DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and Y75B8A.24

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_499596.2 Gene:Y75B8A.24 / 176653 WormBaseID:WBGene00013557 Length:2106 Species:Caenorhabditis elegans


Alignment Length:2502 Identity:476/2502 - (19%)
Similarity:821/2502 - (32%) Gaps:903/2502 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 DVSVMEIAARSLVKLANMPTSKGADSFDFDIKKAFEVLRGERQEYRRHSAVFILRELAIAL---- 166
            :.|:.::||. |.:......|..||:....:...::||  |.||...|:...:::.:..||    
 Worm   113 NTSLSDLAAH-LPRFRQQIVSAQADALACAVSSIYDVL--EDQESLEHNYSHVIKLMCYALGLLR 174

  Fly   167 --PTYFYQHILTFFEVIFNAIFDPKPAIRESAGEALRAALIVTAQRESTKQSSEPQWYRICYDEA 229
              ..:...:......:||....|.....:.:.|..::                    :||..||.
 Worm   175 SIGRFSADYDTPLISLIFPLPVDETKKCKGAGGADIK--------------------HRISSDEF 219

  Fly   230 NGSFNADLGSSKDQKGVTRDDRIHGGLVVFNEL---FRCANATWERRYT----SLKTLFPKTQH- 286
            ....:.| .||.|...:| |.:....:.::|:|   |...|.|...:.|    .|:.||...|. 
 Worm   220 TFDTSCD-ASSSDPLLLT-DSKSSRLIRMYNKLGASFLLNNYTGGLKLTMSSEDLEKLFDSVQRL 282

  Fly   287 --NKFLEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQTHLGEGEHHKGVAKFASQHNVLESAYAQ 349
              :||||:                     :|::.......|.|.........:...|:......:
 Worm   283 MDSKFLES---------------------LDEISGEIFSGGSGVKRNPYKSMSEITNLCCLTLLK 326

  Fly   350 EIL-----------QEHYTSICDNVLEQRTSKSPYVQQALLQILPRLAAFNRAVFVEKYLQTCVS 403
            ::|           ||:    |.|.|::.:..||                    ..||:      
 Worm   327 DVLGPYSVKNSDKNQEN----CGNSLQEASPSSP--------------------ISEKF------ 361

  Fly   404 HLMQILRGKEKDRTVAYITIGYMAVAVQSAIEVHLSSIMTSVKVALPSKDLTSKRKVPVDPAVFA 468
                   .||         |...:....|.::..|||:..|.:.:|.::  .|::|:.:..|. .
 Worm   362 -------AKE---------ISIFSKTALSKLDAELSSLQHSSESSLSTE--VSRQKLNIQSAT-V 407

  Fly   469 CITLLAHAVKSEIADDV---------------KDILEQ--MFYTGLSPALTVCLRELSENVPQLK 516
            |:.|:|.|...::..|.               |.|:.|  ::...:|...|     |:|..|   
 Worm   408 CLQLIAWAAIDDMDADAICTEIIVRLFANQTQKTIISQLPLYLKAISSMAT-----LAEKFP--- 464

  Fly   517 SAITEGLIGILSQVLMNKAAILPYTALPTIAIDGSLMQNGDGATTVLALKTLGTFNFEEQNMLDF 581
            :..|..:|..|.:.|:..|.:|      |.....|.::.|..|..|:      ..:....|::|.
 Worm   465 AVATTAVIQNLQRFLLEPAPML------TKLASDSTLERGKSAGDVI------QHSKSSNNLIDA 517

  Fly   582 VQRCADYFIVHEQQEIRLEAVQ-TCTRLLKLAVQSSESMENSKTLSDTVSHVIERL---LMVA-- 640
            :.:          :::.|:|:: :..:.:..|::||..||     ||:|...:..|   |.|.  
 Worm   518 ITK----------RKLSLDALRNSAIKAICRALKSSIRME-----SDSVQQCLAGLSTKLFVCSN 567

  Fly   641 ----ITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDE-IFEIRELAM-VTIGRLSSIN 699
                :..:.|...|                 ::|..:.:.|.|. ..|:.|:.: :.:.|.:  |
 Worm   568 ANNFVVSLVCENAI-----------------QTLGGIGVGLVDSTAVEVPEMVVQIYLQRFA--N 613

  Fly   700 PAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHEPE 764
            |.   .:|..|||..:.::..:|.....|...|:...:.|.:...:.|..|            .|
 Worm   614 PP---SQLDVTMIRCLAEMWIAGARSIYENVWKLFTQICIESSNRVYSQGN------------NE 663

  Fly   765 SNPGVILNVLRTIGDL------AEVNGGSDEMELWADDLLSILLEMLGDAGSPDKRGVALWTLGQ 823
            ||.....:|...: |:      |.|....|:|     .||..|||:....|...:|      :|:
 Worm   664 SNDQRYTHVSLAV-DVAMSRMAAGVANEDDKM-----TLLVRLLELFVQLGIEGRR------VGE 716

