Protein Alignment mTor and Atm

DIOPT Version :10

• Sequence 1: NP_001260427.1
• Gene: mTor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Sequence 2: XP_038936996.1
• Gene: Atm / 300711
• RGDID: 1593265
• Length: 3096
• Species: Rattus norvegicus
• Alignment Length: 2902
• Identity: 598/2902 - (20%)
• Similarity: 1034/2902 - (35%)
• Gaps: 825/2902 - (28%)

  Fly    16 SRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIF--TMVNATDINEKKGGALAMK-- 76
            :|:.:|:....:.||||......|.|.|........|.|.|.  .:|:.|..|.|    .|||
  Rat   566 NRSFSVKESIMRWLLFYQLEGDLEDSAEPPPILQSNFPHLILEKILVSLTMKNSK----AAMKFF 626

  Fly    77 -----CLINCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARSLVKLANMPTSKGADSFDFDI 136
                 |..:||.:      ..|..:...:|.|......|:..............|:...|...::
  Rat   627 QSAPECEQHCEDT------EEPSFSEAEELFLQTTFDKMDFLTPVKEDTVEKFQSRVGFSVHQNL 685

  Fly   137 KKAFE--VLRGERQEYRRHSAVFILRELAI--------ALPTYFYQHILTFFEVIFNAIFDPKPA 191
            |::.:  :|....|....:|:.....|..:        .|..|.|..::|..|...:.:|....:
  Rat   686 KESLDHYLLGLSEQLLSNYSSEITSSETLVRCSSLLVGVLGCYCYMGVITEDEAYKSELFQKAKS 750

  Fly   192 IRESAGEALRAALIVTAQRESTKQSSEPQWYRIC------------------------------- 225
            :.:.|||::  :|......|.::..|......:|
  Rat   751 LMQCAGESI--SLFKNKTNEESRVGSLRSVIHLCTSCLCRHTKHTLNKIASGFFLRLLTSKLMND 813

  Fly   226 ---------------YD------------------------EANGSFNADLGSSKDQKGVTRDDR 251
                           :|                        |..||.:.||.|......|: |..
  Rat   814 IADICKSLASCTKKPFDYGEEHSLRDDDDDGDGGDGGESLMETQGSSSTDLFSDYSASTVS-DAN 877

  Fly   252 IHG----GLVVFNELFRCANATWERR--YTSLKTLFPKTQHNKFL-------EASSSSSMGSQL- 302
            .:|    .:...|.|    .|.|..|  :..|..|       :||       ::.::|..|:.:
  Rat   878 DYGENQNAVGAANPL----TADWLSRQDHLLLDML-------RFLCLSVTACQSRTASFRGADIR 931

  Fly   303 NTLVPRLKVPFIDKLGSTQTHLG-------EGEHH----KGVAKFASQHNVLESAYAQEILQEHY 356
            ..|:..|....:|...|...|:.       .|:.|    :.|.:.....:::.|.|.::  |:..
  Rat   932 RKLLMLLDPSTLDLTKSLHLHMYLVLLKDLPGKEHLLPMEDVVELLQPLSLVCSLYRRD--QDVC 994

  Fly   357 TSICDNVLE------QRTSKSPYVQQALLQILPRLAAF------NRAVF-VEKYLQTCVSHLMQ- 407
            .:|..|||.      |.:..:...:.|..|.|..:.||      .:.:| |...|..|:..|::
  Rat   995 KTILSNVLHIVTNLGQGSVDTESTRNAQGQFLTVMGAFWHLTKEKKCIFSVRMALVKCLQTLLEA 1059

  Fly   408 -------ILRGKEKDRTV-----AYITIGYMAVAVQSAIEVHLSSIMTSVKVALPSKDLTSKRKV 460
                   ||..|.:|..|     .::..|:..|.:.:|..:  |.:...::....|:.|   :.:
  Rat  1060 DPYSKWAILNVKGQDFPVREAFPQFLADGHHHVRMLAAGSI--SRLFQDMRQGDSSRSL---KAL 1119

  Fly   461 PV--DPAVFACITLLAHAVKSEIADDVK--DILEQMFYTGLSPALTV------C--LRELSENVP 513
            |:  ....|....::|.|...|:..|.:  |:|::: |...|..|||      |  :.|......
  Rat  1120 PLKFQQTSFNSAYMIAEAGIRELLCDSQNPDLLDEI-YNRKSVLLTVIAVVLHCSPICEKQALFA 1183

