DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and tor1

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_596275.1	Gene:	tor1 / 2540473	PomBaseID:	SPBC30D10.10c	Length:	2335	Species:	Schizosaccharomyces pombe

Alignment Length:	2507	Identity:	1020/2507 - (40%)
Similarity:	1461/2507 - (58%)	Gaps:	217/2507 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QFVNGLKSRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIFTMVNATDINEKKGGAL 73
            ::.:.||::|.::|..|...|..:|.:..:|:|.|.||:|.::.:..||.::::.|.:|:.||.|
pombe     2 EYFSDLKNKNESIQLAAADQLKEFVHSSTKELSGESLARFNNDINRRIFELIHSHDSHERFGGIL 66

  Fly    74 AMKCLI--NCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARSLVKLANMPTSKGADSFDFDI 136
            |:..||  ..||.:|   .:|.|.|.||..|...|...||::|:.|..||....:..|:..:|::
pombe    67 AIGKLIEFESEGDVT---NLSRYANYLRMTLPSTDWHSMELSAKVLGHLAASGGTLAAEFVEFEV 128

  Fly   137 KKAFEVLRGERQEYRRHSAVFILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESAGEALR 201
            ::|||.|:|:|||.:|.:|:.|::.||...||..|.:|...|:.::..:.||||.|||:|.:||.
pombe   129 QRAFEWLQGDRQEQKRMAAILIIKALAQNSPTLVYLYISEIFQNLWTGLRDPKPLIRETAADALG 193

  Fly   202 AALIVTAQRESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNELFRCA 266
            |:|.|..|||:..|..       |::|.  ...|:.|..  |..|   :.:||.|:.:.|||
pombe   194 ASLDVVCQREAKVQLQ-------CFNEV--LLQAEHGLR--QSSV---EYLHGSLLAYKELF--- 241

  Fly   267 NATWERRYTSLKTLFPKTQHNKFLEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQTHLGEGEHHK 331
                                                            :|.||
pombe   242 ------------------------------------------------EKSGS------------ 246

  Fly   332 GVAKFASQHNVLESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQALLQILPRLAAFNRAVFVEK 396
                               .::||||..||..|..|..:...:::.::.:||.|:.:|...|.::
pombe   247 -------------------FIREHYTEFCDLALRLREHRDNSIRRCIVFLLPTLSEYNPKKFQQR 292

  Fly   397 YLQTCVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIEVHLSSIMTSVKVALPSKDLTSKRKVP 461
            ||.:.:.:|:..:| |:|::::|:..||.:|:||..|:..:|.:|:..::..|.:|   .:.|..
pombe   293 YLDSFMVYLLSHIR-KDKEKSLAFEAIGRIAMAVNEAMIPYLQNILKVIRDTLTAK---VREKTQ 353

  Fly   462 VDPAVFACITLLAHAVKSEIADDVKDILEQMFYTGLSPALTVCLRELSENVPQLKSAITEGLIGI 526
            .:..||.||.:||.|||.|:.:|.:.:|..:|...||..|...|.:::||:|.|.:.|.|.|:.:
pombe   354 YEKPVFECIGMLAAAVKLELLEDSRSLLGLIFSCELSVHLRQALVKMAENIPPLLAPIQERLLNM 418

  Fly   527 LSQVLMNKAAIL----PYTALPTIAIDGSLMQNGDGAT--TVLALKTLGTFNFEEQNMLDFVQRC 585
            :||:|..|...:    .||...|.............:|  .:|||:|||||||...:::.|:|..
pombe   419 VSQILTGKNFEIRTNDTYTPSFTNIYSAREPDQRSKSTESIILALETLGTFNFTGYSLISFIQES 483

  Fly   586 ADYFIVHEQQEIRLEAVQTCTRLL----------KLAVQSSESMENSKTLSDTVSHVIERLLMVA 640
            ...::.::..|||:.|.:||.::.          .|||:|             |:.|:|:||.:.
pombe   484 VLSYLENDNSEIRIAAARTCCQVFARDPICRKTNPLAVES-------------VAEVLEKLLTLG 535

