DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and tor2

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_595359.2 Gene:tor2 / 2540720 PomBaseID:SPBC216.07c Length:2337 Species:Schizosaccharomyces pombe


Alignment Length:2500 Identity:1059/2500 - (42%)
Similarity:1523/2500 - (60%) Gaps:209/2500 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 GLKSRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIFTMVNATDINEKKGGALAMKC 77
            ||||||..::|||..||..||....||:|.|.|.||.::.:.:::|::::||..::..|..|:..
pombe     6 GLKSRNEEIRNKAANDLYEYVIAYSRELSGEALVQFNNDVNKYVYTLIHSTDPLDRLAGVTAINR 70

  Fly    78 LINCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARSLVKLANMPTSKGADSFDFDIKKAFEV 142
            ||:.||..|.|  |:.:.|.||.:|...|.....:||::|.:||....:..::..:|::|:|.|.
pombe    71 LIDYEGEDTTR--ITRFANYLRIILPGTDQKATVLAAKALGRLAVPGGALTSEFVNFEVKRALEW 133

  Fly   143 LRGERQEYRRHSAVFILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESAGEALRAALIVT 207
            |:|||.|.||::||.||:|||....|..|.||.:.||::::.:.|||..||.::.:||...|.:.
pombe   134 LQGERNENRRYAAVLILKELAKNTSTLIYAHIDSIFELLWHGLRDPKVTIRIASADALSEFLKIV 198

  Fly   208 AQRESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTR--DDRIHGGLVVFNELFRCANATW 270
            .||:|   |...|||....:||             |:||.:  .|.|||.|:|:.:||       
pombe   199 RQRDS---SIRLQWYTSILNEA-------------QRGVAQGSSDYIHGSLLVYRQLF------- 240

  Fly   271 ERRYTSLKTLFPKTQHNKFLEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQTHLGEGEHHKGVAK 335
                                                  ||                         
pombe   241 --------------------------------------LK------------------------- 242

  Fly   336 FASQHNVLESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQALLQILPRLAAFNRAVFVEKYLQT 400
                        |...:.|.|..:.|.:|:.|..|...:::.:.:::..|||:|...||..||..
pombe   243 ------------AGMFMHERYREVSDIILQFRDHKDLLIRKTVTELIATLAAYNPDEFVSNYLHV 295

  Fly   401 CVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIEVHLSSIMTSVKVALPSKDLTSKRKVPVDPA 465
            |:.||:.:|: ||..:.:|:.|||.:|||:.::|..:|..|..|:|.:|   .:..:.|...|.|
pombe   296 CMLHLLNLLK-KENVKMLAFATIGKVAVAITNSIIPYLDPICDSIKESL---KIHIRNKSASDAA 356

  Fly   466 VFACITLLAHAVKSEIADDVKDILEQMFYTGLSPALTVCLRELSENVPQLKSAITEGLIGILSQV 530
            :|.||:||:.|:....::...|:.:.:|.:|||.|....|.:|:.|:|.|...|.|.|:.:||::
pombe   357 IFQCISLLSIALGQAFSNYAYDLFDLIFASGLSEASYRALSDLAHNIPPLLPVIQERLLDMLSKI 421

  Fly   531 LMNKAAILP-----YTALPTIAIDGSLMQNG--DGATTVLALKTLGTFNFEEQNMLDFVQRCADY 588
            |..:..|.|     |.|....:...:.::.|  .....:||||.||.|:|....:.:||:.|...
pombe   422 LSGRPFIPPGCPPQYVARSLKSSKSASLKTGFFPNDVYILALKVLGNFDFSGYILNEFVKDCVVV 486

  Fly   589 FIVHEQQEIRLEAVQTCTRLLKLAVQSSESMENSKTLSDTVSHVIERLLMVAITDMDCNVRIRIL 653
            ::.:...|:|..|..||::|.......|::.:::   ...|:.|:|:||.|.|.|...::|:.:|
pombe   487 YLENNDPEVRKTASITCSQLFARDPILSQTSDHA---IQVVAEVLEKLLTVGICDTVPDIRLTVL 548

  Fly   654 RSLDETFDGKLAQPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPAYVMPKLRTTMIELITDL 718
            .|||..|:..|||.:.:..|||.::||.|.:||.|:..||||:..|||||||.||..|::.:|.|
pombe   549 NSLDSRFNKHLAQADKIRLLFIAINDENFAVRESALRIIGRLNVYNPAYVMPYLRKIMLKTLTIL 613

  Fly   719 KYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHEPESNPGVILNVLRTIGDLAEV 783
            .||.:.|.||::||:|..|:.:.||||.|::.|||:.|:||  ..:|:..|..:::.::|::.::
pombe   614 DYSTIIRTKEENAKLLCLLIAAAPRLIESHVEPILQILLPK--AKDSSSIVAASIVNSLGEICQI 676

  Fly   784 NGGSDEMELWADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINF 848
            :|  :.:..:..||:.:::|.|.|..||.:|..||..||.|.|:||.|:.||.::|.|:||||..
pombe   677 SG--EVIVPFIKDLMPLIIEALQDQSSPIRRAAALKALGNLSSSTGYVIDPYIEFPSLLDILIGI 739

  Fly   849 LKTEQRRSIRRETIRVLGLLGAMDPYKHK-MNKG---LIDSQKDNVLIAYSDGKVDESQDISTAE 909
            .||||..:||||||:::|.|||:||.:|: :.||   ::..|| |:           ..|||.  
pombe   740 TKTEQDITIRRETIKLIGTLGALDPNRHRVLEKGTEKVVPEQK-NI-----------PPDISL-- 790

  Fly   910 LLVNMGNALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLD 974
            |:..:|.:.|||||.|.|.|||.||:||:|:..||:|:|||.:||:::|::|.|:|:|::|..:.
pombe   791 LMSGIGPSSDEYYPTVVITALMSILKDPSLTIHHTAVIQAVMYIFKTMGLRCAPFLSQIIPEFIA 855

  Fly   975 NVRTADNNLREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQNTLINLIEQIAVALG 1039
            .:||...|:.||.||||:|||..|:.||.|::.|:|||||:||..::.||.|:::|||.:|.|:.
pombe   856 VMRTCPTNILEFYFQQLSILVLIVRQHIRSFLPDLFKLIKDFWNPHSNLQFTILSLIESLARAMQ 920

  Fly  1040 CEFRDYLAELIPQILRVLQHDNSKDRMVTRRLLQALQKFGSTLGYYLPLILPPIVKLFDSPYVPQ 1104
            .||:.||..|:..:|::...|.|.|.:.|:::|.|...||.||..|..::|.||::|::...|..
pombe   921 GEFKPYLPSLLVMMLQIFDSDVSVDSVSTKKVLHAFIVFGDTLADYFHMLLDPILRLYERNDVSI 985

  Fly  1105 QVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDA-EPELRDQAMTTLRSLAKQLGKKYLVFVP 1168
            .:....:.||..|:..::.::::||||||::|:|.. ...|...:|.|:.:|..||...:.:|:|
pombe   986 GIKESIMITIGRLSMVINLSEYASRIIHPVMRMLSCNNASLIRVSMDTVCALIYQLNVDFAIFIP 1050

  Fly  1169 MVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELRPSRFKNNEPFVTDRNSNNKNLQVT 1233
            |:.:.|..:.:....|..|:.:......|.......|...:|..    :...:..:..:|.|.|.
pombe  1051 MIDKCLKMNGVTHETYSILVEQFLQEQPLPIKLNPYEKYDKPKL----DVVASAADITSKKLPVN 1111

  Fly  1234 TNELRTAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISCW 1298
            ...||.||:.::|.:||||.||::||.:.||:||||||||||.:||..|..|.||||||:|:|||
pombe  1112 QEILRNAWEASQRSTKDDWQEWIRRLGVALLRESPSHALRACAALAAAYQPLARDLFNASFVSCW 1176

  Fly  1299 TELSPDLKNELTQSLIQALQVTDM-PEITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRAYA 1362
            :||....:.||.:|:..||....: |||.|.:|||||||||.|: |:||:.:.||..|..|.|:|
pombe  1177 SELYDHFQEELVKSIEIALTSPHISPEIIQILLNLAEFMEHDDK-PLPIDIRTLGAYAAKCHAFA 1240

