DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and Atr

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_063917.1 Gene:Atr / 245000 MGIID:108028 Length:2641 Species:Mus musculus


Alignment Length:2674 Identity:547/2674 - (20%)
Similarity:964/2674 - (36%) Gaps:815/2674 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   277 LKTLFPKTQHNKFLEASSSSSMGS-QLNTLVPRLKVPF--------------------------- 313
            ||||||       .||.:..::.. .||.|:.:|.|.|                           
Mouse   302 LKTLFP-------FEAEAYRNIEPVYLNVLLEKLSVMFEDRVLMRLKSDLLKAALCHLLQYFLTF 359

  Fly   314 -----------------------IDKLGSTQTHLG----------EGEHHKGVAKF---ASQHNV 342
                                   :|.|| .|.|:|          :.|..:.:.:.   |.|.|:
Mouse   360 VPAGYESALQVRKVYVTNICRALVDALG-VQKHVGYLLGPFYAALKMESKEIIERIQCQAQQENL 423

  Fly   343 -------------LESAYA---------QEILQEHY--TSICDNVLEQRTSKSPYVQQALLQILP 383
                         |.|:.:         :||:....  .||..|||:|:...        |||..
Mouse   424 SGNNDEVSPKRRKLSSSLSSYKKPSRQPEEIIHVDMDKKSILWNVLKQKAES--------LQISL 480

  Fly   384 RLAAFNRAV--------FVEKYLQTCVSHLM-QILRGKE-KDRTVAY-----ITIGYMAVAVQSA 433
            .......:|        .|.:....|..|.. |.:.|.. ||....|     :.:.:|::...:.
Mouse   481 ECGTLKNSVAEALEGITVVLQLTALCTVHCSHQDMDGHNVKDHQHKYKKKPPVVVTWMSLDFYTK 545

  Fly   434 IEVHLSSIMTSV-KVALPSKDLTSKRKVPVDPAVFACITLLAHAVKSEIADDVKDILEQM----- 492
            :.....|::.|| |:.|         ::.:|..|..|..|:...|||...|.|   ||::     
Mouse   546 VLKSCRSLLESVQKLEL---------ELVIDSMVRICDALMYMQVKSSFKDHV---LEELCGMLS 598

  Fly   493 -----------------FYTGLSPALTVCLRELSENV-----PQ--------------------- 514
                             |.|.|.|        ||:.|     ||                     
Mouse   599 LPWIYSYSDDNSLKMTTFATNLLP--------LSQRVWDSYSPQAQSKCVFLLTLFPRRIFLEWR 655

  Fly   515 --------------LKSAITEGLIGILSQVLMNKAAILPYTALPTIAIDGSLMQNGDGATTVLAL 565
                          ::::..:|...:|.|  .|....:|...:..:..|..:::....:.....:
Mouse   656 TAVYNWALKSSHEVIRASCVKGFFILLHQ--QNSCNQIPKMLVDRVKDDSDMVKKEFASVLGQLV 718

  Fly   566 KTL-GTFNFEEQNMLDFVQRCADYFIV----------HEQQEIRLEAVQTCTRLLKLAVQSSESM 619
            .|| |.|.....     |:.|.::..:          ||....:::| .||...|.|..:::.|.
Mouse   719 CTLHGMFYLSSS-----VEPCFEHMDLFSKNLKATSQHECSSSQVKA-STCKPFLFLLTKNTPSP 777

  Fly   620 ENSKTLSDTVSHVIERL---------------LMVAITDMDCNVRIRILRSLDETFDGKLAQ-PE 668
            .....: |.:.|:.:.|               |:..:.|.|.:|||        .|.|.:.. .|
Mouse   778 VKLAFI-DNLHHLCKHLDFQEDEREVKAVLGTLLNLMEDPDKDVRI--------AFSGNIKYILE 833

  Fly   669 SLNS-------LFITLHDEIF---------EIRELAMVTIGRLSSINPAYVMPKLRTTMIELITD 717
            ||||       ||:....|.:         |:::..::|.|.:.......::|.....::..:..
Mouse   834 SLNSEDGFVKELFVLRMKEAYTHAQIARNNELKDTLILTTGDIGRAAKGDLIPFALLHLLHCLLS 898