  Fly   641 ITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPAYVMP 705
            |.|.|..:|..:|..|||.||..||.|:::..|||.|:||:|.|||:|::.||||:..|||:|||
pombe   536 IADSDPKIRETVLSLLDERFDRHLAHPDNIRCLFIALNDEVFSIREIAIIIIGRLALYNPAHVMP 600

  Fly   706 KLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHEPESNPGVI 770
            .||.|:|:|::|::|||.||.||:||::|..||.....||..|:..|:..::||  ..:::|||.
pombe   601 SLRKTIIQLLSDMEYSGNSRQKEESAQLLKLLVSKARTLIKPYIQSIIHVILPK--AADTSPGVS 663

  Fly   771 LNVLRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRVVTPY 835
            ..::..:|:||.|.|....::: ....:.::|..|.|..|..||..:|..|.:|...:|.|:.||
pombe   664 SAIISALGELASVEGEDMPVDV-RGSFMKLILVNLQDQSSTLKRLASLKCLRKLCGRSGYVIQPY 727

  Fly   836 HKYPVLIDILINFLKTEQRRSIRRETIRVLGLLGAMDPYKHKMNKGLIDSQKDNVLIAYSDGKVD 900
            ..||.|:..||..|::||...||||.:|.||:|||:|||.:...:.:.|..:.:...|:...::.
pombe   728 LDYPPLLGALIGILQSEQPTPIRREVLRTLGVLGALDPYTYLTTEEVSDDLQSSHNNAHGVPQIS 792

  Fly   901 ESQDISTAELLVNMGNALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYL 965
            .:|..|.            |.|..||:..|:.||:|.:||..|:||||||..|...:|.|...:|
pombe   793 AAQYPSL------------ENYAMVAVVTLIGILKDSSLSMHHSSVVQAVMHICSQMGSKSTVFL 845

  Fly   966 AQVLPNLLDNVRTADNNLREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQNTLINL 1030
            .||:|..|..:::...:..||.||||..|.:.:..:|..|:.|||.|.|.||...|.|...::.|
pombe   846 PQVVPTFLQVMQSLSASSAEFYFQQLTTLTSIIGPNIRDYVSDIFNLSKVFWESTTSLLLVILEL 910

  Fly  1031 IEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRMVTRRLLQALQKFGSTLGYYLPLILPPIVK 1095
            |:.||:||..||:.||.:::..:|:....||:..|.|:.::||:...|||.:..|:.|:||.|::
pombe   911 IDAIAIALQDEFKFYLPQILSCMLKAFSLDNTSSRSVSYKVLQSFVIFGSNIEEYMHLVLPVIIR 975

  Fly  1096 LFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVL-DAEPELRDQAMTTLRSLAKQL 1159
            .|:...:|......||:.|..|...::|:|.:|||||||||:| .:..:||...|.||.::..||
pombe   976 SFERDTIPLGFRKSALKCIAQLFQSVNFSDHASRIIHPLVRMLGKSNGDLRAVIMDTLCAIVSQL 1040

  Fly  1160 GKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELRPSRFKNNEPFVTDRN 1224
            |..|.:|:|||.:.|..|:|..|.||.|:|::.....|.......|.:.|||    .:||.|...
pombe  1041 GYDYSIFIPMVNKVLVSHKISHPAYELLVSRLLKGEPLPKDVVVKEFKPRPS----TKPFSTQDE 1101

  Fly  1225 SNNKNLQVTTNELRTAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDL 1289
            ...| |.|....|:.||:.::::::|||.:|::|:||.|||||||.|||:|.:||..|..|.|||
pombe  1102 VLTK-LPVDQASLKAAWESSQKLTRDDWQDWIRRISIELLKESPSSALRSCSTLAGIYHPLARDL 1165

  Fly  1290 FNAAFISCWTELSPDLKNELTQSLIQALQVTDMP-EITQTILNLAEFMEHCDRD-PIPIETKLLG 1352
            ||.:|:|||.||:...|..|.:|:..|:...::. ||.||:|||||:||..|.. ||||  |::.
pombe  1166 FNVSFLSCWDELTESNKKNLVKSIELAMNAPNISVEILQTLLNLAEYMEREDHTLPIPI--KVIS 1228

