DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and atm

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_002664603.3 Gene:atm / 403064 ZFINID:ZDB-GENE-040809-1 Length:3091 Species:Danio rerio


Alignment Length:2751 Identity:556/2751 - (20%)
Similarity:973/2751 - (35%) Gaps:805/2751 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 QRESTKQSSEPQWYRICYDEANGS--FNADLGSSKDQKGVTRDDRIHGGLVVFNELFRCANATWE 271
            :.::|....|..:.:..:|||:.|  |..|    ||.              |::|         :
Zfish   650 ETKATMDEVESLFLQFSFDEAHSSAGFTVD----KDS--------------VYSE---------K 687

  Fly   272 RRYTSLKTLFPKTQHNKFLEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQTHLGEGEHHKGVAKF 336
            .::|.::.|..|.:|:....|....:..|..:|..|...|     |......:|....:..:...
Zfish   688 PQFTVIQALRSKLEHSLLSIAEQLFTCYSPDSTNTPHECV-----LRCVSLLIGVLAAYVCIGML 747

  Fly   337 ASQHNVLESAY--AQEILQE--HYTSICDNVL-EQRTSKSPYVQQALL---------QILPRLAA 387
            :.:...|...:  |:.::.|  ||||...:.| |..|..|  ||..:|         :...:::.
Zfish   748 SEEQACLSPLFLKAKALVHEFSHYTSTAKSKLAENETLAS--VQSVMLLCSDCICRREKGDKMST 810

  Fly   388 FNRAVFVE----KYLQTCVSHLMQILRGKEKDRTVAY----ITIGYMAVAVQSAIEVHL------ 438
            .:|.:|::    :.|........|:|....|..|:..    :.:....:.|.:..|:.|      
Zfish   811 ISRTLFMKTLPVRLLNDLCDMSKQLLSNSGKKDTIVIESEPVDMQTSRIQVDNQEEIDLFEDGDG 875

  Fly   439 -----------------SSIMTSVKVALPSKDLTSKRKVPVDPAVFACITLLAHAVKSEI----- 481
                             |..:|..|.||..:.|:.:     |....:.:..|:....||:     
Zfish   876 TQHITSRPSQSNEEAADSKFITGTKSALSEEHLSKQ-----DLTFLSVLGFLSLCASSELNGGFS 935

  Fly   482 ---ADDVKDILEQMFYTGLSPALTV-----CLRELSENV----PQLKSAITEGLIGILSQVLMNK 534
               .|..:.:|:.:.....|..|.:     .|::|...|    |:..:|:...|..:.|....::
Zfish   936 FKPLDTQRKLLKLLDLADFSQMLHLQMYLSLLKKLPAEVASLDPEEFNALLRPLADVCSLYRQDQ 1000

  Fly   535 ---AAILPYTALPTIAIDGSLMQNGDGATTVLA------LKTLGTFNFEEQNMLDFVQRCADYFI 590
               :||| ::.||:|...| |..:|......:|      ||.:..|.|     |....:|.....
Zfish  1001 EVCSAIL-FSLLPSIRCLG-LSSSGSEQEEDMADIKGSLLKVISGFCF-----LGKSGKCTSSVR 1058

  Fly   591 VHEQQEI--RLEAVQTCTRLLKLAVQSSE---SMENSKTLSDTVSHV-------IERLLMVAITD 643
            |..:|.:  .||| ..|.:...|.::..|   |...|..|:|:..||       :|.|.:.....
Zfish  1059 VALRQCLLALLEA-DPCCKWAVLTLREEELPVSAVLSSLLADSHQHVCMLTALSVESLFLKKALH 1122

  Fly   644 MDCNVRIRILRSLDETFDG-KLAQPESL----NSLFITLHDEIFEIRELAMVTIGRLSSINPAYV 703
            ....:.:. |::....|:. .|...|.:    |.....|.||.|..|...:.::..:.|.:|...
Zfish  1123 SSRKMMLP-LKNQQTAFENIYLKAQEGIRRQKNCPSEDLPDETFNRRATLLKSVSMVMSCSPVCE 1186

  Fly   704 MPKLRTTMIELITDLKYSGMSR---------------NKEQSAKMLDHLVISTPRLISSYMN--- 750
                :..:..|....|.:|:..               |::..:.:..||..    |::.::|   
Zfish  1187 ----KQALFALFQSYKENGIDEQLIKKVLRGISKSLGNRDHKSLINSHLYY----LVAEWLNQKQ 1243

