DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and trr-1

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_001364592.1	Gene:	trr-1 / 174788	WormBaseID:	WBGene00007028	Length:	4062	Species:	Caenorhabditis elegans

Alignment Length:	3274	Identity:	548/3274 - (16%)
Similarity:	1004/3274 - (30%)	Gaps:	1223/3274 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ELREMSQEELAQFFDEFDHHIFTMVNATDINEKKGGALAMKCLINCEGSLTARKGISPYLNRLRD 100
            ::.:||:..:.::..|   .:|.:.:......:.||..|:..:|..    ..||.:..::..:.|
Worm  1169 DIDQMSKVPMCKYLME---KVFKLCHGPAWYARSGGINAIGYMIES----FPRKFVMDFVIDVVD 1226

  Fly   101 LLLINDVSVMEIAARSLVKLANMPTSKGADSFDFDIKKAFEVL----RGERQEYRRHSAVFI--- 158
                   |:||:...::.::    :|..|||....:||...|.    .|:.:|....:.:|:
Worm  1227 -------SIMEVILGTVEEI----SSGSADSAYDCLKKMMRVYFIKEEGQEEENLTLATIFVSAI 1280

  Fly   159 ----------LRELAIALPTYFYQH-----ILTFFEVIFNAIFDPKPAIRESAGEALRAALIVTA 208
                      :||.||.|..:...|     .|..|...|...|:|         |.:|  ::.|.
Worm  1281 SKHYFHSNERVREFAIGLMDHCMVHSRLAPSLDKFYYRFKEFFEP---------ELMR--VLTTV 1334

  Fly   209 QRESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNELFRCANA----- 268
            ...|.                     ||.|.|.|  ||.            |.:|.|.:.
Worm  1335 PTMSL---------------------ADAGGSLD--GVQ------------NYMFNCPDGFDFEK 1364

  Fly   269 --TWERRYTS------LKTLFPKTQHNKFLEASS---------------SSSMGSQLNTLV---P 307
              ...:||.|      ....|...|.|.|.:..:               .|...|.|..||   .
Worm  1365 DMDMYKRYLSHLLDIAQTDTFTLNQRNAFKKCETCPSHFLPPFPITTHIDSMRASALQCLVIAYD 1429

  Fly   308 RLKVPFIDKLGSTQTHLGEGEHHKGVAKFA--SQHNVLESAY-AQEILQEHYTSICDNVLEQRTS 369
            |:|..:|||      .:..|:.||.:...|  |....::..| :.|..:...|.:...|.::.|.
Worm  1430 RMKKQYIDK------GIELGDEHKMIEILALRSSKITVDQVYESDESWRRLMTVLLRAVTDRETP 1488

  Fly   370 K-SPYVQQALLQILPRLAAFNRAVFVEKYLQTCVSHLMQILRG----KEKDRTVAYITIGYMAVA 429
            : :..:..:||::.| ::....|.|...|::.        :.|    .:.||.::|..|    :.
Worm  1489 EIAEKLHPSLLKVSP-ISTIIIATFGASYIRN--------ISGAGDDSDSDRHISYNDI----MK 1540

  Fly   430 VQSAIEVHLSSIMTSVKVALPSKDLTSKRKVPVD-----PAVFA----------------CITLL 473
            .:..:|::...::|.:.|.|.::.:..|....:.     |:.|.                .:.::
Worm  1541 FKCLVELNPKILVTKMAVNLANQMVKYKMSDKISRILSVPSSFTEEELDDFEAEKMKGIRELDMI 1605

  Fly   474 AHAVK-----------SEIADDVKDILEQMFYTGLSPAL-------TVCLRELSENV-------- 512
            .|.||           .:|..|:........|......|       ||.|.:..::|
Worm  1606 GHTVKMLAGCPVTTFTEQIIVDISRFAAHFEYAYSQDVLVNWIDDVTVILNKSPKDVWKFFLSRE 1670

  Fly   513 ----PQLKSAITEGLI----GILSQVLM----------------NKA------------------ 535
                |..:|.|...::    |.|.|..|                ||.
Worm  1671 SILDPARRSFIRRIIVYQSSGPLRQEFMDTPEYFEKLIDLDDEENKDEDERKIWDRDMFAFSIVD 1735

