Protein Alignment Tor and mei-41

DIOPT Version :9

• Sequence 1: NP_001260427.1
• Gene: Tor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Sequence 2: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Alignment Length: 2675
• Identity: 520/2675 - (19%)
• Similarity: 937/2675 - (35%)
• Gaps: 838/2675 - (31%)

  Fly   109 VMEIAARSLVKLANMPTSKGADSFDFDIKKAFEVLRGERQEYRRHSAVFILRELAIALPTYFYQH 173
            |:::..:|||::.     |..:....|.:|...:|||.:|          |.:|.::..    ||
  Fly   367 VVQVLTQSLVEIL-----KKEEVLSKDWQKLIAILRGFKQ----------LEKLILSQS----QH 412

  Fly   174 ILTFFEVIFNAIFDPKPAIRESAGEALRAALIVTAQRESTKQSSEPQWYRICYD--EANGSFNAD 236
                             .|.|..|....:.|.:...:....:.::..|..:...  |.....:|
  Fly   413 -----------------KIAEHEGHIDSSVLAMLPLQCEIIKVADTNWNNLSMQLVELESKCSA- 459

  Fly   237 LGSSKDQKGVTRDDRIHGGLVVFNELFRCANATWERRYTSLKTLFPKTQHNKFLEASSSSSMGSQ 301
                         ||.|..|.:.:.|.:   .|:.|.:  |||   :|||              |
  Fly   460 -------------DRRHIHLEICSLLMQ---ITFIRHF--LKT---QTQH--------------Q 489

  Fly   302 LNTLVPR-LKVPFIDKLGSTQTHLGEGEHHKGVAKFASQHNVLESAYAQEIL-----QEHYTSIC 360
            |..::.| ||:.::..: ..:|.             :|.|..::|.|||:.:     :|.....|
  Fly   490 LLAILQRHLKLSYLCAI-RLETP-------------SSVHTQMQSFYAQQYMRLFQSEETQEIFC 540

  Fly   361 DNV--------------------LEQRTSKSPYVQQALLQILPRLAAFNRAVFVEKYLQTC---V 402
            .|:                    :..|:.::..::..|.....:|:.|.....:|.|...|   .
  Fly   541 SNLPQLYISGFIKPEQLMKALPTINNRSGRAQVIRLLLCSQPGKLSVFKVKDRIELYCPKCRPLP 605

  Fly   403 SHLMQILRGKEKDR---------TVAYITIGYMAVAVQSAIEVHLSSIMTSVKVALP-SKDLTSK 457
            ..|..|..||.|.:         .:..|....:.......|..||..:.....|.|. .::..:.
  Fly   606 KKLPGIYLGKCKQQLPCPDFSSTNLEMIANDLLFYPDFECIAQHLDLLCFEPNVILGLLRETEAL 670

  Fly   458 RKVPVDPAVFACITLLAHAVKSEIADDVKDILEQMFYTGLSPALTVCLRELSE-NVPQLKSAITE 521
            :||.|     ..|..|..|::..    ..:.|||:....|:....:..:.|:| ||.|.:|
  Fly   671 QKVSV-----KVIGQLVSAMRVR----SPEFLEQLANLVLAAIKAMLAKPLTEQNVLQQRS---- 722

  Fly   522 GLIGILSQV--------------------------LMNKAAILPYTALPTIAIDGSLMQNGDGAT 560
             ::.:|:.:                          |:.:.|:|..|.:  .|..|
  Fly   723 -MLNVLTAIAHMEDNEIWLFHWFKMTFFFLVHTRSLVAQEAVLAATEM--CASQG---------- 774

  Fly   561 TVLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRL-EAVQTCTRLLKLAVQSSESMENSKT 624
                |:|:..:|:.:::.||...|.|  ..|:....:|. .:::..|::|........:.:..:.
  Fly   775 ----LQTIHLWNWYKRDALDLTVRLA--LNVYLLDGVRFTRSLRALTKMLGFTCVQEFTCKYHRL 833

  Fly   625 LSDTV-SHVIERLLMVAITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEIRELA 688
            |:..| .|.|       :..:...|.:.|.:.:.:.. |.|     .:..|:.::..:|...|
  Fly   834 LTAMVLPHCI-------VNPLCKGVLVLIAKQMQKHI-GTL-----FSISFLRIYTHVFLTEE-- 883

  Fly   689 MVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKM-LDHLVISTPRLISSYMNPI 752
                            |:|..:.|||:.....|.:.:......|. :..|:|        |.|
  Fly   884 ----------------PELANSCIELVVSCTQSSLQQLMNADVKQTVAELLI--------YFN-- 922

  Fly   753 LKALVPKLHEPESNPGVILNVLR-----TIGDLAEVNGGSDEME---LWADDLLSILLEMLGDAG 809
                        .||..::...:     :||.|.|::..:...|   ..|:..|.::........
  Fly   923 ------------RNPTFVMRSFQSLLQLSIGSLEELSSQTANAEFANFIAERFLGVITYFESCLS 975

