DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and ATM

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_000042.3 Gene:ATM / 472 HGNCID:795 Length:3056 Species:Homo sapiens


Alignment Length:2954 Identity:603/2954 - (20%)
Similarity:1050/2954 - (35%) Gaps:937/2954 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 TTSVVQQFVN-GLK------SRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIFTMV 60
            |||:|...|. |::      :|:.:::....:.||||......|.|.|........|.|.:.   
Human   547 TTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVL--- 608

  Fly    61 NATDINEKKGGALAMKCLINCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARS-------LV 118
                  ||...:|.||   ||:.::...:.:....:..:|...::...|.|:..::       |.
Human   609 ------EKILVSLTMK---NCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLT 664

  Fly   119 KLANMPTSKGADSFDF----DIKKAFE--VLRGERQEYRRHSA--------VFILRELAIALPTY 169
            .:......|...|..|    ::|::.:  :|....|....:|:        |...|.|...|..|
Human   665 IVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLLVGVLGCY 729

  Fly   170 FYQHILTFFEVIFNAIFDPKPAIRESAGEALRAALIVTAQRESTKQSSEPQWYRICYDEANGSFN 234
            .|..::...|...:.:|....::.:.|||:      :|..:..|.:.     :||          
Human   730 CYMGVIAEEEAYKSELFQKAKSLMQCAGES------ITLFKNKTNEE-----FRI---------- 773

  Fly   235 ADLGSSKDQKGVTRDDRIHGGLVVFNELFRC-ANATWERRYTSLKTLFPKTQHNK-----FLEAS 293
               ||.::...:..               || :|.|             |...||     ||...
Human   774 ---GSLRNMMQLCT---------------RCLSNCT-------------KKSPNKIASGFFLRLL 807

  Fly   294 SSSSMGSQLN---TLVPRLKVPF----IDKL-GSTQTHLGEGEHHKGVAKF-----ASQHNVLES 345
            :|..|....:   :|...:|.||    ::.: ..|..:|.|.|....:..|     :|..:..|.
Human   808 TSKLMNDIADICKSLASFIKKPFDRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDANEP 872

  Fly   346 AYAQEI------LQEHYTSICDNVLEQRTSKSPYVQQALLQILPRLAAFNRAVFVE--KYLQTCV 402
            ..:|..      |.|.|.|                :|.||             |::  |:|..||
Human   873 GESQSTIGAINPLAEEYLS----------------KQDLL-------------FLDMLKFLCLCV 908

  Fly   403 SHLMQILRGKEKDRTVAYITIGYMAVAVQ---------SAIE----VHLSSIMTSVK------VA 448
            :             |....|:.:.|..::         |.:|    :||...:..:|      ..
Human   909 T-------------TAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYP 960

  Fly   449 LPSKDLTSKRKVPV---------DPAVFACITLL---AHAVK--------SEIADDVKD------ 487
            ||.:|:....| |:         |..|  |.|:|   .|.||        ||...|.:.      
Human   961 LPMEDVLELLK-PLSNVCSLYRRDQDV--CKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVI 1022

  Fly   488 ------ILEQMFYTGLSPALTVCLRELSENVPQLKSAITEGLIG-------ILSQVLMNKAAILP 539
                  ..|:.:...:..||..||:.|.|..|..|.||. .::|       :.:|.|.:....:.
Human  1023 GAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAIL-NVMGKDFPVNEVFTQFLADNHHQVR 1086

  Fly   540 YTALPTIAIDGSLMQNGDGATTVLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQT 604
            ..|..:|   ..|.|:..|.::.| ||.|         .|...|...:...:..|:.:|      
Human  1087 MLAAESI---NRLFQDTKGDSSRL-LKAL---------PLKLQQTAFENAYLKAQEGMR------ 1132

  Fly   605 CTRLLKLAVQSSESMENSKTLSDTVSHVIERLLMVAITDMDCN---------------------- 647
                     :.|.|.||.:||.:..:.....|.::|:. :.|:                      
Human  1133 ---------EMSHSAENPETLDEIYNRKSVLLTLIAVV-LSCSPICEKQALFALCKSVKENGLEP 1187