  Fly   751 -------------------------PILKALVPKLHEPESNPGVILN---VLRTIGDLAEVNGGS 787
                                     .....|:|.|        |.||   .:::|||    :.|.
Zfish  1244 SDSSYTLQSFPYALLDCCSLEEFFRSSYHVLIPHL--------VFLNDFEGVKSIGD----HLGQ 1296

  Fly   788 DEMELWADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRVVTPYHKYPV------------ 840
            |..:|.|.....|::.:|..        .||  .||......:....:..|.:            
Zfish  1297 DWKQLLAKCFPKIMVNILPH--------FAL--AGQDTHVAQQREKAHRVYDILKNSNCLGKQQI 1351

  Fly   841 -------LIDILINFLKTEQRRSIRRETIRVLGLL----GAMDP------YKHKMNKGLID---- 884
                   |.||::..|.|      ..||....|.|    |.:||      :...:.|..:|    
Zfish  1352 DSLICNNLPDIVVELLMT------LHETAGDKGDLQKFTGELDPAPNPPFFSSYVIKATLDYLSK 1410

  Fly   885 --SQKDNVLIAYSDGKVDESQDISTAELLVNMGNALDEYYPAVAIAALMRILRDPTLSTRHTSVV 947
              |.....|:|     :.....:|...:||.:....||...|..        |...|...|..|.
Zfish  1411 CHSANHKSLVA-----ILSKTPMSIQRILVAVCQKADETTNAYE--------RHRILMMYHLFVS 1462

  Fly   948 QAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADNNLREFLFQQLAI---LVAFVKLHIISYMGDI 1009
            ..:..:...||......|..::..|:.::.:..:...|...:.|::   |::.|....:.|..| 
Zfish  1463 LLLKEVKDGLGGAWAFVLRDIIYTLIHHINSRSSQQDEVSTRSLSLCCDLLSLVCQTAVEYCDD- 1526

  Fly  1010 FKLIKEFWTINTPLQNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRMVTRRLLQA 1074
                    .:.:.||..:..|..|:..      :..::|.:..:||.|..:|.::||:.:.    
Zfish  1527 --------ALESHLQVIVGTLTAQVTE------QSAISEQVLSLLRFLVMENPENRMLRKS---- 1573

  Fly  1075 LQKFGSTLGYYLPLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSR--IIH----- 1132
                       :||:.|          .|:|.:...|....: |.:.....|:.|  |.|     
Zfish  1574 -----------IPLLEP----------FPEQPNFAELRAAQH-ALKYSSGAFTLRQEIEHFLSVA 1616

  Fly  1133 -----PLVRVLDAEPELRDQAMTTLRSLAKQLGK---------KYLVFVPMVQRTLNKHRIV--D 1181
                 ||.| |:...:|:.|    |.|..:|:|:         ...:.|.:|...|...:|.  .
Zfish  1617 SCDSLPLAR-LEGLKDLKRQ----LHSHKQQIGQLLKECHADLDSCILVNLVLNLLQLCKIAANH 1676

  Fly  1182 PEYEELLSKIKSC---------STLADSYGAGESELRPSRFKNNEP----FVTDRNSNN------ 1227
            |...:::.....|         |::|..:|..:...|.::..:|.|    |:...:.:|      
Zfish  1677 PGGGDIMKAAGRCLGELGPVDLSSIALHHGKDQLYARAAKLFHNVPHQWIFIILNSMDNALTNHS 1741

  Fly  1228 -----------KNLQVT--------------------TNELRT--------AWQVT-----RRVS 1248
                       |::..|                    .|..|:        |..||     |..|
Zfish  1742 IAVRQTAGLCIKDILATQSGIEFGEIHKSKRDPLLAYLNPFRSSKKREPIMAMDVTPESRDRLTS 1806

  Fly  1249 KDDWV-------EWLKRLSIGLLKES--PSHALRACRSLAQ-------------EYDTLLRDL-- 1289
            .|.|:       :|||.|.:.||...  .:.||...|.|.:             .:|.||.|:  
Zfish  1807 ADLWLMQPDGHKDWLKNLCMALLDSGGVRNEALLLTRPLCEVKTDFCQRMLPLFVHDILLGDVDG 1871