  Fly   824 LIS-ATGRVVTPYHKYPVLIDILINFLK--------TEQRRSIRRETIRVLGLLG------AMDP 873
            .:| :|.::.|......||:..:.:.|:        |.:.||:.|:......:||      ::.|
 Worm   717 KVSKSTVKMSTSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWP 781

  Fly   874 YKHKMNKGLIDSQKDNVLIAYS-------DGKVDESQDISTAELLVNMGNALDEY-YPAVAI--- 927
             :...|.....:.|..||||..       |.....|..||..||.......|.|. :.|.|:   
 Worm   782 -EEWYNAVCETATKTPVLIATENLRSELIDNAAIRSDSISPQELQEMRNTVLAELSHQAEAVPLI 845

  Fly   928 --------AALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCV--------PYLAQVLPNLL--- 973
                    ..|:.:.|..|:...|.:.|.|.:..|:.:..|.:        ..:....|.:.   
 Worm   846 NRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFFKYIEDKTMRKDKSGLWTCMLAAAPRIFLEW 910

  Fly   974 --------DNVRTADNNLREFLFQQLAILVAFVKLHI--ISYMGD--IFKLIKEF----WTINTP 1022
                    ||    |....|.|......|:.....|:  :..:.|  :.:|:|.|    |  ||.
 Worm   911 CEKMMKRRDN----DEPTEEALVWHAQFLLFKFNHHLREVRKVADACLSQLVKAFPYLLW--NTK 969

  Fly  1023 LQNTLINLIEQIAVAL----GC-----------------------------EFRDYLAELIPQIL 1054
            :..|::.|::::...|    .|                             :|...:.:::.:.|
 Worm   970 VLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVVKDFSMRVKQILKEAL 1034

  Fly  1055 R---VLQHDNSKDRMVTRRLLQALQKFGSTLGYYLPLILPP-----------IVKLFD-SPYVPQ 1104
            |   ...|.|         ||:.:.||||.....:.|.:..           :..|:. |.|:.|
 Worm  1035 RWAPASTHSN---------LLEYVSKFGSERDAAMQLAIDATSEGSGKSGSYLTSLYKRSNYLGQ 1090

  Fly  1105 QVSMVALETINNLACQLDFTDFSSRIIHPLVRVL--------DAEPE----LRDQAMTTLRSLAK 1157
            ...|:|    ..|:..:|.....:::|..|.:..        |.|.|    |......:||||.:
 Worm  1091 VKGMLA----TTLSGDIDQVTAENQLIDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNE 1151

  Fly  1158 QLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTL---------ADS--YGAG--ESEL- 1208
            :: ...||..|::..|.:...:....:..|||......:|         |||  :|.|  |.|: 
 Worm  1152 RI-LSLLVRTPLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVV 1215

  Fly  1209 ----------RPSRFKNNEP------FVTDR---NSNNKNLQVTTNELRTAWQVTRRVSKDDWVE 1254
                      ||....|..|      |:.:|   .|.:...|:...|:..:..::..:       
 Worm  1216 GGSPLCQKLERPPPSANFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHI------- 1273

  Fly  1255 WLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISCWTELSPDLK---NELTQSLIQA 1316
                 ..|.|     |...||.              |.|.::     .|..|   |::|:. |:|
 Worm  1274 -----GTGHL-----HGSTACS--------------NPASLA-----GPSRKETINQVTRG-IEA 1308

  Fly  1317 LQVTDMPEITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRAYAKALRY--------KEEEFL 1373
            :.|..  .:...:|.:.: .:.|...|    |.:|    :..|.|:.|..|        .:.|..
 Worm  1309 VGVRF--RLLSCVLGMVQ-QDACLLRP----TNVL----IRQRVYSCAFHYFTIAPQGPTQPEER 1362

  Fly  1374 LREDSQVFESLILINNKLQQREAAEGLLTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLKTD 1438
            ||||.:                    ||||:             :|.|.| |:.....|...|||
 Worm  1363 LREDIR--------------------LLTRF-------------FEHLKN-DKHYMQKEALAKTD 1393

  Fly  1439 SSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRC 1503
            .:.:                  :|:.......||.........|:.|.|| |..:...|      
 Worm  1394 KNLV------------------MSSTMSQMQTNFEKSLLISGTPVTATAA-GTPNTSLM------ 1433

  Fly  1504 IPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELE 1568
            :|..|.    |...|.            :...:.:..|..:..:|:|                  
 Worm  1434 LPPSTN----YANTLT------------LSSQKSMAATSASIRSGKS------------------ 1464

