DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tor and Pik3c2b

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_006249816.1 Gene:Pik3c2b / 289021 RGDID:1306541 Length:1633 Species:Rattus norvegicus


Alignment Length:1378 Identity:249/1378 - (18%)
Similarity:434/1378 - (31%) Gaps:501/1378 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1087 PLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDA----EPELRDQ 1147
            |..|||.|.::|:|.:|.:....:...|:    |.|..:..|.:..|..::|.|    |.||.:.
  Rat   155 PPPLPPRVSIWDAPPLPPRKGSPSPSKIS----QPDDINSFSLVEQPSDKLLGAQDPGEGELPNG 215

  Fly  1148 AMTTLRSLAKQLGKKYLV-------FVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAG- 1204
            .           |:::::       ....:.| ||.....|       |:|.|.:|.....|.| 
  Rat   216 G-----------GQRHVLGSVDYDGINDAITR-LNLKSTYD-------SEILSDATRGWKEGRGP 261

  Fly  1205 -----ESELRP-SRFKNNEPFV-----TDRNSNNKNLQVTTNELRTAWQVTRRV----------- 1247
                 ::..:| :|.|...|.|     |.|.:|.||.....|...:|..|:.|.           
  Rat   262 LDFSKDTSGKPVARSKTMPPQVPPRTYTPRYANRKNATPGKNRRISAAPVSSRTHTVTNGHELFE 326

  Fly  1248 ---SKDDWV----EWLKRLSIGLLKESPSHALRAC---------RSLAQEYD---TLLRD-LFNA 1292
               .:|:.|    ..|..|..|  .::..::|..|         ..|..|.:   |:|.| |...
  Rat   327 VSEERDEEVAAFCHMLDILRTG--SDTQDYSLTGCVWSTVTPSPEHLGDEVNLKVTVLCDSLREP 389

  Fly  1293 AFISCWTELSPDLKNELTQSL------IQALQVTD-------MPEITQT--ILNLAEFMEHCDRD 1342
            ...:|....:.||.  :.|:|      ::.:.|.|       :.|..|.  .|...|:::||.:.
  Rat   390 LTFTCNCSSTVDLL--IYQTLCYTHDELREVDVGDFVLKPCGLEEFLQNKHALGSHEYIQHCRKF 452

  Fly  1343 PIPIETKLLGTRAMACRAYAKALRYKEEEFLLR--EDSQVFESL-ILINNKLQQREAAEGLLTRY 1404
            .|.|..:|:..:|:             ...|.|  .|.|...:| .||:  ||:|...:   |..
  Rat   453 DINIRLQLMEQKAI-------------RSDLARTVNDDQSPSTLNYLIH--LQERPVKQ---TIS 499

  Fly  1405 RNAANELNVQGRWYEKLHNWDEA--LEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKH 1467
            |.|.:.|      ::..||..:|  |...:..||.|           |.::::            
  Rat   500 RQALSLL------FDTYHNEVDAFLLAEGDFPLKAD-----------RVVQSV------------ 535

  Fly  1468 EWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRC----IPEDTQDGSYYRAVLAVHHDDFETA 1528
                     |:....||||....:.  .|:.:...|    .|:..:|.|    ||.|..:..:..
  Rat   536 ---------KAICNALAAVETPEIT--SALNQLPPCPSRMQPKIQKDPS----VLTVRENREKVV 585

  Fly  1529 QRLIDETRDLLDTELTSMAGESYERAYGAMV--CVQMLAELEEVIQYKLIPERREPLKTMWWKRL 1591
            :.|.....||::...::...:......|:..  .||........:.:.:....|.|:  :|....
  Rat   586 EALTAAILDLVELYCSTFNADFQTAVPGSRKHDLVQEACHFSGALAFTVYGTHRIPI--IWATSY 648

  Fly  1592 Q----------GGQRLVE--DWRRI-------------------IQVHSLVVKPHEDIHTWLKYA 1625
            :          ||:.|..  ..||.                   :||:.|   |.|.:.....||
  Rat   649 EEFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIIWDQQICFPVQVNRL---PRETLLCATLYA 710

