DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tor and let-363

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_491549.2 Gene:let-363 / 172167 WormBaseID:WBGene00002583 Length:2695 Species:Caenorhabditis elegans


Alignment Length:2778 Identity:948/2778 - (34%)
Similarity:1447/2778 - (52%) Gaps:463/2778 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 KSRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIFTMVNATD--------------- 64
            ::|:.| |.:|.::|..||::||:    :|...|.|.|       :||.|               
 Worm    60 ENRDAN-QRQAARELSRYVRSELK----DEPNTFSDAF-------LNAIDGRTDIASQSAIYNCM 112

  Fly    65 -----INEKKGGALAMKCLINCEGSLTARKGISPYLNRLRDLLLIN-----DVSVMEIAARSLVK 119
                 |::|:.|...:.||.........|     |.|.|  |.::|     |...:::|:::|..
 Worm   113 KSNSNIDQKRAGIYLIVCLAETHSGNVIR-----YANYL--LKMLNNGNGLDEDTVKMASKALAF 170

  Fly   120 LANMPTSKGADSFDFDIKKAFEVL------------RGERQEYRRHSAVFILRELAIALPTYFYQ 172
            |.....|..|:..|..:....|.|            :.|..:.||.:|..:.||||:|.||.|:.
 Worm   171 LIATCKSYAAELVDRCLDHCHEWLGQNVPHSQQPKNQQEIDQIRRLAASHLSRELALATPTAFFL 235

  Fly   173 HILTFFEVIFNAIFDPKPAIRESAGEALRAALIVTAQRESTKQSSEPQWYRICYDEA-NGSFNAD 236
            .:..||:.||||:.|..||:|.:..:||...|.:.:|||:   .::.:|::.|:||| .|..|. 
 Worm   236 RVNLFFKYIFNAVRDKNPAVRIAGIDALHVVLTIVSQREA---KNKTEWFKKCFDEALEGQPNP- 296

  Fly   237 LGSSKDQKGVTRDDRIHGGLVVFNELFRCANATWERRYTSLKTLFPKTQHNKFLEASSSSSMGSQ 301
              |.||..     ||.|...::.|||.|.::..:|         ..:.:.::|::          
 Worm   297 --SQKDDL-----DRWHAVALILNELLRISDQRFE---------LIRCESSQFIK---------- 335

  Fly   302 LNTLVPRLKVPFIDKLGSTQTHLGEGEHHKGV--AKFASQHNVLESAYAQEILQEHYTSICDNV- 363
                               |..|.|.| .:||  .....|..::||..|::::.|.:..|.|.| 
 Worm   336 -------------------QKFLKEDE-EEGVEWLVLTKQQTIVESVTARKLVLERFPKILDCVR 380

  Fly   364 ----LEQRTS-----KSPYVQQALLQILPRLAAFNRA--VFVEKYLQTCVSHLMQILRGKEKDRT 417
                |..:||     .|.|:...|:|:|||:.||.:.  .|......|..:.|.:        ..
 Worm   381 QIIPLANKTSSTKQQSSIYLNTVLMQLLPRICAFPQCDRTFQTISFDTSFTILQR--------NA 437

  Fly   418 VAYITIGYMAVAVQSAIEVHLSSIMTSVKVALPSKDLTSKRKVPVDPAVFACITLLAHAVKSEIA 482
            ||...||.|.::.......|:...::.:..|:  |..|:.   .|....|..:.|...|...::.
 Worm   438 VAAPAIGMMMLSNPDVHATHIEKTISFISAAI--KKTTNS---DVLDNYFTFLFLFVDAYHEQVT 497

  Fly   483 DDVKDILEQMFYTGLSPALTVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYTALP--T 545
            ..:|.|:.|:....||.:|...|:.:...:|:|:..:.:|::..:.|.|  ..:::|..:.|  .
 Worm   498 TQIKAIIPQLMDITLSRSLANVLKMIMMRIPKLRLNVQDGVMASVYQTL--TGSLIPPKSEPIGR 560

  Fly   546 IAIDGSLMQNGDG-----ATTVLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTC 605
            .|...:::|..:.     ...|||:..||.|.|....:...:|..|||::..:..||||.||.:|
 Worm   561 PASPKAILQKAETDPKELQRIVLAVDVLGEFYFSRGALQRIMQYVADYYLTADNVEIRLAAVSSC 625

  Fly   606 TRLLK--LAVQSSESMENSKTLSDTVSHVIERLLMVAITDMDCNVRIRILR---SLDETFDGKLA 665
            ..::.  :.|....:.:...:|..|:..|:..:..|.:.|.|..||::::.   .:...|...||
 Worm   626 CEMVVPFVGVYKKVTSDKRNSLLQTIYGVLRAVCSVIVNDQDVRVRMQVISCFGQMPRPFLAHLA 690