  Fly   536 ---------AILPYTALPTIAIDGSLMQNGDGATTVLALKTLGTFNFEEQ---NMLDFVQRCADY 588
                     .|.|.:.:|.|.                  |......|.|:   ..|..|::..:.
Worm  1736 RISKSCPEWLISPNSPIPRIK------------------KLFSETEFNERYVVRALTEVKKFQEE 1782

  Fly   589 FIVHEQQEIRLEA----VQTCTRLLKLAVQSSE------SMENSKTLSDTVSHVIERLLMVAITD 643
            .||....|.:.:.    :.|..|.|:|.:...:      |..|...::| :|.:.|.|....|..
Worm  1783 IIVKRMTEHKYKVPKLILNTFLRYLRLNIYDYDLFIVIASCFNGNFVTD-LSFLREYLETEVIPK 1846

  Fly   644 MDCNVR----IRILRSLD---ETFDGKLAQPESLNSLFI-TLH--------DEIFEIREL----- 687
            :....|    :||::..|   :|....:...::|..|.| |||        |||.....:
Worm  1847 VPLQWRRELFLRIMQKFDTDPQTAGTSMQHVKALQYLVIPTLHWAFERYDTDEIVGTAPIDDSDS 1911

  Fly   688 ------------------------------AMVTI-------------------------GRLSS 697
                                          .||.:                         |||..
Worm  1912 SMDVDPAGSSDNLVARLTSVIDSHRNYLSDGMVIVFYQLCTLFVQNASEHIHNNNCKKQGGRLRI 1976

  Fly   698 IN----PAYVM-----PKLRTT------------------MIELITDLKYSGMSRNKEQSAKMLD 735
            :.    |...|     |.:|.|                  ::::...|..:.....::|..|.:|
Worm  1977 LMLFAWPCLTMYNHQDPTMRYTGFFFLANIIERFTINRKIVLQVFHQLMTTYQQDTRDQIRKAID 2041

  Fly   736 HLVISTPRLIS-------SYMNPILKALVPKLHEPESNPGVILNVLRTIGDLAEV---------N 784
               |.||.|.:       ..::.:.|.|:.:.|..:....|...|:|.......|         |
Worm  2042 ---ILTPALRTRMEDGHLQILSHVKKILIEECHNLQHVQHVFQMVVRNYRVYYHVRLELLTPLLN 2103

  Fly   785 G-------GSDEMELW-----ADDLLSILLE-----------MLGD--AGSPDKRGVALWTLGQL 824
            |       .:..:|.|     |.::..::::           ::.|  |...||:      |.:|
Worm  2104 GVQRALVMPNSVLENWQTRRHAVEICEMVIKWELFRTLKTDHIISDEEALEVDKQ------LDKL 2162

  Fly   825 ISATG-------------------RVVTPYHKYPVLIDILINFLKTEQRRS-------------- 856
            .:|:.                   |.:...|. .|::::|:.|..|..:.|
Worm  2163 RTASSTDRFDFEEAHNKRDMPDAQRTIIKEHA-DVIVNMLVRFCMTFHQNSGSSSTSQSGNHGVE 2226

  Fly   857 -------IRRETIRVLGLLGAMDPYKHKMNKGLIDSQKDNVLIAYSDGKVDESQDIST---AELL 911
                   :.|..:|. .:.|....::..|.:..:....||.|          ..|||:   |..:
Worm  2227 LTKKCQLLLRAALRP-SMWGEFVSFRLTMIEKFLSIPNDNAL----------RNDISSTAYANTI 2280

  Fly   912 VNMGNALD------EYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLAQVLP 970
            .|..:.||      ...|..::..:||.|:.|.:...:..          :...|....:.|::.
Worm  2281 QNAQHTLDMLCNIIPVMPKTSLMTMMRQLQRPLIQCLNNG----------AQNFKMTRLVTQIVS 2335

  Fly   971 NLLDNVRTADNNLREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQNTL--INLIEQ 1033
            .||:....:.|.|.|  .:||       ..:|..::.:.|..:.....::.|:...|  .:|:..
Worm  2336 RLLEKTNVSVNGLDE--LEQL-------NQYISRFLHEHFGSLLNCRNLSGPVLGVLGAFSLLRT 2391

  Fly  1034 IAVALGCEFRDYLAELIPQILRVLQH---------DNSKDRMVTRRLLQALQKFGSTLGYYLPLI 1089
            |.   |.| ..||..|:|..::|::.         .||:|..:.:.....:.:.   |...:.|:
Worm  2392 IC---GHE-PAYLDHLMPSFVKVMERAAKEHLAYVANSQDGNMVKNFFPDVAEL---LCACMELV 2449

  Fly  1090 LPPIVKLFDSPYVPQQVSM-VALETINNLACQLDFTDFSSRIIHPLVRVLDAEPELRDQAMTTLR 1153
            .|.:          ..:|| :....:..:..:|.......:||...|::|.|....:|...|.|.
Worm  2450 RPRV----------DHISMEIKRSIVGGIIAELIIKSNHDKIIQTSVKLLGAMISTQDMEFTILT 2504

  Fly  1154 SLAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTL-ADSYGAGESELRPSRFKNNE 1217
            .|            |::.|.          ...:::|.|:|..| ||......:....|.::|:|
Worm  2505 VL------------PLLVRI----------QSIIVTKFKNCKDLIADYLVVVITVFENSEYRNSE 2547

  Fly  1218 P-------FVTDRNSNNKNLQVTTNELRTAWQ----------VTRR----VSKDDWVE-----WL 1256
            .       |.....|::..   |..:....|:          :..|    :...||.:     ||
Worm  2548 AGSRLWEGFFWGLKSSDPQ---TREKFSIVWEKTWPHMATVDIAHRMKYIMQNQDWSKFKHAFWL 2609

  Fly  1257 KRLSIGLLK------ESPSH-----ALRAC----RSLAQEYDTLLRDLFNAAFISCWTELSP-DL 1305
            |....|:|:      ..|::     .|..|    |::  ||...|:|             .| ::
Worm  2610 KFALWGMLRTIAKRPTDPNNKRKKVILLNCATPWRTI--EYAAKLKD-------------QPMEV 2659

  Fly  1306 KNELTQSLIQALQVTDMPEITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRA----YAKALR 1366
            :.|:.:...:.::|.:......:    .:..|..:::.:.:|..|.|.:.:...|    :|.||.
Worm  2660 ETEMKREEPEPMEVDEKDSQDDS----KDAGEPKEKEKLTLELLLAGQQELLDEASNYDFADALD 2720

  Fly  1367 YKEEEFLLREDSQVFESLILINNK-----LQQRE-----------AAEGLLTRYRNAANELNVQG 1415
            ...:......::||...:.::..|     |.|.|           .:.|:...|:....: :|..
Worm  2721 TVSQITFALNENQVTSKMWVVLFKSFWSSLSQSEIEDFTALVVPFMSSGVHNNYQTGVQD-SVLA 2784

  Fly  1416 RWYE------------------KLHNWDEALEHYERNLKTDSSDLEARL-----------GHMRC 1451
            .|.|                  |...|...:...|.::.|....|...|           |.:..
Worm  2785 VWLEAVGDAVHLPSRLIEFISSKHECWHTGIRLLENHIWTIPKQLNNTLLREMKVAPGLAGDIET 2849

  Fly  1452 LEALGD-WSELSNVTKHEWENFGTEAKSRA---GPLAAVAAWGLQDWEAMREYVRCIPEDTQDGS 1512
            ||:||. ::|:|     |::.|....:.||   ..:.|::|..|.|.|..:.|:    |.:...:
Worm  2850 LESLGTLYNEIS-----EFDQFAAIWERRAVFPDTMRAMSAMQLGDMELAQSYL----EKSMSST 2905

  Fly  1513 YYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQYKLIP 1577
            |......::.::...:::.:.   .::|.|.     :.:...|        :....|::|::.:.
Worm  2906 YETLAPTINPNNTSNSEKHVS---PIIDKEY-----DHWMEMY--------ITNCSELLQWQNVA 2954