  Fly  1626 SLCRKSGSLHLSH--KTLVMLLG--TDPKLNPNQPLPCNQPQV-------TYAYTKYMAAN-NQL 1678
            ......||...::  |.:...||  |.|..|..|.|.|.:..:       ..:..::.|.| :|.
  Rat   711 LPIPPPGSSSEANKQKRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENSSARWSAPNFHQP 775

  Fly  1679 QEAYEQLTHFVSTYSQELSCLPPE---------ALKQQDQRLMARCYLRMAT-WQNKLQDSIRPD 1733
            .....|:....|.:..:.:..|.:         :|:::|||.:.....:.:. |   |.|:.:..
  Rat   776 DSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDITQKESLYW---LSDADKKQ 837

  Fly  1734 AIQGALECFEKATSYD------PNW--------YKAWHLWAYMNFKVVQAQKSALDKQQPPGASM 1784
            ..:....|..:.:|..      |:|        |.....|.:||.:                .::
  Rat   838 LWEKRYYCHTEVSSLPLVLASAPSWEWACLPDIYALLQQWTHMNHQ----------------DAL 886

  Fly  1785 GMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEALLSGM 1849
            |:...:..|                             |:..|:...|....:.||:        
  Rat   887 GLLHATFPD-----------------------------QEVRRMAVQWIGSLSDAEL-------- 914

  Fly  1850 KLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAF 1914
                    |..:|||:                          |||.|...:.|.......:.|  
  Rat   915 --------LDYLPQLV--------------------------QALKYECYLDSPLVRFLLKRA-- 943

  Fly  1915 KILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAM 1979
             |.|....|                                    ||        |.:|:     
  Rat   944 -ISDLRVTH------------------------------------YF--------FWLLK----- 958

  Fly  1980 LERGPQTLKETSFSQAY-----------GRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKI 2033
                 .:||::.||..|           |:.|.|.:.              .:.|.:  :...|:
  Rat   959 -----DSLKDSQFSIRYQYLLAALLCCCGKGLREEFN--------------RQCWLV--NTLAKL 1002

  Fly  2034 SRQLPQLT-----------------------SLELPYVSPKLMTCKDLELAVPGSYNPGQELIRI 2075
            ::|:.:.|                       |..|| :||.|:        |.|           
  Rat  1003 AQQVREATPSARQGILRAGLEEVRQFFALNGSCRLP-LSPSLL--------VKG----------- 1047

  Fly  2076 SIIKTNLQVITSKQRPRKLCIRGSN--GKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTF 2138
             |:..:.....|...|.||..:..:  |::...:.|..:|||||...:|:..:::.:.:.:....
  Rat  1048 -IVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDM 1111

  Fly  2139 RRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLM 2203
            |..:    :.........|::..:|:.:||                                   
  Rat  1112 RMVI----FRCFSTGRGKGMVEMIPNAETL----------------------------------- 1137

  Fly  2204 QKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLML 2268
            :|::|.....|..:...||..|...:|..:.:.:...|:..|.|...:..||||:.|||..|:||
  Rat  1138 RKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIML 1202

  Fly  2269 DRMSGKILHIDFG 2281
             :.:|.:.|||||
  Rat  1203 -KTTGHMFHIDFG 1214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 249/1378 (18%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 14/107 (13%)
PIKKc_TOR 2075..2353 CDD:270713 44/209 (21%)
FATC 2440..2471 CDD:280430
Pik3c2bXP_006249816.1 PI3K_rbd 363..465 CDD:395642 22/103 (21%)
C2A_PI3K_class_II 621..793 CDD:175979 32/176 (18%)
PI3Ka_II 812..980 CDD:238441 43/314 (14%)
PI3Kc_C2_beta 986..1339 CDD:119421 57/306 (19%)
PX_PI3K_C2_beta 1368..1476 CDD:132823
C2B_PI3K_class_II 1504..1626 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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