DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and pik3cg

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_021330656.1 Gene:pik3cg / 406598 ZFINID:ZDB-GENE-040426-2532 Length:1113 Species:Danio rerio


Alignment Length:1327 Identity:250/1327 - (18%)
Similarity:441/1327 - (33%) Gaps:471/1327 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1168 PMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELRPSRFKNNEPFVTDRNSNNKNLQV 1232
            |:|:|..||.|      ...:....|.|.::..:.|.|..| |:..||::...|      ..|.|
Zfish    26 PVVRREENKRR------RRRMKAFTSASAVSMEHIAVEFVL-PTTNKNSKTLDT------LQLDV 77

  Fly  1233 TTNELRTAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISC 1297
            |.|     |.|             :::.:.|...:.:..|  |....|:|               
Zfish    78 TGN-----WTV-------------EQVKVQLWHRAVTSKL--CPEFYQKY--------------- 107

  Fly  1298 WTELSPDLKNELTQSLIQALQVTDMPEITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRAYA 1362
                |||....|.|......::.|..::.||                           :.|..|.
Zfish   108 ----SPDYCILLYQKKGNWYEIYDKQQVFQT---------------------------LDCIRYW 141

  Fly  1363 KALRYKEEEFLLREDSQVFESLILINNKLQQREAAEGLLTRYRNAANEL---------NVQGRWY 1418
            ||||               :.:..|:..::|:.|.:.|  :|:...|.|         ||.    
Zfish   142 KALR---------------KDVGKIHLVVRQQPAEDSL--QYQRFLNHLIGYDVTDVSNVH---- 185

  Fly  1419 EKLHNWDEALEHYERNL----KTDSSDLEARLGHMRCLEALGDW-----------SELSN----V 1464
                  |:.||...|.|    |.:.||.:..      |.::..|           |::||    :
Zfish   186 ------DDELEFTRRKLLTPRKIELSDRDPN------LYSMDPWMTTTPMPEYLLSKISNNHILM 238

  Fly  1465 TKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPEDTQD---GSYY------RAVLAV 1520
            ..|:                          |...:.::...:||..   .|::      ||:|.:
Zfish   239 VIHK--------------------------ETTSQTIKVSIDDTPVQVLQSFFAKITNKRALLGI 277

  Fly  1521 HHDDFETAQRLIDETRDLLDTELTSMAGESYERAYG---------AMVCVQMLAELEEVIQYKLI 1576
            ..|..|:            |..|.....|.|  .||         ...|::...|:..|:::...
Zfish   278 SEDVSES------------DFVLRVCGREEY--LYGNNAIKDFHWIRQCLKNGEEIHLVLEHPPN 328

  Fly  1577 PERREPLKTMWWKRLQGGQRLVEDWRRIIQVH---SLVVKPHEDIHT---WLKYASLCRKSGSLH 1635
            ||:....|..|.:        |:|...:...|   ::..|.||.:.|   |             .
Zfish   329 PEQDVVQKEDWSQ--------VDDCTGVAGTHEQLTITEKDHEKVFTISLW-------------D 372

  Fly  1636 LSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLP 1700
            .:.|..|.:||.|..:     ||.|...:.:.                           |.|...
Zfish   373 CNRKFRVKILGIDIPV-----LPRNSELIVFV---------------------------EASIFH 405

  Fly  1701 PEALKQQDQRLMARCYLRMATWQNKLQDSIR-PDAIQGA-----LEC--FEKATSYDPNWYKAWH 1757
            .:.|..| :|..::.:.....|...|:.:|: .|..:||     :.|  .:..||.:........
Zfish   406 GQQLLAQ-ERTSSKPFTEEVIWNTWLEFNIKIKDLPKGARLSLQVSCGKAQTQTSKETECKNKSR 469

  Fly  1758 LWAYMNFKVVQAQKSAL-------------DKQQPPGASMGMTMGSGLDSD-------LMIIQRY 1802
            |..|:|..:|. .:|.|             :|.:...:.....:.|..:.|       .:::.:|
Zfish   470 LLYYVNLLLVD-HRSLLRQGEFILHMWKMPEKSEDNSSVNADKLTSATNPDKNNSMAVAILLDKY 533

