DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and Pik3c2a

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_035213.2	Gene:	Pik3c2a / 18704	MGIID:	1203729	Length:	1686	Species:	Mus musculus

Alignment Length:	1445	Identity:	272/1445 - (18%)
Similarity:	456/1445 - (31%)	Gaps:	586/1445 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1081 TLGYYLPLILPPIVKLFD-----SPYVPQQVSMVALETINNLA--CQL-------DFTDFSSRII 1131
            :|..|.||:.|.:.|||:     |.::....:...||..|:.|  |.|       |...|....:
Mouse   211 SLPVYRPLVSPDMAKLFEKIASTSEFLKNGKARTDLEIANSKASVCNLQISPKSEDINKFDWLDL 275

  Fly  1132 HPL-------VRVLDAEPELRDQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELL- 1188
            .||       |.||:.|.|.:|..:     ||:                       ||....||
Mouse   276 DPLSKPKVDYVEVLEHEEEKKDPVL-----LAE-----------------------DPWDAVLLE 312

  Fly  1189 SKIKSCSTLADSYGAGESELRPSRFKNNEPFVTDRNSNNKNLQ---VTTNE---LRTAWQVTR-- 1245
            .:..||.                         .:|..|.|:|.   ||.::   :||| |.|:
Mouse   313 ERSPSCH-------------------------LERKVNGKSLSGATVTRSQSLIIRTA-QFTKAQ 351

  Fly  1246 -RVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISCWTELSPDLKNEL 1309
             :||:.|              .:.:.:|....||.||::
Mouse   352 GQVSQKD--------------PNGTSSLPTGSSLLQEFE-------------------------- 376

  Fly  1310 TQSLIQALQVTDMPEITQTILNLA---EFMEHCDR-----DPIPIETKLLGTRA----------- 1355
                   :|..::....|:|:.|.   .:.:||..     .|:.::..:.|..|
Mouse   377 -------VQNDEVAAFCQSIMKLKTKFPYTDHCTNPGYLLSPVTVQRNMCGENASVKVSIEIEGL 434

  Fly  1356 -----MACRAYAKALRYKEEEFLLREDSQVFESLILINNKLQQREAAEGLLTRYRNAANELNVQG 1415
                 ..|...:..      |.:      :.::|..:::.|                 |:::| |
Mouse   435 QLPVTFTCDVSSTV------EII------IMQALCWVHDDL-----------------NQVDV-G 469

  Fly  1416 RWYEKLHNWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRA 1480
            .:..|:...:|.|::                .|     .||....:.|..|  |:   ||.|.:.
Mouse   470 SYILKVCGQEEVLQN----------------NH-----CLGSHEHIQNCRK--WD---TEIKLQL 508

  Fly  1481 GPLAAVA---AWGLQDWEA---MREYVRCIP------------EDTQDGSYYRAVLAV-----HH 1522
            ..|:|:.   |...:|.||   :.:|:..|.            |:..|..:|:..||:     |.
Mouse   509 LTLSAMCQNLARTAEDDEAPVDLNKYLYQIEKPYKEVMTRHPVEELLDSYHYQVELALQTENQHR 573

  Fly  1523 --DDFETAQRLIDETRDLLDT----------------------ELTSMAGESYER--AYGAMVCV 1561
              |....|.|.|....|.::|                      ::||::|....:  ..|::
Mouse   574 AVDQVIKAVRKICSALDGVETPSVTEAVKKLKRAVNLPRNKSADVTSLSGSDTRKNSTKGSL--- 635

  Fly  1562 QMLAELEEVIQYKLIPERREPLKTMWWKRL--------------QGGQRLVEDWRRIIQVHSLVV 1612
                ..|..:|..:     :.|.|..:..|              :|.:.:.|.|....|:...|.
Mouse   636 ----NPENPVQVSM-----DHLTTAIYDLLRLHANSSRCSTGCPRGSRNIKEAWTATEQLQFTVY 691

  Fly  1613 KPHEDIHTWL----KYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMA 1673
            ..|.....|:    ||..:|      .|||.      |.| ...|.|    ::...||....|:.
Mouse   692 AAHGISSNWVSNYEKYYLIC------SLSHN------GKD-LFKPIQ----SKKVGTYKNFFYLI 739

  Fly  1674 ANNQL--------QEAYEQLTHFV--STYSQELSCLP--------PEALKQQDQRLMARCYLRMA 1720
            ..::|        |...|.:.|..  ...:|.....|        ||||.:....|..  :.|..
Mouse   740 KWDELIIFPIQISQLPLESVLHLTLFGVLNQSSGSSPDSNKQRKGPEALGKVSLTLFD--FKRFL 802

