DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and vps-34

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_491741.1	Gene:	vps-34 / 172280	WormBaseID:	WBGene00006932	Length:	901	Species:	Caenorhabditis elegans

Alignment Length:	907	Identity:	185/907 - (20%)
Similarity:	310/907 - (34%)	Gaps:	312/907 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1651 LNP----NQ-----PLPCNQPQVTY-AYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALK 1705
            |||    ||     .:.||..|:.| ..|.:....:..|.|.::|   :..:::.|: ||   ::
Worm    40 LNPVRRLNQLFAEITVYCNNQQIGYPVCTSFHTPPDSSQLARQKL---IQKWNEWLT-LP---IR 97

  Fly  1706 QQDQRLMARCYLRMATWQNKLQDSI-------RPDAIQGALECFEK---------------ATSY 1748
            ..|  |....:|.:..|::: .|.|       |....|..|..|.|               :|:.
Worm    98 YSD--LSRDAFLHITIWEHE-DDEIVNNSTFSRRLVAQSKLSMFSKRGILKSGVIDVQMNVSTTP 159

  Fly  1749 DPNWYKAWHLWAYMN---------FKVVQAQKSALDKQQP---PGASMGMTM------GSGLDSD 1795
            || :.|....|.|.:         ||.|..|...|.:..|   |.||..:.|      .|..|..
Worm   160 DP-FVKQPETWKYSDAWGDEIDLLFKQVTRQSRGLVEDVPWLDPFASRRIEMIRAKYKYSSPDRH 223

  Fly  1796 LMIIQRYAV-----------------------PAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGN 1837
            :.::...|.                       .:|.|....:|......:.|...||.      :
Worm   224 VFLVLEMAAIRLGPTFYKVVYYEDETKNMRVSTSVNGGVGIVSACTRYCVADPELLLE------S 282

  Fly  1838 HAEV-YEALLSGMKLIEINTWLQVIP--QLIARIDT-------------HRQLVGQLIHQLLMDI 1886
            .||| :.|:...::.:|.....||.|  |...|::|             .|.||.:..|.|
Worm   283 LAEVKHSAMTRRIRDVEDERHRQVKPNKQAKDRLETIVNLPSSQVLTREQRDLVWKFRHYL---- 343

  Fly  1887 GKNHPQAL---------VYPLTVASKSA-----SLARRNAAFKILDSMRKH-------------- 1923
             :..|:||         |:|..|.:..|     .|.....|.::|.|...|
Worm   344 -RQFPKALNKYLRSVNWVHPQEVKTALALMNDWELIEAEDALELLSSAFTHPAVRAYSVSRLLEA 407

  Fly  1924 -SPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQTL 1987
             ||   ||.::...:|::.  |.:||..:..||.:.:               |:.:..|....::
Worm   408 ASP---EQVLLYLPQLVQA--LKYEQGQQLPEEGNPV---------------PVVSEEEGKIPSV 452

  Fly  1988 KETSFSQAYGRELTEAYEWSQRYKTS----AVVMDLDRAWD-----IYYH--------------- 2028
            ..|...:..||::|...:...|...|    ..::|...|..     :|:|
Worm   453 ATTPTEELEGRDMTVVTKKEARKAASGDLATFLIDYALASPKVSNYLYWHLKTEIESTKESKEEH 517

  Fly  2029 --VFQKISRQL-----------PQLTSLELPYV---------------SPKLMTCKDLE------ 2059
              ::|.|..:|           .|:.||....:               ..:|...|..|
Worm   518 SKMYQNIQDRLMEALVKRPDTRAQVDSLHQQQIFVEDLIILMNEAKARGGRLNESKSAEFRTMLS 582

  Fly  2060 -----LAVPGSYNPGQELIRI-SIIKTNLQVITSKQRPRKLCIR--GSNGK-------DYMYLLK 2109
                 |.:.|.:.|.....|: |:|........|:..|.|:..:  ..|||       :|..:.|
Worm   583 RAKHMLDLKGVHLPLDPSFRLSSVIPDTASFFKSEMMPAKISFKVLQPNGKADRNIPEEYTVIFK 647

  Fly  2110 GHEDLRQDERVMQLFSLVNTLL----LDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHT 2170
            ..:|||||:.:.|:..|::.:|    ||        |.:..|.|:......|.:..:
Worm   648 TGDDLRQDQLIQQMVRLIDIILKKGQLD--------LKLTPYLVLSTGVGQGFVQCI-------- 696

  Fly  2171 LIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELW 2235
                 :.|....:.::::.              .|::....|:.:           |:.......
Worm   697 -----KSKPLRAIQEQYKA--------------HKMDCIREAMKE-----------LRPGDGPFG 731

  Fly  2236 FERR--NNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIP 2298
            .|..  :||.||||..|::.|||||||||..||:|.. :||:.|:|||    ..:.|:..|...|
Worm   732 IEPNVIDNYVRSLAGYSVIMYILGLGDRHLDNLLLCE-NGKLFHVDFG----FILGRDPKPMPPP 791

  Fly  2299 FRLTRMLIKAME----------VTGIEGTYRRTCESVMLVLRRNKDSLM----AVLEAFVYD 2346
            .:||..:::.|.          |..::..||        :|||:.:.|:    .:|:|.:.|
Worm   792 MKLTSEMVQVMGGVKSKQFLEFVQHVDSAYR--------ILRRHSNVLLNLFSLMLDAGIPD 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	185/907 (20%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	19/122 (16%)
		PIKKc_TOR	2075..2353	CDD:270713	70/302 (23%)
		FATC	2440..2471	CDD:280430
vps-34	NP_491741.1	C2_PI3K_class_III	21..193	CDD:176042	37/163 (23%)
		PI3Ka_III	303..509	CDD:238442	45/230 (20%)
		PI3Kc_III	543..898	CDD:270628	79/362 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000