DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and PI4KA

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_477352.3 Gene:PI4KA / 5297 HGNCID:8983 Length:2102 Species:Homo sapiens


Alignment Length:2423 Identity:433/2423 - (17%)
Similarity:757/2423 - (31%) Gaps:972/2423 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   358 SICDNVLEQRTSKSPYVQQALLQILPRLAAFNRAVFVE------KYLQTCV-------------- 402
            |:.|.:||           .|||:|..|....:|:.::      ||...|:              
Human   148 SLRDEILE-----------VLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNME 201

  Fly   403 ------------SHLMQILRGKEKDRTVAY------ITIGYMAVAVQSAIEVHLSSIMTSVKVAL 449
                        .|.:::|...|..|..::      :....:.|..:..::...||: :|:....
Human   202 ESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSV-SSISQVS 265

  Fly   450 PSKDLTSKRKVPVDPAVFACITLLAHAVKSEIADDVKDILEQMFYTGLSPALTV----------- 503
            |.:.:..    |..|...|     .|..::....|...:..:.:::.:|.:.:|           
Human   266 PERGMPP----PSSPGGSA-----FHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKE 321

  Fly   504 ------CLRELSENVPQL-KSAITEGLIGILSQVL-MNKAAILPYTAL--PTIAIDGSLMQNGDG 558
                  .||||...|.:: :.|:.:.|..|::.|: .|.:|.|.||:.  |.......::::   
Human   322 FNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRD--- 383

  Fly   559 ATTVLALKTLGTFNFEEQNMLDFVQRCADYF-------------IVHEQQEI---------RLEA 601
              |:..:|.|.|         .||:...|:.             |:|:...|         |.:|
Human   384 --TLYYMKDLPT---------SFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQA 437

  Fly   602 VQTCTRLLKLAVQSSESMEN----------SKTLSDTV--------------------------- 629
            ...|..|:..||:..:..||          |||.|..:                           
Human   438 NAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHS 502

  Fly   630 ------------SHVIERLL-------MVAITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFI 675
                        |.|:.:|.       .||..|:..:|......|......||.:||....    
Human   503 VTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYE---- 563

  Fly   676 TLHDEIFEIRELAMVTIGRL----SSINPAYVMPKLRTTMIELITDLKYSGMSRNK------EQS 730
                   ::|::|:..|.|.    .:::|..|     ...:..:::..|.....:|      :.:
Human   564 -------QLRDIAIDNICRCLKAGLTVDPVIV-----EAFLASLSNRLYISQESDKDAHLIPDHT 616

  Fly   731 AKMLDHLVIS---TPRLISSYMNPILKALVPKLHEPESNPGVILNVLRTIGDLAEVNGGSDEMEL 792
            .:.|.|:.::   ||::    |.|||:.|..|..:|.|...|:  ::..:|.|. :.|..     
Human   617 IRALGHIAVALRDTPKV----MEPILQILQQKFCQPPSPLDVL--IIDQLGCLV-ITGNQ----- 669

  Fly   793 WADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSI 857
                  .|..|              :|.|.|.||.....|.    |....|     .|....|..
Human   670 ------YIYQE--------------VWNLFQQISVKASSVV----YSATKD-----YKDHGYRHC 705

  Fly   858 RRETIRVLGLLGAMDPYKHKMNKGLIDSQKDNVLIAYSDGKVDESQDISTAELLVNMG------- 915
            ....|..|..:.|....:|     |:|....|:|                 ||.|.:|       
Human   706 SLAVINALANIAANIQDEH-----LVDELLMNLL-----------------ELFVQLGLEGKRAS 748

  Fly   916 NALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTAD 980
            ....|..||:..::..                       .:||: .:|.:| ||...|..::.|.
Human   749 ERASEKGPALKASSSA-----------------------GNLGV-LIPVIA-VLTRRLPPIKEAK 788

  Fly   981 NNLREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQNTLINLIEQIAVALGCEFRDY 1045
            ..|:                          ||.::||     |.:.|:....:.:.....|:.:.
Human   789 PRLQ--------------------------KLFRDFW-----LYSVLMGFAVEGSGLWPEEWYEG 822