  Fly   718 LKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHEPE-----SNPGVILNV---- 773
            ...|.......:...::....:......|.|..||.:.||..||..:     |.|.....:    
Mouse   899 KSASVSGAAYTEIRALVAAKSVKLQNFFSQYKKPICQFLVESLHSSQMTALPSAPCQSSEIRKQD 963

  Fly   774 --------LRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATGR 830
                    |.|:.::|.|....| :..:....|.:||..|....|| .....:.|||:.::.:.|
Mouse   964 VAHHREMALNTLSEIANVFDFPD-LNRFLTRTLQVLLPDLAAKASP-AASALIRTLGKQLNVSRR 1026

  Fly   831 -VVTPYHKYPVLIDILINFLKTEQRRS---IRRETIRVLG--------------LLGAMDPYKHK 877
             ::....|| :...::.:..|.|..|:   ::.||...||              ||...:.|:..
Mouse  1027 EILINNFKY-IFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQQV 1090

  Fly   878 MNKGLIDSQKDNVLIAY--SDGKVDESQDISTAELLVN-----------------MGNALDEYYP 923
            .| ||      ::|.::  ||......:||::.||:.:                 :.:::.....
Mouse  1091 FN-GL------SILASFASSDDPYQGPRDITSPELMADYLQPKLLGILAFFNMQLLSSSVGIEDK 1148

  Fly   924 AVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLG------------------IKCV------PY 964
            .:|:.:||.:::  .:..:|.|.|:.........|                  ::|:      |.
Mouse  1149 KMALTSLMSLMK--LMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHAYLGPL 1211

  Fly   965 LAQVLPNLLDNVRTADNNLREFLFQQLAI-----LVAFVKLHIISYMGD------IFKLIKEF-- 1016
            |:.|:..||..:......... :|..|.|     :..|  ||.|.::.|      |..:::|:  
Mouse  1212 LSHVIVALLPLIHMQPKETAA-IFHYLIIENRDAVQDF--LHEIYFLPDHPELEKIKAVLQEYRK 1273

  Fly  1017 -WTINTPLQNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRM-VTRRLLQALQKFG 1079
             .:..|.||.||     |::                  ::.:||:|...|: ....|.:.|.|..
Mouse  1274 ETSETTDLQTTL-----QLS------------------MKAIQHENVDVRIHALTSLKETLYKNQ 1315

  Fly  1080 STLGYYLPLILPPIVKLFDS----PYVPQQVSMV--ALETINN---LAC-------------QLD 1122
            ..|..|..          ||    |.:.|.|:::  ..:..|:   |.|             :||
Mouse  1316 EKLIKYAT----------DSETVEPVISQLVTVILKGCQDANSQARLLCGECLGELGAIDPGRLD 1370

  Fly  1123 FTDFSSRIIHPLVRVLDAEPELRDQAMTT-------LRSLAKQLGKKYLVFVPMVQRTLNKHRIV 1180
            |:              ..|.:.:|....|       ...|..:|.:.||.:.       :..|..
Mouse  1371 FS--------------TTETQGKDFTFVTGVEDLSFAYGLLMELTRAYLAYA-------DNSRAQ 1414

  Fly  1181 DP---EYEELLSKIKSCSTLADSYGAGESELRPSRFKNN-----EPFVTDRNSNNKNLQVTTNEL 1237
            |.   ..:|||| |..|..: .|.|.|....:  ||..:     ||.:   |:..|:.|.:|:  
Mouse  1415 DSAAYAIQELLS-IYDCREM-QSNGPGYQLWK--RFPEHVREILEPHL---NTRYKSSQKSTD-- 1470

  Fly  1238 RTAWQ-VTRRV--SK--DDWVEWLKRLS---IGLLKESPSHALRACRSLAQEYD-----TLLRDL 1289
               |. ||:.:  ||  :::.||....:   |..::::.:..:..|.|:..::|     .||..:
Mouse  1471 ---WSGVTKPIYLSKLGNNFAEWSSSWAGYLITKVRDNLASKIFTCCSIMMKHDFKVTIYLLPHI 1532