  Fly   514 QLKSAITEGLIGILSQVLMNK--------------AAILPYTALPTIAIDGSLMQNGDGATTVLA 564
            ..||....||...|.:.::.|              |:.|.|..|..:.:..             |
  Rat  1184 LCKSVKENGLEPHLVKKVLEKVSESFGCRCLEDFMASHLDYLVLEWLNLQD-------------A 1235

  Fly   565 LKTLGTFNFEEQNML---DFVQRCADYFIVHEQQEIRLEAVQTCTRLLKLAVQSSESMENSKTLS 626
            ..:|.:|.|...|.:   ||.:.|....|.|                  |.::  :..:..|:::
  Rat  1236 KYSLSSFPFTLLNYMSVEDFYRSCYKILIPH------------------LVIR--KHFDEVKSIA 1280

  Fly   627 DTVSHVIERLLMVAITDMDC--NVRIRILR--SLDETFDGKLAQP-ESLNSLFITLHDEIFEIRE 686
            :.:....:.||      :||  .:.:.||.  :.:.|.|...||. |:...::.||..|.|..::
  Rat  1281 NQIQRCWKSLL------IDCFPKMLVHILPYFACEGTGDSSSAQKRETATEVYDTLKGEDFLGKQ 1339

  Fly   687 LAMVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLD---------------- 735
            :..|.|..|..|            ::||:..|..:..| :..||..:.|
  Rat  1340 IDQVFISNLPEI------------VVELLMTLHETADS-DSGQSPDLCDFSGDLDPAPNPPYFPS 1391

  Fly   736 HLVISTPRLISSYMNPILKALVPKLHE-PESNPGVILNVLRTIGDLAEVNGGSDE------MELW 793
            |::.:|...|||......|:::..|.: |:|...::|.:..   ..||.|....:      ..|:
  Rat  1392 HVIKATFAYISSCHKTKFKSILEILSKIPDSYQKILLAICE---QAAETNNVFKKHRILKIYHLF 1453

  Fly   794 ADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIR 858
            ...||..:...||.|          |..                  ||.|::...:
  Rat  1454 VSLLLKDIQSGLGGA----------WAF------------------VLRDVIYTLI--------- 1481

  Fly   859 RETIRVLGLLGAMDPYKHKMNKGLIDSQKDNVLIAYSDGKVDESQDISTAELLVNMGN------- 916
                             |.:||....:...:|:                  .::.:.|
  Rat  1482 -----------------HYINKSCYQADSSSVI------------------FVLPVSNEAWRSLP 1511

  Fly   917 ALDEYYPAVAIA---------------ALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLA 966
            ||.||...|..:               .|.|:.|  |..|.....::....:.....|..|.| .
  Rat  1512 ALREYPTGVTSSHFTDVSLRSFSLCCDLLSRVCR--TAVTHCKDALENHLHVIVGTLIPLVDY-Q 1573

  Fly   967 QVLPNLLDNVR--TADNNLREFLFQQLAIL------VAFVKLHI----ISYMGDIFKLIKE---F 1016
            :|...:||.::  ..||...:.||..:.:|      |.|..|.:    |.|.|..|.|::|   |
  Rat  1574 EVQEQVLDLLKYLVIDNKDNKNLFVTIKLLDPFPDHVVFKDLRLTQQKIKYSGGPFTLLEEINHF 1638

  Fly  1017 WTIN--TPLQNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRMVTR---RLLQ--- 1073
            .:::  .||..|.:..::.:...|. :.:|.:.:|:    |..| ||.:|.:|.:   .|||
  Rat  1639 LSVSAYNPLPLTRLEGLKDLRRQLE-QHKDQMLDLV----RASQ-DNPQDGIVVKLVVSLLQLSK 1697

  Fly  1074 ----------ALQKFGSTLGYYLPLILPPIVKLF--DSPY-----VPQ----QVSMVALETINNL 1117
                      .|:..|..||...||....|....  |:||     :|:    |.:::.|..:||
  Rat  1698 MAVNQTGEREVLEAVGRCLGEIGPLDFSTIAVQHSKDTPYTKAYGLPEDRELQWTLIMLTALNN- 1761

  Fly  1118 ACQLDFTDFSSRIIHPLVRVLDAEPELRDQAMTTLRS-LAKQLGKKYLVFVPMVQRTLNKHRIVD 1181
                              .:::...::|..|.|.|:: ||.:.|..:          ...|:
  Rat  1762 ------------------TLVEDSVKIRSAAATCLKNILATKTGHIF----------WENHK--- 1795

