DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and Atm

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_038936996.1 Gene:Atm / 300711 RGDID:1593265 Length:3096 Species:Rattus norvegicus


Alignment Length:2902 Identity:598/2902 - (20%)
Similarity:1034/2902 - (35%) Gaps:825/2902 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 SRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIF--TMVNATDINEKKGGALAMK-- 76
            :|:.:|:....:.||||......|.|.|........|.|.|.  .:|:.|..|.|    .|||  
  Rat   566 NRSFSVKESIMRWLLFYQLEGDLEDSAEPPPILQSNFPHLILEKILVSLTMKNSK----AAMKFF 626

  Fly    77 -----CLINCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARSLVKLANMPTSKGADSFDFDI 136
                 |..:||.:      ..|..:...:|.|......|:..............|:...|...::
  Rat   627 QSAPECEQHCEDT------EEPSFSEAEELFLQTTFDKMDFLTPVKEDTVEKFQSRVGFSVHQNL 685

  Fly   137 KKAFE--VLRGERQEYRRHSAVFILRELAI--------ALPTYFYQHILTFFEVIFNAIFDPKPA 191
            |::.:  :|....|....:|:.....|..:        .|..|.|..::|..|...:.:|....:
  Rat   686 KESLDHYLLGLSEQLLSNYSSEITSSETLVRCSSLLVGVLGCYCYMGVITEDEAYKSELFQKAKS 750

  Fly   192 IRESAGEALRAALIVTAQRESTKQSSEPQWYRIC------------------------------- 225
            :.:.|||::  :|......|.::..|......:|                               
  Rat   751 LMQCAGESI--SLFKNKTNEESRVGSLRSVIHLCTSCLCRHTKHTLNKIASGFFLRLLTSKLMND 813

  Fly   226 ---------------YD------------------------EANGSFNADLGSSKDQKGVTRDDR 251
                           :|                        |..||.:.||.|......|: |..
  Rat   814 IADICKSLASCTKKPFDYGEEHSLRDDDDDGDGGDGGESLMETQGSSSTDLFSDYSASTVS-DAN 877

  Fly   252 IHG----GLVVFNELFRCANATWERR--YTSLKTLFPKTQHNKFL-------EASSSSSMGSQL- 302
            .:|    .:...|.|    .|.|..|  :..|..|       :||       ::.::|..|:.: 
  Rat   878 DYGENQNAVGAANPL----TADWLSRQDHLLLDML-------RFLCLSVTACQSRTASFRGADIR 931

  Fly   303 NTLVPRLKVPFIDKLGSTQTHLG-------EGEHH----KGVAKFASQHNVLESAYAQEILQEHY 356
            ..|:..|....:|...|...|:.       .|:.|    :.|.:.....:::.|.|.::  |:..
  Rat   932 RKLLMLLDPSTLDLTKSLHLHMYLVLLKDLPGKEHLLPMEDVVELLQPLSLVCSLYRRD--QDVC 994

  Fly   357 TSICDNVLE------QRTSKSPYVQQALLQILPRLAAF------NRAVF-VEKYLQTCVSHLMQ- 407
            .:|..|||.      |.:..:...:.|..|.|..:.||      .:.:| |...|..|:..|:: 
  Rat   995 KTILSNVLHIVTNLGQGSVDTESTRNAQGQFLTVMGAFWHLTKEKKCIFSVRMALVKCLQTLLEA 1059

  Fly   408 -------ILRGKEKDRTV-----AYITIGYMAVAVQSAIEVHLSSIMTSVKVALPSKDLTSKRKV 460
                   ||..|.:|..|     .::..|:..|.:.:|..:  |.:...::....|:.|   :.:
  Rat  1060 DPYSKWAILNVKGQDFPVREAFPQFLADGHHHVRMLAAGSI--SRLFQDMRQGDSSRSL---KAL 1119

  Fly   461 PV--DPAVFACITLLAHAVKSEIADDVK--DILEQMFYTGLSPALTV------C--LRELSENVP 513
            |:  ....|....::|.|...|:..|.:  |:|::: |...|..|||      |  :.|......
  Rat  1120 PLKFQQTSFNSAYMIAEAGIRELLCDSQNPDLLDEI-YNRKSVLLTVIAVVLHCSPICEKQALFA 1183

  Fly   514 QLKSAITEGLIGILSQVLMNK--------------AAILPYTALPTIAIDGSLMQNGDGATTVLA 564
            ..||....||...|.:.::.|              |:.|.|..|..:.:..             |
  Rat  1184 LCKSVKENGLEPHLVKKVLEKVSESFGCRCLEDFMASHLDYLVLEWLNLQD-------------A 1235

