DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tor and piki-1

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_510529.1 Gene:piki-1 / 181618 WormBaseID:WBGene00009552 Length:1607 Species:Caenorhabditis elegans


Alignment Length:1447 Identity:275/1447 - (19%)
Similarity:474/1447 - (32%) Gaps:526/1447 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1097 FDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDAEPELRDQAMTTLRSLAKQLGK 1161
            |.||..|.::|..:  |::..:.|....|.|                ::.|.:|.|         
 Worm   187 FLSPIKPFEISFNS--TVDTSSNQTGSHDHS----------------IQYQPLTHL--------- 224

  Fly  1162 KYLVFVPMVQRTLNKHRIVDPEYEELLS-KIKSCSTLADSYGAGESELRPSRFKNNEP-----FV 1220
                :||.|..:||.      .|..||: .:...|...||..|.:.|:|    |..:|     :.
 Worm   225 ----YVPYVMHSLNS------SYGALLNGDLIDLSAFEDSSNASQDEIR----KEFDPLFISTYS 275

  Fly  1221 TDRNSNNKNLQVTTNELRTAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTL 1285
            ||..|.:.::.....      ..::.:.:.:.|...|.:...:...|.|..|..|.:..:|....
 Worm   276 TDTPSPDNSMPAVNA------YFSKPIDEPECVGGAKLIQENIEFPSSSFCLIDCPNGIEEQVKK 334

  Fly  1286 LRDLFNAAFISCWTELSPDLKNELTQSLIQALQVTDMPEITQTILNLAEFMEH------------ 1338
            |          |...|   ::.::|.....|..| |....|.:.:.:..:.:|            
 Worm   335 L----------CKRNL---IRKDMTPDFFIAPTV-DYMVTTASTVKVVVYKDHSWKANKSNGKAM 385

  Fly  1339 -CDRDPIPIETKLLGTRAMAC--------RAYAKALRYKEEEFLLRED---SQVFESLILINN-- 1389
             |..|.   :..::.|:|::.        :.|...: |...:||..:.   |.::....|:|.  
 Worm   386 ICAIDE---KMDIITTQALSLFDSELPTDKEYGLKI-YGLNQFLSSDSLLGSNLYTGHCLLNGDD 446

  Fly  1390 -KLQQREAAEGLLTRYRNAANELNV---QGRWYEK-LHNWDEALEHYERNLKTDSSDLEARLGHM 1449
             ||                  :|.|   ..|.||: |.:|:......:.:...|..|:|..|||:
 Worm   447 VKL------------------DLGVFAPNSRIYEQTLESWNLMKSQVKYSTVVDKEDVENTLGHL 493

  Fly  1450 RCLEALGDWSELSNVTKHEWE---NFGTEAKSRAGP--------LAAVAAWGL---QDWEAMREY 1500
            .        ||:|     ::|   |.|:..|..:..        |......|:   :.:..|::|
 Worm   494 A--------SEMS-----QYEIAFNDGSTLKLSSSSQRVKQVIMLLCKCLHGIVPEKLYNEMQKY 545

  Fly  1501 VRCIPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLA 1565
            :....||.         |..|.:||      :.|....|         |.|.|      |.    
 Worm   546 LASTTEDQ---------LVHHRNDF------LREIHSFL---------ELYCR------CT---- 576

  Fly  1566 ELEEVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRII--QVHSLVVKPHEDIHTWLKYASLC 1628
                |.:|. ||    ||:.:...:::...::  |:.:|:  .|||:   |.   |...:|:...
 Worm   577 ----VSRYN-IP----PLQIITKPKVEVLSKM--DFLQIMLNSVHSI---PE---HWQSQYSEFY 624

  Fly  1629 RKSGSLHLSHKTLVM--LLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVST 1691
            .   ||.|.|.|.|:  .....||...|.......|...||..|.:   |..|  |.:.|..|.:
 Worm   625 M---SLDLYHGTQVLDGFSNKVPKTIKNDHFFPRIPLDLYAKFKRL---NLCQ--YPRETRIVVS 681

  Fly  1692 YSQELSCLPPEALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAW 1756
            .|                          .|.:|..|                .|..|:|      
 Worm   682 IS--------------------------GTVRNSAQ----------------AANEYNP------ 698

  Fly  1757 HLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAV-------QG-FFRS 1813
                                                  |::::...:||..       || .|..
 Worm   699 --------------------------------------DIVMLGYCSVPLYDENLFMRQGPLFLP 725