  Fly  1182 PEYEELLSKIKSCSTLADSYGAGESELRPSRFKNNE--PFVTD---RNSNNKNLQVTTNELRTAW 1241
                          |.||.........|.||.|..|  .||.:   ...::.||.|..:|
  Rat  1796 --------------TSADPMLTYLQPFRASRKKFLELPQFVKEDALEGLDDVNLWVPQSE----- 1841

  Fly  1242 QVTRRVSKDDWVEWL----------KRLSIGLLKESPSHALRACRSLAQE--YDTLLRDLFNAAF 1294
                  |.|.|::.|          |...:.|||.........|:.:...  :|.||:|...:
  Rat  1842 ------SHDIWIKTLTCAFLDSGGIKSEILQLLKPMCEVKTDFCQMVLPYLIHDVLLQDTHES-- 1898

  Fly  1295 ISCW-TELSPDLKNELTQSLIQALQVTDM-------------------PEITQTILNLAEFMEHC 1339
               | |.||..::...|.....:.|.:..                   .:..:|:|.:.:::...
  Rat  1899 ---WRTLLSTHVRGFFTNCFKHSSQASRSATPANSDSESENFLRCCLDKKSQRTMLAVVDYLRRQ 1960

  Fly  1340 DR--------DPIPIETKLLGTR--AMACRAYAKALRYKE---------EEFLLREDSQVFE--- 1382
            .|        |...::...|...  |.:|.|:..||.|.|         |:   .:.|..||
  Rat  1961 KRPSSGTAFEDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYSDKKNMDEQ---EKRSPTFEEGS 2022

  Fly  1383 ---SLILINNKLQQR---EAAEGLLTRYRNAANELNVQG-------------RWYEKLHNWDEAL 1428
               ::..::.|.::.   ...:.||..||:.....::.|             |.||....|::||
  Rat  2023 QGTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKVLQPLTRIRTYEHEATWEKAL 2087

  Fly  1429 EHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAV---AAWG 1490
            ..|:  |:|..|....:.|.::.|:.||    ||::.....:....|.:...|.|..:   |||.
  Rat  2088 VTYD--LETTISSSTRQSGIIQALQNLG----LSHILSIYLKGLDHERREWCGELQELHYQAAWR 2146

  Fly  1491 LQDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAY 1555
            ...|:......:.:...:...|.|.|:..:.:.:|.|....:...|.....||:..:.||....|
  Rat  2147 NMQWDLCTSANQELEGTSYHESLYNALQCLRNREFSTFYDSLRHARVKEVEELSKGSLESVYSLY 2211

  Fly  1556 GAMVCVQMLAELE---EVIQYKLIPERREPLKTMWWKRLQGGQRLVED----------WRRIIQV 1607
            ..:..:|.:.|||   |:....:....|..:...|.|..|    |::|          ..|.:.:
  Rat  2212 PTLSRLQAVGELENSGELFSRSVTDRERSEVYLKWQKHSQ----LLKDSDFSFQEPLMALRTVIL 2272

  Fly  1608 HSLVVKPHE--------DIHT--WLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQP 1662
            ..||.|..|        ||.|  .::::.|.|...:..|..:.:..:...:|.:.........:.
  Rat  2273 EILVQKEMENSQGGCSKDILTKHLVEFSVLARTFKNTQLPERAIFKIKQYNPAICGISEWHLEEA 2337

  Fly  1663 QVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQRLMARC----------YL 1717
            ||.:|..:...|.:.|::..::|..........|..|..|.|:.....|...|          ||
  Rat  2338 QVFWAKKEQSLALSILKQMIKKLDSSFRENEAGLKGLHAECLRVCGNWLAETCLENPAVIMQTYL 2402

  Fly  1718 RMATWQNKLQDSIRPDAIQ---GALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQP 1779
            ..|.   |:..|...|:.:   |.::.|.....:....|:  .:..||.....:.:::.|.:.:
  Rat  2403 EKAV---KVAGSYDGDSRELRNGQMKAFLSLARFSDTQYQ--RIENYMKSSEFENKQALLKRAK- 2461

  Fly  1780 PGASMGMTMGSGLDSDLMII--------------------QRYAVPAVQGFFRSISLIKGNSLQD 1824
              ..:|:.....:.::...|                    :|:...||:.:   ||.:......|
  Rat  2462 --EEVGLIREHKIQTNRYTIKVQRELELDECALRALKEDRKRFLCKAVENY---ISCLLSGEEHD 2521

