DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and age-1

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_496462.2 Gene:age-1 / 174762 WormBaseID:WBGene00000090 Length:1182 Species:Caenorhabditis elegans


Alignment Length:1034 Identity:186/1034 - (17%)
Similarity:333/1034 - (32%) Gaps:404/1034 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1559 VCVQMLA--------ELEEVIQYKLIPERR--------EPLKTMWWKRLQGGQRLV--------- 1598
            ||.:|:.        |..:.:.:..:.|.|        :|....|:.:|.|....|         
 Worm   274 VCEKMMKIQIEFNPNETPKSLLHTFLYEMRKLDVYDTDDPADEGWFLQLAGRTTFVTNPDVKLTS 338

  Fly  1599 --------EDWR---RIIQVHSLVVKPHEDIHTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLN 1652
                    |.:|   .:::..|||:|.:            ||                       
 Worm   339 YDGVRSELESYRCPGFVVRRQSLVLKDY------------CR----------------------- 368

  Fly  1653 PNQPLPCNQPQVTYAYTKYMAAN----------NQLQEAYEQLTHFVSTYSQELSCLPPEALKQQ 1707
               |.|..:|....|:.:.:|.:          .|.:.:...:|.|..|.|     |...:|...
 Worm   369 ---PKPLYEPHYVRAHERKLALDVLSVSIDSTPKQSKNSDMVMTDFRPTAS-----LKQVSLWDL 425

  Fly  1708 DQRLMAR--------------CYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHL 1758
            |..||.|              .|:|       ::.|:....:..|.:...|..:....|.|..:.
 Worm   426 DANLMIRPVNISGFDFPADVDMYVR-------IEFSVYVGTLTLASKSTTKVNAQFAKWNKEMYT 483

  Fly  1759 W-AYMNFKVVQAQKSALDKQQPPGASMGMTMGSG---LDSDLMIIQRYAVPAVQGFFRSISLIKG 1819
            : .||             |..||.|.:.:.:..|   |.|     :.:.|..|     ::||   
 Worm   484 FDLYM-------------KDMPPSAVLSIRVLYGKVKLKS-----EEFEVGWV-----NMSL--- 522

  Fly  1820 NSLQDTLR----LLTLWF--DYGNHAEVYEALLSGMKL-------IEI----------------- 1854
            ...:|.||    |..||.  ...|.:.:.|   :|.::       |||                 
 Worm   523 TDWRDELRQGQFLFHLWAPEPTANRSRIGE---NGARIGTNAAVTIEISSYGGRVRMPSQGQYTY 584

  Fly  1855 -----NTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAF 1914
                 :||.:.:           .::|......:.|.|....|.||             :::.:.
 Worm   585 LVKHRSTWTETL-----------NIMGDDYESCIRDPGYKKLQMLV-------------KKHESG 625

  Fly  1915 KILDS------------MRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVK 1967
            .:|:.            ::|..|.|:   ::.||    :|.:|.::     |..|.||.      
 Worm   626 IVLEEDEQRHVWMWRRYIQKQEPDLL---IVLSE----LAFVWTDR-----ENFSELYV------ 672

  Fly  1968 GMFEILEP--LHAML-----------------ERGPQTLKETSFSQAYGRELTEAYEWSQRYKTS 2013
             |.|..:|  :.|.|                 |:..:.|...:| ..:...|.:|.::..|.::.
 Worm   673 -MLEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKLNEQLSPVTF-HLFILPLIQALKYEPRAQSE 735

  Fly  2014 AVVMDLDRA-----------W------------DIYYHVFQKIS------------------RQL 2037
            ..:|.|.||           |            |:....:::||                  ||:
 Worm   736 VGMMLLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEEYRRISLLMEAYLRGNEEHIKIITRQV 800

  Fly  2038 PQLTSL---------------------ELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTN 2081
            ..:..|                     ||..:|.|:   ::::..:...|..|:.:|..:|    
 Worm   801 DMVDELTRISTLVKGMPKDVATMKLRDELRSISHKM---ENMDSPLDPVYKLGEMIIDKAI---- 858

  Fly  2082 LQVITSKQRPRKLCIRGSNGKDYMYL------LKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRR 2140
              |:.|.:||..|..:..|.|..::|      .|..:|||||..|:|:..:::.:.    .....
 Worm   859 --VLGSAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGDDLRQDMLVLQVLEVMDNIW----KAANI 917

  Fly  2141 NLAIQRYAVIPLSTNSGLIGWVPHCDT----------LHTLIRD---------------YRDKKK 2180
            :..:..|||:|:....|:|..||:|.|          ::|.:|.               ..|:||
 Worm   918 DCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNKWIRKQCGIEDEKK 982

  Fly  2181 VPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRS 2245
              .:::..|........|:...|:|                             :||..:.:..|
 Worm   983 --KSKKDSTKNPIEKKIDNTQAMKK-----------------------------YFESVDRFLYS 1016

  Fly  2246 LAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFP-EKIPFRLTRMLIKAM 2309
            ....|:..||:|:.|||..||||.. .||..|||||.......|:.... ::.||.||...:..:
 Worm  1017 CVGYSVATYIMGIKDRHSDNLMLTE-DGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTVI 1080

  Fly  2310 EV-TGIEGT------YRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGN 2361
            .. ..::|.      ::..|.....|:..|:|..::     ::..:|...|.::..|.:
 Worm  1081 RSGKSVDGNSHELQKFKTLCVEAYEVMWNNRDLFVS-----LFTLMLGMELPELSTKAD 1134

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 186/1034 (18%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 23/138 (17%)
PIKKc_TOR 2075..2353 CDD:270713 68/316 (22%)
FATC 2440..2471 CDD:280430
age-1NP_496462.2 PI3K_p85B 98..177 CDD:197539
PI3K_rbd 241..360 CDD:197540 13/85 (15%)
C2_PI3K_like 420..574 CDD:176026 37/189 (20%)
PI3Ka 606..798 CDD:214537 36/224 (16%)
PKc_like 793..1181 CDD:304357 80/392 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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