  Fly   666 QPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQS 730
            |||.|...|:.||||..|:::..:..:|||:.:|||.|:|:||..::|.::.::.||.:|.::.|
 Worm   691 QPEMLEVQFMALHDEKLEMQQACVTLLGRLAELNPALVLPRLRLMLLETLSQMQQSGQARLEQHS 755

  Fly   731 AKMLDHLVISTPRLISSYMNPILKALVPKLHEPESNPGVILNVLRTIGDLAEVNGGSDEMELWAD 795
            |||:..|...:|:.:..|:..::.|::|||...:....|...||..:.::|.:.|......|  .
 Worm   756 AKMIAQLAKQSPKFMRPYVGSLMIAMIPKLRNDQKYAEVTAQVLNAVSEIAVIGGAEIVKNL--K 818

  Fly   796 DLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIRRE 860
            .|...|..|:.|:.|..||..||..:|.:..:|..||.||..||.|:|.|:..|||....::|||
 Worm   819 PLFEKLTHMINDSSSLHKREAALRAIGGICRSTAYVVDPYRDYPSLLDDLLRILKTVMSNTMRRE 883

  Fly   861 TIRVLGLLGAMDPYKHKMNKGLIDSQKD-----NVLIAYSDGKVDESQDISTAELLVNMGN---- 916
            .|:.||:|||:|||.||:..|.:.|...     ::.|:.:|.| |..|||      ::..|    
 Worm   884 AIKTLGILGAIDPYTHKVFTGSVQSSTAISTALSLPISETDSK-DPRQDI------IHWFNYEKC 941

  Fly   917 ALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADN 981
            .|:|:|||:.||.||.:::|.. |..:..:.||:..||:|||.....|..||:|.|::..|.|..
 Worm   942 TLEEFYPAITIANLMLMMQDED-SQSYAEIAQAIVTIFRSLGDMAPLYTEQVIPRLIEVCRRATE 1005

  Fly   982 -----NLREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQNTLINLIEQIAVALGCE 1041
                 |||||..||||..||.::.|...||..||.:|.:.|..:..::..:|.::..:..|:|.:
 Worm  1006 SSNRANLREFFLQQLANFVAIIRKHAAPYMPAIFTIIADAWKEDISVKMVVIEVLTDMGTAIGND 1070

  Fly  1042 FRDYLAELIPQILRVLQHDNSKDRMVTRRLLQALQKFGSTLGYYLPLILPPIVKLFDSPYVPQQV 1106
            |..|..||||.:|.|||.|.:|:|::|.::::::||....:..:|.|:|||::.:.|...:...:
 Worm  1071 FSKYTGELIPYLLTVLQTDKTKERVLTVKVMESIQKLTHCIVQHLHLVLPPLLIILDDFSLKLSI 1135

  Fly  1107 SMVALETINNLACQLDFTDFSSRII----HPLVRVLDAEPELRDQAMTTLRSLAKQLGKKYLVFV 1167
            ...||.|:.::..|:|.:.::.|::    |.:     :..|:||:.:..|..:.|||||.:.:|.
 Worm  1136 RNTALSTVLHMTQQVDVSAYAPRMMQSWHHNI-----STAEMRDKLLLLLIEIIKQLGKFFDIFK 1195

  Fly  1168 PMVQRTLNKHRIVD----PEYEELLSK------IKSCSTLADSYG--------AGESELRPSRFK 1214
            ..|.:.|..:.:..    .:|.:|..:      :.:.|..|.|.|        ||......:.:.
 Worm  1196 RGVDQKLRDYNLDKSVHYEQYRKLAQRAQMSRDVLTSSVFAGSNGNIQYSSTQAGMRGQANNVYA 1260

  Fly  1215 NNE----------------------------------------PFVTDRNSNNKNLQVTTNELR- 1238
            ||:                                        |......|....:|:|...|. 
 Worm  1261 NNDLHERLMNGSIDSGASRQDNRDDYYRYGVEEKISEEVPKVAPTTARPTSELVTVQITKQRLNK 1325

  Fly  1239 ----TAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISCWT 1299
                ..|:.....|||:|::||.::.||.|....|.:|||..||..::..|.||||.|||:|.||
 Worm  1326 DALMPQWKNENLTSKDEWLQWLMKIRIGFLTYGSSPSLRAASSLGDQHPHLARDLFPAAFMSVWT 1390