  Fly  1353 TRAMACRAYAKALRYKEEEFLLREDSQV----FESLILINNKLQQREAAEGLLTRYRNAANELNV 1413
            ..|..|..|||||.|.|.:|:.....:|    .||||.|||.|||.:||.|:| :|.....:.::
pombe  1229 AHASKCNVYAKALHYTELQFVQETKEEVSISTIESLITINNHLQQSDAAVGML-QYTKEHKQFSL 1292

  Fly  1414 QGRWYEKLHNWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKS 1478
            :..||||||.||:||..||...:...|..|..:|.:||..|||||..||.:.:..|.....|.:.
pombe  1293 KETWYEKLHRWDDALAAYEHREREGDSSFEINIGKLRCYYALGDWDHLSELAQKAWVTSEQEHRE 1357

  Fly  1479 RAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTEL 1543
            ...||||.|||||..|..:.|||..:..|.||..::.|:.|||...:..|...|:..||:|..:|
pombe  1358 AIAPLAAAAAWGLGQWNLISEYVSAMDRDPQDKEFFSAISAVHLGQYNKAYGHIERHRDILVNDL 1422

  Fly  1544 TSMAGESYERAYGAMVCVQMLAELEEVIQYK---LIPERREPLKTMWWKRLQGGQRLVEDWRRII 1605
            :|:.||||.||||.||..|||:||||:|.||   ......:.||..|.|||:|.|:.|:.|...:
pombe  1423 SSIIGESYNRAYGIMVKSQMLSELEEIIDYKKNMQYENNLDSLKKTWRKRLEGCQKNVDVWHNTL 1487

  Fly  1606 QVHSLVVKPHEDIHTWLKYASLCRKSGSLHLSHKTLVMLLGTDP-KLNPNQPLPCNQPQVTYAYT 1669
            :..:||:.|.:....|:|.|.|||:|..|.||::.|..|:|.|| ...|...|....|.|.|.|.
pombe  1488 RFRALVLSPQDSPEMWIKLADLCRRSDRLKLSNQCLTYLMGRDPSNAYPLDSLKLLNPHVVYTYL 1552

  Fly  1670 KYMAANNQLQEAYEQLTHFVSTYSQE-----------LSCLPPEALKQQDQRLMARCYLRMATWQ 1723
            ||:.|.:|...|..:|..|.|..|.:           :..|...::..:::..:|||:.::..|:
pombe  1553 KYLWATDQKNIAVSELEEFTSYLSSKHGYKMGDSSKLVDILASSSVSSEERSFLARCFHKLGKWK 1617

  Fly  1724 NKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTM 1788
            ..||||:..::::..|.|:..||.:|.:||||||.||..||:||     ...:|...|.:..|
pombe  1618 KSLQDSVNQESVRDILNCYFYATLFDKSWYKAWHSWALANFEVV-----GYYEQTEHGVTQDM-- 1675

  Fly  1789 GSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEALLSGMKLIE 1853
                      .::|.|||::|||.|..|.:.|||||.||||.|||.:|.|::|..|::.|...:.
pombe  1676 ----------YEQYIVPAIKGFFHSSVLNQKNSLQDILRLLNLWFKFGEHSDVAAAIVEGFSNVP 1730

  Fly  1854 INTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILD 1918
            ::|||:|||||||||.|....|...:||||.|||:.|||||||.|||:|||.:..::::|..|:|
pombe  1731 MDTWLEVIPQLIARIHTSSSSVRASVHQLLSDIGRVHPQALVYSLTVSSKSTNPQQKHSAKSIMD 1795

  Fly  1919 SMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERG 1983
            ||..||.|||.||::.|:|||||||||||.|:|||||||:.||.|.::..|.:|::|||..||:|
pombe  1796 SMLSHSDTLVRQALLVSQELIRVAILWHELWYEGLEEASQAYFSDHDISLMIDIVKPLHETLEKG 1860

  Fly  1984 PQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYV 2048
            |.||.|.||:|.:|.:|.:|..:.|::.......:|:::||:||.||::|.:|||::..|||.||
pombe  1861 PSTLSEISFAQTFGYDLRKARSYWQKFLQDGDPTELNQSWDLYYQVFRRIQKQLPRIKHLELQYV 1925