  Fly   810 SPD----KRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIRRETIRVLGLLGA 870
            .|.    .:...|::|||::...|.......::.::  .:::|:.|.|...::|..:::..:
  Fly   976 EPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKII--AMLSFVHTLQEPRLQRICLKIWHI--- 1035

  Fly   871 MDPYKHKMNKGLIDSQKDNV------LIAYSDGKVDESQDISTAELLVN---MGNALDEYY---- 922
               :.|.:|...:......:      |:|.:: .|.:..|:....:|.|   :|..:.:.|
  Fly  1036 ---FLHVVNVQELGPSLGRIVATLQPLLADNE-SVKQVNDLYEFIILRNASMLGTFITDLYFLDR 1096

  Fly   923 -----PAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADNN 982
                 |::     .:.:|      |||:          .|.:|.:.......|.|:|.:|....:
  Fly  1097 MENVSPSI-----QKCIR------RHTA----------HLDLKGLAEEENQSPPLVDQLRFLQKH 1140

  Fly   983 LREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQNTLINLIEQIAVALGCEFRDYLA 1047
            :.:...|        |:::.:.::||:|...:      ..|.:|:::.:.             |.
  Fly  1141 ITDECLQ--------VRVYALQHLGDLFGRRR------PKLNSTILSELP-------------LE 1178

  Fly  1048 ELIPQILRVL----QHDNSKDRMVTRRLLQALQKFGSTLGYYLPLILPPIVKLFDSPYVPQQVSM 1108
            .::.||:.||    |||:|:.:|.:.:.|       ..||            ..|:.|:|...
  Fly  1179 PMLEQIVNVLMAGCQHDDSQLQMASAKCL-------GELG------------AIDASYLPSNY-- 1222

  Fly  1109 VALETINNLACQLDFTDFSSRIIHPLVRVLDAEPELRDQAMTTLRSLAK----QLGKKYL-VFVP 1168
                            :|:|....||..:.|      |.|:..|.||.:    |...|:: .|..
  Fly  1223 ----------------NFASPQHLPLNILSD------DFAVLALTSLCRGYQFQQNTKHVDSFSL 1265

  Fly  1169 MVQRTLNKHRIVDPE------YEELLSKIK--------SCSTLADSYGAGESELRPSRFKNNEPF 1219
            .:|.||....|...|      ::.|.::::        ||.|...         |||... .:|.
  Fly  1266 AIQETLAICGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVH---------RPSTCL-QQPL 1320

  Fly  1220 VTDRNSNNKNLQVTTNELRTAWQVTRRVSKDDWV-EWLKRLSIGLLKESPSHALRACRSLAQEYD 1283
            .....|:|                    ..::|. .|..||...|......|.|.:.:...:...
  Fly  1321 FGSHYSHN--------------------YYEEWAFLWASRLIDYLPSSGRRHLLSSYKPCIKRDS 1365

  Fly  1284 TLLRDLFNAAFISCWTELSPDLKNELTQSLIQALQ------------------------------ 1318
            .:|...:....:....|.:.:.:|.:.:..:..||
  Fly  1366 NMLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRK 1430

  Fly  1319 ------------VTDMPEITQTILNLA--------EFMEHCDRD-------------PIPIET-- 1348
                        |:|..|.:..:..||        :|::...|:             |..|::
  Fly  1431 YAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPETIDSNY 1495

  Fly  1349 -----------KLLGTRA-MACRAYAKALRYKEEEFLLREDS-----QVFESLILINNKLQQREA 1396
                       |||.:|| ..|..||:||.|.|......||.     :.|..|:.:...|:..::
  Fly  1496 RKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDS 1560

  Fly  1397 AEGLLTRYRNAANELNVQGRWYEK-----------LHNWDEALEHYERNLKTDSSDLEARLGHMR 1450
            .||.            ||.|.|:.           :....:.:..||:.|   ||..:.:..|:|
  Fly  1561 VEGA------------VQVRSYDMSVTQDILVNRLVERQQDMITSYEQLL---SSTDQMQPDHVR 1610

  Fly  1451 C--------------LEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYV 1501
            .              |.|.|.|..||:  ::..:.| .|.||.       ..|.|..::.|.|..
  Fly  1611 AMIDAYLRDTPKTAQLIADGLWQRLSD--RYSDQCF-AECKSE-------LLWRLGSYDEMEELQ 1665

  Fly  1502 RCIPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAG---ESYERAYGAMVCVQM 1563
            ...|.....|............:|::   |:|..|:.:..||.|.:.   .||..||.|::.:.:
  Fly  1666 SNWPAQCSQGCLKLRRPLTTRIEFDS---LLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHL 1727

  Fly  1564 LAEL---EEVIQYKLIPERREP-----LKTM---WWKRLQGGQR---------------LVEDWR 1602
            :.||   :|::: ||..:|.|.     :|..   |..|||..|.               |.|..|
  Fly  1728 VHELHCSQELVE-KLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQR 1791

