Protein Alignment mTor and let-363

DIOPT Version :10

• Sequence 1: NP_001260427.1
• Gene: mTor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Sequence 2: NP_491549.2
• Gene: let-363 / 172167
• WormBaseID: WBGene00002583
• Length: 2695
• Species: Caenorhabditis elegans
• Alignment Length: 2778
• Identity: 948/2778 - (34%)
• Similarity: 1447/2778 - (52%)
• Gaps: 463/2778 - (16%)

  Fly    15 KSRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIFTMVNATD--------------- 64
            ::|:.| |.:|.::|..||::||:    :|...|.|.|       :||.|
 Worm    60 ENRDAN-QRQAARELSRYVRSELK----DEPNTFSDAF-------LNAIDGRTDIASQSAIYNCM 112

  Fly    65 -----INEKKGGALAMKCLINCEGSLTARKGISPYLNRLRDLLLIN-----DVSVMEIAARSLVK 119
                 |::|:.|...:.||.........|     |.|.|  |.::|     |...:::|:::|..
 Worm   113 KSNSNIDQKRAGIYLIVCLAETHSGNVIR-----YANYL--LKMLNNGNGLDEDTVKMASKALAF 170

  Fly   120 LANMPTSKGADSFDFDIKKAFEVL------------RGERQEYRRHSAVFILRELAIALPTYFYQ 172
            |.....|..|:..|..:....|.|            :.|..:.||.:|..:.||||:|.||.|:.
 Worm   171 LIATCKSYAAELVDRCLDHCHEWLGQNVPHSQQPKNQQEIDQIRRLAASHLSRELALATPTAFFL 235

  Fly   173 HILTFFEVIFNAIFDPKPAIRESAGEALRAALIVTAQRESTKQSSEPQWYRICYDEA-NGSFNAD 236
            .:..||:.||||:.|..||:|.:..:||...|.:.:|||:   .::.:|::.|:||| .|..|.
 Worm   236 RVNLFFKYIFNAVRDKNPAVRIAGIDALHVVLTIVSQREA---KNKTEWFKKCFDEALEGQPNP- 296

  Fly   237 LGSSKDQKGVTRDDRIHGGLVVFNELFRCANATWERRYTSLKTLFPKTQHNKFLEASSSSSMGSQ 301
              |.||..     ||.|...::.|||.|.::..:|         ..:.:.::|::
 Worm   297 --SQKDDL-----DRWHAVALILNELLRISDQRFE---------LIRCESSQFIK---------- 335

  Fly   302 LNTLVPRLKVPFIDKLGSTQTHLGEGEHHKGV--AKFASQHNVLESAYAQEILQEHYTSICDNV- 363
                               |..|.|.| .:||  .....|..::||..|::::.|.:..|.|.|
 Worm   336 -------------------QKFLKEDE-EEGVEWLVLTKQQTIVESVTARKLVLERFPKILDCVR 380

  Fly   364 ----LEQRTS-----KSPYVQQALLQILPRLAAFNRA--VFVEKYLQTCVSHLMQILRGKEKDRT 417
                |..:||     .|.|:...|:|:|||:.||.:.  .|......|..:.|.:        ..
 Worm   381 QIIPLANKTSSTKQQSSIYLNTVLMQLLPRICAFPQCDRTFQTISFDTSFTILQR--------NA 437

  Fly   418 VAYITIGYMAVAVQSAIEVHLSSIMTSVKVALPSKDLTSKRKVPVDPAVFACITLLAHAVKSEIA 482
            ||...||.|.::.......|:...::.:..|:  |..|:.   .|....|..:.|...|...::.
 Worm   438 VAAPAIGMMMLSNPDVHATHIEKTISFISAAI--KKTTNS---DVLDNYFTFLFLFVDAYHEQVT 497

  Fly   483 DDVKDILEQMFYTGLSPALTVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYTALP--T 545
            ..:|.|:.|:....||.:|...|:.:...:|:|:..:.:|::..:.|.|  ..:::|..:.|  .
 Worm   498 TQIKAIIPQLMDITLSRSLANVLKMIMMRIPKLRLNVQDGVMASVYQTL--TGSLIPPKSEPIGR 560

  Fly   546 IAIDGSLMQNGDG-----ATTVLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTC 605
            .|...:::|..:.     ...|||:..||.|.|....:...:|..|||::..:..||||.||.:|
 Worm   561 PASPKAILQKAETDPKELQRIVLAVDVLGEFYFSRGALQRIMQYVADYYLTADNVEIRLAAVSSC 625