  Fly  1290 FNAAFISC--------WTELSPDLKNELTQSLIQALQVTDMPEI-TQTILNLAEFMEHCDR---- 1341
            .....:.|        :.|:...||::...::......:|:.:: |||:.::.:.:....|    
Mouse  1533 LVYVLLGCNQEDQQEVYAEIMAVLKHDEQHAISTQDSASDLCQLSTQTVFSVLDHLTQWARHKFQ 1597

  Fly  1342 ------------------------------------DPIPIETKLLGTRAMACRAYAKALRYKEE 1370
                                                |.||.:|  |...:...:||.:|:.: .|
Mouse  1598 ALNAEKLAQNKPKGGKVNKILSNVNFEDYQSVTRFLDLIPQDT--LAVASFRSKAYTRAVMH-FE 1659

  Fly  1371 EFLLREDSQVFESLILINNKLQQREAAEGL--LTRYRNAANELNVQGRWYEKLHNWDEALEHYER 1433
            .|:..:...:.:.|..:..........:|:  ::..|.|...|..|...:|.:....:|...|:|
Mouse  1660 SFITEKKQNIQKHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESIGLLRDATACYDR 1724

  Fly  1434 NLKTDSSDLEARLGHMRCLEALGDWSELSNV---------TKHEWENFGTEAKSRAGPLAAVAAW 1489
            .::.:...:....|.::.:..||   :||.|         .:.||.:       ........|||
Mouse  1725 AIQLEPDQIIHYHGVVKSMLGLG---QLSTVITQVNGVHANRSEWTD-------ELNTYRVEAAW 1779

  Fly  1490 GLQDWEAMREYVRCIPEDTQDGS-------YYRAVLAVHHDD---FETAQRLIDETRDLLDTELT 1544
            .|..|:.:..|:      ..||.       ..:.:|:....|   |....:|: ....::.....
Mouse  1780 KLSQWDLVENYL------AADGKSTTWSVRLGQLLLSAKKRDTTTFYDTLKLV-RAEQIVPLSAA 1837

  Fly  1545 SMAGESYERAYGAMVCVQMLAELEEVIQYKLIP-ERREPLKTM------WWKRLQGGQRLVEDWR 1602
            |....||:|.|..:|.:.||.|||    :.|.| .|:.|..:.      |..||:..|.......
Mouse  1838 SFERGSYQRGYEFIVRLHMLCELE----HSLKPLFRKSPGDSCNEDSLNWGARLEMTQNSYRAKE 1898

  Fly  1603 RIIQVH----SLVVKP--HEDI-HTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCN 1660
            .|:.:.    ||..:|  :|.: ..||:.|.:.||:|    .|:|..           |..|...
Mouse  1899 PILALRRALLSLNKRPDYNEMVGECWLQSARVARKAG----HHQTAY-----------NALLNAG 1948

  Fly  1661 QPQVTYAY---TKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQRLM--ARCYLRMA 1720
            :.::...|   .|::.:...:.:|...|...|     || |.|......:.:.::  .|..|.:.
Mouse  1949 ESRLAELYVERAKWLWSKGDVHQALIVLQKGV-----EL-CFPENKSPSESKHMLIHGRATLLVG 2007

  Fly  1721 TWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKA-WHLWAYMNFKVVQAQKSALDKQQPPGASM 1784
            .:..:.. :...:|:   ::.::..|.:.|.|... ::|..|.:..:.....:.::||       
Mouse  2008 RFMEETA-NFESNAV---MKKYKDVTLFLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQ------- 2061

  Fly  1785 GMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSL--QDTLRLLTLWFDYGNHAEVYEALLS 1847
                     .||:   ||   .|..|.||:..  ||..  |...|:|:||.|:|  |:.||....
Mouse  2062 ---------GDLI---RY---IVLHFGRSLQY--GNQFIYQSMPRMLSLWLDFG--AKAYEWEKG 2107

  Fly  1848 GMK--------LIEINT-------------WLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHP 1891
            |..        |.:||:             :|....|||:||......|..::.:::..:...:|
Mouse  2108 GRSDRLQMRNDLAKINSVLTEHTNRLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYP 2172

  Fly  1892 QALVYPLTVASKSASLARRNAAFKILDS---MRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGL 1953
            |..::.:|..|||:...|.|...:||..   |:|.....|..|...:::|              |
Mouse  2173 QQAMWMMTAVSKSSYPMRVNRCKEILTKAIHMKKSLEKFVGDATRLTDKL--------------L 2223

