DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and Atm

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_011240687.1 Gene:Atm / 11920 MGIID:107202 Length:3077 Species:Mus musculus


Alignment Length:2892 Identity:593/2892 - (20%)
Similarity:1025/2892 - (35%) Gaps:824/2892 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 SRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIF--TMVNATDINEKKGGALAMK-- 76
            :|:.:|:....:.||||...:..|.|.|........|.|.:.  .:|:.|..|.|    .|||  
Mouse   566 NRSFSVKESIMRWLLFYQLEDDLEDSTELPPILQSNFPHLVVEKILVSLTMKNSK----AAMKFF 626

  Fly    77 -----CLINCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARSLVKLANMPTSKGADSFDFDI 136
                 |..:||..      ..|..:.:.:|.|......|:.    |..:......|...|..|.:
Mouse   627 QSVPECEQHCEDK------EEPSFSEVEELFLQTTFDKMDF----LTTVKEYAVEKFQSSVGFSV 681

  Fly   137 KKAFE------VLRGERQEYRRHSAVFILRELAI--------ALPTYFYQHILTFFEVIFNAIFD 187
            ::..:      :|....|....:|:.....|..:        .|..|.|..|:|..|...:.:|.
Mouse   682 QQNLKESLDHYLLGLSEQLLSNYSSEITSSETLVRCSSLLVGVLGCYCYMGIITEDEAHKSELFQ 746

  Fly   188 PKPAIRESAGEALRAALIVTAQRESTKQSSEPQWYRICYD------------EANGSFNADLGSS 240
            ...::.:.|||::  :|......|.::..|......:|..            .|:|.|...|.|.
Mouse   747 KAKSLMQCAGESI--SLFKNKTNEESRIGSLRNVMHLCTSCLCIHTKHTPNKIASGFFLRLLTSK 809

  Fly   241 ---------KDQKGVTR-----------DDRIHGGLVVFNELFRCANATWERRYTSLKTLFPKTQ 285
                     |.....|:           ||...||         |                    
Mouse   810 LMNDIADICKSLASCTKKPLDHGVHPGEDDEDGGG---------C-------------------- 845

  Fly   286 HNKFLEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQT-----------HLGEGEH-------HKG 332
             :..:||...||.|  |:|..|...|...:..|..|.           :|.:.:|       ..|
Mouse   846 -DSLMEAEGPSSTG--LSTAYPASSVSDANDYGENQNAVGAMSPLAADYLSKQDHLLLDMLRFLG 907

  Fly   333 VAKFASQ-HNVLESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQALLQILPR------------ 384
            .:..||| |.|  |....:|.::....:..::|:.......::...||:.||.            
Mouse   908 RSVTASQSHTV--SFRGADIRRKLLLLLDSSILDLMKPLHLHMYLVLLKDLPGNEHSLPMEDVVE 970

  Fly   385 --------LAAFNRAVFVEKYLQTCVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIEVHLS-- 439
                    .:...|...|.|.:.:.|.|::..|.....|.....|..|:. :.|..|. .||:  
Mouse   971 LLQPLSLVCSLHRRDQDVCKTILSNVLHIVTNLGQGSVDMESTRIAQGHF-LTVMGAF-WHLTKE 1033

  Fly   440 -SIMTSVKVAL-----------PSKD---LTSK-RKVPVDPAVFACITLLAHAVKSEIADDVKDI 488
             ..:.||::||           |..:   |..| :..||:.|....:....|.|:...|..|..:
Mouse  1034 KKCVFSVRMALVKCLQTLLEADPYSEWAILNVKGQDFPVNEAFSQFLADDHHQVRMLAAGSVNRL 1098

  Fly   489 LEQM----FYTGLSPALTVCLRELS-ENVPQLKSAITEGLI------GILSQVLMNKAAILPYTA 542
            .:.|    |...|. ||.:..::.| .|......|...||:      .:|.::...|:.:|...|
Mouse  1099 FQDMRQGDFSRSLK-ALPLKFQQTSFNNAYTTAEAGIRGLLCDSQNPDLLDEIYNRKSVLLMMIA 1162

  Fly   543 L-----------PTIAIDGSLMQNGDGATTVLALKTLGTFNFEEQNMLDFVQRCADYFIVH---- 592
            :           ...|:..|:.:|......|..:....:.:|..:::.||:....||.::.    
Mouse  1163 VVLHCSPVCEKQALFALCKSVKENRLEPHLVKKVLEKVSESFGCRSLEDFMISHLDYLVLEWLNL 1227

