DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tor and Pi4kb

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_001280644.1	Gene:	Pi4kb / 107650	MGIID:	1334433	Length:	816	Species:	Mus musculus

Alignment Length:	325	Identity:	70/325 - (21%)
Similarity:	127/325 - (39%)	Gaps:	94/325 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2031 QKISRQLPQL-TSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKL 2094
            :::|.||... |:.:.....|..:..|:          |.||.:|
Mouse   508 RRLSEQLAHTPTAFKRDPEDPSAVALKE----------PWQEKVR-------------------- 542

  Fly  2095 CIRGSNGKDYMYL---------LKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVI 2150
              |...|..|.:|         :|..:||||:....|:...:.::...:    |..|.|:.|.::
Mouse   543 --RIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQE----RVPLWIKPYKIL 601

  Fly  2151 PLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQ 2215
            .:|.:||:|..|.:..::|.:       ||    |...::|::        .:|     ||.
Mouse   602 VISADSGMIEPVVNAVSIHQV-------KK----QSQLSLLDY--------FLQ-----EHG--- 639

  Fly  2216 TQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDF 2280
                         |.::|.:...:.|:.:|.|...:|.|:|.:.|||..|::|| ..|.|:||||
Mouse   640 -------------SYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLD-AEGHIIHIDF 690

  Fly  2281 GDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGT----YRRTCESVMLVLRRNKDSLMAVLE 2341
            |.....:.....| |...|:||...:..|  .|:.|.    |:......::..|::.|.::.::|
Mouse   691 GFILSSSPRNLGF-ETSAFKLTTEFVDVM--GGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVE 752

Fly 2342 2341
Mouse 753 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	70/325 (22%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	0/2 (0%)
		PIKKc_TOR	2075..2353	CDD:270713	60/280 (21%)
		FATC	2440..2471	CDD:280430
Pi4kb	NP_001280644.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Interaction with ACBD3. /evidence=ECO:0000250\|UniProtKB:Q9UBF8	2..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..120
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..318
		PI4Kc_III_beta	529..816	CDD:270712	65/304 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900