DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tor and Pik3c2b

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_001092746.2 Gene:Pik3c2b / 240752 MGIID:2685045 Length:1632 Species:Mus musculus


Alignment Length:1387 Identity:263/1387 - (18%)
Similarity:444/1387 - (32%) Gaps:519/1387 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1087 PLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHP--LVRVLDAE----PELR 1145
            |..|||.|.::|:|.:|.:....:...|:.   ..|...|||....|  |:...|.|    |:.|
Mouse   155 PPPLPPRVSIWDAPPLPPRKGSPSPSKISQ---PNDINSFSSAEQPPDKLLVAQDPEEGELPDGR 216

  Fly  1146 DQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAG------ 1204
            .|..|        ||......:......||.....|       |:|.|.:|.....|.|      
Mouse   217 GQGHT--------LGSVDYDGINDAITRLNLKSTYD-------SEISSDATRGWKEGRGPLDFNK 266

  Fly  1205 ESELRP-SRFKNNEPFV-----TDRNSNNKNLQVTTNELRTAWQVTRRVSKDDWVEWLKRLSIGL 1263
            ::..:| :|.|...|.|     |.|.:|.||.....|         ||:|         ...:| 
Mouse   267 DTSGKPVARSKTMPPQVPPRTYTSRYANRKNATPGNN---------RRIS---------AAPVG- 312

  Fly  1264 LKESPSHALRACRSL---AQEYD----------TLLR---DLFNAAFISC-WTELSP-------- 1303
               |..|.:.....|   ::|.|          .:||   |:.:.:...| |:.::|        
Mouse   313 ---SRPHTVANGHELFEVSEERDEEVAAFCHMLDILRTGSDIQDYSLTGCVWSTVTPSPEHLGDE 374

  Fly  1304 ----------DLKNELT--------------QSL------IQALQVTD-------MPEITQT--I 1329
                      .|:..||              |:|      ::.:.|.|       :.|..|.  .
Mouse   375 VNLKVTVLCDSLREPLTFTCNCSSTVDLLIHQTLCYTHDELREVDVGDFVLKPCGLEEFLQNKHA 439

  Fly  1330 LNLAEFMEHCDRDPIPIETKLLGTRAMACRAYAKALRYKEEEFLLR--EDSQVFESL-ILINNKL 1391
            |...|::::|.:..|.|..:|:..:|:             ...|.|  .|.|...:| .||:  |
Mouse   440 LGSHEYIQYCRKFDISIRLQLMEQKAI-------------RSDLARTVNDDQSPSTLNYLIH--L 489

  Fly  1392 QQREAAEGLLTRYRNAANELNVQGRWYEKLHNWDEA--LEHYERNLKTDSSDLEARLGHMRCLEA 1454
            |:|...:   |..|.|.:.|      ::..||..:|  |...:..||.|           |.:::
Mouse   490 QERPVKQ---TISRQALSLL------FDTYHNEVDAFLLADGDFPLKAD-----------RVVQS 534

  Fly  1455 LGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRC----IPEDTQDGSYYR 1515
            :                     |:....||||....:.  .|:.:...|    .|:..:|.|   
Mouse   535 V---------------------KAICNALAAVETPEIT--SALNQLPPCPSRMQPKIQKDPS--- 573

  Fly  1516 AVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMV--CVQMLAELEEVIQYKLIPE 1578
             ||:|..:..:..:.|.....||::...::...:......|:..  .||........:.:.:...
Mouse   574 -VLSVRENREKVVEALTAAILDLVELYCSTFNADFQTAVPGSRKHDLVQEACHFPGALAFTVYGT 637

  Fly  1579 RREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGSLHLSH--KTL 1641
            .|.|:  :|                        ...:||.:.            |..|||  |.|
Mouse   638 HRIPI--IW------------------------ATSYEDFYL------------SCSLSHGGKEL 664

  Fly  1642 VMLLGTDPKLNPNQPLPCNQPQVTYA-YTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALK 1705
                             |:..|...| ::||             |.|.: .:.|:: |.|.:..:
Mouse   665 -----------------CSPLQTRRAHFSKY-------------LFHLI-IWDQQI-CFPVQVNR 697