  Fly  1825 --TLRLLTLWFDYGNHAEVYEAL-LSGMKLIEINTWLQVIPQLIARIDTHRQLVG-----QLIHQ 1881
              ..||.:||.:....:||...: ..||| |....:|.::.||.||:.|  ::.|     ::::.
  Rat  2522 LWVFRLCSLWLENSGVSEVNGMMKRDGMK-ISSYKFLPLMYQLAARMGT--KMTGGLGFHEVLNN 2583

  Fly  1882 LLMDIGKNHPQ---ALVYPLTVASKSASLARRNAA--FKILDSMRKHSPTLVEQAVMCSEELIRV 1941
            |:..|..:||.   .::..|..|:|...|::...|  .:|..:..|.|..|.|
  Rat  2584 LISRISMDHPHHTLFIILALANANKDEFLSKPETARRGRITKNAPKESSQLDE------------ 2636

  Fly  1942 AILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEW 2006
                     :..|.|||:                :|.:.......:|:.       ..|.:||
  Rat  2637 ---------DRAEAASRI----------------IHTIRSARRTMVKDM-------EALCDAY-- 2667

  Fly  2007 SQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSP--KLMTCKD-----LELAV-- 2062
                   .::.:||            .|:...|...:.:|...|  ||...:|     :|:.|
  Rat  2668 -------IILANLD------------ASQWRNQRKGISIPANQPITKLKNLEDVVVPTMEIKVDP 2713

  Fly  2063 PGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLV 2127
            .|.|   ::|:.|...||..::......|:.:...||:||:...|:||.:|||||..:.|:|.:.
  Rat  2714 TGEY---EKLVTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMC 2775

  Fly  2128 NTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGW----VPHCDTL-------HTLIRDYRDKKKV 2181
            |.||..:.:|.:|.|.|..|.|:|||..||::.|    :|..:.|       |   :.|| ...:
  Rat  2776 NMLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIGEYLVNNEEGAH---KRYR-PNDL 2836

  Fly  2182 PLNQEHRTML-----NFAPDYD-HLTLMQKVE-VFEHALGQTQGDDLAKLLWLKSPSSELWFERR 2239
            ..||..:.|:     :|...|: .:|:.|..| ||.:..       :.|.|   .|:  :|||:|
  Rat  2837 SANQCQKKMMEVQKKSFEEKYETFMTICQNFEPVFRYFC-------MEKFL---DPA--VWFEKR 2889

  Fly  2240 NNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFE---VAMTREKFPEKIPFRL 2301
            ..||||:|..|:|||||||||||..|::::..|.:::|||.|..||   :..|    ||.:||||
  Rat  2890 LAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT----PETVPFRL 2950

  Fly  2302 TRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNW-----RLLDVDKKGN 2361
            :|.::..|.:||:||.:||.||..|.|:|.::::|:.::|..:||||.:|     :.|.:.::..
  Rat  2951 SRDIVDGMGITGVEGVFRRCCEKTMEVMRSSQEALLTIVEVLLYDPLFDWTMNPLKALYLQQRPE 3015

  Fly  2362 DAVAGAGAPGGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADET-NSKASQVIKR 2425
            |.......|     |........|:.|:                       |:: |..|.:|:.|
  Rat  3016 DETDLQSTP-----SADDQECKRSLSDT-----------------------DQSFNKVAERVLMR 3052

  Fly  2426 VKCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGW 2467
            ::.||.|.:..|..||.  .||.||||||.:.:||.:.:.||
  Rat  3053 LQEKLKGVEEGTVLSVG--GQVNLLIQQAMDPKNLSRLFPGW 3092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mTor	NP_001260427.1	TEL1	308..2471	CDD:227365	530/2507 (21%)
		HEAT repeat	632..658	CDD:293787	6/29 (21%)
		HEAT repeat	668..698	CDD:293787	8/29 (28%)
		HEAT repeat	706..736	CDD:293787	7/45 (16%)
		HEAT repeat	749..780	CDD:293787	5/31 (16%)
		HEAT repeat	798..823	CDD:293787	5/24 (21%)
		HEAT repeat	841..870	CDD:293787	2/28 (7%)
		HEAT repeat	880..917	CDD:293787	3/43 (7%)
		HEAT repeat	925..954	CDD:293787	6/43 (14%)
Atm	XP_038936996.1	TAN	8..165	CDD:463317
		FAT	2137..2529	CDD:396714	72/406 (18%)
		PIKKc_ATM	2723..3002	CDD:270715	107/298 (36%)
		FATC	3066..3095	CDD:460514	14/29 (48%)