  Fly  1046 LAELIPQ-----------ILRVLQHDNS-KDRMVTRRLLQALQKFGSTLGYYLPLILPPIVKLFD 1098
            :.|:..:           :..|||:::: |:..||...|..|:   ||           |:.|.|
Human   823 VCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELR---ST-----------IINLLD 873

  Fly  1099 SPYVPQQVSMVALETINNLACQLDFTDFSSRIIH----PLVRVL-DAEPE--------LRDQAMT 1150
            .|  |:         ::.|..:|||. .|:.::.    ..:||| ..:|:        ..|:|:.
Human   874 PP--PE---------VSALINKLDFA-MSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQ 926

  Fly  1151 TLRSLAKQ-----LGKKYLVFVPMV---------QRTLNKH-RIVDPEYEELLSKIKSCSTLADS 1200
            ..:|...|     ..|.:..|:.|:         :..|.:| :.:...:..:..:|:   .:||.
Human   927 KDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNFNHIHKRIR---RVADK 988

  Fly  1201 YGAGESELRPSRFKNNEPFVTDRNSNNKNLQVTTNELRTAWQVTRRVSKDDWVEWLKRLSIGLLK 1265
            |.:|..:..|                  :|..:...|:|...:.:.:|..        ||..:.|
Human   989 YLSGLVDKFP------------------HLLWSGTVLKTMLDILQTLSLS--------LSADIHK 1027

  Fly  1266 ESPSHAL-------------RACRSLAQEYDTLLRDLFNAAFISCWTELSPDLKNELT--QSLIQ 1315
            :.|.:.:             .|..|:.:::......:...|.....|.....|:..|.  |:.:.
Human  1028 DQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVS 1092

  Fly  1316 AL-QVTDMPEITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRAYAKALRYKEEEFLLREDSQ 1379
            .| |.|.:...|::||:.|.:.:         :...||           |.:..|....:::|..
Human  1093 GLSQHTGLAMATESILHFAGYNK---------QNTTLG-----------ATQLSERPACVKKDYS 1137

  Fly  1380 VFESLILINNKLQQREAAE--GLL-----TRYRNAANELNVQGRWYEKLHNWDEAL-----EHYE 1432
            .|    :.:..|:.|.|.|  |::     |...:..|::.||     .||:   ||     :||.
Human  1138 NF----MASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQ-----DLHS---ALDRSHPQHYT 1190

  Fly  1433 R------NLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGL 1491
            :      .:...|.|.:.:|.|..|      |..|....:|..|             .|:|.|  
Human  1191 QAMFKLTAMLISSKDCDPQLLHHLC------WGPLRMFNEHGME-------------TALACW-- 1234

  Fly  1492 QDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGE---SYER 1553
             :|                       |....|..|.             ..:..|||.   :.|:
Human  1235 -EW-----------------------LLAGKDGVEV-------------PFMREMAGAWHMTVEQ 1262

  Fly  1554 AYGAMVCVQMLAELE--------EVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSL 1610
            .:|.     ..||::        |..|.|..|..                               
Human  1263 KFGL-----FSAEIKEADPLAASEASQPKPCPPE------------------------------- 1291

  Fly  1611 VVKPHEDIHTWL----------KY---------ASLCRKSGSLHLS----------------HKT 1640
             |.||   :.|:          ||         :||.::|.||::.                .|.
Human  1292 -VTPH---YIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKL 1352

  Fly  1641 LVM---LLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPE 1702
            |.:   ||..|  :.||..:                 .|.|:|      ...||.....|| ||:
Human  1353 LTLGLSLLHAD--VVPNATI-----------------RNVLRE------KIYSTAFDYFSC-PPK 1391

  Fly  1703 ALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVV 1767
            ...|.::||.....:.:..|.....|.                                   |.:
Human  1392 FPTQGEKRLREDISIMIKFWTAMFSDK-----------------------------------KYL 1421

  Fly  1768 QAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLW 1832
            .|.:......|...:::.:|:||            ...|.||:..:..|..|.|.......::..
Human  1422 TASQLVPPDNQDTRSNLDITVGS------------RQQATQGWINTYPLSSGMSTISKKSGMSKK 1474