  Fly  2049 SPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHED 2113
            ||||:...||||||||:|...:.:||||......:||:||||||:|.|.||:||||.|:||||||
pombe  1926 SPKLLDACDLELAVPGTYGHNKPVIRISHFHHTFEVISSKQRPRRLTIHGSDGKDYQYVLKGHED 1990

  Fly  2114 LRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDK 2178
            |||||||||||.|.||||..|.:||:|.|.|:||.|||||.||||:|||||.||||.||:::|.|
pombe  1991 LRQDERVMQLFGLCNTLLTTDSETFKRRLNIERYTVIPLSPNSGLLGWVPHSDTLHFLIKEFRSK 2055

  Fly  2179 KKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYT 2243
            :.:.||.|||.||..|||.|.|||:||:||||:.:..|.|.||..:|||||.|||.|.:||.:||
pombe  2056 RNILLNLEHRMMLQMAPDCDSLTLLQKLEVFEYVMANTDGYDLYHVLWLKSRSSEAWLDRRTSYT 2120

  Fly  2244 RSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKA 2308
            :|||||||||||||||||||||||:||.||||:||||||||||||.|||||||||||||||||.|
pombe  2121 QSLAVMSMVGYILGLGDRHPSNLMMDRYSGKIIHIDFGDCFEVAMHREKFPEKIPFRLTRMLINA 2185

  Fly  2309 MEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGR 2373
            |||:||:|||:.|||.||.|||.|.:||||||||||||||:||||:              .....
pombe  2186 MEVSGIQGTYKITCELVMRVLRSNTESLMAVLEAFVYDPLINWRLM--------------TKSSF 2236

  Fly  2374 GGSGMQDSLSNSVEDS----LPMAKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTGTD 2434
            |.|......|:|||:.    ...|:...|....:..|::   |:..|.::.||:|||..||||.|
pombe  2237 GASTTLRPTSSSVEEKGRSYTHRARHADYAALSETNGVN---AEGLNERSIQVLKRVSNKLTGKD 2298

  Fly  2435 FQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPFW 2471
            |..::.:..::|||.||||||..||||:||:|||.||
pombe  2299 FDLKEQLPVKAQVEKLIQQATAPENLCRCYVGWCSFW 2335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	930/2204 (42%)
		HEAT repeat	632..658	CDD:293787	10/25 (40%)
		HEAT repeat	668..698	CDD:293787	15/29 (52%)
		HEAT repeat	706..736	CDD:293787	16/29 (55%)
		HEAT repeat	749..780	CDD:293787	7/30 (23%)
		HEAT repeat	798..823	CDD:293787	8/24 (33%)
		DUF3385	831..999	CDD:288698	60/167 (36%)
		HEAT repeat	841..870	CDD:293787	14/28 (50%)
		HEAT repeat	880..917	CDD:293787	4/36 (11%)
		HEAT repeat	925..954	CDD:293787	15/28 (54%)
		Rapamycin_bind	1937..2034	CDD:285924	48/96 (50%)
		PIKKc_TOR	2075..2353	CDD:270713	200/277 (72%)
		FATC	2440..2471	CDD:280430	18/30 (60%)
tor1	NP_596275.1	HEAT_EZ	144..193	CDD:290247	19/48 (40%)
		TEL1	195..2335	CDD:227365	948/2309 (41%)
		HEAT repeat	527..553	CDD:293787	10/25 (40%)
		HEAT repeat	563..593	CDD:293787	15/29 (52%)
		HEAT repeat	601..631	CDD:293787	16/29 (55%)
		HEAT repeat	644..673	CDD:293787	7/30 (23%)
		DUF3385	723..879	CDD:288698	60/167 (36%)
		Rapamycin_bind	1814..1911	CDD:285924	48/96 (50%)
		PIKKc_TOR	1952..2230	CDD:270713	200/277 (72%)
		FATC	2305..2335	CDD:280430	18/29 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	382	1.000	Domainoid score	I129
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1593	1.000	Inparanoid score	I8
OMA	1	1.010	-	-		QHG53650
OrthoFinder	1	1.000	-	-		FOG0003052
OrthoInspector	1	1.000	-	-		otm47286
orthoMCL	1	0.900	-	-		OOG6_100794
Panther	1	1.100	-	-	O	PTHR11139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2407
TreeFam	1	0.960	-	-
	11	10.830