DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and Pik3c2a

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_001101970.1	Gene:	Pik3c2a / 361632	RGDID:	1310389	Length:	1687	Species:	Rattus norvegicus

Alignment Length:	1428	Identity:	280/1428 - (19%)
Similarity:	464/1428 - (32%)	Gaps:	551/1428 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1081 TLGYYLPLILPPIVKLFD-----SPYVPQQVSMVALETINNLA--CQL-------DFTDFSSRII 1131
            :|..|.||:.|.:.||||     |.::....:...||..|:.|  |.|       |...|....:
  Rat   211 SLPVYRPLVSPDMAKLFDKIASTSEFLKNGKARTDLEIANSKASVCNLQISPKSEDINKFDWLDL 275

  Fly  1132 HPL-------VRVLDAEPELRDQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLS 1189
            .||       |.||:.|.|.::..:     ||:                       ||....||
  Rat   276 DPLSKPKIDCVEVLEHEEEKKNPVL-----LAE-----------------------DPWDAVLL- 311

  Fly  1190 KIKSCSTLADSYGAGESELRPSRFKNNEPFVTDRNSNNKNLQ---VTTNE---LRTAWQVTR--- 1245
                           |.....||.       .:|..|.|:|.   ||.::   :||. |||:
  Rat   312 ---------------EERSPTSRH-------LERKVNGKSLSGATVTRSQSLIVRTT-QVTKAQS 353

  Fly  1246 RVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISCWTELSPDLKNELT 1310
            :||:.|              .:.:.:|....||.||:                     :::||
  Rat   354 QVSQKD--------------PNGTSSLATGSSLLQEF---------------------EVQNE-- 381

  Fly  1311 QSLIQALQVTDMPEITQTILNLA---EFMEHCDR-----DPIPIETKLLGTRA------------ 1355
                      ::....|:|:.|.   .:.:||..     .|:.::..:.|..|
  Rat   382 ----------EVAAFCQSIMKLKTKFPYTDHCTNPGYLLSPVTVQRNMCGENASVKVSIEIEGFQ 436

  Fly  1356 ----MACRAYAKALRYKEEEFLLREDSQVFESLILINNKLQQREAAEGLLTRYRNAANELNVQGR 1416
                ..|...:..            |..:.::|..:::.|                 |:::| |.
  Rat   437 QPVTFTCDVSSTV------------DIIIMQALCWVHDDL-----------------NQVDV-GS 471

  Fly  1417 WYEKLHNWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAG 1481
            :..|:...:|.|::                .|     .||....:.|..|  |:   ||.|.:..
  Rat   472 YILKVCGQEEVLQN----------------NH-----CLGSHEHIQNCRK--WD---TEIKLQLL 510

  Fly  1482 PLAAVA---AWGLQDWEA---MREYVRCIP------------EDTQDGSYYRAVLAV-----HH- 1522
            ..:|:.   |...:|.||   :.:|:..|.            |:..|..:|:..||:     |.
  Rat   511 TFSAMCQNLARTAEDDEAPVDLNKYLYQIEKPYKEVMTRHPVEELLDSYHYQVELALQTENQHRA 575

  Fly  1523 -DDFETAQRLIDETRDLLDT----------------------ELTSMAG--ESYERAYGAMVCVQ 1562
             |....|.|.|....|.::|                      ::||::|  .|.....|::
  Rat   576 IDQVIKAVRKICSALDGVETPAVTEAVKKLKRAVNLPRNKSADVTSLSGGDTSKNSTRGSL---- 636

  Fly  1563 MLAELEEVIQ----------YKLIPERREPLKTMWWKRL----QGGQRLVEDWRRIIQVHSLVVK 1613
               .||..:|          |.|:     .|.|...|..    ||.:.:.|.|....|:...|..
  Rat   637 ---NLENPVQVSMDHLTAAIYDLL-----RLHTNSCKSSTVCPQGSRNIKEAWTATEQLQFTVYA 693

  Fly  1614 PHEDIHTWL----KYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAA 1674
            .|.....|:    ||..:|      .|||.      |.| ...|.|    ::...||....|:..
  Rat   694 AHGISSNWVSNYEKYYLIC------SLSHN------GKD-LFKPIQ----SKKVGTYKNFFYLIK 741