  Fly   606 TRLLK--LAVQSSESMENSKTLSDTVSHVIERLLMVAITDMDCNVRIRILR---SLDETFDGKLA 665
            ..::.  :.|....:.:...:|..|:..|:..:..|.:.|.|..||::::.   .:...|...||
 Worm   626 CEMVVPFVGVYKKVTSDKRNSLLQTIYGVLRAVCSVIVNDQDVRVRMQVISCFGQMPRPFLAHLA 690

  Fly   666 QPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQS 730
            |||.|...|:.||||..|:::..:..:|||:.:|||.|:|:||..::|.::.::.||.:|.::.|
 Worm   691 QPEMLEVQFMALHDEKLEMQQACVTLLGRLAELNPALVLPRLRLMLLETLSQMQQSGQARLEQHS 755

  Fly   731 AKMLDHLVISTPRLISSYMNPILKALVPKLHEPESNPGVILNVLRTIGDLAEVNGGSDEMELWAD 795
            |||:..|...:|:.:..|:..::.|::|||...:....|...||..:.::|.:.|......|  .
 Worm   756 AKMIAQLAKQSPKFMRPYVGSLMIAMIPKLRNDQKYAEVTAQVLNAVSEIAVIGGAEIVKNL--K 818

  Fly   796 DLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIRRE 860
            .|...|..|:.|:.|..||..||..:|.:..:|..||.||..||.|:|.|:..|||....::|||
 Worm   819 PLFEKLTHMINDSSSLHKREAALRAIGGICRSTAYVVDPYRDYPSLLDDLLRILKTVMSNTMRRE 883

  Fly   861 TIRVLGLLGAMDPYKHKMNKGLIDSQKD-----NVLIAYSDGKVDESQDISTAELLVNMGN---- 916
            .|:.||:|||:|||.||:..|.:.|...     ::.|:.:|.| |..|||      ::..|
 Worm   884 AIKTLGILGAIDPYTHKVFTGSVQSSTAISTALSLPISETDSK-DPRQDI------IHWFNYEKC 941

  Fly   917 ALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADN 981
            .|:|:|||:.||.||.:::|.. |..:..:.||:..||:|||.....|..||:|.|::..|.|..
 Worm   942 TLEEFYPAITIANLMLMMQDED-SQSYAEIAQAIVTIFRSLGDMAPLYTEQVIPRLIEVCRRATE 1005

  Fly   982 -----NLREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQNTLINLIEQIAVALGCE 1041
                 |||||..||||..||.::.|...||..||.:|.:.|..:..::..:|.::..:..|:|.:
 Worm  1006 SSNRANLREFFLQQLANFVAIIRKHAAPYMPAIFTIIADAWKEDISVKMVVIEVLTDMGTAIGND 1070

  Fly  1042 FRDYLAELIPQILRVLQHDNSKDRMVTRRLLQALQKFGSTLGYYLPLILPPIVKLFDSPYVPQQV 1106
            |..|..||||.:|.|||.|.:|:|::|.::::::||....:..:|.|:|||::.:.|...:...:
 Worm  1071 FSKYTGELIPYLLTVLQTDKTKERVLTVKVMESIQKLTHCIVQHLHLVLPPLLIILDDFSLKLSI 1135

  Fly  1107 SMVALETINNLACQLDFTDFSSRII----HPLVRVLDAEPELRDQAMTTLRSLAKQLGKKYLVFV 1167
            ...||.|:.::..|:|.:.::.|::    |.:     :..|:||:.:..|..:.|||||.:.:|.
 Worm  1136 RNTALSTVLHMTQQVDVSAYAPRMMQSWHHNI-----STAEMRDKLLLLLIEIIKQLGKFFDIFK 1195

  Fly  1168 PMVQRTLNKHRIVD----PEYEELLSK------IKSCSTLADSYG--------AGESELRPSRFK 1214
            ..|.:.|..:.:..    .:|.:|..:      :.:.|..|.|.|        ||......:.:.
 Worm  1196 RGVDQKLRDYNLDKSVHYEQYRKLAQRAQMSRDVLTSSVFAGSNGNIQYSSTQAGMRGQANNVYA 1260