  Fly  1833 FDYGNHAEVY----EALLSGMKLIEIN---TWLQVI--PQLIARIDTHRQLVGQLIHQLLMDIGK 1888
            .:.|:....|    ..||..:...||.   ||...:  |:|  .:|               ..|:
Human  1475 TNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPEL--ELD---------------QAGE 1522

  Fly  1889 NHPQALVYPLTVA---SKSASLARRN--------------------AAFKILDSMRKHSPTLVE- 1929
            |         :||   ||..||:.:.                    |.||..:::......||. 
Human  1523 N---------SVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRL 1578

  Fly  1930 --QAVMCSEELIRVAILWH-------EQWH----------EGLEEASRLY--------FGDRNVK 1967
              .||....|.|:..:.||       |..|          .||...|.:|        :|.:.::
Human  1579 DPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLR 1643

  Fly  1968 GMFEILEPLHAMLERGPQTLKETSFSQ-AYGRE-----------LTEAYEWSQRYKTSAVVMD-- 2018
            ..     |..|:|...||.::...:.: .|.||           |...:.|:.  ||: :.:|  
Human  1644 SF-----PPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNM--KTN-IYLDEE 1700

  Fly  2019 -----------LDR------------AWDIY---YHVFQKISRQLPQLTSLELPYVSPK------ 2051
                       ||:            |.|.|   :..|.||:    .::::..||  ||      
Human  1701 GHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKIT----NVSAIIKPY--PKGDERKK 1759

  Fly  2052 --LMTCKDLELAVPGSYNPGQ-ELIRISI-IKTNLQVITSKQRPR------KLC----------- 2095
              |....::::. ||.|.|.. |.|.:.| .|:...:.::.:.|.      |.|           
Human  1760 ACLSALSEVKVQ-PGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLR 1823

  Fly  2096 ----------IRGSNGKDYMY---LLKGHEDLRQDERVMQLFSLVNTLL----LDDPDTFRRNLA 2143
                      .:.::|:...:   :.|..:|.|||...:|:..|...:.    ||        |.
Human  1824 CRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLD--------LF 1880

  Fly  2144 IQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPD---YDHLTLMQK 2205
            :..|.|:..:...|:|..:|.|.:                    |..|....|   ||:.|    
Human  1881 VFPYRVVATAPGCGVIECIPDCTS--------------------RDQLGRQTDFGMYDYFT---- 1921

  Fly  2206 VEVFEHALGQTQGDDLAKLLWLKSPSSELWFER-RNNYTRSLAVMSMVGYILGLGDRHPSNLMLD 2269
                     :..||:           |.|.|:: |.|:.||:|..|::.::|.:.|||..|:|||
Human  1922 ---------RQYGDE-----------STLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLD 1966

  Fly  2270 RMSGKILHIDFGDCFE------------VAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTC 2322
            : .|.|:|||||..||            :.:|.|         :..::...||.|..: .:...|
Human  1967 K-KGHIIHIDFGFMFESSPGGNLGWEPDIKLTDE---------MVMIMGGKMEATPFK-WFMEMC 2020

  Fly  2323 ESVMLVLRRNKDSLMAVL 2340
            ....|.:|...|::::::
Human  2021 VRGYLAVRPYMDAVVSLV 2038

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 433/2423 (18%)
HEAT repeat 632..658 CDD:293787 7/32 (22%)
HEAT repeat 668..698 CDD:293787 4/33 (12%)
HEAT repeat 706..736 CDD:293787 3/35 (9%)
HEAT repeat 749..780 CDD:293787 10/30 (33%)
HEAT repeat 798..823 CDD:293787 4/24 (17%)
DUF3385 831..999 CDD:288698 29/174 (17%)
HEAT repeat 841..870 CDD:293787 5/28 (18%)
HEAT repeat 880..917 CDD:293787 8/43 (19%)
HEAT repeat 925..954 CDD:293787 0/28 (0%)
Rapamycin_bind 1937..2034 CDD:285924 31/161 (19%)
PIKKc_TOR 2075..2353 CDD:270713 65/317 (21%)
FATC 2440..2471 CDD:280430
PI4KANP_477352.3 PI4Ka 1547..1722 CDD:238443 33/182 (18%)
PI4Kc_III_alpha 1783..2101 CDD:270711 66/319 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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