DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and PIK3CD

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_016856965.1 Gene:PIK3CD / 5293 HGNCID:8977 Length:1103 Species:Homo sapiens


Alignment Length:1052 Identity:203/1052 - (19%)
Similarity:340/1052 - (32%) Gaps:371/1052 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1530 RLI----DETRDLLDTELTSMAGESYE-------------RAYGAMVCVQMLAELEEV-----IQ 1572
            ||:    |..:.|::::::.:.|:...             ||.....|.:..|..:::     :|
Human   100 RLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQ 164

  Fly  1573 YKLIPERREPLKTMWWK---RLQGGQRLV------EDWRRIIQVHS------------------- 1609
            |. .|.:.||....|..   ||.....||      .:.....||.:                   
Human   165 YS-FPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVF 228

  Fly  1610 ---LVVKPHEDI-------HTWL---------KYASLCRKSG-SLHLS--HKTLVMLLGTDPKLN 1652
               ||.:| ||.       |.:|         :|...|..|| :.||:  |.:.::.: .|.:.|
Human   229 RQPLVEQP-EDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAM-RDEQSN 291

  Fly  1653 P----------NQPLPCNQP------------QVTYAYTKYMAANNQLQ--------EAYEQLTH 1687
            |          ..|:|..:|            ::.......:.|:.:::        ...|.|..
Human   292 PAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 356

  Fly  1688 FVSTYSQELS-CLPPEALKQQDQRLMARCYLRMATWQNKLQDSIR-PDAIQGALECF------EK 1744
            .||  |.|:| |..|                   .|:.:|:..|. .|..:.|..||      ||
Human   357 TVS--SSEVSVCSEP-------------------VWKQRLEFDINICDLPRMARLCFALYAVIEK 400

  Fly  1745 ATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLD----SDLMIIQRYAVP 1805
            |                   |..::.|....|...|.|...:.:....|    .:..:....:||
Human   401 A-------------------KKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVP 446

  Fly  1806 AVQG-FFRSISLIKGNSLQDTLRLLTLWF-DYGNHAEVYEAL--LSGMKLIEINTWLQVIPQLI- 1865
            ..:| .......::.|...|:...|.:.. :...|...|.||  |.|..|:....|.   |:|: 
Human   447 DEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKLPGGMLLASREWR---PELLW 508

  Fly  1866 ----ARIDTHRQLVGQLIHQL--------------------LMDIGKNHPQALVYPLTVASKSAS 1906
                |......:::|..:..|                    ::::|::.....|...........
Human   509 MRLHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLLQILELGRHSECVHVTEEEQLQLREI 573

  Fly  1907 LARRNA----------AFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLY- 1960
            |.||.:          .:|:...:::|.|          |.|.|:.::  .:|::..:.|..|| 
Human   574 LERRGSGELYEHEKDLVWKLRHEVQEHFP----------EALARLLLV--TKWNKHEDVAQMLYL 626

  Fly  1961 -------------------FGDRNVKGMFEIL-------EPLHAMLERGPQTLKETSFSQAYGRE 1999
                               |.|.:| |.|.|.       :.|...|.:..|.||..|:...   |
Human   627 LCSWPELPVLSALELLDFSFPDCHV-GSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDC---E 687

  Fly  2000 LTEAYEWSQRYKTSAVVMDLDRA-----------WDI--------------------------YY 2027
            ||:..              ||||           |.:                          :.
Human   688 LTKFL--------------LDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHM 738

  Fly  2028 HVFQKISRQLPQLTSLELPYV------SPKLMTCKDLELA------------VPGSYNPGQELIR 2074
            .|..|....|.:|.:|. .:|      :||..|.:.:.|.            :....:|...|..
Human   739 KVLMKQGEALSKLKALN-DFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAE 802

  Fly  2075 ISIIKTNLQVITSKQRPRKLCIRGSN-----GKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDD 2134
            :.:.:...  :.||.:|  |.|..||     |.....:.|..:|||||...:|:..|::.|...:
Human   803 VCVEQCTF--MDSKMKP--LWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQE 863

  Fly  2135 PDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDH 2199
                ..:|.:..|..:|....:|||..|...||:          ..:.||:.:            
Human   864 ----GLDLRMTPYGCLPTGDRTGLIEVVLRSDTI----------ANIQLNKSN------------ 902

  Fly  2200 LTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERR-NNYTRSLAVMSMVGYILGLGDRHP 2263
               |.....|...         |.|.||||.:.....:|. ..:|.|.|...:..|:||:||||.
Human   903 ---MAATAAFNKD---------ALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHS 955

  Fly  2264 SNLMLDRMSGKILHIDFGDCFEVAMTREKF---PEKIPFRLTRMLIKAMEVTGIEGT-----YRR 2320
            .|:|: |.||::.|||||..  :...:.||   .|::||.||...:..::......:     :|.
Human   956 DNIMI-RESGQLFHIDFGHF--LGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRG 1017

  Fly  2321 TCESVMLVLRRN 2332
            .||....:|||:
Human  1018 YCERAYTILRRH 1029

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 203/1052 (19%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 28/160 (18%)
PIKKc_TOR 2075..2353 CDD:270713 70/272 (26%)
FATC 2440..2471 CDD:280430
PIK3CDXP_016856965.1 PI3K_p85B 32..107 CDD:308030 2/6 (33%)
PI3K_rbd 175..281 CDD:307097 21/106 (20%)
C2_PI3K_class_I_beta_delta 314..481 CDD:176075 32/206 (16%)
PI3Ka 562..743 CDD:214537 35/210 (17%)
PI3Kc_IA_delta 735..1101 CDD:270718 82/341 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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