  Fly   648 --VRIRILRSLDETF------DGKLAQPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPAY-- 702
              |: ::|..:.|||      |...:..:.|...::.|.|..:.:.....:.: ..::|...|  
Human  1188 HLVK-KVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILL-NYTNIEDFYRS 1250

  Fly   703 ----VMPKL--RTTMIE--------------LITD---------LKY--------SGMSRNKEQS 730
                ::|.|  |:...|              |:||         |.|        |||::.:|.:
Human  1251 CYKVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETA 1315

  Fly   731 AKM-------------LDHLVISTPRLISSYMNPILKALVPKLHEPESNPGVILNVLRTIGDLAE 782
            .|:             :|||.||.       :..|:..|:..||||.::..      ....||.:
Human  1316 TKVYDMLKSENLLGKQIDHLFISN-------LPEIVVELLMTLHEPANSSA------SQSTDLCD 1367

  Fly   783 VNGGSDE------------------MELWADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATG 829
            .:|..|.                  :.......|..:||:|  :.|||.....|..:.:..:.|.
Human  1368 FSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL--SKSPDSYQKILLAICEQAAETN 1430

  Fly   830 RVVTPYHKYPVL------IDILINFLKTEQRRSIRRETIRVLGLLGAMDPYKHKMNKGLIDSQKD 888
            .|   |.|:.:|      :.:|:..:|:              ||.||.         ..:.....
Human  1431 NV---YKKHRILKIYHLFVSLLLKDIKS--------------GLGGAW---------AFVLRDVI 1469

  Fly   889 NVLIAYSDGKVDESQDIS------TAELLVNMGNALDEYYPAVAIAALMRILRDPTLSTRHTSVV 947
            ..||.|.:.:.....|:|      ..:||..:......|            .:|...:..|..|.
Human  1470 YTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTY------------CKDALENHLHVIVG 1522

  Fly   948 QAVTFIFQSLGIKCVPYLAQVLPNLLDNVR--TADNNLREFLFQQLAIL------VAFVKLHI-- 1002
            ..:..:::.:         :|...:||.::  ..||...|.|:..:.:|      |.|..|.|  
Human  1523 TLIPLVYEQV---------EVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQ 1578

  Fly  1003 --ISYMGDIFKLIKE---FWTINT----PLQNT--LINLIEQIAVALGCEFRDYLAELIPQILRV 1056
              |.|....|.|::|   |.:::.    ||...  |.:|..|:.:     .:|.:.:    |:|.
Human  1579 QKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLEL-----HKDQMVD----IMRA 1634

  Fly  1057 LQHDNSKDRMVTR---RLLQ-------------ALQKFGSTLGYYLPLILPPI------------ 1093
            .| ||.:|.::.:   .|||             .|:..||.||...|:....|            
Human  1635 SQ-DNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTK 1698

  Fly  1094 -VKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDAEPELRDQAMTTLRS-LA 1156
             :|||:...:  |.:.:.|..:||            .::...|:|       |..|:|.|:: ||
Human  1699 ALKLFEDKEL--QWTFIMLTYLNN------------TLVEDCVKV-------RSAAVTCLKNILA 1742

  Fly  1157 KQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELRPSRFKNNEPFVT 1221
            .:.|..:.....|.         .||    :|:.::...|....:      |...||....||  
Human  1743 TKTGHSFWEIYKMT---------TDP----MLAYLQPFRTSRKKF------LEVPRFDKENPF-- 1786

  Fly  1222 DRNSNNKNLQVTTNELRTAWQVTRRVSKDDWVEWL----------KRLSIGLLKESPSHALRACR 1276
             ...::.||.:..:|           :.|.|::.|          |...:.|||.........|:
Human  1787 -EGLDDINLWIPLSE-----------NHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQ 1839