  Fly   565 LKTLGTFNFEEQNML---DFVQRCADYFIVHEQQEIRLEAVQTCTRLLKLAVQSSESMENSKTLS 626
            ..:|.:|.|...|.:   ||.:.|....|.|                  |.::  :..:..|:::
  Rat  1236 KYSLSSFPFTLLNYMSVEDFYRSCYKILIPH------------------LVIR--KHFDEVKSIA 1280

  Fly   627 DTVSHVIERLLMVAITDMDC--NVRIRILR--SLDETFDGKLAQP-ESLNSLFITLHDEIFEIRE 686
            :.:....:.||      :||  .:.:.||.  :.:.|.|...||. |:...::.||..|.|..::
  Rat  1281 NQIQRCWKSLL------IDCFPKMLVHILPYFACEGTGDSSSAQKRETATEVYDTLKGEDFLGKQ 1339

  Fly   687 LAMVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLD---------------- 735
            :..|.|..|..|            ::||:..|..:..| :..||..:.|                
  Rat  1340 IDQVFISNLPEI------------VVELLMTLHETADS-DSGQSPDLCDFSGDLDPAPNPPYFPS 1391

  Fly   736 HLVISTPRLISSYMNPILKALVPKLHE-PESNPGVILNVLRTIGDLAEVNGGSDE------MELW 793
            |::.:|...|||......|:::..|.: |:|...::|.:..   ..||.|....:      ..|:
  Rat  1392 HVIKATFAYISSCHKTKFKSILEILSKIPDSYQKILLAICE---QAAETNNVFKKHRILKIYHLF 1453

  Fly   794 ADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIR 858
            ...||..:...||.|          |..                  ||.|::...:         
  Rat  1454 VSLLLKDIQSGLGGA----------WAF------------------VLRDVIYTLI--------- 1481

  Fly   859 RETIRVLGLLGAMDPYKHKMNKGLIDSQKDNVLIAYSDGKVDESQDISTAELLVNMGN------- 916
                             |.:||....:...:|:                  .::.:.|       
  Rat  1482 -----------------HYINKSCYQADSSSVI------------------FVLPVSNEAWRSLP 1511

  Fly   917 ALDEYYPAVAIA---------------ALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLA 966
            ||.||...|..:               .|.|:.|  |..|.....::....:.....|..|.| .
  Rat  1512 ALREYPTGVTSSHFTDVSLRSFSLCCDLLSRVCR--TAVTHCKDALENHLHVIVGTLIPLVDY-Q 1573

  Fly   967 QVLPNLLDNVR--TADNNLREFLFQQLAIL------VAFVKLHI----ISYMGDIFKLIKE---F 1016
            :|...:||.::  ..||...:.||..:.:|      |.|..|.:    |.|.|..|.|::|   |
  Rat  1574 EVQEQVLDLLKYLVIDNKDNKNLFVTIKLLDPFPDHVVFKDLRLTQQKIKYSGGPFTLLEEINHF 1638

  Fly  1017 WTIN--TPLQNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRMVTR---RLLQ--- 1073
            .:::  .||..|.:..::.:...|. :.:|.:.:|:    |..| ||.:|.:|.:   .|||   
  Rat  1639 LSVSAYNPLPLTRLEGLKDLRRQLE-QHKDQMLDLV----RASQ-DNPQDGIVVKLVVSLLQLSK 1697

  Fly  1074 ----------ALQKFGSTLGYYLPLILPPIVKLF--DSPY-----VPQ----QVSMVALETINNL 1117
                      .|:..|..||...||....|....  |:||     :|:    |.:::.|..:|| 
  Rat  1698 MAVNQTGEREVLEAVGRCLGEIGPLDFSTIAVQHSKDTPYTKAYGLPEDRELQWTLIMLTALNN- 1761

  Fly  1118 ACQLDFTDFSSRIIHPLVRVLDAEPELRDQAMTTLRS-LAKQLGKKYLVFVPMVQRTLNKHRIVD 1181
                              .:::...::|..|.|.|:: ||.:.|..:          ...|:   
  Rat  1762 ------------------TLVEDSVKIRSAAATCLKNILATKTGHIF----------WENHK--- 1795

  Fly  1182 PEYEELLSKIKSCSTLADSYGAGESELRPSRFKNNE--PFVTD---RNSNNKNLQVTTNELRTAW 1241
                          |.||.........|.||.|..|  .||.:   ...::.||.|..:|     
  Rat  1796 --------------TSADPMLTYLQPFRASRKKFLELPQFVKEDALEGLDDVNLWVPQSE----- 1841