  Fly  1603 RIIQVHSLVVKPH---EDIHTWLKYASLCRKSGSLHLSHKTLVMLLGTDP--------KL---NP 1653
            |:...:.|:  ||   |....||..|.:.|.:|.|..:...::......|        ||   ..
  Fly  1792 RLTDRNHLL--PHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKG 1854

  Fly  1654 NQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFV------STYSQELSCLPPEALKQQDQRLM 1712
            :|.:..|..:...:..:.....|..|.|.||...|.      :.||.|...|..:|:.:..|..:
  Fly  1855 DQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAI 1919

  Fly  1713 A------RCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQK 1771
            |      .|:::||.:..|:.     :|.||.
  Fly  1920 AVHRQSESCHVQMAQFLEKIL-----EARQGG--------------------------------- 1946

  Fly  1772 SALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYG 1836
                |.:|.|           :.|.|:|.     .:..:.:|:.....:..|...||::||.|..
  Fly  1947 ----KSEPTG-----------EQDDMLIN-----VMVNYAKSLRYGSEHVYQSMPRLISLWLDTT 1991

  Fly  1837 NHA-------EVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQAL 1894
            ..:       ::.:.|.:....:....:..|..|:::|:......|..::..:::.:.:.:||..
  Fly  1992 ESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQS 2056

  Fly  1895 VYPLTVASKSASLARRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRL 1959
            ::.|....|||...|......:|...|..:.|..
  Fly  2057 LWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQ------------------------------- 2090

  Fly  1960 YFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWD 2024
                       ::|:..:::.||         ......:|:|    ..:.||.|    |||..
  Fly  2091 -----------KLLQDFNSLTER---------LMDLTNKEVT----LDRTYKLS----DLDTR-- 2125

  Fly  2025 IYYHVFQKISRQLPQLTSLELP---YVSPKLMTCKDLELAVPGSYNPGQ---------ELIRISI 2077
                 ..|:.:| |:.:.:.||   |:.|.|....|.. :..||:.|..         :.|.||.
  Fly  2126 -----LSKLCKQ-PEFSQILLPFEKYMQPTLPLNSDSN-SSEGSHLPANQSTVNWFPYQQIYISG 2183

  Fly  2078 IKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNL 2142
            .:.::.::.|..:|:||.||.|:||||..|:|..:|||:|.|:|:...||...|..|....:|.|
  Fly  2184 FQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRL 2248

  Fly  2143 AIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVE 2207
            .|:.|||:|.:...||:.|:|:..:..::..:...::::.::.  |.:.:.|... |.::.:|.|
  Fly  2249 HIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMST--RQLQSLAVPL-HESIERKRE 2310

  Fly  2208 VFEHALGQTQGDDLAKLLWLK----SPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLML 2268
            ||...|.........:  ||:    :|.|  |:|.||.|.|::||||||||||||||||..|::.
  Fly  2311 VFTKQLVPAHPPVFQE--WLRQRFATPHS--WYEARNTYIRTVAVMSMVGYILGLGDRHGENILF 2371

  Fly  2269 DRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLRRNK 2333
            ...:|..:|:||...|...... .:||.:|||||..:|.||...|:||::|:.||..:.:|::..
  Fly  2372 AEGNGDAVHVDFNCLFNQGELL-PYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQES 2435

  Fly  2334 DSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLSNSVEDSLPMAKSKPY 2398
            .:||::|..||||                    .||...:|.:
  Fly  2436 KTLMSILRPFVYD--------------------VGAQTRKGAA---------------------- 2458

  Fly  2399 DPTLQQGGLHNNVADETNSKASQVIKRVKCKLTG-TDFQTEKSV--NEQSQVELLIQQATNNENL 2460
                             .:|.::.::|:..:|.| ...|...|:  :.:.||..||.:||..:||
  Fly  2459 -----------------TAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKVDNL 2506

  Fly  2461 CQCYIGWCPF 2470
            ...||||..|
  Fly  2507 ASMYIGWGAF 2516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	483/2474 (20%)
		HEAT repeat	632..658	CDD:293787	3/25 (12%)
		HEAT repeat	668..698	CDD:293787	3/29 (10%)
		HEAT repeat	706..736	CDD:293787	6/30 (20%)
		HEAT repeat	749..780	CDD:293787	5/35 (14%)
		HEAT repeat	798..823	CDD:293787	4/28 (14%)
		DUF3385	831..999	CDD:288698	26/185 (14%)
		HEAT repeat	841..870	CDD:293787	4/28 (14%)
		HEAT repeat	880..917	CDD:293787	7/45 (16%)
		HEAT repeat	925..954	CDD:293787	4/28 (14%)
		Rapamycin_bind	1937..2034	CDD:285924	12/96 (13%)
		PIKKc_TOR	2075..2353	CDD:270713	100/281 (36%)
		FATC	2440..2471	CDD:280430	14/33 (42%)
mei-41	NP_523369.2	UME	955..1060	CDD:214825	14/112 (13%)
		FAT	1653..1985	CDD:280429	80/395 (20%)
		PIKKc_ATR	2181..2448	CDD:270625	98/274 (36%)
		FATC	2486..2517	CDD:280430	13/31 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10493at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850