DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and PIK3C2A

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_001308307.1	Gene:	PIK3C2A / 5286	HGNCID:	8971	Length:	1686	Species:	Homo sapiens

Alignment Length:	1404	Identity:	260/1404 - (18%)
Similarity:	455/1404 - (32%)	Gaps:	504/1404 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1081 TLGYYLPLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDAEPELR 1145
            :|..|.|::...:.||||      :::..: |.:.|...:.|.....|::.:     |...|:..
Human   211 SLPIYRPVVSTDMAKLFD------KIASTS-EFLKNGKARTDLEITDSKVSN-----LQVSPKSE 263

  Fly  1146 DQAMTTLRSLAKQLGK-KYLVFVPMVQRTLNKHRIVDPEYEE----LLSKIKSCSTLADSYGAGE 1205
            |            :.| .:|...|:.:..::...::|.|.|:    ||:|....:.|.:......
Human   264 D------------ISKFDWLDLDPLSKPKVDNVEVLDHEEEKNVSSLLAKDPWDAVLLEERSTAN 316

  Fly  1206 SELRPSRFKNNEPFVTDRNSNNKNLQVTTNELRTAWQVTRRVSKDDWVEWLKRLSIGLLKESP-- 1268
            ..|             :|..|.|:|.|.|        |||..|.:.....|.:....:.::.|
Human   317 CHL-------------ERKVNGKSLSVAT--------VTRSQSLNIRTTQLAKAQGHISQKDPNG 360

  Fly  1269 SHALRACRSLAQEYDTLLRDLFNAAFISCWTE-----------------LSP------------- 1303
            :.:|....||.||.:....::  |||....|:                 |||
Human   361 TSSLPTGSSLLQEVEVQNEEM--AAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGENAS 423

  Fly  1304 ------------------DLKNELTQSLIQA-----------------LQVTDMPEITQT--ILN 1331
                              |:.:.:...::||                 |:|....|:.|.  .|.
Human   424 VKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQNNHCLG 488

  Fly  1332 LAEFMEHCDRDPIPIETKLLGTRAMACRAYAKALRYKEEEFLLREDSQVFESLILINNKLQQ--- 1393
            ..|.:::|.:....|..:||...|| |:..|:.          .||.   |:.:.:|..|.|
Human   489 SHEHIQNCRKWDTEIRLQLLTFSAM-CQNLART----------AEDD---ETPVDLNKHLYQIEK 539

  Fly  1394 -------REAAEGLLTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLKTDSSDLEARLGHMRC 1451
                   |...|.||..|.|.. ||.:|      :.|...|::...:.::...|.|:. :..:..
Human   540 PCKEAMTRHPVEELLDSYHNQV-ELALQ------IENQHRAVDQVIKAVRKICSALDG-VETLAI 596

  Fly  1452 LEALGDWSELSNVTKHEWEN----FGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDGS 1512
            .|::.......|:.:.:..:    ||.|..||:....::.                 ||:....|
Human   597 TESVKKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLN-----------------PENPVQVS 644

  Fly  1513 YYRAVLAVHH------------DDFETAQRLIDE---TRDLLDTELTSMAG------ESYERAYG 1556
            ..:...|::.            .|...:.:.:.|   |.:.|...:.:..|      .:||:.|
Human   645 INQLTAAIYDLLRLHANSGRSPTDCAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYY- 708

  Fly  1557 AMVCVQMLA----ELEEVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRI---IQVHSLVVKP 1614
             ::|  .|:    :|.:.||.|.:...:.....:.|..|            |   ||:..|   |
Human   709 -LIC--SLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDEL------------IIFPIQISQL---P 755

  Fly  1615 HEDIHTWLKYASLCRKSGSLHLSHKTLVMLL----GTDPKLNPNQPLPCNQPQVT---YAYTKYM 1672
            .|.:               |||   ||..:|    |:.|..|..:..|....:|:   :.:.:::
Human   756 LESV---------------LHL---TLFGILNQSSGSSPDSNKQRKGPEALGKVSLPLFDFKRFL 802