  Fly  1242 QVTRRVSKDDWVEWL----------KRLSIGLLKESPSHALRACRSLAQE--YDTLLRDLFNAAF 1294
                  |.|.|::.|          |...:.|||.........|:.:...  :|.||:|...:  
  Rat  1842 ------SHDIWIKTLTCAFLDSGGIKSEILQLLKPMCEVKTDFCQMVLPYLIHDVLLQDTHES-- 1898

  Fly  1295 ISCW-TELSPDLKNELTQSLIQALQVTDM-------------------PEITQTILNLAEFMEHC 1339
               | |.||..::...|.....:.|.:..                   .:..:|:|.:.:::...
  Rat  1899 ---WRTLLSTHVRGFFTNCFKHSSQASRSATPANSDSESENFLRCCLDKKSQRTMLAVVDYLRRQ 1960

  Fly  1340 DR--------DPIPIETKLLGTR--AMACRAYAKALRYKE---------EEFLLREDSQVFE--- 1382
            .|        |...::...|...  |.:|.|:..||.|.|         |:   .:.|..||   
  Rat  1961 KRPSSGTAFEDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYSDKKNMDEQ---EKRSPTFEEGS 2022

  Fly  1383 ---SLILINNKLQQR---EAAEGLLTRYRNAANELNVQG-------------RWYEKLHNWDEAL 1428
               ::..::.|.::.   ...:.||..||:.....::.|             |.||....|::||
  Rat  2023 QGTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKVLQPLTRIRTYEHEATWEKAL 2087

  Fly  1429 EHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAV---AAWG 1490
            ..|:  |:|..|....:.|.::.|:.||    ||::.....:....|.:...|.|..:   |||.
  Rat  2088 VTYD--LETTISSSTRQSGIIQALQNLG----LSHILSIYLKGLDHERREWCGELQELHYQAAWR 2146

  Fly  1491 LQDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAY 1555
            ...|:......:.:...:...|.|.|:..:.:.:|.|....:...|.....||:..:.||....|
  Rat  2147 NMQWDLCTSANQELEGTSYHESLYNALQCLRNREFSTFYDSLRHARVKEVEELSKGSLESVYSLY 2211

  Fly  1556 GAMVCVQMLAELE---EVIQYKLIPERREPLKTMWWKRLQGGQRLVED----------WRRIIQV 1607
            ..:..:|.:.|||   |:....:....|..:...|.|..|    |::|          ..|.:.:
  Rat  2212 PTLSRLQAVGELENSGELFSRSVTDRERSEVYLKWQKHSQ----LLKDSDFSFQEPLMALRTVIL 2272

  Fly  1608 HSLVVKPHE--------DIHT--WLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQP 1662
            ..||.|..|        ||.|  .::::.|.|...:..|..:.:..:...:|.:.........:.
  Rat  2273 EILVQKEMENSQGGCSKDILTKHLVEFSVLARTFKNTQLPERAIFKIKQYNPAICGISEWHLEEA 2337

  Fly  1663 QVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQRLMARC----------YL 1717
            ||.:|..:...|.:.|::..::|..........|..|..|.|:.....|...|          ||
  Rat  2338 QVFWAKKEQSLALSILKQMIKKLDSSFRENEAGLKGLHAECLRVCGNWLAETCLENPAVIMQTYL 2402

  Fly  1718 RMATWQNKLQDSIRPDAIQ---GALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQP 1779
            ..|.   |:..|...|:.:   |.::.|.....:....|:  .:..||.....:.:::.|.:.: 
  Rat  2403 EKAV---KVAGSYDGDSRELRNGQMKAFLSLARFSDTQYQ--RIENYMKSSEFENKQALLKRAK- 2461

  Fly  1780 PGASMGMTMGSGLDSDLMII--------------------QRYAVPAVQGFFRSISLIKGNSLQD 1824
              ..:|:.....:.::...|                    :|:...||:.:   ||.:......|
  Rat  2462 --EEVGLIREHKIQTNRYTIKVQRELELDECALRALKEDRKRFLCKAVENY---ISCLLSGEEHD 2521

  Fly  1825 --TLRLLTLWFDYGNHAEVYEAL-LSGMKLIEINTWLQVIPQLIARIDTHRQLVG-----QLIHQ 1881
              ..||.:||.:....:||...: ..||| |....:|.::.||.||:.|  ::.|     ::::.
  Rat  2522 LWVFRLCSLWLENSGVSEVNGMMKRDGMK-ISSYKFLPLMYQLAARMGT--KMTGGLGFHEVLNN 2583