  Fly  1363 KALRYKEEEFLLRE-----DSQVFESLILINNKLQQREAAEGLLTRYRNAANELNVQGRWYEKLH 1422
            |||.|||.||:..|     .....|:||.|||:|||.:||.|:| ::....:::|::..|||||.
pombe  1241 KALHYKELEFIEEELVTKPSVDTIEALISINNQLQQPDAAIGIL-KHAQQHDKMNLKETWYEKLQ 1304

  Fly  1423 NWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVA 1487
            .|::||..||:.....:.:.|..:|.:|||.|||:|..||.:.:..|.:.|.:|:....||:..|
pombe  1305 RWEDALSAYEKREAAGAGNFEITMGKLRCLHALGEWDRLSQLAQENWIHAGHDARRYIAPLSVAA 1369

  Fly  1488 AWGLQDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYE 1552
            ||||..||.|.||:..:..::.|.:::.|::|:|...||.|...|...|||||||||::.||||.
pombe  1370 AWGLGQWEQMDEYISVMKSESPDKAFFNAIVALHRSQFEEAASYITRARDLLDTELTALVGESYN 1434

  Fly  1553 RAYGAMVCVQMLAELEEVIQYKLI---PERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKP 1614
            |||...|.||||:||||:|.||..   ||.||.:|..|.:||:|.||.|:.|:|::::.|||:.|
pombe  1435 RAYSVAVRVQMLSELEEIITYKKAEDKPEVREMIKKTWVRRLKGCQRNVDVWQRMLRIRSLVISP 1499

  Fly  1615 HEDIHTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQ 1679
            .:::..|:|:|:||||||.:.|:.|:|.:||..|..|:.:..|....|.:.||..|::.|.:..:
pombe  1500 RDNMEMWIKFANLCRKSGRISLAKKSLNLLLEDDENLDNSLVLKKTHPSIVYANLKFLWAVDDKR 1564

  Fly  1680 EAYEQLTHFVSTYSQELSCLPP--------EALKQQDQ-----RLMARCYLRMATWQNKLQDSIR 1731
            :|...:..|.|....:::..|.        ...|.|::     .|:||||.:...||.:::::..
pombe  1565 KALNSMQEFTSQLISDINVDPALFVQSTSVNTQKSQEEIQYYFHLLARCYHKQGQWQQEIENNWS 1629

  Fly  1732 PDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDL 1796
            ..:..|.|:.:..||.:|..||||||.||..||:.|:..:.:  ::|.|.|:             
pombe  1630 EGSFDGVLQSYMYATQFDSKWYKAWHSWALANFEAVKFLEQS--EEQIPSAA------------- 1679

  Fly  1797 MIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVI 1861
              .::|.:|||:|||:||:|.||| ||||||||.|||.:||::.|...|..|:..:.|:.||.||
pombe  1680 --YEQYIIPAVKGFFKSIALSKGN-LQDTLRLLNLWFKFGNNSNVINTLNVGISTVNIDIWLDVI 1741

  Fly  1862 PQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILDSMRKHSPT 1926
            |||||||......|.:.:||||.|:|:.||||||||||||:||.|.||:|||..|:||::.|||.
pombe  1742 PQLIARIHASSLSVRKSVHQLLSDVGRAHPQALVYPLTVAAKSQSSARQNAALAIMDSLKTHSPR 1806

  Fly  1927 LVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETS 1991
            |||||.:.|.||||.||||||||||||||||||||||.|::|||.:|.|||.||||||:||:|.|
pombe  1807 LVEQARLVSHELIRAAILWHEQWHEGLEEASRLYFGDHNIEGMFAVLRPLHEMLERGPETLREIS 1871

  Fly  1992 FSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCK 2056
            |.||:||:|.||.:...|::.:..:.||::|||:||.||:||.:||||||:|:|.||||||:...
pombe  1872 FQQAFGRDLVEARDCCIRFEQTGDISDLNQAWDLYYQVFKKIRKQLPQLTTLDLQYVSPKLLHVH 1936

  Fly  2057 DLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVM 2121
            ||||||||:|..|:.:|||........|||||||||:|.|:||:||||.|:||||||:|||||||
pombe  1937 DLELAVPGTYVSGKPVIRIVKFYPTFNVITSKQRPRRLSIKGSDGKDYQYVLKGHEDIRQDERVM 2001

