QKISRQLPQL-TSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKL 2094
            :::|.||... |:.:.....|..:..|:          |.||.:|                    
Human   520 RRLSEQLAHTPTAFKRDPEDPSAVALKE----------PWQEKVR-------------------- 554

  Fly  2095 CIRGSNGKDYMYL---------LKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVI 2150
              |...|..|.:|         :|..:||||:....|:...:.::...:    |..|.|:.|.::
Human   555 --RIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQE----RVPLWIKPYKIL 613

  Fly  2151 PLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQ 2215
            .:|.:||:|..|.:..::|.:       ||    |...::|::        .:|     ||.   
Human   614 VISADSGMIEPVVNAVSIHQV-------KK----QSQLSLLDY--------FLQ-----EHG--- 651

  Fly  2216 TQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDF 2280
                         |.::|.:...:.|:.:|.|...:|.|:|.:.|||..|::|| ..|.|:||||
Human   652 -------------SYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLD-AEGHIIHIDF 702

  Fly  2281 GDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGT----YRRTCESVMLVLRRNKDSLMAVLE 2341
            |.....:.....| |...|:||...:..|  .|::|.    |:......::..|::.|.::.::|
Human   703 GFILSSSPRNLGF-ETSAFKLTTEFVDVM--GGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVE 764

  Fly  2342  2341
            Human   765  764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 70/325 (22%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 0/2 (0%)
PIKKc_TOR 2075..2353 CDD:270713 60/280 (21%)
FATC 2440..2471 CDD:280430
PI4KBXP_011507936.1 PI4Kc_III_beta 541..849 CDD:270712 65/304 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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