  Fly  1814 ISLIKGNSLQDTLRLLTLWFDYGNHAEVYEA----LLSGMKLIEINTW-------LQVIPQLIAR 1867
            ::|:|   .|..|:      .:|.:..:.:|    |:...|:.:...:       :|.|||..|.
 Worm   726 LTLLK---KQPMLK------PFGPYPYIKDARDPILIMSFKIWDTEIYFPNVVIDMQCIPQDFAT 781

  Fly  1868 IDTHRQLVGQLIHQLLMDIGKNH--------PQALVYPLTVASKSASLARRNAAFK-ILDSMRKH 1923
            :|...|       :.|:::.:|.        .|.|::     .|...|..:..|.. :|.|::..
 Worm   782 LDIETQ-------EYLLELIENQDTSTLETDDQDLIW-----QKRLHLTNQPEALPLVLSSLQDW 834

  Fly  1924 SPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAM--LERGPQT 1986
            |...|.:.....||       |.....|...|.....:.|..::.        ||:  |.||   
 Worm   835 SFGFVMRVYQILEE-------WAPLRPEIAMEFLLPKYPDERIRA--------HAVQSLARG--- 881

  Fly  1987 LKETSFSQAYGRELTEAYEWSQRYKTSAVV--------MDLDRAWDIYYHVFQKISRQLPQLTSL 2043
              .|.|......:..||..: :.|:.||:.        :.||..::||:.:.|::......    
 Worm   882 --STDFLYHTIPQFIEALRF-ELYEKSALADFILELSFVSLDFTFEIYWQLQQRVDHCAVD---- 939

  Fly  2044 ELPYVSPKLMTCKDLELAVPGSY-NPG----------------------------QELIRISIIK 2079
            :|||.    :.|::|:..:...: ||.                            .|:.|:..::
 Worm   940 DLPYA----IRCQNLQQKMIDEHENPNLKTDIKLQHELLNELDSIQDDLRSKSGDSEIERLHRLR 1000

  Fly  2080 TNLQVITSK------------------------------QRPRKLCIRGSNGKDYMYLLKGHEDL 2114
            |.|.::.||                              .:|.|:..||.| .:|..:.|..:|:
 Worm  1001 TRLGILDSKLLQNKVRLPICPAFDCTGVRIEECSVFNSNAKPLKIVFRGLN-MNYSIIHKRDDDM 1064

  Fly  2115 RQDERVMQLFSLVNTLLLDDPDTFRR----NLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDY 2175
            |||..||:        :|::.|...:    :|.:..:.::|:....|:...|.:|.||..:    
 Worm  1065 RQDAFVMK--------MLNEMDRIWKSNGLDLRMITFRIMPVGYRRGMGELVLNCATLMEI---- 1117

  Fly  2176 RDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWF-ERR 2239
                                        ||    |..|.....|::.:...:|..|.|..: |.:
 Worm  1118 ----------------------------QK----EEGLRGVLNDEILRKWLMKHNSDEFAYKEAQ 1150

  Fly  2240 NNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDF----GDCFEVAMTREKFPEKIPFR 2300
            .|:.||.|...:|.|:||:||||..|::..: :|.:.||||    ||....|..|.   :::||.
 Worm  1151 ENFIRSCAGWCIVTYVLGIGDRHNDNILFTK-NGHVFHIDFGKYMGDWQMAAGFRR---DRVPFV 1211

  Fly  2301 LTRMLIKAMEVTGIEGTYRRT----CESVMLVLRRNKDSLMAVLE---------------AFVYD 2346
            .|..:...:........|.:.    |......|||||::|..:|.               |||.:
 Worm  1212 FTTEMFHVINNGRAPTQYNQKFIDYCCKAFNHLRRNKNTLTNLLRIMACSDIPGINMDSLAFVEN 1276

  Fly  2347 PLLNWRLLDVDKKGNDA 2363
            .|:      :|....||
 Worm  1277 NLM------LDLSDTDA 1287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 275/1447 (19%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 22/106 (21%)
PIKKc_TOR 2075..2353 CDD:270713 73/335 (22%)
FATC 2440..2471 CDD:280430
piki-1NP_510529.1 PI3K_rbd 348..456 CDD:197540 20/130 (15%)
C2A_PI3K_class_II 593..775 CDD:175979 48/292 (16%)
PI3Ka_II 784..948 CDD:238441 38/204 (19%)
PI3Kc_II 964..1315 CDD:270710 78/379 (21%)
PX_domain 1346..1454 CDD:295365
C2B_PI3K_class_II 1473..1604 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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