Protein Alignment mTor and SMG1

DIOPT Version :10

• Sequence 1: NP_001260427.1
• Gene: mTor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Sequence 2: XP_005255239.1
• Gene: SMG1 / 23049
• HGNCID: 30045
• Length: 3689
• Species: Homo sapiens
• Alignment Length: 2718
• Identity: 564/2718 - (20%)
• Similarity: 958/2718 - (35%)
• Gaps: 843/2718 - (31%)

  Fly   205 IVTAQR-ESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNELFRCANA 268
            :|:.|| :.|:..::.|      ::..|.::.:.||.         :..:|...:..|| |..|.
Human    65 VVSRQRHDDTRVHADIQ------NDEKGGYSVNGGSG---------ENTYGRKSLGQEL-RVNNV 113

  Fly   269 TWERRYTSL----KTLFPKTQHNKFLEASSSSSMGSQLNTLVPRL--------KVPFIDKLGSTQ 321
            | ...:||:    :.|..|.. .|..|.|.|.|..|:|:.|:.|:        ::..:.:|   :
Human   114 T-SPEFTSVQHGSRALATKDM-RKSQERSMSYSDESRLSNLLRRITREDDRDRRLATVKQL---K 173

  Fly   322 THLGEGEHHKGVAK-----FASQHNVL--ESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQALL 379
            ..:.:.|:...:.|     .|:.|:||  .|...||:.||  .:.|..:|   .:...|..:.:.
Human   174 EFIQQPENKLVLVKQLDNILAAVHDVLNESSKLLQELRQE--GACCLGLL---CASLSYEAEKIF 233

  Fly   380 QILPRLAAFNRAVFVE-KYLQTCVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIEVHLSSIMT 443
            :.:  .:.|:.:...| |.|..|.::......|::|              |..|.:::    :||
Human   234 KWI--FSKFSSSAKDEVKLLYLCATYKALETVGEKK--------------AFSSVMQL----VMT 278

  Fly   444 SVKVALPSKDLTSKRKVPVDPAVFA----CITLLA------------------------HAVKSE 480
            |::..|.:.|         .|.:..    ||.|:|                        |..|..
Human   279 SLQSILENVD---------TPELLCKCVKCILLVARCYPHIFSTNFRDTVDILVGWHIDHTQKPS 334

  Fly   481 IADDVKDILEQM--FYTGLSPALTVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYTAL 543
            :...|...|:.:  |:.......|..|.:..|::    .|..|.|..:.|...:::....|..:|
Human   335 LTQQVSGWLQSLEPFWVADLAFSTTLLGQFLEDM----EAYAEDLSHVASGESVDEDVPPPSVSL 395

  Fly   544 PTIA----IDGSLMQN-GD------GATTVLALKTLGTFNFEEQNMLDFVQRCAD-----YFIVH 592
            |.:|    :..::::: |:      |.....|..|         ::|..|.||..     :|
Human   396 PKLAALLRVFSTVVRSIGERFSPIRGPPITEAYVT---------DVLYRVMRCVTAANQVFF--- 448

  Fly   593 EQQEIRLEAVQTCTRLLKLAVQSS-------------ESMENSKTL-SDTVSHVIERLLMVAITD 643
              .|..|.|...|..:|..::..|             :.:||.:|. :|.:..|:..|.::.
Human   449 --SEAVLTAANECVGVLLGSLDPSMTIHCDMVITYGLDQLENCQTCGTDYIISVLNLLTLIV--- 508

  Fly   644 MDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPAYVMPKLR 708
                  .:|...|..:|..||..|.| ..||:..|.|    :|:..|......::.....:|.|.
Human   509 ------EQINTKLPSSFVEKLFIPSS-KLLFLRYHKE----KEVVAVAHAVYQAVLSLKNIPVLE 562

  Fly   709 TTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHEPES-------- 765
            |..                               :||...|...|..|:..|..||:
Human   563 TAY-------------------------------KLILGEMTCALNNLLHSLQLPEACSEIKHEA 596

  Fly   766 ---------NPGVI----LNVLRTIGDLAEVNGGSDEMELWA--DDLLSILLEMLGDAGS----- 810
                     |...:    |:.|.|||     |..:..:.:||  ..:.::|.:.|....|
Human   597 FKNHVFNVDNAKFVVIFDLSALTTIG-----NAKNSLIGMWALSPTVFALLSKNLMIVHSDLAVH 656

  Fly   811 -PDKRGVALWTL------------------------GQLISATGRVVTPYHKYPVLIDILINFLK 850
             |..:...|:||                        |.:|| |....|..| :.:::::|...||
Human   657 FPAIQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVIS-TVTTATKKH-FSIILNLLGILLK 719

