Protein Alignment Tor and Pik3cd

DIOPT Version :9

• Sequence 1: NP_001260427.1
• Gene: Tor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Sequence 2: XP_006538704.1
• Gene: Pik3cd / 18707
• MGIID: 1098211
• Length: 1074
• Species: Mus musculus
• Alignment Length: 1034
• Identity: 195/1034 - (18%)
• Similarity: 336/1034 - (32%)
• Gaps: 364/1034 - (35%)

  Fly  1530 RLI----DETRDLLDTELTSMAGESYE-------------RAYGAMVCVQMLAELEEV-----IQ 1572
            ||:    |..:.|::::::.:.|:...             |......|.:..|..:::     :|
Mouse   100 RLVAREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQ 164

  Fly  1573 YKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQV------------------------------ 1607
            |. .|.:.||....|    :.|...|.:...::.|
Mouse   165 YS-FPLQLEPSARGW----RAGLLRVSNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALRKK 224

  Fly  1608 -----HSLVVKPHE------DIHTWL---------KYASLCRKSG-SLHLS--HKTLVMLLGTDP 1649
                 ..||.:|.|      ..|.:|         :|...|..|| :.||:  |.:.::.: .|.
Mouse   225 ATVFRQPLVEQPEEYALQVNGRHEYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSSILAM-RDE 288

  Fly  1650 KLNP----------NQPLPCNQPQVTYAYTKYMAANNQLQE-----AYEQLTHFVST---YSQEL 1696
            :.||          ..|:|..:|.....::.....:.:|.|     |.|::...|..   :..|:
Mouse   289 QSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFSIELIEGRKVNADERMKLVVQAGLFHGNEM 353

  Fly  1697 SCLPPEALKQQDQRLMARCYLRMATWQNKLQDSIRP-DAIQGALECF------EKATSYDPNWYK 1754
            .|   :.:...:..:.:.     ..|:.:|:..|.. |..:.|..||      |||
Mouse   354 LC---KTVSSSEVNVCSE-----PVWKQRLEFDISVCDLPRMARLCFALYAVVEKA--------- 401

  Fly  1755 AWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLD----SDLMIIQRYAVPAVQG-FFRSI 1814
                      |..::.|....|...|.|...:.:....|    .:..:....:||..:| .....
Mouse   402 ----------KKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPA 456

  Fly  1815 SLIKGNSLQDTLRLLTLWF-DYGNHAEVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQL 1878
            ..::||...::...|.::. :...|...:.||   .|::|:....:     ..||....||   .
Mouse   457 GTVRGNPNTESAAALVIYLPEVAPHPVYFPAL---EKILELGRHGE-----RGRITEEEQL---Q 510

  Fly  1879 IHQLLMDIGK----NHPQALVYPLTVASKSASLARRNAAFKILDSMRKHSPTLVEQAVMCSEELI 1939
            :.::|...|.    .|.:.||:                  |:...:::|.|          |.|.
Mouse   511 LREILERRGSGELYEHEKDLVW------------------KMRHEVQEHFP----------EALA 547

  Fly  1940 RVAIL--WHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTE 2002
            |:.::  |::  ||.:.:.||.....|..:|.:.:  |.|..|        .|..||.    |..
Mouse   548 RLLLVTKWNK--HEDVAQVSREGGSGRQPRGRWTV--PAHPYL--------TTKLSQM----LYL 596

  Fly  2003 AYEWSQRYKTSAVVMDLDRAW-DIYYHVFQKISRQLPQLTSLEL-PYVSPKLMTCK-----DLEL 2060
            ...|.:....||:.: ||.:: |.|...|  ..:.|.:||..|| .|:...:...|     |.||
Mouse   597 LCSWPELPVLSALEL-LDFSFPDCYVGSF--AIKSLRKLTDDELFQYLLQLVQVLKYESYLDCEL 658

  Fly  2061 A--------------------------VP---------------GS-------YNPGQELIRI-- 2075
            .                          ||               ||       ...|:.|.::
Mouse   659 TKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKA 723

  Fly  2076 --SIIKTNLQVITSKQRPR--KLCIR--------------------------------------- 2097
              ..:|.:.|..|..|...  .:|:|
Mouse   724 LNDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCSVEQCTFMDSKMKP 788

  Fly  2098 ----------GSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPL 2152
                      ||.| :...:.|..:|||||...:|:..|::.|...:    ..:|.:..|..:|.
Mouse   789 LWIMYSSEEAGSAG-NVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQE----GLDLRMTPYGCLPT 848

  Fly  2153 STNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQ 2217
            ...:|||..|.|.||:          ..:.||:.:               |.....|...
Mouse   849 GDRTGLIEVVLHSDTI----------ANIQLNKSN---------------MAATAAFNKD----- 883

  Fly  2218 GDDLAKLLWLKSPSSELWFERR-NNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFG 2281
                |.|.||||.:.....:|. ..:|.|.|...:..|:||:||||..|:|: |.||::.|||||
Mouse   884 ----ALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMI-RESGQLFHIDFG 943

  Fly  2282 DCFEVAMTREKF---PEKIPFRLTRMLIKAMEVTGIEGT-----YRRTCESVMLVLRRN 2332
            ..  :...:.||   .|::||.||...:..::......:     :|..||....:|||:
Mouse   944 HF--LGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRH 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	195/1034 (19%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	24/99 (24%)
		PIKKc_TOR	2075..2353	CDD:270713	72/322 (22%)
		FATC	2440..2471	CDD:280430
Pik3cd	XP_006538704.1	PI3K_p85B	32..107	CDD:396665	2/6 (33%)
		PI3K_rbd	182..281	CDD:395642	15/98 (15%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	29/193 (15%)
		PI3Ka	504..713	CDD:214537	49/258 (19%)
		PI3Kc_IA_delta	705..1072	CDD:270718	74/338 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900