  Fly  1215 NNE----------------------------------------PFVTDRNSNNKNLQVTTNELR- 1238
            ||:                                        |......|....:|:|...|.
 Worm  1261 NNDLHERLMNGSIDSGASRQDNRDDYYRYGVEEKISEEVPKVAPTTARPTSELVTVQITKQRLNK 1325

  Fly  1239 ----TAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISCWT 1299
                ..|:.....|||:|::||.::.||.|....|.:|||..||..::..|.||||.|||:|.||
 Worm  1326 DALMPQWKNENLTSKDEWLQWLMKIRIGFLTYGSSPSLRAASSLGDQHPHLARDLFPAAFMSVWT 1390

  Fly  1300 ELSPDLKNELTQSLIQALQVTDMPEITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRAYAKA 1364
            ||..|::|:||..|::|:. |.:||:.||||||||||:|.::.|:||...:||..|...:|:|||
 Worm  1391 ELDSDVQNDLTSCLLRAIS-TGIPELIQTILNLAEFMDHSEKGPLPISHDVLGRWAEQTKAFAKA 1454

  Fly  1365 LRYKEEEFLLREDSQ--VF-----------ESLILINNKLQQREAAEGLLTRYRNAANELNVQ-- 1414
            .||||...|.:..|.  .|           :|||...|||..:|.|.|:: ||.. .||:|.|
 Worm  1455 CRYKEMSVLKKSGSMQTTFTRKVKLEPNDCQSLITYANKLNVQEEAAGVV-RYAE-RNEMNFQMR 1517

  Fly  1415 GRWYEKLHNWDEALEHYERNLKTDSS--DL-------------------EARLGHMRCLEALGDW 1458
            |||||||:.|::||..||...|..||  :|                   |||:..||||||||.|
 Worm  1518 GRWYEKLNEWEKALGAYELEEKKKSSCPNLQVYDEKDHLMTPEEAATAEEARMHEMRCLEALGRW 1582

  Fly  1459 SELSNVTKHEWENFGTEAKS------------RAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDG 1511
            .||::.:....:..|....|            :...:||..||.:.:||.|.:||..|.|:||||
 Worm  1583 DELNSKSVVWADQRGNRNDSVRDEINKKQLDHKMAVIAARGAWAVDNWERMADYVSVISENTQDG 1647

  Fly  1512 SYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQYKLI 1576
            :..|||:|||:|:...|..||::.|:::|:|||:||.|||||||..||.||.:|||||.|:||..
 Worm  1648 AMLRAVVAVHNDENTKAMGLIEKVREMIDSELTAMANESYERAYIPMVSVQQMAELEEAIEYKTR 1712

  Fly  1577 PERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGSLHLSHKTL 1641
            ||||..:..:|.:||||.:|.||.|:|:|.:..||:.|.|.....:|::|:|||.|...:|...|
 Worm  1713 PERRPRIALLWSRRLQGCRRNVEQWQRLIMLRGLVLSPQEMHPLRVKFSSMCRKQGKNSMSRAVL 1777

  Fly  1642 VMLLGTDPKLNPNQPL-----PCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLP- 1700
            ..||    .|..|..|     |.::|.:..|..|.:..::...||...|....:.:::.::.:|
 Worm  1778 RELL----SLPANSDLVRAKAPFDKPLLVLALAKQLYQDDHKDEAIRALEDLANHWNKRINPIPK 1838

  Fly  1701 -------PEALKQQDQRLMARCYLRMATW-------------------------QNKLQDSIRPD 1733
                   |.:.| :..|:.|:..|::..|                         |.:.::|..|:
 Worm  1839 ATGRELIPPSTK-EPARICAKVLLKLGEWTELKSKTSNNMQVGELSFVRQQVSPQYRTKESRTPE 1902

  Fly  1734 --AIQGALECFEKATSYDPNWYKAWHLWAYMNFKVV----------------------------- 1767
              |.:..:..:::||.|||.|:|.||..|..:|..|
 Worm  1903 TIAFENTINYYQQATQYDPGWHKVWHKLASTHFYAVCRERPHPTTVISPPQQPQQPKKMHIPPVT 1967

  Fly  1768 -------QAQKS---------------ALDKQQPP--GASMG-------MTMGSGL--------- 1792
                   .||||               .:|...||  |:.:|       ::..|.|
 Worm  1968 RATSPPPPAQKSPQPAPFHSITEPLSVIIDYPVPPPLGSLVGLPPMPAYLSSNSSLPPQHHHVSP 2032