  Fly  1290 ---------FNAAFISCWTELSPDLKNELTQSLIQALQVTDMPEITQ----TILNLAEFMEHCDR 1341
                     ..:.|..|....:| .....|..|..:...||.....|    ::.::...::|..:
Zfish  1872 SWRQLLSTHIQSFFSQCRRPSTP-TSRPTTPMLSDSGNTTDAANQCQIDKASLRSMLAVIDHLRQ 1935

  Fly  1342 DPIPIE--TKLLGT-----------------RAMACRAYAKALRYKE---------EEFLLREDS 1378
            ...|:.  :...||                 .|..|.|:..||.|.|         .|...|..|
Zfish  1936 QSRPLAPGSNEYGTVCDSNFWLDLNYLEVAGAAQMCSAHFTALLYSEIYVDKIRSNMEQNRRSQS 2000

  Fly  1379 Q-----VFE--SLILINNKLQQREAAEG-------LLTRYRNAANELNVQG-------------R 1416
            :     .||  |..|..:.|.:|...:.       |:..||......::.|             |
Zfish  2001 RASRRITFEDNSQTLSVSNLNERSLEDSGFSLQDLLIEVYRCIGEPDSLYGCGGGKLTSPLTRIR 2065

  Fly  1417 WYEKLHNWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAG 1481
            .||....|::||..|:  |.::..::..::|.:..|:..|..|.||... |..|..|.|......
Zfish  2066 TYEHEAMWEKALVSYD--LHSNLPEVTRQIGIVEGLQNFGLCSILSTYL-HGLEKDGMEWGPELR 2127

  Fly  1482 PLAAVAAWGLQDWEAMREYVRC-IPEDTQ------DGSYYRAVLAVHHDDFETAQRLIDETRDLL 1539
            .|...|||....|:       | :||..:      :.|.:.|:.|:...:|...::.::..|...
Zfish  2128 ELRFQAAWRSTQWD-------CDLPERNEKLKPGINESLFNALQALRDKEFSLFEQTLNYARGRE 2185

  Fly  1540 DTELTSMAGESYERAYGAMVCVQMLAELEEVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRI 1604
            ..||...:.|:....|.|:..:|.::||:.|.:....|.....|..::.|..|....|.:....:
Zfish  2186 VEELCRGSLEAVSSLYPALCNLQRISELQSVEELFSRPVTDSSLNEVYRKWQQHSDLLTDSDFSL 2250

  Fly  1605 IQ--------VHSLVVKPHED-------IHTW----LKYASLCRKSGS--------LHLSHKTLV 1642
            ::        :...::....|       |.|:    ::...|.|.:|:        .|:....||
Zfish  2251 VEPVLALRSSIQEALISSETDPDRKNYLISTYSSHLMELCRLARSAGNTQLAERAVFHMKQHNLV 2315

  Fly  1643 MLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHF-------VSTYSQEL---- 1696
            | .|:.   :.:......:.||.:...::..|...|::...:|...       |..||:.|    
Zfish  2316 M-SGSG---SSSWAWQLEEAQVFWVKKEHGLALELLKQMIHKLDDLVCVNPAVVPVYSECLRLCG 2376

  Fly  1697 -----SCLPPEA--------------------LKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQ 1736
                 |||...|                    ||.:.|....:.|..:|.:.         ||..
Zfish  2377 SWLAESCLESPAVILENYLERAVEVIEEHCGGLKSKLQSQKTQAYFSLARFS---------DAQY 2432

  Fly  1737 GALECFEKATSYDPNWY----KAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLM 1797
            ..:|.:.|::.:: |.:    ||......|..:.|...:..:..|:.  ..:.:...:.|.:|. 
Zfish  2433 QGIENYMKSSEFE-NKHALLEKAKEEVDLMRERKVNNNRYTVKVQRE--LELDVKALANLQADR- 2493

  Fly  1798 IIQRYAVPAVQGFFRSISLIKGNSLQDT--LRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQV 1860
              .|:.:.||:.:...:.|   ....||  .||.:||.:..:...|.:.:.||:|.|....:|.:
Zfish  2494 --NRFLLKAVENYIECLEL---GEEHDTWVFRLASLWLENADVKAVNDKMKSGVKKIPSYKFLPL 2553

  Fly  1861 IPQLIARIDTH------RQLVG--QLIHQLLMDIGKNHPQ---ALVYPLTVASKSASLARRNAAF 1914
            :.||.||:.|.      .|.||  .::::|:.....:||.   .::..|..|:|..|.:|..:: 
Zfish  2554 MYQLAARMGTKVSSSMASQDVGFHHVLNELICQSSVDHPHHTLFIILALVNANKDDSFSRSRSS- 2617