  Fly  1803 AVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVIPQLIAR 1867
            ..|......:....|:|...|.         :..||..         |..|         |:||.
Zfish   534 CYPVALPKSKDSPDIEGERGQR---------EMPNHLR---------KQFE---------QIIAT 571

  Fly  1868 IDTH------RQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILDSMRKHSPT 1926
            ...|      ::|:.....:.:.|     |:|  ||                 |.|.|::...  
Zfish   572 DPLHPLTSEDKELLWHFRQECMRD-----PKA--YP-----------------KFLSSVKWGK-- 610

  Fly  1927 LVEQAVMCSEELIRVAILWHEQWHE-GLE-EASRLYFGDRNVK----------GMFEIL------ 1973
              ::||..:..|:..:.:|.....: ||. :....:|.|.||:          |..::|      
Zfish   611 --QEAVAITHYLLERSTIWDRSVLDVGLVLQLLDCHFSDENVRTIAVRKLETLGDDDVLRYLLQL 673

  Fly  1974 ------EPLH-AMLERGPQTLKETSFSQAYGR--------ELTEAYEWSQRYKTSAVVM------ 2017
                  ||.| :.|.|  ..||....|:..|.        |:.::..:.|||   ||::      
Zfish   674 VQAVKFEPYHDSALAR--FLLKRALRSKRIGHFLFWFLRSEIAQSMHYQQRY---AVILEAYLRG 733

  Fly  2018 -------DLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLM--TCKDLE----LAVPGS---- 2065
                   |..:..:| ....||::|::.|: |.|...:|.:::  ..:.||    |.:|.|    
Zfish   734 CGEEMLQDFRKQVEI-TEALQKVAREIKQI-SAEKYDISAQVVFQLRQKLEGLQVLGLPDSFKVP 796

  Fly  2066 YNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSN----GKDYM-YLLKGHEDLRQDERVMQLFS 2125
            |:||  |...:::....:|:.||::|..|..:.::    ..|.: .:.|..:|||||..::|:..
Zfish   797 YDPG--LRAGALVIEQCKVMASKKKPLWLQFKRADPTTLSSDTIGIIFKDGDDLRQDMLILQILL 859

  Fly  2126 LVNTLL-LDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRT 2189
            ::.::. |:..|     |::..|..|......|:|..|....|:              .|.:..|
Zfish   860 IMESIWELESLD-----LSLLPYGCISTGNKIGMIEIVKDATTI--------------ANIQQST 905

  Fly  2190 MLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGY 2254
            :.|                    .|..:.:.|::.|..|..:.:...:..:.:..|.....:..|
Zfish   906 VGN--------------------TGAFKDEILSQWLREKCVNEDKHQQAVDRFVFSCGGYCVATY 950

  Fly  2255 ILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKF----PEKIPFRLTRMLIKAMEVTGIE 2315
            :||:||||..|:|:.. :|.:.|||||   .:....:.|    .|::||.||...:..|..||.:
Zfish   951 VLGIGDRHNDNIMITE-TGNLFHIDFG---HILGNYKSFLGISKERVPFVLTPDFLYLMGTTGKK 1011

  Fly  2316 GT-----YRRTCESVMLVLRRNKDSLM 2337
            .:     ::..|....|.||.:.:.|:
Zfish  1012 SSPNFLQFQNVCLKAYLALRHHTNLLI 1038

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 250/1327 (19%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 29/142 (20%)
PIKKc_TOR 2075..2353 CDD:270713 59/278 (21%)
FATC 2440..2471 CDD:280430
pik3cgXP_021330656.1 PI3K_rbd 221..327 CDD:307097 22/145 (15%)
C2_PI3K_class_I_gamma 366..537 CDD:176044 34/217 (16%)
PI3Ka_I 559..735 CDD:238444 44/226 (19%)
PI3Kc_IB_gamma 739..1105 CDD:270627 77/347 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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