  Fly  2122 QLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQE 2186
            |||.|.|.|||.||:||:|.|:||||.|||||.:|||:|||...||||.||||||:.:|:.||.|
pombe  2002 QLFGLCNNLLLADPETFKRLLSIQRYPVIPLSPDSGLLGWVLDSDTLHVLIRDYRESRKILLNIE 2066

  Fly  2187 HRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSM 2251
            ||.::..|||||.|||:|||||||:||..|.|.||.::|||||.|||.|..||.||:|:||||||
pombe  2067 HRLIIQMAPDYDRLTLLQKVEVFEYALLSTTGQDLYRVLWLKSRSSEAWLNRRTNYSRTLAVMSM 2131

  Fly  2252 VGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEG 2316
            |||||||||||||||||||.:|.|:||||||||||||.||||||||||||||||:.||||:||||
pombe  2132 VGYILGLGDRHPSNLMLDRYTGNIIHIDFGDCFEVAMHREKFPEKIPFRLTRMLVNAMEVSGIEG 2196

  Fly  2317 TYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLL-----DVDKKGNDAVAGAGAPGGRGGS 2376
            |:|.|||.||.|||.||:|:||||||||||||:||||.     .:|:|               .|
pombe  2197 TFRITCEHVMRVLRTNKESVMAVLEAFVYDPLINWRLAPAYSPSIDEK---------------QS 2246

  Fly  2377 GMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTGTDFQTEKSV 2441
            ...::|.....|.|...:......||::    ....:..|.:|..|:.||..||||.||:.::.:
pombe  2247 NEPNTLLGETIDGLHRKRLNEEGITLEE----RQKPEILNQRAITVLNRVSNKLTGRDFKPQQQL 2307

  Fly  2442 NEQSQVELLIQQATNNENLCQCYIGWCPFW 2471
            :..||||.||.|||:.||||.||||||.||
pombe  2308 DVPSQVEKLILQATSIENLCLCYIGWCSFW 2337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 963/2201 (44%)
HEAT repeat 632..658 CDD:293787 11/25 (44%)
HEAT repeat 668..698 CDD:293787 13/29 (45%)
HEAT repeat 706..736 CDD:293787 13/29 (45%)
HEAT repeat 749..780 CDD:293787 9/30 (30%)
HEAT repeat 798..823 CDD:293787 9/24 (38%)
DUF3385 831..999 CDD:288698 77/171 (45%)
HEAT repeat 841..870 CDD:293787 17/28 (61%)
HEAT repeat 880..917 CDD:293787 10/39 (26%)
HEAT repeat 925..954 CDD:293787 16/28 (57%)
Rapamycin_bind 1937..2034 CDD:285924 63/96 (66%)
PIKKc_TOR 2075..2353 CDD:270713 202/277 (73%)
FATC 2440..2471 CDD:280430 19/30 (63%)
tor2NP_595359.2 TEL1 194..2337 CDD:227365 984/2308 (43%)
HEAT repeat 479..509 CDD:293787 9/29 (31%)
HEAT repeat 565..592 CDD:293787 13/26 (50%)
HEAT repeat 604..637 CDD:293787 12/32 (38%)
HEAT repeat 646..672 CDD:293787 8/27 (30%)
HEAT_EZ 662..715 CDD:290247 15/54 (28%)
HEAT repeat 685..715 CDD:293787 12/29 (41%)
DUF3385 722..880 CDD:288698 77/171 (45%)
Rapamycin_bind 1817..1914 CDD:285924 63/96 (66%)
PIKKc_TOR 1955..2233 CDD:270713 202/277 (73%)
FATC 2307..2337 CDD:280430 19/29 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 382 1.000 Domainoid score I129
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3637
Inparanoid 1 1.050 1593 1.000 Inparanoid score I8
OMA 1 1.010 - - QHG53650
OrthoFinder 1 1.000 - - FOG0003052
OrthoInspector 1 1.000 - - otm47286
orthoMCL 1 0.900 - - OOG6_100794
Panther 1 1.100 - - LDO PTHR11139
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1538
SonicParanoid 1 1.000 - - X2407
TreeFam 1 0.960 - -
1413.860

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