  Fly   593 EQQEIRLEA--------------VQTCTRLL--KLAVQSSESMENSKTLSDTVSHVIERLLMVAI 641
            :..|..|.:              .::|.::|  .|.::|  ..:..|::::.:....:.||    
Mouse  1228 QDTEYSLSSFPFMLLNYTSIEDFYRSCYKILIPHLVIRS--HFDEVKSIANQIQKCWKSLL---- 1286

  Fly   642 TDMDC--NVRIRILR--SLDETFDGKLAQP-ESLNSLFITLHDEIFEIRELAMVTIGRLSSINPA 701
              :||  .:.:.||.  :.:.|.|..::|. |:...::.||..|.|..:::..|.|..|..|   
Mouse  1287 --VDCFPKILVHILPYFAYEGTRDSYVSQKRETATKVYDTLKGEDFLGKQIDQVFISNLPEI--- 1346

  Fly   702 YVMPKLRTTMIELITDLKYSGMSRNKE--QSAK-----------MLDHLVIS--------TPRLI 745
                     ::||:..|..:..|.:.:  |||.           .|..|.::        .|...
Mouse  1347 ---------VVELLMTLHETADSADSDASQSATALCDFSGYAGLTLGELAVADGDLDPAPNPPYF 1402

  Fly   746 SSYMNPILKALVPKLHEPESNPGVILNVLRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGS 810
            .|::.....|.:...|:.:...  ||.:|..|                .|....|||.:...|..
Mouse  1403 PSHVIQATFAYISNCHKTKFKS--ILEILSKI----------------PDSYQKILLAICEQAAE 1449

  Fly   811 PDKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIRRETIRVLGLLGAMDPYK 875
            .:.           :....|::..||   :.:.:|:..:::              ||.||.    
Mouse  1450 TNN-----------VFKKHRILKIYH---LFVSLLLKDIQS--------------GLGGAW---- 1482

  Fly   876 HKMNKGLIDSQKDNVLIAYSDGKVDESQDISTAELLVNMGNALDEYYPAVAIAALMRILRDPTLS 940
                 ..:.......||.|.:.:.....|:|....             ::....|.|:.      
Mouse  1483 -----AFVLRDVIYTLIHYINKRSSHFTDVSLRSF-------------SLCCDLLSRVC------ 1523

  Fly   941 TRHTSVVQAVTFIFQSLGI---KCVPYL--AQVLPNLLDNVR--TADNNLREFLFQQLAIL---- 994
              ||:|.|....:...|.:   ..:|.:  .:|...:||.::  ..||...:.|...:.:|    
Mouse  1524 --HTAVTQCKDALESHLHVIVGTLIPLVDYQEVQEQVLDLLKYLVIDNKDNKNLSVTIKLLDPFP 1586

  Fly   995 --VAFVKLHI----ISYMGDIFKLIKE---FWTIN--TPLQNTLINLIEQIAVALGCEFRDYLAE 1048
              |.|..|.:    |.|.|..|.|::|   |.:::  .||..|.:..::.:...|. :.:|.:.:
Mouse  1587 DHVIFKDLRLTQQKIKYSGGPFSLLEEINHFLSVSAYNPLPLTRLEGLKDLRRQLE-QHKDQMLD 1650

  Fly  1049 LIPQILRVLQHDNSKDRMVTR---RLLQ-------------ALQKFGSTLGYYLPLILPPI---- 1093
            |    ||..| ||.:|.:|.:   .|||             .|:..|..||...||....|    
Mouse  1651 L----LRASQ-DNPQDGIVVKLVVSLLQLSKMAVNQTGEREVLEAVGRCLGEIGPLDFSTIAVQH 1710

  Fly  1094 ------VKLFDSPYVPQ-QVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDAEPELRDQAMTT 1151
                  .|.:..|...: |.:::.|..:||                   .:::...::|..|.|.
Mouse  1711 NKDVSYTKAYGLPEDRELQWTLIMLTALNN-------------------TLVEDSVKIRSAAATC 1756

  Fly  1152 LRS-LAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELRPSRFKN 1215
            |:: ||.::|..:..         |.....||....|                            
Mouse  1757 LKNILATKIGHIFWE---------NYKTSADPMLTYL---------------------------- 1784

  Fly  1216 NEPFVTDRNSNNKNLQVTTNELRTAWQVTRRVSKDD----------WVE-------WLKRLSIGL 1263
             :||   |.|..|.|:|.            |..|:|          ||.       |:|.|:...
Mouse  1785 -QPF---RTSRKKFLEVP------------RSVKEDVLEGLDAVNLWVPQSESHDIWIKTLTCAF 1833