  Fly  1675 NNQL--------QEAYEQLTHFV--STYSQELSCLP--------PEALKQQDQRLMARCYLRMAT 1721
            .::|        |...|.:.|..  ...:|.....|        ||||.:....|..  :.|..|
  Rat   742 WDELIIFPIQISQLPLESVLHLTLFGVLNQSSGSSPDSNKQRKGPEALGKVSLTLFD--FKRFLT 804

  Fly  1722 WQNK---LQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGAS 1783
            ...|   |..|...::|.||:.  :|               :|:..::|      |....|..|.
  Rat   805 CGTKLLYLWTSSHTNSIPGAIP--QK---------------SYVMERIV------LQVDFPSPAF 846

  Fly  1784 MGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEALLSG 1848
            ..:.....:|.:  |||:|.:.|::      :.|||..|....|..:......:.|.::|.....
  Rat   847 DIIYTSPQIDRN--IIQQYKLEALE------NEIKGKLLDIVHRDSSFGLSKEDKAFLWEKRYYC 903

  Fly  1849 MKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVAS----KSASLAR 1909
            :|                                       ||..|  |..:||    |.|:||:
  Rat   904 LK---------------------------------------HPNCL--PKILASAPNWKWANLAK 927

  Fly  1910 RN------------AAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHE------------QWH 1950
            ..            ||.::||            |....:|:..:|:.|.|            |:.
  Rat   928 TYSLLHQWPPLCPLAALELLD------------AKFADQEVRSLAVSWIEAISDDELTDLLPQFV 980

  Fly  1951 EGLEEASRLYFGDRNVK-------GMFEILEPLHAMLERGPQTLKETSFSQAY-----------G 1997
            :.|:  ..:|.....|:       |..:|...|:.:|:   ..|.:|.|...|           |
  Rat   981 QALK--YEIYLNSSLVRFLLSRALGNIQIAHSLYWLLK---DALHDTRFGSRYEHVLGALLSVGG 1040

  Fly  1998 RELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKI------SRQLPQLTSLELPYVSPKLMTCK 2056
            :.|.|  |.|::.|...::..          |.:|:      :||:....|:|..........|:
  Rat  1041 KGLRE--ELSKQMKLVQLLGG----------VAEKVRQASGSARQVVLQKSMERVQSFFLRNKCR 1093

  Fly  2057 DLELAVPGSYNPGQELIRISIIKTNLQV-----ITSKQRPRKLCIRGSN--GKDYMYLLKGHEDL 2114
                 ||         ::.|::...|.:     .:|...|.|:.:..::  |::...:.|..|||
  Rat  1094 -----VP---------LKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADPLGEEINVMFKVGEDL 1144

  Fly  2115 RQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLST--NSGLIGWVPHCDTLHTLIRDYRD 2177
            |||...:|:..:::.:.|      :..|.::......|||  :.|::..||..|||
  Rat  1145 RQDMLALQMIKIMDKIWL------KEGLDLRMVIFKCLSTGRDQGMVELVPASDTL--------- 1194

  Fly  2178 KKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLK--SPSSELWFERRN 2240
                                      :|::|.....|..:...||:  ||:  :||.|.:.:...
  Rat  1195 --------------------------RKIQVEYGVTGSFKDKPLAE--WLRKYNPSEEEYEKASE 1231

  Fly  2241 NYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFP-EKIPFRLT 2302
            |:..|.|...:..|:||:.|||..|:|| |.:|.:.|||||.....|.....|. ::.||.||
  Rat  1232 NFIYSCAGCCVATYVLGICDRHNDNIML-RSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLT 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	280/1428 (20%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	24/132 (18%)
		PIKKc_TOR	2075..2353	CDD:270713	60/240 (25%)
		FATC	2440..2471	CDD:280430
Pik3c2a	NP_001101970.1	PI3K_rbd	411..514	CDD:279173	22/158 (14%)
		C2A_PI3K_class_II	678..850	CDD:175979	44/213 (21%)
		PI3Ka_II	871..1039	CDD:238441	39/225 (17%)
		PI3Kc_C2_alpha	1044..1396	CDD:270720	73/320 (23%)
		PX_PI3K_C2_alpha	1427..1535	CDD:132822
		C2B_PI3K_class_II	1561..1682	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900