  Fly  1706 QQDQRLMARCYLRM----------ATWQNKLQDSIRPDAI----------QGALECFEKATSYDP 1750
            ...:.|:......:          |..|.::     |:|:          :..|.|..|.....|
Mouse   698 LPRETLLCATLYALPVPPPGGSSEANKQKRV-----PEALGWVTTPLFNFRQVLTCGRKLLGLWP 757

  Fly  1751 -NWYKAWHLWAYMNFK-----VVQAQ--KSALDKQ--QPPG--ASMGMTMGSGLDSDLMIIQRYA 1803
             ....:...|:..||.     ::|..  .||.|.:  .|||  .|.....||..:.|    ||  
Mouse   758 ATQENSGARWSAPNFHQPDSVILQIDFPSSAFDIKFTSPPGDKFSPRYEFGSLREED----QR-- 816

  Fly  1804 VPAVQGFFRSISLIKGNSLQDTLRLLT------LWFD-YGNHAEVYEALLSGMKLI--EINTW-L 1858
                        .:|..:.:::|..||      ||.. |..|.||     |.:.|:  ...:| .
Mouse   817 ------------KLKDITQKESLYWLTDADKKQLWEKRYYCHTEV-----SSLPLVLASAPSWEW 864

  Fly  1859 QVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILDSMRKH 1923
            ..:|.:.|       |:.|..|.       ||..|             |...:|.|.        
Mouse   865 ACLPDIYA-------LLQQWTHM-------NHQDA-------------LGLLHATFP-------- 894

  Fly  1924 SPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGM-FE--ILEPL-HAMLERG- 1983
                       .:|:.|:|:    ||...|.:|..|.:..:.|:.: :|  :..|| ..:|:|. 
Mouse   895 -----------DQEVRRMAV----QWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAI 944

  Fly  1984 -------------PQTLKETSFSQAY-----------GRELTEAYEWSQRYKTSAVVMDLDRAWD 2024
                         ..:||::.||..|           |:.|.|.:.              .:.|.
Mouse   945 SDLRVTHYFFWLLKDSLKDSQFSIRYQYLLAALLCCCGKGLREEFN--------------RQCWL 995

  Fly  2025 IYYHVFQKISRQLPQLT-----------------------SLELPYVSPKLMTCKDLELAVPGSY 2066
            :  :...|:::|:.:.|                       |..|| :||.|:        |.|  
Mouse   996 V--NTLAKLAQQVREATPSARQGILRVGLEEVKQFFALNGSCRLP-LSPSLL--------VKG-- 1047

  Fly  2067 NPGQELIRISIIKTNLQVITSKQRPRKLCIRGSN--GKDYMYLLKGHEDLRQDERVMQLFSLVNT 2129
                      |:..:.....|...|.||..:..:  |::...:.|..:|||||...:|:..:::.
Mouse  1048 ----------IVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSK 1102

  Fly  2130 LLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFA 2194
            :.:.:....|..:    :.........|::..:|:.:||                          
Mouse  1103 IWVQEGLDMRMVI----FRCFSTGRGKGMVEMIPNAETL-------------------------- 1137

  Fly  2195 PDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLG 2259
                     :|::|.....|..:...||..|...:|..:.:.:...|:..|.|...:..||||:.
Mouse  1138 ---------RKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYILGIC 1193

  Fly  2260 DRHPSNLMLDRMSGKILHIDFG 2281
            |||..|:|| :.:|.:.|||||
Mouse  1194 DRHNDNIML-KTTGHMFHIDFG 1214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 263/1387 (19%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 24/125 (19%)
PIKKc_TOR 2075..2353 CDD:270713 44/209 (21%)
FATC 2440..2471 CDD:280430
Pik3c2bNP_001092746.2 PI3K_rbd 363..465 CDD:366310 16/101 (16%)
C2A_PI3K_class_II 621..793 CDD:175979 38/246 (15%)
PI3Ka_II 812..980 CDD:238441 46/240 (19%)
PI3Kc_C2_beta 986..1339 CDD:119421 57/306 (19%)
PX_PI3K_C2_beta 1368..1476 CDD:132823
C2B_PI3K_class_II 1504..1626 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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