  Fly  1882 LLMDIGKNHPQ---ALVYPLTVASKSASLARRNAA--FKILDSMRKHSPTLVEQAVMCSEELIRV 1941
            |:..|..:||.   .::..|..|:|...|::...|  .:|..:..|.|..|.|            
  Rat  2584 LISRISMDHPHHTLFIILALANANKDEFLSKPETARRGRITKNAPKESSQLDE------------ 2636

  Fly  1942 AILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEW 2006
                     :..|.|||:                :|.:.......:|:.       ..|.:||  
  Rat  2637 ---------DRAEAASRI----------------IHTIRSARRTMVKDM-------EALCDAY-- 2667

  Fly  2007 SQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSP--KLMTCKD-----LELAV-- 2062
                   .::.:||            .|:...|...:.:|...|  ||...:|     :|:.|  
  Rat  2668 -------IILANLD------------ASQWRNQRKGISIPANQPITKLKNLEDVVVPTMEIKVDP 2713

  Fly  2063 PGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLV 2127
            .|.|   ::|:.|...||..::......|:.:...||:||:...|:||.:|||||..:.|:|.:.
  Rat  2714 TGEY---EKLVTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMC 2775

  Fly  2128 NTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGW----VPHCDTL-------HTLIRDYRDKKKV 2181
            |.||..:.:|.:|.|.|..|.|:|||..||::.|    :|..:.|       |   :.|| ...:
  Rat  2776 NMLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIGEYLVNNEEGAH---KRYR-PNDL 2836

  Fly  2182 PLNQEHRTML-----NFAPDYD-HLTLMQKVE-VFEHALGQTQGDDLAKLLWLKSPSSELWFERR 2239
            ..||..:.|:     :|...|: .:|:.|..| ||.:..       :.|.|   .|:  :|||:|
  Rat  2837 SANQCQKKMMEVQKKSFEEKYETFMTICQNFEPVFRYFC-------MEKFL---DPA--VWFEKR 2889

  Fly  2240 NNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFE---VAMTREKFPEKIPFRL 2301
            ..||||:|..|:|||||||||||..|::::..|.:::|||.|..||   :..|    ||.:||||
  Rat  2890 LAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT----PETVPFRL 2950

  Fly  2302 TRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNW-----RLLDVDKKGN 2361
            :|.::..|.:||:||.:||.||..|.|:|.::::|:.::|..:||||.:|     :.|.:.::..
  Rat  2951 SRDIVDGMGITGVEGVFRRCCEKTMEVMRSSQEALLTIVEVLLYDPLFDWTMNPLKALYLQQRPE 3015

  Fly  2362 DAVAGAGAPGGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADET-NSKASQVIKR 2425
            |.......|     |........|:.|:                       |:: |..|.:|:.|
  Rat  3016 DETDLQSTP-----SADDQECKRSLSDT-----------------------DQSFNKVAERVLMR 3052

  Fly  2426 VKCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGW 2467
            ::.||.|.:..|..||.  .||.||||||.:.:||.:.:.||
  Rat  3053 LQEKLKGVEEGTVLSVG--GQVNLLIQQAMDPKNLSRLFPGW 3092

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 530/2507 (21%)
HEAT repeat 632..658 CDD:293787 6/29 (21%)
HEAT repeat 668..698 CDD:293787 8/29 (28%)
HEAT repeat 706..736 CDD:293787 7/45 (16%)
HEAT repeat 749..780 CDD:293787 5/31 (16%)
HEAT repeat 798..823 CDD:293787 5/24 (21%)
DUF3385 831..999 CDD:288698 31/197 (16%)
HEAT repeat 841..870 CDD:293787 2/28 (7%)
HEAT repeat 880..917 CDD:293787 3/43 (7%)
HEAT repeat 925..954 CDD:293787 6/43 (14%)
Rapamycin_bind 1937..2034 CDD:285924 11/96 (11%)
PIKKc_TOR 2075..2353 CDD:270713 107/303 (35%)
FATC 2440..2471 CDD:280430 14/28 (50%)
AtmXP_038936996.1 TAN 8..165 CDD:402988
FAT 2137..2529 CDD:396714 72/406 (18%)
PIKKc_ATM 2723..3002 CDD:270715 107/298 (36%)
FATC 3066..3095 CDD:396715 14/29 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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