  Fly  1264 LKES--PSHALRACRSLAQE-------------YDTLLRD-------LFNA----AFISCW---- 1298
            |...  .|..|:..:.:.:.             :|.||:|       |.:|    .|.||:    
Mouse  1834 LDSGGINSEILQLLKPMCEVKTDFCQMLLPYLIHDVLLQDTHESWRTLLSAHVRGFFTSCFKHSS 1898

  Fly  1299 ------TELSPDLKNE--LTQSLIQALQVTDMPEITQTILNLAEFMEHCDR--------DPIPIE 1347
                  |..:.|.::|  |...|.:..|        :|:|.:.:::....|        |...::
Mouse  1899 QASRSATPANSDSESENFLRCCLDKKSQ--------RTMLAVVDYLRRQKRPSSGTAFDDAFWLD 1955

  Fly  1348 TKLLGTR--AMACRAYAKALRYKE---------EEFLLREDSQVFE------SLILINNKLQQR- 1394
            ...|...  |.:|.|:..||.|.|         |:   .:.|..||      ::..::.|.::. 
Mouse  1956 LNYLEVAKVAQSCSAHFTALLYAEIYSDKKSTDEQ---EKRSPTFEEGSQGTTISSLSEKSKEET 2017

  Fly  1395 --EAAEGLLTRYRNAANELNVQG-------------RWYEKLHNWDEALEHYERNLKTDSSDLEA 1444
              ...:.||..||:.....::.|             |.||....|::||..|:  |:|..|....
Mouse  2018 GISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPLTRIRTYEHEATWEKALVTYD--LETSISSSTR 2080

  Fly  1445 RLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAV---AAWGLQDWEAMREYVRCIPE 1506
            :.|.::.|:.||    ||::.....:....|.:.....|..:   |||....|.......:.:..
Mouse  2081 QSGIIQALQNLG----LSHILSVYLKGLDYERREWCAELQELRYQAAWRNMQWGLCASAGQEVEG 2141

  Fly  1507 DTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELE--- 1568
            .:...|.|.|:..:.:.:|.|....:...|.....||:..:.||....|..:..:|.:.|||   
Mouse  2142 TSYHESLYNALQCLRNREFSTFYESLRYARVKEVEELSKGSLESVYSLYPTLSRLQAIGELENSG 2206

  Fly  1569 EVIQYKLIPERREPLKTMWWKRLQGGQRLVED----------WRRIIQVHSLVVKPHE------- 1616
            |:....:....|......|.|..|    |::|          ..|.:.:.:||.|..|       
Mouse  2207 ELFSRSVTDRERSEAYWKWQKHSQ----LLKDSDFSFQEPLMALRTVILETLVQKEMERSQGACS 2267

  Fly  1617 -DIHT--WLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQL 1678
             ||.|  .::::.|.|...:..|..:.:..:...:..:.........:.||.:|..:...|.:.|
Mouse  2268 KDILTKHLVEFSVLARTFKNTQLPERAIFKIKQYNSAICGISEWHLEEAQVFWAKKEQSLALSIL 2332

  Fly  1679 QEAYEQLTHFVSTYSQE-----LSCLPPEALKQQDQRLMARC----------YLRMATWQNKLQD 1728
            ::..::|.   |::..:     |..:..|.|:.....|...|          ||..|.......|
Mouse  2333 KQMIKKLD---SSFKDKENDAGLKVIYAECLRVCGSWLAETCLENPAVIMQTYLEKAVKVAGSYD 2394

  Fly  1729 SIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLD 1793
            ....:...|.::.|.....:....|:  .:..||.....:.:::.|.:.:   ..:|:.....:.
Mouse  2395 GNSRELRNGQMKAFLSLARFSDTQYQ--RIENYMKSSEFENKQTLLKRAK---EEVGLLREHKIQ 2454

  Fly  1794 SDLMII--------------------QRYAVPAVQGFFRSISLIKGNSLQD--TLRLLTLWFDYG 1836
            ::...:                    :|:...||:.:..  .|:.|.. .|  ..||.:||.:..
Mouse  2455 TNRYTVKVQRELELDECALRALREDRKRFLCKAVENYIN--CLLSGEE-HDLWVFRLCSLWLENS 2516