  Fly  1793 --------DSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGN--HAEVYEALLS 1847
                    .::..:..::|..||:.|.:::....|:.|:|||||:.||||:|:  ..:||.||..
 Worm  2033 LSNDSPSNSAENKLYLKHAAHAVRCFAKALMCSPGSRLEDTLRLMQLWFDHGDDKDQDVYFALTE 2097

  Fly  1848 GMKLIEINTWLQVIPQLIARID-THRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRN 1911
            .:..:.:.|||:.||||:||:| ...|...||:.::|.:|.::.|||::|.|||||:|..:.|..
 Worm  2098 TIFDLPVTTWLEAIPQLMARLDCPDDQKSVQLVLRVLCEIARHRPQAVIYALTVASRSKDVHRSK 2162

  Fly  1912 AAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPL 1976
            .|..:|:.|.::...||.:|.:.:|||:|.|||||||||:.|::|||:||.|.||:.||:.|..:
 Worm  2163 NAGTVLEKMMEYHSKLVREASLVTEELVRCAILWHEQWHDALDDASRVYFHDNNVQAMFDALRNM 2227

  Fly  1977 HAMLERG-PQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQL 2040
            :.::::| |.|:||.||.|.|..:|.||..:.|.:::|..|.||::||:||..||:|:..||..|
 Worm  2228 NDLMQKGAPTTMKEHSFQQTYSSDLKEAGRYVQAFESSGNVKDLNQAWEIYCSVFKKLRDQLATL 2292

  Fly  2041 TSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYM 2105
            .||:|.||||.|::.|||||.|||:|:|...::.|....:.:.||||||||||:.||||||.||.
 Worm  2293 NSLDLVYVSPNLVSAKDLELVVPGTYDPSAPIVSIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQ 2357

  Fly  2106 YLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHT 2170
            :|||||||.||||||||||.||||||.::.:|.||||.||||:::.||.:||||||||:||||||
 Worm  2358 FLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHT 2422

  Fly  2171 LIRDYRDKK-KVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSEL 2234
            |:::||:|| |:||:.||:|:...:.:.:|||||||:::||.||..|||:||..:|||||||||:
 Worm  2423 LVKEYREKKAKIPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKSPSSEV 2487

  Fly  2235 WFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPF 2299
            ||:||.|||||:|.||||||||||||||||||||||::||::||||||||||||.||||||::||
 Worm  2488 WFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPF 2552

  Fly  2300 RLTRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAV 2364
            |||||||.||||||::|.|..|.|.|:.:||.|::||:||||||||||::||||::..||.
 Worm  2553 RLTRMLINAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWRLVEGMKKD---- 2613

  Fly  2365 AGAGAPGGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCK 2429
                 |..|..:|.:.:::.:|   ||                       ::|....:::.:|.|
 Worm  2614 -----PKTRKDTGGRQNMAGAV---LP-----------------------SSSTTDSIMETIKRK 2647

  Fly  2430 LTGTDF-QTEKSVNEQ-----SQVELLIQQATNNENLCQCYIGWCPFW 2471
            |.||:| .|:.|...:     .|:.:|.:|||:..||||.||||||||
 Worm  2648 LDGTEFVHTDGSTPPEPLQVTEQLAMLTEQATSPLNLCQSYIGWCPFW 2695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mTor	NP_001260427.1	TEL1	308..2471	CDD:227365	863/2445 (35%)
		HEAT repeat	632..658	CDD:293787	6/28 (21%)
		HEAT repeat	668..698	CDD:293787	11/29 (38%)
		HEAT repeat	706..736	CDD:293787	10/29 (34%)
		HEAT repeat	749..780	CDD:293787	7/30 (23%)
		HEAT repeat	798..823	CDD:293787	8/24 (33%)
		HEAT repeat	841..870	CDD:293787	13/28 (46%)
		HEAT repeat	880..917	CDD:293787	10/45 (22%)
		HEAT repeat	925..954	CDD:293787	8/28 (29%)
let-363	NP_491549.2	HEAT repeat	654..683	CDD:293787	6/28 (21%)
		TEL1	683..2695	CDD:227365	778/2069 (38%)
		HEAT repeat	693..722	CDD:293787	11/28 (39%)
		HEAT repeat	731..764	CDD:293787	11/32 (34%)
		HEAT repeat	774..805	CDD:293787	7/30 (23%)
		PIKKc_TOR	2327..2606	CDD:270713	192/278 (69%)