  Fly   851 TEQRRSIRRETIRVLGLLGAM-------------DPYKHKMNKGLIDS----------QKDNVLI 892
            .:......|:.:....|..|:             .|..||..|||:.:          |..:.|.
Human   720 KDNLNQDTRKLLMTWALEAAVLMKKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQACSSLH 784

  Fly   893 AYS----DGKVDESQDISTAELLVNMGNALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFI 953
            |.|    |..:....|:...: ||:.|..:.:.:..:    |..|..|..||..:.:.:|.::..
Human   785 ALSSSLPDDLLQRCVDVCRVQ-LVHSGTRIRQAFGKL----LKSIPLDVVLSNNNHTEIQEISLA 844

  Fly   954 FQSLGIKCVPY------LAQVLPNLL--DNVRTADNNLREFLF---------QQLAILVAFVKLH 1001
            .:|...|....      .:.|:..:|  ::.||..:|..|.||         .|..|....:|..
Human   845 LRSHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQSTIPRNLLKTD 909

  Fly  1002 IISYMGDI-----FKLIKEFWTINTPL---QNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQ 1058
            .:.:...|     |.::.:   :.|||   |:| ...||.|       .|...|..:.....|.|
Human   910 AVLWQWAIWEAAQFTVLSK---LRTPLGRAQDT-FQTIEGI-------IRSLAAHTLNPDQDVSQ 963

  Fly  1059 ---------HDNSKDRMVTRRLLQALQK-----FGSTLGYYLPLILPP-IVKLFDSPYVPQQVSM 1108
                     |.|::.|:|.  |||.|:.     :.:..|....|..|| :::.|.  |.
Human   964 WTTADNDEGHGNNQLRLVL--LLQYLENLEKLMYNAYEGCANALTSPPKVIRTFF--YT------ 1018

  Fly  1109 VALETINNLACQLDFTDFSSRIIHPLVRV--LDAEP--------ELRDQAMTTLRSLAKQL---- 1159
                  |...||    |:.:||...::||  |..:|        :|..:..||..|...:|
Human  1019 ------NRQTCQ----DWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTI 1073

  Fly  1160 ---------------------------GKKYLVFVPMVQRTLNKHRIVDPEYEELLSKI------ 1191
                                       ||..|....:.|:...:......||:|.|..:
Human  1074 MMVVEALCELHCPEAIQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCC 1138

  Fly  1192 -----KSCSTLADSYGAGESELRPSRFKNNEPFVT----DRNSNNKNLQVTTNELRTAWQVTRRV 1247
                 ||..|||:   ||.:...|....|.|...|    ..:|:.:.:....|:....:     :
Human  1139 ISSFDKSVLTLAN---AGRNSASPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACECY-----I 1195

  Fly  1248 SKDDWV---EWLKRLSIGLLKESPSHALRACRSLAQEYDTL--LRDLFNAAFISCWTE------- 1300
            |..||.   ||...:. .|.|.:.|.:|    :|..:::.:  |....:..|:.| ||
Human  1196 SIADWAAVQEWQNAIH-DLKKSTSSTSL----NLKADFNYIKSLSSFESGKFVEC-TEQLELLPG 1254

  Fly  1301 -----------------------LSPDLKNELTQS-----------LIQALQVTDMPEITQTIL- 1330
                                   |||| ..||.:|           |..||...:..:..|:|.
Human  1255 ENINLLAGGSKEKIDMKKLLPNMLSPD-PRELQKSIEVQLLRSSVCLATALNPIEQDQKWQSITE 1318

  Fly  1331 NLAEFMEHCDR---DPIPIET-------KLLGTRAMAC--------------------------- 1358
            |:.::::...|   .|:.:.|       .:|.|..:.|
Human  1319 NVVKYLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSEALR 1383

  Fly  1359 -------RAYAKALRY-----------KEEEFLLREDSQVFESLILINNKLQQREAAEGLLTRYR 1405
                   |.:.:||||           ||:...:|  |.:.| |.|...|..::.....|.||..
Human  1384 SCKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIR--SHLME-LGLTAAKFARKRGNVSLATRLL 1445

  Fly  1406 NAANELNVQGR---------WYEKLHNWDEALEHYERNLKTDSSDLEARLGH-MRCLEALGDWS- 1459
            ...:|:.: |:         .::||....:..|.:...|..:.:.|....|. ...:|.|...:
Human  1446 AQCSEVQL-GKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQSTHAMEMLSSCAI 1509

  Fly  1460 ELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDD 1524
            ......|.|:    ..|||    :..:|.|...:|:.:...::.:         ||   |.|..:
Human  1510 SFCKSVKAEY----AVAKS----ILTLAKWIQAEWKEISGQLKQV---------YR---AQHQQN 1554

  Fly  1525 FETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVI--QYKLIPERREPLKTMW 1587
            |.....|......|::....:...|.|.|..........:.|.:.::  .|.|...:...:...|
Human  1555 FTGLSTLSKNILTLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSW 1619