  Fly  1277 SLAQE--YDTLLRDL-----------FNAAFISCWTELSPDLKNELTQSLIQALQ-----VTDMP 1323
            ::...  :|.||:|.           ....|.||....|...::....:|....:     ..| .
Human  1840 TVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLD-K 1903

  Fly  1324 EITQTILNLAEFMEHCDR--------DPIPIETKLLGTR--AMACRAYAKALRY----------- 1367
            :..:|:|.:.::|....|        |...::...|...  |.:|.|:..||.|           
Human  1904 KSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMD 1968

  Fly  1368 -KEEEFLLREDSQVFESLILINNKLQQR---EAAEGLLTRYRNAANELNVQG------------- 1415
             :|:..|..|:.....::..::.|.::.   ...:.||..||:.....::.|             
Human  1969 DQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRL 2033

  Fly  1416 RWYEKLHNWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTK---HEWENFGTEAK 1477
            |.||....|.:||..|:......||..:|  |.::.|:.||....||...|   :|.:::..|.:
Human  2034 RTYEHEAMWGKALVTYDLETAIPSSTRQA--GIIQALQNLGLCHILSVYLKGLDYENKDWCPELE 2096

  Fly  1478 SRAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDGSY----YRAVLAVHHDDFETAQRLIDETRDL 1538
            .    |...|||....|    ::...:.::.:..||    |.|:.::...:|.|....:...|..
Human  2097 E----LHYQAAWRNMQW----DHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVK 2153

  Fly  1539 LDTELTSMAGESYERAYGAMVCVQMLAELEEV-------IQYKLIPE------------------ 1578
            ...|:...:.||....|..:..:|.:.|||.:       :.::.:.|                  
Human  2154 EVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFS 2218

  Fly  1579 RREP--------LKTMWWKRLQGGQRLVEDWRRIIQVH----SLVVK-------PHEDIHTWLKY 1624
            .:||        |:.:..|.:...||  |..:.|:..|    |::.:       |...|....:|
Human  2219 FQEPIMALRTVILEILMEKEMDNSQR--ECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQY 2281

  Fly  1625 ASL----------------CRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYM- 1672
            .|:                .:|..||.||     :|.....||:.:  ...|.|.:...||:.: 
Human  2282 NSVSCGVSEWQLEEAQVFWAKKEQSLALS-----ILKQMIKKLDAS--CAANNPSLKLTYTECLR 2339

  Fly  1673 AANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQRLMARCYLRMA-----TWQNKLQDSIRP 1732
            ...|.|.|                :||       ::..::.:.||..|     .:..:..|.:| 
Human  2340 VCGNWLAE----------------TCL-------ENPAVIMQTYLEKAVEVAGNYDGESSDELR- 2380

  Fly  1733 DAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLM 1797
               .|.::.|.....:....|:  .:..||.....:.:::.|.:.:   ..:|:.....:.::..
Human  2381 ---NGKMKAFLSLARFSDTQYQ--RIENYMKSSEFENKQALLKRAK---EEVGLLREHKIQTNRY 2437

  Fly  1798 II--------------------QRYAVPAVQGFFRSISLIKGNSLQD--TLRLLTLWFDYGNHAE 1840
            .:                    :|:...||:.:..  .|:.|.. .|  ..||.:||.:....:|
Human  2438 TVKVQRELELDELALRALKEDRKRFLCKAVENYIN--CLLSGEE-HDMWVFRLCSLWLENSGVSE 2499

  Fly  1841 VYEAL-LSGMKLIEINTWLQVIPQLIARIDTHRQLVG-----QLIHQLLMDIGKNHPQALVYPLT 1899
            |...: ..||| |....:|.::.||.||:.|  :::|     ::::.|:..|..:||...:: :.
Human  2500 VNGMMKRDGMK-IPTYKFLPLMYQLAARMGT--KMMGGLGFHEVLNNLISRISMDHPHHTLF-II 2560