  Fly  1578 ERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLV---VKPHEDIHTWLKYASLCRKSGSLHLSHK 1639
            :..........:.|......:.||..:.:..|.:   :.|                  |.||.:
Worm  2955 DVCNGKDMQHVRGLINAASHIPDWNVVEECKSQIAGCIPP------------------SFHLDY- 3000

  Fly  1640 TLVMLLGTDPKLNPNQP------------LPCNQPQ----------VTYAYTKYMAANNQLQEAY 1682
            ||..|:.|..::|.|..            ..|.:..          |:|.:.|.:.|.|.::|..
Worm  3001 TLFNLMSTVMRMNENSSPTHMKERCKIAIQECTEAHISRWRALPSVVSYGHVKILQAMNLVREIE 3065

  Fly  1683 EQLTHFVSTYSQELSCLPPEALKQQ-DQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKAT 1746
            |         |.::.....||...: ||.||......|..::|:                 ...|
Worm  3066 E---------STDIRIALLEAPSNKVDQALMGDMKSLMKVFRNR-----------------TPTT 3104

  Fly  1747 SYDPNWYKAWHLW-----------------------AYMNFKVV------QAQ------------ 1770
            |.|..:...|:.|                       |..|..:|      |||
Worm  3105 SDDMGFVSTWYDWRNQIHGMMLQRFEYWDKVGLNVAATGNQSIVPIHSMAQAQLAVAKHAKNLGF 3169

  Fly  1771 ----KSALDK-----------QQPPGASMGMTM----GSGLD---------------SDLMI--I 1799
                |..|:|           .|....:.|.|:    .|..|               .|:.|  :
Worm  3170 HNLTKDLLNKLAGLTAIPMMDAQDKVCTYGKTLRDMANSAADERVKNELLCEALEVLEDVRIDDL 3234

  Fly  1800 QRYAVPAV------------------QGFFRSISLIK-GNSLQDT-LRLLTLWFDY--------- 1835
            |:..|.|:                  ..|..:..|:. .||:..| ::|:..|..:
Worm  3235 QKDQVAALLYHRANIHSVLDQAENADYTFSAASQLVDLQNSVTTTGIKLMKNWGHHLYKRFFSTT 3299

  Fly  1836 ----------------------------------------------GNHAEVYEALLSGMKLIEI 1854
                                                          |:|..:...:...:..:.:
Worm  3300 VCKETGNNFGRQALACYFIAARVDNDIKARKPIAKILWLSKHLNACGSHEVMNRVIKKQLHSLNL 3364

  Fly  1855 NTWLQVIPQLIA-----------------------RIDTH-RQLVG-----------QLIHQLLM 1884
            ..||..:|||:.                       ::..| |:.|.           ....|:.|
Worm  3365 FNWLYWLPQLVTDVRYKPNSNFVLILCKMAAAHPLQVFYHIREAVSVDDIDSVLEEDYTDEQMSM 3429

  Fly  1885 DI------GKNHPQALVYPLTVASKSASLARRNAAFKILDSMR--------KHSPTLVEQ----- 1930
            |:      ..:.|...:..:.:..:...:...:...|.||.|.        :|:..|.:|
Worm  3430 DVSDEDCFADDPPFDRILKICLKYRPTDIRVFHRVLKELDEMNETWVERHLRHAICLKDQMFKDF 3494

  Fly  1931 ---------AVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERG--- 1983
                     .:..||::..:.:.|.:|..|.|     :||.........||......::.:|
Worm  3495 SEQMDATFNEMQYSEDVTMMTLRWRKQLEEDL-----VYFQQNYNLDFLEIRNKRKMIVTKGCMG 3554

  Fly  1984 ---PQTLKETSFSQAYGRELTEAYEWSQRY-----KTSAVVMDLD-RAWDI-----YYHV----- 2029
               .|.:.|...||.:    ||.......:     .|:.:|..|| .|.|.     |..:
Worm  3555 VEKSQIMFEKELSQVF----TEPAGMQDEFDFVTNMTNMMVSQLDIHAVDAPRPQGYIRIVLDWI 3615