  Fly  1300 ELSPDLKNELTQSLIQALQVTDMPEITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRAYAKA 1364
            ||..|::|:||..|::|:. |.:||:.||||||||||:|.::.|:||...:||..|...:|:|||
 Worm  1391 ELDSDVQNDLTSCLLRAIS-TGIPELIQTILNLAEFMDHSEKGPLPISHDVLGRWAEQTKAFAKA 1454

  Fly  1365 LRYKEEEFLLREDSQ--VF-----------ESLILINNKLQQREAAEGLLTRYRNAANELNVQ-- 1414
            .||||...|.:..|.  .|           :|||...|||..:|.|.|:: ||.. .||:|.|  
 Worm  1455 CRYKEMSVLKKSGSMQTTFTRKVKLEPNDCQSLITYANKLNVQEEAAGVV-RYAE-RNEMNFQMR 1517

  Fly  1415 GRWYEKLHNWDEALEHYERNLKTDSS--DL-------------------EARLGHMRCLEALGDW 1458
            |||||||:.|::||..||...|..||  :|                   |||:..||||||||.|
 Worm  1518 GRWYEKLNEWEKALGAYELEEKKKSSCPNLQVYDEKDHLMTPEEAATAEEARMHEMRCLEALGRW 1582

  Fly  1459 SELSNVTKHEWENFGTEAKS------------RAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDG 1511
            .||::.:....:..|....|            :...:||..||.:.:||.|.:||..|.|:||||
 Worm  1583 DELNSKSVVWADQRGNRNDSVRDEINKKQLDHKMAVIAARGAWAVDNWERMADYVSVISENTQDG 1647

  Fly  1512 SYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQYKLI 1576
            :..|||:|||:|:...|..||::.|:::|:|||:||.|||||||..||.||.:|||||.|:||..
 Worm  1648 AMLRAVVAVHNDENTKAMGLIEKVREMIDSELTAMANESYERAYIPMVSVQQMAELEEAIEYKTR 1712

  Fly  1577 PERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGSLHLSHKTL 1641
            ||||..:..:|.:||||.:|.||.|:|:|.:..||:.|.|.....:|::|:|||.|...:|...|
 Worm  1713 PERRPRIALLWSRRLQGCRRNVEQWQRLIMLRGLVLSPQEMHPLRVKFSSMCRKQGKNSMSRAVL 1777

  Fly  1642 VMLLGTDPKLNPNQPL-----PCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLP- 1700
            ..||    .|..|..|     |.::|.:..|..|.:..::...||...|....:.:::.::.:| 
 Worm  1778 RELL----SLPANSDLVRAKAPFDKPLLVLALAKQLYQDDHKDEAIRALEDLANHWNKRINPIPK 1838

  Fly  1701 -------PEALKQQDQRLMARCYLRMATW-------------------------QNKLQDSIRPD 1733
                   |.:.| :..|:.|:..|::..|                         |.:.::|..|:
 Worm  1839 ATGRELIPPSTK-EPARICAKVLLKLGEWTELKSKTSNNMQVGELSFVRQQVSPQYRTKESRTPE 1902

  Fly  1734 --AIQGALECFEKATSYDPNWYKAWHLWAYMNFKVV----------------------------- 1767
              |.:..:..:::||.|||.|:|.||..|..:|..|                             
 Worm  1903 TIAFENTINYYQQATQYDPGWHKVWHKLASTHFYAVCRERPHPTTVISPPQQPQQPKKMHIPPVT 1967

  Fly  1768 -------QAQKS---------------ALDKQQPP--GASMG-------MTMGSGL--------- 1792
                   .||||               .:|...||  |:.:|       ::..|.|         
 Worm  1968 RATSPPPPAQKSPQPAPFHSITEPLSVIIDYPVPPPLGSLVGLPPMPAYLSSNSSLPPQHHHVSP 2032

  Fly  1793 --------DSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGN--HAEVYEALLS 1847
                    .::..:..::|..||:.|.:::....|:.|:|||||:.||||:|:  ..:||.||..
 Worm  2033 LSNDSPSNSAENKLYLKHAAHAVRCFAKALMCSPGSRLEDTLRLMQLWFDHGDDKDQDVYFALTE 2097

  Fly  1848 GMKLIEINTWLQVIPQLIARID-THRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRN 1911
            .:..:.:.|||:.||||:||:| ...|...||:.::|.:|.::.|||::|.|||||:|..:.|..
 Worm  2098 TIFDLPVTTWLEAIPQLMARLDCPDDQKSVQLVLRVLCEIARHRPQAVIYALTVASRSKDVHRSK 2162

