Protein Alignment Tor and Pik3c3

DIOPT Version :9

• Sequence 1: NP_001260427.1
• Gene: Tor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Sequence 2: NP_852079.2
• Gene: Pik3c3 / 225326
• MGIID: 2445019
• Length: 887
• Species: Mus musculus
• Alignment Length: 1099
• Identity: 223/1099 - (20%)
• Similarity: 372/1099 - (33%)
• Gaps: 372/1099 - (33%)

  Fly  1335 FMEHCDRDPIPIETK---LLGTRAMACRAYAKALR---------YKEEEFLLREDSQVFESLILI 1387
            ::..||.| |.::.|   |.|.|..  ::|...|.         |:|....|....|||
Mouse     9 YIYSCDLD-INVQLKIGSLEGKREQ--KSYKAVLEDPMLKFSGLYQETCSDLYVTCQVF------ 64

  Fly  1388 NNKLQQREAAEG------LLTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLKTDSSDLEARL 1446
                     |||      :.|.|:..:.      ||     ||:|.|:     |.....||...
Mouse    65 ---------AEGKPLALPVRTSYKAFST------RW-----NWNEWLK-----LPVKYPDLPRN- 103

  Fly  1447 GHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWG-----------LQDWEAMREY 1500
                           :.|....|:.:|..:....|. ..|:.:|           |:.|
Mouse   104 ---------------AQVALTIWDVYGPGSAVPVGG-TTVSLFGKYGMFRQGMHDLKVW------ 146

  Fly  1501 VRCIPEDTQDGSY-----YRAVLAVHHDDFETAQRLIDETR-------DLLDTELT----SMAGE 1549
                |....|||.     .|....:..|......:|....|       |.|| .||    .|..|
Mouse   147 ----PNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLD-RLTFREIEMINE 206

  Fly  1550 SYERAYGAMV------CVQMLAELEEVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQVH 1608
            |.:|:...|.      ||:...:...::.|:...:...|:.|.:        .||:.....:.:.
Mouse   207 SEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSF--------ELVKVPDPQMSME 263

  Fly  1609 SLVVKPHEDIHTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLN------PNQPLPCNQPQVTYA 1667
            :||...|.      |.|...|...|.|    .|.....|..:||      |.:.|...:..:.:.
Mouse   264 NLVESKHH------KLARSLRSGPSDH----DLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWK 318

  Fly  1668 YTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQRLMARCYLRMATWQNKLQDSIRP 1732
            :..|:  .||    .:.||.|:...:.:   ||.||  :|...|:.:       |        :|
Mouse   319 FRYYL--TNQ----EKALTKFLKCVNWD---LPQEA--KQALELLGK-------W--------KP 357

  Fly  1733 DAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLM 1797
            ..::.:||....            |   |.|..|.:...:.|.:..              |.||:
Mouse   358 MDVEDSLELLSS------------H---YTNPTVRRYAVARLRQAD--------------DEDLL 393

  Fly  1798 IIQRYAVPAVQGF-FRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEALL-SGMKLIEINTWLQV 1860
            :   |.:..||.. :.:...|| |.|:.|.:        .:.....|:|. ||:...:|::
Mouse   394 M---YLLQLVQALKYENFDDIK-NGLEPTKK--------DSQTSASESLSNSGVSSGDIDS---- 442

  Fly  1861 IPQLIARIDTHRQLVGQLIHQLLMDI--------------GKNHPQAL-VYPLTVASKSASLARR 1910
                           .|:|...|..:              |:|..|.| .:.::.|.|:::||..
Mouse   443 ---------------SQIITNPLPPVASPPPASKAKEVSDGENLEQDLCTFLISRACKNSTLANY 492

  Fly  1911 NAAFKIL-----DSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASR-LYFGDRNVKGM 1969
            ...:.|:     |:.::...|                   ||.:...:...|: |..||::|:.|
Mouse   493 LYWYVIVECEDQDTQQRDPKT-------------------HEMYLNVMRRFSQALLKGDKSVRVM 538

  Fly  1970 FEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKIS 2034
            ..:|......::|....:|      |..||.....:.::|.:  |::.|.::
Mouse   539 RSLLAAQQTFVDRLVHLMK------AVQRESGNRKKKNERLQ--ALLGDNEK------------- 582

  Fly  2035 RQLPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGS 2099
                              |...|:|| :|....| |..|| .||.....:..|...|.:|..:..
Mouse   583 ------------------MNLSDVEL-IPLPLEP-QVKIR-GIIPETATLFKSALMPAQLFFKTE 626

  Fly  2100 NGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGW--- 2161
            :|..|..:.|..:|||||:.::|:.||::.||..:    ..:|.:..|.|:..||..|.:.:
Mouse   627 DGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKE----NLDLKLTPYKVLATSTKHGFMQFIQS 687

  Fly  2162 VPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLW 2226
            ||..:.|.|                ..::.||...|
Mouse   688 VPVAEVLDT----------------EGSIQNFFRKY----------------------------- 707

  Fly  2227 LKSPSSE----LWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVA 2287
              :||..    :..|..:.|.:|.|...::.||||:||||..||:|.: :||:.|||||    ..
Mouse   708 --APSETGPYGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTK-TGKLFHIDFG----YI 765

  Fly  2288 MTREKFPEKIPFRLTRMLIKAMEVTGIE--GTYRRTCESVMLVLRRNKDSLMAVLEAFV 2344
            :.|:..|...|.:|.:.:::.|..|..|  ..:|:.|.:..|.|||..:.::.:....|
Mouse   766 LGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMV 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	223/1099 (20%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	17/97 (18%)
		PIKKc_TOR	2075..2353	CDD:270713	69/279 (25%)
		FATC	2440..2471	CDD:280430
Pik3c3	NP_852079.2	C2_PI3K_class_III	26..186	CDD:176042	41/219 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..170		4/20 (20%)
		PI3Ka_III	283..503	CDD:238442	56/309 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..466		10/77 (13%)
		PI3Kc_III	539..883	CDD:270628	87/384 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900