  Fly  1721 TWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMG 1785
            |...||                             .:||...:...:            |||
Mouse   803 TCGTKL-----------------------------LYLWTSSHTNSI------------PGA--- 823

  Fly  1786 MTMGSGLDSDLMIIQR------YAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEA 1844
                  :.....:::|      :..||....:.|..:.:....||.|             |..|:
Mouse   824 ------IPKKSYVMERIVLQVDFPSPAFDIIYTSPQIDRNIIQQDKL-------------ETLES 869

  Fly  1845 LLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKN------HPQALVYPLTVAS- 1902
            .:.| ||::|               .||.....|..:..:.:.:|      ||..|  |..:||
Mouse   870 DIKG-KLLDI---------------IHRDSSFGLSKEDKVFLWENRYYCLKHPNCL--PKILASA 916

  Fly  1903 ---KSASLARRN------------AAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHE----- 1947
               |.|:||:..            ||.::||            |....:|:..:|:.|.|
Mouse   917 PNWKWANLAKTYSLLHQWPPLCPLAALELLD------------AKFADQEVRSLAVSWMEAISDD 969

  Fly  1948 -------QWHEGLEEASRLYFGDRNVK-------GMFEILEPLHAMLERGPQTLKETSFSQAY-- 1996
                   |:.:.|:  ..:|.....|:       |..:|...|:.:|:   ..|.:|.|...|
Mouse   970 ELADLLPQFVQALK--YEIYLNSSLVRFLLSRALGNIQIAHSLYWLLK---DALHDTHFGSRYEH 1029

  Fly  1997 ---------GRELTEAYEWSQRYK------------------TSAVVMDLDRAWDIYYHVFQKIS 2034
                     |:.|.|  |.|::.|                  |..||  |.::.:.....|.:..
Mouse  1030 VLGALLSVGGKGLRE--ELSKQMKLVQLLGGVAEKVRQASGSTRQVV--LQKSMERVQSFFLRNK 1090

  Fly  2035 RQLPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGS 2099
            .:||         :.|.|: .|:|.:                   .:....:|...|.|:.:..:
Mouse  1091 CRLP---------LKPSLV-AKELNI-------------------KSCSFFSSNAMPLKVTMVNA 1126

  Fly  2100 N--GKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLST--NSGLIG 2160
            :  |::...:.|..||||||...:|:..:::.:.|      :..|.::......|||  :.|::.
Mouse  1127 DPLGEEINVMFKVGEDLRQDMLALQMIKIMDKIWL------KEGLDLRMVIFRCLSTGRDRGMVE 1185

  Fly  2161 WVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLL 2225
            .||..|||                                   :|::|.....|..:...||:
Mouse  1186 LVPASDTL-----------------------------------RKIQVEYGVTGSFKDKPLAE-- 1213

  Fly  2226 WLK--SPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAM 2288
            ||:  :||.|.:.:...|:..|.|...:..|:||:.|||..|:|| |.:|.:.|||||.....|.
Mouse  1214 WLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIML-RSTGHMFHIDFGKFLGHAQ 1277

  Fly  2289 TREKFP-EKIPFRLT 2302
            ....|. ::.||.||
Mouse  1278 MFGSFKRDRAPFVLT 1292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	272/1445 (19%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	27/144 (19%)
		PIKKc_TOR	2075..2353	CDD:270713	58/235 (25%)
		FATC	2440..2471	CDD:280430
Pik3c2a	NP_035213.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Interaction with clathrin, sufficient to induce clathrin assembly. /evidence=ECO:0000250\|UniProtKB:O00443	2..142
		ETS_PEA3_N	<40..>210	CDD:368026
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..68
		PI3K_rbd	421..513	CDD:366310	21/147 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	615..640		5/31 (16%)
		C2A_PI3K_class_II	677..849	CDD:175979	42/240 (18%)
		PI3Ka_II	869..1038	CDD:238441	39/203 (19%)
		PI3Kc_C2_alpha	1043..1395	CDD:270720	73/327 (22%)
		PX_PI3K_C2_alpha	1426..1534	CDD:132822
		Interaction with PtdIns(4,5)P2-containing membranes. /evidence=ECO:0000269\|PubMed:16338929	1488..1493
		C2B_PI3K_class_II	1560..1681	CDD:176027
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O00443	1606..1617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900