  Fly  1912 AAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPL 1976
            .|..:|:.|.::...||.:|.:.:|||:|.|||||||||:.|::|||:||.|.||:.||:.|..:
 Worm  2163 NAGTVLEKMMEYHSKLVREASLVTEELVRCAILWHEQWHDALDDASRVYFHDNNVQAMFDALRNM 2227

  Fly  1977 HAMLERG-PQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQL 2040
            :.::::| |.|:||.||.|.|..:|.||..:.|.:::|..|.||::||:||..||:|:..||..|
 Worm  2228 NDLMQKGAPTTMKEHSFQQTYSSDLKEAGRYVQAFESSGNVKDLNQAWEIYCSVFKKLRDQLATL 2292

  Fly  2041 TSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYM 2105
            .||:|.||||.|::.|||||.|||:|:|...::.|....:.:.||||||||||:.||||||.||.
 Worm  2293 NSLDLVYVSPNLVSAKDLELVVPGTYDPSAPIVSIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQ 2357

  Fly  2106 YLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHT 2170
            :|||||||.||||||||||.||||||.::.:|.||||.||||:::.||.:||||||||:||||||
 Worm  2358 FLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHT 2422

  Fly  2171 LIRDYRDKK-KVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSEL 2234
            |:::||:|| |:||:.||:|:...:.:.:|||||||:::||.||..|||:||..:|||||||||:
 Worm  2423 LVKEYREKKAKIPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKSPSSEV 2487

  Fly  2235 WFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPF 2299
            ||:||.|||||:|.||||||||||||||||||||||::||::||||||||||||.||||||::||
 Worm  2488 WFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPF 2552

  Fly  2300 RLTRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAV 2364
            |||||||.||||||::|.|..|.|.|:.:||.|::||:||||||||||::||||::..||.    
 Worm  2553 RLTRMLINAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWRLVEGMKKD---- 2613

  Fly  2365 AGAGAPGGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCK 2429
                 |..|..:|.:.:::.:|   ||                       ::|....:::.:|.|
 Worm  2614 -----PKTRKDTGGRQNMAGAV---LP-----------------------SSSTTDSIMETIKRK 2647

  Fly  2430 LTGTDF-QTEKSVNEQ-----SQVELLIQQATNNENLCQCYIGWCPFW 2471
            |.||:| .|:.|...:     .|:.:|.:|||:..||||.||||||||
 Worm  2648 LDGTEFVHTDGSTPPEPLQVTEQLAMLTEQATSPLNLCQSYIGWCPFW 2695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 863/2445 (35%)
HEAT repeat 632..658 CDD:293787 6/28 (21%)
HEAT repeat 668..698 CDD:293787 11/29 (38%)
HEAT repeat 706..736 CDD:293787 10/29 (34%)
HEAT repeat 749..780 CDD:293787 7/30 (23%)
HEAT repeat 798..823 CDD:293787 8/24 (33%)
DUF3385 831..999 CDD:288698 72/181 (40%)
HEAT repeat 841..870 CDD:293787 13/28 (46%)
HEAT repeat 880..917 CDD:293787 10/45 (22%)
HEAT repeat 925..954 CDD:293787 8/28 (29%)
Rapamycin_bind 1937..2034 CDD:285924 48/97 (49%)
PIKKc_TOR 2075..2353 CDD:270713 192/278 (69%)
FATC 2440..2471 CDD:280430 16/35 (46%)
let-363NP_491549.2 HEAT repeat 654..683 CDD:293787 6/28 (21%)
TEL1 683..2695 CDD:227365 778/2069 (38%)
HEAT repeat 693..722 CDD:293787 11/28 (39%)
HEAT repeat 731..764 CDD:293787 11/32 (34%)
HEAT repeat 774..805 CDD:293787 7/30 (23%)
HEAT repeat 819..854 CDD:293787 11/34 (32%)
DUF3385 854..1028 CDD:288698 72/181 (40%)
HEAT repeat 863..887 CDD:293787 10/23 (43%)
Extensin_2 1970..2032 CDD:252669 11/61 (18%)
Rapamycin_bind 2188..2286 CDD:285924 48/97 (49%)
PIKKc_TOR 2327..2606 CDD:270713 192/278 (69%)
FATC 2664..2695 CDD:280430 15/30 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 373 1.000 Domainoid score I471
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1428 1.000 Inparanoid score I51
Isobase 1 0.950 - 0.896241 Normalized mean entropy S1632
OMA 1 1.010 - - QHG53650
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 1 1.000 - - FOG0003052
OrthoInspector 1 1.000 - - oto18531
orthoMCL 1 0.900 - - OOG6_100794
Panther 1 1.100 - - LDO PTHR11139
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1538
SonicParanoid 1 1.000 - - X2407
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1312.960

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