  Fly  1673 AANNQLQEAYEQLTHFVST--------YSQELSCL----PPEAL------KQQDQRLMARCYLRM 1719
            ....:|...:.. :|..|.        |..|...|    |..|.      .|.|:.::.:..|.
Human   803 TCGTKLLYLWTS-SHTNSVPGTVTKKGYVMERIVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLE- 865

  Fly  1720 ATWQN----KLQDSIRPDAIQGALE------------------CFEKATSYDPNW--------YK 1754
             |.:|    ||.|.:..|:..|..:                  |..|..:..|||        |.
Human   866 -TLENDIKGKLLDILHKDSSLGLSKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWVNLAKTYS 929

  Fly  1755 AWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKG 1819
            ..|.|                                             ||:.... ::.|:..
Human   930 LLHQW---------------------------------------------PALYPLI-ALELLDS 948

  Fly  1820 NSLQDTLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLM 1884
            ......:|.|.:                        ||::.|..     |....|:.|.:
Human   949 KFADQEVRSLAV------------------------TWIEAISD-----DELTDLLPQFV----- 979

  Fly  1885 DIGKNHPQALVYPLTVASKSASLARRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQW 1949
                   |||.|.:.:.|                       :||:  .:.|..|..:.|..:..|
Human   980 -------QALKYEIYLNS-----------------------SLVQ--FLLSRALGNIQIAHNLYW 1012

  Fly  1950 HEGLEEASR-LYFGDRNVKGMFEILEPLHAMLERG-----PQTLKETSFSQAYGRELTEAYEWSQ 2008
            .  |::|.. :.|..|     :|  ..|.|:|..|     .:.||:|...|..|    ...|..:
Human  1013 L--LKDALHDVQFSTR-----YE--HVLGALLSVGGKRLREELLKQTKLVQLLG----GVAEKVR 1064

  Fly  2009 RYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELI 2073
            :...||..:.|.|:.:.....|||...:||         :.|.|: .|:|.:.....::.....:
Human  1065 QASGSARQVVLQRSMERVQSFFQKNKCRLP---------LKPSLV-AKELNIKSCSFFSSNAVPL 1119

  Fly  2074 RISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTF 2138
            :::::..:                 ..|::...:.|..||||||...:|:..:::.:.|
Human  1120 KVTMVNAD-----------------PMGEEINVMFKVGEDLRQDMLALQMIKIMDKIWL------ 1161

  Fly  2139 RRNLAIQRYAVIPLST--NSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLT 2201
            :..|.::......|||  :.|::..||..|||
Human  1162 KEGLDLRMVIFKCLSTGRDRGMVELVPASDTL--------------------------------- 1193

  Fly  2202 LMQKVEVFEHALGQTQGDDLAKLLWLK--SPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPS 2264
              :|::|.....|..:...||:  ||:  :||.|.:.:...|:..|.|...:..|:||:.|||..
Human  1194 --RKIQVEYGVTGSFKDKPLAE--WLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHND 1254

  Fly  2265 NLMLDRMSGKILHIDFGDCFEVAMTREKFP-EKIPFRLT 2302
            |:|| |.:|.:.|||||.....|.....|. ::.||.||
Human  1255 NIML-RSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLT 1292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	260/1404 (19%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	25/102 (25%)
		PIKKc_TOR	2075..2353	CDD:270713	55/233 (24%)
		FATC	2440..2471	CDD:280430
PIK3C2A	NP_001308307.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		Interaction with clathrin, sufficient to induce clathrin assembly. /evidence=ECO:0000269\|PubMed:16215232	2..142
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..367		2/18 (11%)
		PI3K_rbd	409..512	CDD:279173	15/102 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..639		6/37 (16%)
		C2A_PI3K_class_II	677..849	CDD:175979	40/209 (19%)
		PI3Ka_II	870..1038	CDD:238441	43/288 (15%)
		PI3Kc_C2_alpha	1043..1395	CDD:270720	74/325 (23%)
		PX_PI3K_C2_alpha	1426..1534	CDD:132822
		Interaction with PtdIns(4,5)P2-containing membranes. /evidence=ECO:0000250\|UniProtKB:Q61194	1488..1493
		C2B_PI3K_class_II	1560..1681	CDD:176027
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:11606566	1608..1619
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900