  Fly  2030 ------FQKISRQLPQLTS-------------LELPYVSPKLMTCKDLELAVPGSYNPGQELIRI 2075
                  |.::.|::|..:|             :|:||....::..|:..|.  .|...||.:..:
Worm  3616 RAIRRRFDRLPRRIPLESSSPYLARFSHRTGCIEMPYDLLNVLRAKNHTLM--ASNQTGQYISML 3678

  Fly  2076 SIIKTNLQ-VITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFR 2139
            |..:.|.: ||...|..||:.|||..||...:.||.........||.|:|..::.:|..|.::.|
Worm  3679 SRFEPNFEIVIKGGQVIRKIYIRGQTGKSAAFYLKKSVQDEPTNRVPQMFKHLDHVLQTDRESAR 3743

  Fly  2140 RNL--------------------AIQRYAVIP--------------------LSTNSGLIGWVPH 2164
            |:|                    ::|.||:.|                    .:|.:|  .:.|.
Worm  3744 RHLHAPTVLQMRVGQKTTLYEVASVQPYAMPPDCTRNYPASQIDIVHPYDVLTATFNG--SYYPD 3806

  Fly  2165 CDTLHTLIRDYRDKKKV------PLNQE------------H----------RTMLNFAPDYDHLT 2201
            ...||...|..:....:      |.||:            |          |.|:.|...||:||
Worm  3807 DMVLHFFERFAQSSSSIGQPLPTPTNQDGTVAPPRLTEAHHIKNIIYEDFARDMIPFRLLYDYLT 3871

  Fly  2202 LMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNL 2266
                                     .:.|...:::..:.....||||:|.:.|...|....|..:
Worm  3872 -------------------------ARYPDPVMYYAMKKQLLHSLAVLSTIEYHCNLTPMGPDQM 3911

  Fly  2267 MLDRMSGKILHIDFGDCFEVAMTR-----EKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVM 2326
            |:...:|.:.:..:.  ||:...|     :.|..::|||||..|                  |::
Worm  3912 MMTMNTGVLSNPSYR--FEIRGGRSLHDIQHFGHEVPFRLTPNL------------------SIL 3956

  Fly  2327 LVLRRNKDSLMAVLEA----------FVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDS 2381
            :.:.::.|.|.::..|          .:..||: |                            |.
Worm  3957 VGVAQDGDLLWSMAAASKCLMKKEPEVIMRPLV-W----------------------------DE 3992

  Fly  2382 LSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTGTDFQTEKSVNEQSQ 2446
            .:|:.:    ..||:     ||....|         .::..|..|..||..|: ..:..:.:...
Worm  3993 FANNTD----CDKSR-----LQVFACH---------ASNSYINGVASKLRNTN-SADAKLRKDDC 4038

  Fly  2447 VELLIQQATNNENLCQ---CYIGW 2467
            |. ||.:|.:::||.:   .|..|
Worm  4039 VS-LISRAKDSDNLARMPPTYHAW 4061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	487/2949 (17%)
		HEAT repeat	632..658	CDD:293787	7/32 (22%)
		HEAT repeat	668..698	CDD:293787	14/98 (14%)
		HEAT repeat	706..736	CDD:293787	5/47 (11%)
		HEAT repeat	749..780	CDD:293787	6/30 (20%)
		HEAT repeat	798..823	CDD:293787	5/37 (14%)
		DUF3385	831..999	CDD:288698	34/197 (17%)
		HEAT repeat	841..870	CDD:293787	6/49 (12%)
		HEAT repeat	880..917	CDD:293787	8/39 (21%)
		HEAT repeat	925..954	CDD:293787	4/28 (14%)
		Rapamycin_bind	1937..2034	CDD:285924	23/124 (19%)
		PIKKc_TOR	2075..2353	CDD:270713	72/361 (20%)
		FATC	2440..2471	CDD:280430	8/31 (26%)
trr-1	NP_001364592.1	PIKK_TRRAP	3678..4017	CDD:270707	79/432 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910