  Fly  1569 EVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGS 1633
              |:.||                     .:|:.||              |.||:|          
 Worm  1465 --IETKL---------------------SIEEDRR--------------IKTWMK---------- 1482

  Fly  1634 LHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSC 1698
                .:.::|||                                           |:...:.||.
 Worm  1483 ----QRNMLMLL-------------------------------------------VANEIERLSA 1500

  Fly  1699 -LPPEALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYK-----AWH 1757
             |.|.||.|:|..|.:..:||.|..|                   .|||..:.|.::     ||.
 Worm  1501 WLHPLALAQEDCALDSEEFLRGAFTQ-------------------AKATGGEKNIWREQAQLAWD 1546

  Fly  1758 LWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSL 1822
            :          :.:.|:   |.|....|       ..:|:   :|....|:|....::     .:
 Worm  1547 I----------SPELAI---QLPSRFRG-------SPELV---KYVDVLVRGQPEPVA-----HI 1583

  Fly  1823 QDTLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIG 1887
            .:.|.|.     .||.:.|:|.  |.|.  .:.||.:..|.:...:.|.|             |.
 Worm  1584 PEALPLF-----LGNGSTVFET--SDMS--HVLTWARCSPVMALSLLTPR-------------IY 1626

  Fly  1888 KNHPQALVYPLTV-ASKSASLARRNAAFKILDSMRKHSPTLVEQAV------MCSEELIRVA--- 1942
            ..||.::.|.:.| .|.||            |.:..:.|.:| |||      ..||.:|.:|   
 Worm  1627 PMHPISMQYAVRVLRSYSA------------DELLLYIPQIV-QAVRYDTMGYISELIIWLAGHS 1678

  Fly  1943 ------ILWHEQWHEGLEEASRLYFGDRNVKG--MFE----ILEPLHAMLERGPQTLKETSF--- 1992
                  ::|:.|.:...:|.|:       ||.  :||    |::.:.:.||...:...|..|   
 Worm  1679 QLLSHQLIWNMQTNMFTDEESK-------VKDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLF 1736

  Fly  1993 -------------------SQAYGRELTEAYEWSQRYKTS---AVVMDLDRAWDIYYHVFQKISR 2035
                               .:|..:.|.:....:..|..|   ||::|||            .|.
 Worm  1737 HQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDLD------------YSS 1789

  Fly  2036 QLPQLTSLELPYVSP-KLMTCKDLELAVPG----SYNPGQELIRISIIKTNLQVITSKQRPRKLC 2095
            ..|..::.:.|:::. ::..|...||...|    |.:.|:      ..:.:|:.: .|.:..::|
 Worm  1790 GTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGK------TTEADLEEL-KKVQDSRVC 1847

  Fly  2096 IRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLL--LDDPDTFRRNLAIQRYAVIPLSTNSGL 2158
            .:.:       :.|..:|:|||...:||..|:..:.  |..|      :.:..|.|:..|...|:
 Worm  1848 WQAA-------IFKVGDDVRQDMLALQLMQLMKNVWAGLGLP------VRVFPYRVVATSPGCGV 1899

  Fly  2159 IGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQ-GDDLA 2222
            |..||                    |.:.|..|....|:.         ::|:.  :|| ||:  
 Worm  1900 IECVP--------------------NSKSRDQLGRQTDFG---------LYEYF--KTQYGDE-- 1931

  Fly  2223 KLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFE-- 2285
                    |||.:.|.|.|:.||:|..|:..::|.:.|||..|:|:| :.|.|:|||||..||  
 Worm  1932 --------SSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNGNIMID-LDGHIIHIDFGFMFESS 1987

  Fly  2286 -----------------VAMTREKFPEKIPFR 2300
                             ||:...|. |..|||
 Worm  1988 PGGNLGFEPDFKLSEEMVAIMGGKM-EAAPFR 2018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 433/2284 (19%)
HEAT repeat 632..658 CDD:293787 5/34 (15%)
HEAT repeat 668..698 CDD:293787 6/31 (19%)
HEAT repeat 706..736 CDD:293787 7/29 (24%)
HEAT repeat 749..780 CDD:293787 5/30 (17%)
HEAT repeat 798..823 CDD:293787 6/24 (25%)
DUF3385 831..999 CDD:288698 42/219 (19%)
HEAT repeat 841..870 CDD:293787 8/42 (19%)
HEAT repeat 880..917 CDD:293787 11/43 (26%)
HEAT repeat 925..954 CDD:293787 7/39 (18%)
Rapamycin_bind 1937..2034 CDD:285924 24/136 (18%)
PIKKc_TOR 2075..2353 CDD:270713 62/248 (25%)
FATC 2440..2471 CDD:280430
Y75B8A.24NP_499596.2 PI4Ka 1544..1720 CDD:238443 50/245 (20%)
PI4Kc_III_alpha 1781..2105 CDD:270711 75/313 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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