  Fly  1588 ---------WKR------LQG-GQRLVEDWRRIIQ---VHSLVVKPHEDIHTWLKYASLCRKSGS 1633
                     |.|      .|| |.||:...:..:|   ..::..:..|.|:..|..| :||.:|
Human  1620 AALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQA-VCRPAG- 1682

  Fly  1634 LHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSC 1698
                                     .....:|...|:  :.:|:..:..:.:      :.|.:|.
Human  1683 -------------------------IQDEDITLQITE--SEDNEEDDMVDVI------WRQLISS 1714

  Fly  1699 LPPEALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMN 1763
            .|                     |.::|.:|    |.:|.::.:.|......:.||. ...||..
Human  1715 CP---------------------WLSELDES----ATEGVIKVWRKVVDRIFSLYKL-SCSAYFT 1753

  Fly  1764 FKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRL 1828
            |..:.|.:..||:..|   .:.::......:|.||:..                       ||||
Human  1754 FLKLNAGQIPLDEDDP---RLHLSHRVEQSTDDMIVMA-----------------------TLRL 1792

  Fly  1829 LTLWFDYGNHA-EVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQ 1892
            |.|..   .|| |:.:.|..|::......|..:||||.:|::.....|.|.|..||..:.::.|.
Human  1793 LRLLV---KHAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPH 1854

  Fly  1893 ALVYPL---TVASKSASLARRN------------------------------------------- 1911
            .::||.   |::..|.|.|..|
Human  1855 LILYPAIVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGL 1919

  Fly  1912 ---------AAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQW-------H-------EGL 1953
                     ...||:|.:...:||:|.|..|...||.||.:||.|.|       |       :.|
Human  1920 NEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRRIQQL 1984

  Fly  1954 EEASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEA------YEWSQRYKT 2012
            |:..:....:..::..    |.:..|.|:....:|...|:..:.|.:|.|      .:|.|....
Human  1985 EDEVKRVQNNNTLRKE----EKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWFQDNYG 2045

  Fly  2013 SAVVMDLDR------------AWDIYYHVFQKISRQLPQLTS--LELPYVSPKLMTCKDLELAVP 2063
            .|:...|::            :|..:..:...:.::..:..|  |.|..:||.|....:.|:|:|
Human  2046 DAIENALEKLKTPLNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLEEISPWLAAMTNTEIALP 2110

  Fly  2064 GSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVN 2128
            |..: .::.:.|..:...:.::.:|.:|:||...||:||.|.||.||.|||..|||:||..|:||
Human  2111 GEVS-ARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVN 2174

  Fly  2129 TLL--LDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQE----H 2187
            |:.  ::..:|.|  ...:.|:|.||.|.||||.||.....|..|.:.::.::.....|:    :
Human  2175 TMFATINRQETPR--FHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSY 2237

  Fly  2188 RTMLN--------------FAPDYDHLTLMQKVE-----------VFEHALGQTQGDDLAKLLWL 2227
            :|..|              ..|....:.|...|.           |.|..:..|..:.|||.||.
Human  2238 QTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWS 2302

  Fly  2228 KSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREK 2292
            ...:.:.|:....:|.||.|||||||||:||||||..|:::|..:|:::|||:..|||....:..
Human  2303 SCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGNIKVD 2367

  Fly  2293 F---------------------------PEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLR 2330
            |                           |||:|||:|:.:..|:.|||:||.:|.:||.|:.::|
Human  2368 FTFMRAKCFLVKGQKYNDLSFQGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMR 2432

  Fly  2331 RNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLS 2383
            |.:::|:.:|||||||||::|      ..|.:| ..|||..|.||...:...|
Human  2433 RGRETLLTLLEAFVYDPLVDW------TAGGEA-GFAGAVYGGGGQQAESKQS 2478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mTor	NP_001260427.1	TEL1	308..2471	CDD:227365	538/2610 (21%)
		HEAT repeat	632..658	CDD:293787	4/25 (16%)
		HEAT repeat	668..698	CDD:293787	7/29 (24%)
		HEAT repeat	706..736	CDD:293787	2/29 (7%)
		HEAT repeat	749..780	CDD:293787	12/51 (24%)
		HEAT repeat	798..823	CDD:293787	7/54 (13%)
		HEAT repeat	841..870	CDD:293787	5/28 (18%)
		HEAT repeat	880..917	CDD:293787	12/50 (24%)
		HEAT repeat	925..954	CDD:293787	6/28 (21%)
SMG1	XP_005255239.1	SMG1_N	32..140	CDD:435799	20/92 (22%)
		SMG1	631..1242	CDD:464869	130/661 (20%)
		PIKKc_SMG1	2121..2454	CDD:270714	114/340 (34%)
		FATC	3659..3688	CDD:460514