  Fly  1954 EEASRLYFGDRNVKGM---FEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAV 2015
            |..::...|..:...|   |::|:.|          :::.:||:.                    
Mouse  2224 ELCNKSVDGSNSTLSMSTHFKMLKRL----------VEDPTFSEI-------------------- 2258

  Fly  2016 VMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPG--SYNPGQELIRISII 2078
                                 |..|.|:.:|.: |.::.........||  :|..|.:.:     
Mouse  2259 ---------------------LIPLQSVMIPTL-PSVLGAHANHDPFPGHWAYLAGFDDV----- 2296

  Fly  2079 KTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLA 2143
               :::::|.|:|:|:.::||:||.|:.:.|..:|||:|.|:|:..||:|..|..|.::.||.|.
Mouse  2297 ---VEILSSLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELH 2358

  Fly  2144 IQRYAVIPLSTNSGLIGWVPHCDTLHTLI-RDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVE 2207
            |:.||||||:...|:|.||.:...|..:: :.|::|......:|.|..:  .|  ....|.:|::
Mouse  2359 IRTYAVIPLNDECGIIEWVNNTAGLRPILTKIYKEKGVYMTGKELRQCM--LP--KSAALSEKLK 2419

  Fly  2208 VFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMS 2272
            ||:..|.........:......|....|:..|:.|.||.||||||||||||||||..|::.|..:
Mouse  2420 VFQELLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFT 2484

  Fly  2273 GKILHIDF------GDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLRR 2331
            |:.:|:||      |:.|||       ||.:|||||..::..|...|.||.:||.||..:.::|.
Mouse  2485 GECVHVDFNCLFNKGETFEV-------PEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRD 2542

  Fly  2332 NKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLSNSVEDSLPMAKSK 2396
            .::.||:||:.|::|||:.|   ....||:     :.||....|..:.:             |:|
Mouse  2543 QREPLMSVLKTFLHDPLVEW---SKPVKGH-----SKAPLNETGEVVNE-------------KAK 2586

  Fly  2397 PYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLC 2461
            .:...::|             :...||| .:.::||.....|      ..|..|||:||:...||
Mouse  2587 THVLDIEQ-------------RLQGVIK-TRNRVTGLPLSIE------GHVHYLIQEATDENLLC 2631

  Fly  2462 QCYIGWCPF 2470
            |.|:||.|:
Mouse  2632 QMYLGWTPY 2640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 536/2642 (20%)
HEAT repeat 632..658 CDD:293787 7/40 (18%)
HEAT repeat 668..698 CDD:293787 11/45 (24%)
HEAT repeat 706..736 CDD:293787 1/29 (3%)
HEAT repeat 749..780 CDD:293787 10/47 (21%)
HEAT repeat 798..823 CDD:293787 8/24 (33%)
DUF3385 831..999 CDD:288698 39/232 (17%)
HEAT repeat 841..870 CDD:293787 9/45 (20%)
HEAT repeat 880..917 CDD:293787 9/55 (16%)
HEAT repeat 925..954 CDD:293787 6/28 (21%)
Rapamycin_bind 1937..2034 CDD:285924 10/99 (10%)
PIKKc_TOR 2075..2353 CDD:270713 103/284 (36%)
FATC 2440..2471 CDD:280430 13/31 (42%)
AtrNP_063917.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..447 2/23 (9%)
HEAT repeat 690..720 CDD:293787 2/29 (7%)
HEAT repeat 729..788 CDD:293787 11/65 (17%)
HEAT 1 799..835 9/43 (21%)
HEAT repeat 802..837 CDD:293787 11/42 (26%)
UME 1119..1225 CDD:214825 13/107 (12%)
HEAT 2 1329..1365 6/35 (17%)
NR_LBD 1529..>1607 CDD:299703 10/77 (13%)
FAT 1771..2092 CDD:280429 77/380 (20%)
TEL1 <2123..2641 CDD:227365 171/644 (27%)
PIKKc_ATR 2290..2564 CDD:270625 104/295 (35%)
FATC 2610..2641 CDD:280430 14/37 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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