  Fly  1915 KILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAM 1979
              ..|.|:.||..:|:|     |:.|..|                           :::....|.
Zfish  2618 --KSSARQPSPLDLERA-----EVARKII---------------------------DVVRKKRAK 2648

  Fly  1980 LERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLE 2044
            :.:..:.|     ..||   :|.||..:.|:||                          :..::.
Zfish  2649 MVKDIEML-----CNAY---ITLAYMDASRHKT--------------------------EKKAIP 2679

  Fly  2045 LPYVSPKLMTCKDLE-LAVP---------GSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGS 2099
            :|...| ||..|||| :.:|         |.|   ::::.:...|.:..:......|:.:...||
Zfish  2680 IPAEQP-LMQIKDLEDVIIPTMDIKVDPSGRY---EDVVTVRSFKRHFHLAGGVNLPKIIDCEGS 2740

  Fly  2100 NGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGW--- 2161
            :|.....|:||.:|||||..:.|:|.:.:|||..:.:|.:|.|.|:||.|:|.|..||::.|   
Zfish  2741 DGISRRQLVKGQDDLRQDAVMQQVFHMCSTLLQRNAETRKRKLNIRRYKVVPFSQRSGVLEWCSG 2805

  Fly  2162 -VPHCDTL-------HTLIR-------------------DYRDKKKVPLNQEHRTMLNFAPDYDH 2199
             ||..:.|       |...|                   ::.||    |........||.|.:.:
Zfish  2806 TVPIGEFLVDPQKGAHKRFRPQDWANMLCRKKMMEAQRMEFNDK----LQAFTEVCQNFRPVFRY 2866

  Fly  2200 LTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPS 2264
            ..:.:.::                      |:  :|.|||..||||:|..|:||||:||||||..
Zfish  2867 FCMERFLD----------------------PA--IWLERRLAYTRSVATSSIVGYIVGLGDRHIQ 2907

  Fly  2265 NLMLDRMSGKILHIDFGDCFE---VAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVM 2326
            |:::|..:.:::|||.|..||   :..|    ||.:||||:|.::..|.:||:||.:||.||..|
Zfish  2908 NILIDEQTSELVHIDLGVAFEQGKILPT----PETVPFRLSRDIVDGMGITGVEGVFRRCCEKTM 2968

  Fly  2327 LVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDK---KGNDAVAGAGA-----PGGRGGSGMQDSLS 2383
            .|:|.::::|:.::|..:||||.:|.:..:..   :.:|..|...|     |||           
Zfish  2969 EVMRSSQEALLTIVEVLLYDPLFDWTMNPLKAFYLQQHDEQAELNATLNPTPGG----------- 3022

  Fly  2384 NSVEDSLPMAKSKPYDPTLQQGGLHNNVADET--NSKASQVIKRVKCKLTGTDFQTEKSVNEQSQ 2446
            :.:|                   .|...:|..  |..|.:|:.|::.||.|.:..|..||.  .|
Zfish  3023 DEIE-------------------THRKASDSQSFNKVAERVLLRLQEKLKGVEDGTVLSVG--GQ 3066

  Fly  2447 VELLIQQATNNENLCQCYIGW 2467
            |.||||||.:.:||.:.:.||
Zfish  3067 VNLLIQQAMDPKNLSRLFPGW 3087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 536/2650 (20%)
HEAT repeat 632..658 CDD:293787 4/32 (13%)
HEAT repeat 668..698 CDD:293787 7/33 (21%)
HEAT repeat 706..736 CDD:293787 4/44 (9%)
HEAT repeat 749..780 CDD:293787 9/61 (15%)
HEAT repeat 798..823 CDD:293787 4/24 (17%)
DUF3385 831..999 CDD:288698 35/205 (17%)
HEAT repeat 841..870 CDD:293787 9/32 (28%)
HEAT repeat 880..917 CDD:293787 8/42 (19%)
HEAT repeat 925..954 CDD:293787 4/28 (14%)
Rapamycin_bind 1937..2034 CDD:285924 13/96 (14%)
PIKKc_TOR 2075..2353 CDD:270713 97/310 (31%)
FATC 2440..2471 CDD:280430 14/28 (50%)
atmXP_002664603.3 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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