  Fly  1900 VASKSAS---------LARRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEE 1955
            :|..:|:         :|||:   :|..::.|.|..|.|                     :..|.
Human  2561 LALANANRDEFLTKPEVARRS---RITKNVPKQSSQLDE---------------------DRTEA 2601

  Fly  1956 ASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLD 2020
            |:|:                :..:..|.||.::..       ..|.:||         .::.:||
Human  2602 ANRI----------------ICTIRSRRPQMVRSV-------EALCDAY---------IILANLD 2634

  Fly  2021 RA-WDIYYHVFQKISRQLPQLTSLELPYVSP--KLMTCKD-----LELAV--PGSYNPGQELIRI 2075
            .. |        |..|:     .:.:|...|  ||...:|     :|:.|  .|.|.   .|:.|
Human  2635 ATQW--------KTQRK-----GINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYG---NLVTI 2683

  Fly  2076 SIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRR 2140
            ...|...::......|:.:...||:||:...|:||.:|||||..:.|:|.:.||||..:.:|.:|
Human  2684 QSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKR 2748

  Fly  2141 NLAIQRYAVIPLSTNSGLIGW-----------VPHCDTLHTLIR--DYR----DKKKVPLNQEHR 2188
            .|.|..|.|:|||..||::.|           |.:.|..|...|  |:.    .||.:.:.::  
Human  2749 KLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKK-- 2811

  Fly  2189 TMLNFAPDYD-HLTLMQKVE-VFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSM 2251
               :|...|: .:.:.|..: ||.:..       :.|.|   .|:  :|||:|..||||:|..|:
Human  2812 ---SFEEKYEVFMDVCQNFQPVFRYFC-------MEKFL---DPA--IWFEKRLAYTRSVATSSI 2861

  Fly  2252 VGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFE---VAMTREKFPEKIPFRLTRMLIKAMEVTG 2313
            |||||||||||..|::::..|.:::|||.|..||   :..|    ||.:||||||.::..|.:||
Human  2862 VGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT----PETVPFRLTRDIVDGMGITG 2922

  Fly  2314 IEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGM 2378
            :||.:||.||..|.|:|.::::|:.::|..:||||.:|.:..:...                   
Human  2923 VEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL------------------- 2968

  Fly  2379 QDSLSNSVEDSLPMAKSKPYDPTLQQGG--LHNNVAD---ETNSKASQVIKRVKCKLTGTDFQTE 2438
              .|....||...:      .|||....  ...|::|   ..|..|.:|:.|::.||.|.:..|.
Human  2969 --YLQQRPEDETEL------HPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTV 3025

  Fly  2439 KSVNEQSQVELLIQQATNNENLCQCYIGW 2467
            .||.  .||.||||||.:.:||.:.:.||
Human  3026 LSVG--GQVNLLIQQAIDPKNLSRLFPGW 3052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 540/2612 (21%)
HEAT repeat 632..658 CDD:293787 5/49 (10%)
HEAT repeat 668..698 CDD:293787 3/29 (10%)
HEAT repeat 706..736 CDD:293787 13/75 (17%)
HEAT repeat 749..780 CDD:293787 6/30 (20%)
HEAT repeat 798..823 CDD:293787 8/24 (33%)
DUF3385 831..999 CDD:288698 31/187 (17%)
HEAT repeat 841..870 CDD:293787 5/34 (15%)
HEAT repeat 880..917 CDD:293787 7/42 (17%)
HEAT repeat 925..954 CDD:293787 3/28 (11%)
Rapamycin_bind 1937..2034 CDD:285924 13/97 (13%)
PIKKc_TOR 2075..2353 CDD:270713 105/299 (35%)
FATC 2440..2471 CDD:280430 14/28 (50%)
ATMNP_000042.3 TAN 8..165 CDD:402988
Interaction with ABL1. /evidence=ECO:0000269|PubMed:9168117 1373..1382 1/8 (13%)
FAT 2097..2489 CDD:396714 72/443 (16%)
PIKKc_ATM 2683..2962 CDD:270715 105/299 (35%)
FATC 3026..3055 CDD:396715 14/29 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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