DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and PIK3C2B

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_001364263.1	Gene:	PIK3C2B / 5287	HGNCID:	8972	Length:	1634	Species:	Homo sapiens

Alignment Length:	1402	Identity:	260/1402 - (18%)
Similarity:	446/1402 - (31%)	Gaps:	549/1402 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1087 PLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDAEPELRDQAMTT 1151
            |..|||...::|:|.:|.:..                :..||:|..|             ..:.|
Human   156 PPPLPPRASIWDTPPLPPRKG----------------SPSSSKISQP-------------SDINT 191

  Fly  1152 LRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPE----------------YE---ELLSKIKSCST- 1196
            . ||.:||..|.|           :|||::.|                |:   :.::::...||
Human   192 F-SLVEQLPGKLL-----------EHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNLKSTY 244

  Fly  1197 ----LADS-----YGAG------ESELRP-SRFKNNEPFV-----TDRNSNNKNLQVTTNELRTA 1240
                |.|:     .|.|      ::..:| :|.|...|.|     ..|..|.||.....|...:|
Human   245 DAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNATPGKNRRISA 309

  Fly  1241 WQVTRR------------VS--KDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFN 1291
            ..|..|            ||  :|:.|            .:..|.|...||.:.     ::|.|.
Human   310 APVGSRPHTVANGHELFEVSEERDEEV------------AAFCHMLDILRSGSD-----IQDYFL 357

  Fly  1292 AAFISCWTELSP---------DLK-NELTQSLIQALQVT-------DMPEITQTILNLAEFMEHC 1339
            ..::  |:.::|         :|| ..|...|.:||..|       |: .|.||:....:.:.:.
Human   358 TGYV--WSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDL-LIYQTLCYTHDDLRNV 419

  Fly  1340 D-----RDPIPIETKLLGTRAMACRAYAKALRYKEEEFLLREDSQVFESLIL-------INN--- 1389
            |     ..|..:|..|....|:....|.:..|..:.:..|    |:.|..::       :|:
Human   420 DVGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRL----QLMEQKVVRSDLARTVNDDQS 480

  Fly  1390 --------KLQQREAAEGLLTRYRNAANELNVQGRWYEKLHNWDEA--LEHYERNLKTDSSDLEA 1444
                    .||:|...:   |..|.|.:.|      ::..||..:|  |...:..||.|
Human   481 PSTLNYLVHLQERPVKQ---TISRQALSLL------FDTYHNEVDAFLLADGDFPLKAD------ 530

  Fly  1445 RLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRC----IP 1505
                 |.::::                     |:....||||....:.  .|:.:...|    .|
Human   531 -----RVVQSV---------------------KAICNALAAVETPEIT--SALNQLPPCPSRMQP 567

  Fly  1506 EDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMV--CVQMLAELE 1568
            :..:|.|    ||||..:..:..:.|.....||::....:...:......|:..  .||......
Human   568 KIQKDPS----VLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFA 628

  Fly  1569 EVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGS 1633
            ..:.:.:....|.|:  :|                        ...:||.:.            |
Human   629 RSLAFTVYATHRIPI--IW------------------------ATSYEDFYL------------S 655

  Fly  1634 LHLSH--KTLVMLLGTDPKLNPNQPLPCNQPQVTYA-YTKYMAANNQLQEAYEQLTHFVSTYSQE 1695
            ..|||  |.|                 |:..|...| ::||             |.|.: .:.|:
Human   656 CSLSHGGKEL-----------------CSPLQTRRAHFSKY-------------LFHLI-VWDQQ 689

  Fly  1696 LSCLPPEALKQQDQRLMARCYLRM----------ATWQNKLQDSIRPDAI----------QGALE 1740
            : |.|.:..:...:.|:......:          |..|.::     |:|:          :..|.
Human   690 I-CFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRV-----PEALGWVTTPLFNFRQVLT 748

  Fly  1741 CFEK------ATSYDPNWYKAWHLWAYMNFK-----VVQAQ--KSALDKQ--QPPG--ASMGMTM 1788
            |..|      ||..:|:     ..|:..||.     ::|..  .||.|.:  .|||  .|.....
Human   749 CGRKLLGLWPATQENPS-----ARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEF 808

  Fly  1789 GSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLT------LWFD-YGNHAEVYEALL 1846
            ||..:.|    ||.....:|              :::|..||      ||.. |..|:||
Human   809 GSLREED----QRKLKDIMQ--------------KESLYWLTDADKKRLWEKRYYCHSEV----- 850

  Fly  1847 SGMKLI--EINTW-LQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLA 1908
            |.:.|:  ...:| ...:|.:..       |:.|..|.       ||..|             |.
Human   851 SSLPLVLASAPSWEWACLPDIYV-------LLKQWTHM-------NHQDA-------------LG 888

  Fly  1909 RRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGM-FE- 1971
            ..:|.|.                   .:|:.|:|:    ||...|.:|..|.:..:.|:.: :|
Human   889 LLHATFP-------------------DQEVRRMAV----QWIGSLSDAELLDYLPQLVQALKYEC 930

  Fly  1972 -ILEPL-HAMLERG--------------PQTLKETSFSQAY-----------GRELTEAYEWSQR 2009
             :..|| ..:|:|.              ...||::.||..|           |:.|.|.:.
Human   931 YLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLCCCGKGLREEFN---- 991

  Fly  2010 YKTSAVVMDLDRAWDIYYHVFQKISRQLPQL----------TSLE-------------LPYVSPK 2051
                      .:.|.:  :...|:::|:.:.          |.||             || :||.
Human   992 ----------RQCWLV--NALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLP-LSPS 1043

  Fly  2052 LMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSN--GKDYMYLLKGHEDL 2114
            |:        |.|            |:..:.....|...|.||..:..:  |::...:.|..:||
Human  1044 LL--------VKG------------IVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDL 1088

  Fly  2115 RQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKK 2179
            |||...:|:..:::.:.:.:....|..:    :.........|::..:|:.:||
Human  1089 RQDMLTLQMIRIMSKIWVQEGLDMRMVI----FRCFSTGRGRGMVEMIPNAETL----------- 1138

  Fly  2180 KVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTR 2244
                                    :|::|.....|..:...||..|...:|..:.:.:...|:..
Human  1139 ------------------------RKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIY 1179

  Fly  2245 SLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFG 2281
            |.|...:..|:||:.|||..|:|| :.:|.:.|||||
Human  1180 SCAGCCVATYVLGICDRHNDNIML-KTTGHMFHIDFG 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	260/1402 (19%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	24/125 (19%)
		PIKKc_TOR	2075..2353	CDD:270713	43/209 (21%)
		FATC	2440..2471	CDD:280430
PIK3C2B	NP_001364263.1	Interaction with GRB2. /evidence=ECO:0000269\|PubMed:11533253	2..298		36/182 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..188		11/60 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..315		14/55 (25%)
		PI3K_rbd	364..466	CDD:395642	22/106 (21%)
		C2A_PI3K_class_II	622..794	CDD:175979	40/251 (16%)
		PI3Ka_II	813..981	CDD:238441	45/240 (19%)
		PI3Kc_C2_beta	987..1340	CDD:119421	57/306 (19%)
		PX_PI3K_C2_beta	1369..1477	CDD:132823
		C2B_PI3K_class_II	1505..1627	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900