DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and Pi3K59F

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster

Alignment Length:	854	Identity:	168/854 - (19%)
Similarity:	292/854 - (34%)	Gaps:	280/854 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1566 ELEEVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRK 1630
            |.|..::|||      |.|          .:||......||:.:||.:.|..:       :...:
  Fly   238 EPEGDVKYKL------PAK----------PKLVSVPDSEIQMENLVERKHHRL-------ARSER 279

  Fly  1631 SGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQE 1695
            ||.             :|....|...:......:.|.|......:::.|:...:...::|::.:.
  Fly   280 SGI-------------SDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKA 331

  Fly  1696 LSCLPPEALKQQDQRLMARCYLRMATWQNKLQDSI----------RPDAIQGALECFEKATSYDP 1750
            |:                 .:|:...|  ||:|.:          .|..::.|||....
  Fly   332 LT-----------------KFLKCINW--KLEDEVTQALWMLANWAPMDVEDALELLSP------ 371

  Fly  1751 NWYKAWHLWAYMNFKVVQAQKSALDK-QQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGF---- 1810
                        .|...|.:|.|:.: .|.|            |.||::   |.:..||..
  Fly   372 ------------TFTHPQVRKYAVSRLAQAP------------DEDLLL---YLLQLVQALKYED 409

  Fly  1811 -----------------FRSI-----SLIKGNSLQDTLRLLTLWFDYGNHAEVYEALLSGM--KL 1851
                             .|||     ||:..:||.|                 ..|..||:  .:
  Fly   410 PRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSD-----------------LSATSSGLHGSV 457

  Fly  1852 IEINTWLQVIPQLIARIDTHRQLV----------GQLIHQLLMDIGKNHPQALVYPLTVASKSAS 1906
            |..|   |....::|.|.:.:.:.          ||      ..:...:|.|   |.|..|.|..
  Fly   458 IPAN---QRAASVLAAIKSDKSVSPGSAGGSGSGGQ------GSVALPNPSA---PATPGSSSLP 510

  Fly  1907 LARRNAAFKILDSMRKHS-PT-----LVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRN 1965
            ....:.|..:.:.:...| |.     |:::|  |:...:.....|:....  :||...:...|..
  Fly   511 CDSNSNALMLAEGISFGSVPANLCTFLIQRA--CTNATLANYFYWYLSIE--VEEVESVRKQDER 571

  Fly  1966 VKGMFE-ILEPLHAMLERGPQTLKETSFSQAYGRELTE---------AYEWSQRYKTSAVVMDLD 2020
            ...|:. :|:....:||.|...|:...::....|...:         |.|...|.|.:.....|.
  Fly   572 AHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLL 636

  Fly  2021 RAWDIYYHVFQKISRQLPQLTSLE-LPY-VSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQ 2083
            ...|::     |::     .|:.| :|: :.|::...|    .||         :|.|:.|:.|.
  Fly   637 AEQDMF-----KVN-----FTNFEPIPFPLDPEIYITK----IVP---------MRTSLFKSALM 678

  Fly  2084 VITSKQRPRKLC-IRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRR---NLAI 2144
                   |.||. :......:|..:.|..:|||||:.::|:.:|::.||       ||   :|.:
  Fly   679 -------PAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLL-------RRENLDLKL 729

  Fly  2145 QRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVF 2209
            ..|.|:..|:..|.:.:|..|.....|.|:         ...|.......| .|:.......||.
  Fly   730 TPYKVLATSSKHGFLQYVDSCTVAEVLARE---------GNIHNFFRKHHP-CDNGPYGISAEVM 784

  Fly  2210 EHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGK 2274
            :                              .|.:|.|...::.|:||:||||..||:| ..:||
  Fly   785 D------------------------------TYIKSCAGYCVITYLLGVGDRHLDNLLL-TTNGK 818

  Fly  2275 ILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEG----TYRRTCESVMLVLRRNKDS 2335
            :.|||||    ..:.|:..|...|.:|::.:::||  .||..    .:|:.|.:..|.|||:.:.
  Fly   819 LFHIDFG----YILGRDPKPMPPPMKLSKEMVEAM--GGISSEHHHEFRKQCYTAYLHLRRHANV 877

  Fly  2336 LMAVLEAFV 2344
            ::.:....|
  Fly   878 MLNLFSLMV 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	168/854 (20%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	18/106 (17%)
		PIKKc_TOR	2075..2353	CDD:270713	68/278 (24%)
		FATC	2440..2471	CDD:280430
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042
		PI3Ka_III	284..561	CDD:238442	59/361 (16%)
		PI3Kc_III	601..945	CDD:270628	84/370 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900