  Fly  1837 NHAEVYEAL-LSGMKLIEINTWLQVIPQLIARIDTHRQLVG-----QLIHQLLMDIGKNHPQ--- 1892
            ..:||...: ..||| |....:|.::.||.||:.|  ::.|     ::::.|:..|..:||.   
Mouse  2517 GVSEVNGMMKKDGMK-ISSYKFLPLMYQLAARMGT--KMTGGLGFHEVLNNLISRISLDHPHHTL 2578

  Fly  1893 ALVYPLTVASKSASLA-----RRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEG 1952
            .::..|..|:|...|:     ||:   :|..|..|.:..|.|                     :.
Mouse  2579 FIILALANANKDEFLSKPETTRRS---RITKSTSKENSHLDE---------------------DR 2619

  Fly  1953 LEEASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVM 2017
            .|.|:|:                :|::                             |.|...:|.
Mouse  2620 TEAATRI----------------IHSI-----------------------------RSKRCKMVK 2639

  Fly  2018 DLDRAWDIYYHVF-QKISRQLPQLTSLELPYVSP--KLMTCKD-----LELAV--PGSYNPGQEL 2072
            |::...|.|..:. ...|:...|...:.:|...|  ||...:|     :|:.|  .|.|   :.|
Mouse  2640 DMEALCDAYIILANMDASQWRAQRKGINIPANQPITKLKNLEDVVVPTMEIKVDPTGEY---ENL 2701

  Fly  2073 IRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDT 2137
            :.|...||..::......|:.:...||:||:...|:||.:|||||..:.|:|.:.||||..:.:|
Mouse  2702 VTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTET 2766

  Fly  2138 FRRNLAIQRYAVIPLSTNSGLIGW-----------VPHCDTLHTLIRDYRDKKKVPLNQEHRTML 2191
            .:|.|.|..|.|:|||..||::.|           |...|..|   |.|| ......||..:.|:
Mouse  2767 RKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYLVNSEDGAH---RRYR-PNDFSANQCQKKMM 2827

  Fly  2192 -----NFAPDYD-HLTLMQKVE-VFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVM 2249
                 :|...|| .:|:.|..| ||.:..       :.|.|   .|:  :|||:|..||||:|..
Mouse  2828 EVQKKSFEEKYDTFMTICQNFEPVFRYFC-------MEKFL---DPA--VWFEKRLAYTRSVATS 2880

  Fly  2250 SMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFE---VAMTREKFPEKIPFRLTRMLIKAMEV 2311
            |:|||||||||||..|::::..|.:::|||.|..||   :..|    ||.:||||:|.::..|.:
Mouse  2881 SIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT----PETVPFRLSRDIVDGMGI 2941

  Fly  2312 TGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNW-----RLLDVDKKGNDAVAGAGAPG 2371
            ||:||.:||.||..|.|:|.::::|:.::|..:||||.:|     :.|.:.::..|         
Mouse  2942 TGVEGVFRRCCEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPED--------- 2997

  Fly  2372 GRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADET-NSKASQVIKRVKCKLTGTDF 2435
                        .|...|.|.|..:....:|..       .|:: |..|.:|:.|::.||.|.:.
Mouse  2998 ------------ESDLHSTPNADDQECKQSLSD-------TDQSFNKVAERVLMRLQEKLKGVEE 3043

  Fly  2436 QTEKSVNEQSQVELLIQQATNNENLCQCYIGW 2467
            .|..||.  .||.||||||.:.:||.:.:.||
Mouse  3044 GTVLSVG--GQVNLLIQQAMDPKNLSRLFPGW 3073

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 526/2545 (21%)
HEAT repeat 632..658 CDD:293787 6/29 (21%)
HEAT repeat 668..698 CDD:293787 8/29 (28%)
HEAT repeat 706..736 CDD:293787 8/42 (19%)
HEAT repeat 749..780 CDD:293787 6/30 (20%)
HEAT repeat 798..823 CDD:293787 4/24 (17%)
DUF3385 831..999 CDD:288698 29/180 (16%)
HEAT repeat 841..870 CDD:293787 3/28 (11%)
HEAT repeat 880..917 CDD:293787 5/36 (14%)
HEAT repeat 925..954 CDD:293787 6/28 (21%)
Rapamycin_bind 1937..2034 CDD:285924 10/97 (10%)
PIKKc_TOR 2075..2353 CDD:270713 110/303 (36%)
FATC 2440..2471 CDD:280430 14/28 (50%)
AtmXP_011240687.1 TAN 8..165 CDD:371644
FAT 2128..2510 CDD:367004 65/396 (16%)
PIKKc_ATM 2704..2983 CDD:270715 110/298 (37%)
FATC 3047..3076 CDD:367005 14/29 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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