DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and mtor

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:XP_031761369.1 Gene:mtor / 100491970 XenbaseID:XB-GENE-993118 Length:2532 Species:Xenopus tropicalis


Alignment Length:2578 Identity:1407/2578 - (54%)
Similarity:1788/2578 - (69%) Gaps:167/2578 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SVVQQFVNGLKSRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIFTMVNATDINEKK 69
            :::|||.|||:|||...:.||.:||..||.|||||:||||..||:||.:|.||..|:::|::|:|
 Frog    11 TMLQQFANGLRSRNEETRIKAAKDLQHYVTTELREVSQEEATQFYDELNHFIFEFVSSSDVSERK 75

  Fly    70 GGALAMKCLINCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARSLVKLANMPTSKGADSFDF 134
            ||.||:..||..||....|  ||.:.|.||:||..:|..|||:|::::.:||....:..|:..:|
 Frog    76 GGILAIVSLIGVEGGNATR--ISRFANYLRNLLPSSDPGVMEMASKAMGRLAMAGDTFTAEYVEF 138

  Fly   135 DIKKAFEVLRGERQEYRRHSAVFILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESAGEA 199
            ::|:|.|.|..:|.|.|||:||.:|||||::.||:|:|.:..||:.||.|::|||.||||.|..|
 Frog   139 EVKRALEWLGADRNEGRRHAAVLVLRELAVSAPTFFFQQVQPFFDNIFFAVWDPKQAIREGAVAA 203

  Fly   200 LRAALIVTAQRESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNELFR 264
            |||.||:|.||| .|:..:|.|||..|:||...|:..|..   :||:.|||||||.|::.|||.|
 Frog   204 LRACLILTTQRE-PKELQKPLWYRQTYEEAERGFDETLSK---EKGMNRDDRIHGALLIINELVR 264

  Fly   265 CANATWERRYTSLKTLFPKTQ----HNKFLEASSSSSMGSQLNTLVPRLKVPF------------ 313
            .::...||....::.:   ||    |:|  ......:.|     |.||...||            
 Frog   265 ISSMEGERLREEMEEI---TQQQMVHDK--HCKDLMTFG-----LKPRHITPFASFQSVQPQPSN 319

  Fly   314 --IDKLGST--QTHLGEGEHHKGVAKFASQHNVLESAYAQEILQEHYTSICDNVLEQRTSKSPYV 374
              :..||.|  |..||     .|.|....:..::||...:|:::|.:..||..||:.|:||:|.:
 Frog   320 ALLSLLGYTGQQGILG-----YGAAPMPDKTTLVESRACRELVEEKFDQICRWVLKCRSSKNPLI 379

  Fly   375 QQALLQILPRLAAFNRAVF-VEKYLQTCVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIEVHL 438
            |..:|.:|||||||..:.| .:.||...:|||:..:| |||:||||:..:|.::|||:|.|.::|
 Frog   380 QMTILNVLPRLAAFRPSAFTADLYLPDTMSHLLSCVR-KEKERTVAFQALGLISVAVRSEIRLYL 443

  Fly   439 SSIMTSVKVALPSKDLTSKRK--VPVDPAVFACITLLAHAVKSEIADDVKDILEQMFYTGLSPAL 501
            ..|:..||.|||.||...||:  :.||..||.||::||.::...|..|:|::||.|...||||||
 Frog   444 PKILEHVKAALPPKDFAHKRQKSIQVDATVFTCISMLARSMGPSIQQDIKELLEPMLSVGLSPAL 508

  Fly   502 TVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAILP--------------YTALPTIAIDGSL 552
            |..|.:||.::||||..|.:||:.:||.|||:|....|              .|.:|.|:..||:
 Frog   509 TAVLYDLSRHIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAQQLSSPSLTNIPEISDVGSI 573

  Fly   553 MQNGDGATTVLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTCTRLLKLAVQ-SS 616
                     .|||:|||||.||..::..||:.|||:|:..|.:|||:||.:||:|||..::| .|
 Frog   574 ---------TLALRTLGTFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIQLLS 629

  Fly   617 ESMENSKTLSDTVSHVIERLLMVAITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEI 681
            .....|:|....|:.|:.:||:|.|||.|.::|..:|.||||.||..|||.|:|.:||:.|:||:
 Frog   630 GHGHVSQTAVQVVADVLGKLLVVGITDPDPDIRYCVLASLDERFDTHLAQAENLQALFVALNDEV 694

  Fly   682 FEIRELAMVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLIS 746
            |||||||:.|||||||:|||:|||.||..:|:::|:|::||:.|||||||:||.|||.:.||||.
 Frog   695 FEIRELAICTIGRLSSMNPAFVMPFLRKMLIQILTELEHSGVGRNKEQSARMLGHLVSNAPRLIR 759

  Fly   747 SYMNPILKALVPKLHEPESNPGVILNVLRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGSP 811
            .||.||||||:.||.:|:.||||:.|||.|||:||:|:|  .||..|.|:|..|:::||.|:...
 Frog   760 PYMEPILKALILKLRDPDPNPGVVTNVLATIGELAQVSG--LEMRKWMDELFPIIMDMLQDSSLL 822

  Fly   812 DKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIRRETIRVLGLLGAMDPYKH 876
            .||.|||||||||:::||.||.||.|||.|:::|:|||||||.:.||||.|||||||||:|||||
 Frog   823 AKRQVALWTLGQLVASTGYVVEPYRKYPSLLEVLLNFLKTEQNQGIRREAIRVLGLLGALDPYKH 887

  Fly   877 KMNKGLIDSQKDNVLIAYSDGKVD-ESQDISTAELLVNMGN-ALDEYYPAVAIAALMRILRDPTL 939
            |:|.|:||..:|...::.|:.|.: :|.|.||:|:|||||| .|||:||||::..|||||||.:|
 Frog   888 KVNIGMIDQSRDASALSLSESKANQDSADYSTSEMLVNMGNLPLDEFYPAVSVVTLMRILRDQSL 952

  Fly   940 STRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADNNLRE----------------FLF 988
            |..||.||||:||||:|||:|||.:|.||:|..|..:|..|||:||                |:|
 Frog   953 SNHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLSAIRLCDNNMRESHQPSPQKRTSLMSPQFMF 1017

  Fly   989 QQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQNTLINLIEQIAVALGCEFRDYLAELIPQI 1053
            |||.:||.||:.||..||.:||.|||::||:|.|:|:|:|.|||||.::||.||:.||.:|||.:
 Frog  1018 QQLGMLVGFVRSHIRPYMDEIFALIKDYWTMNNPIQSTIILLIEQIVLSLGGEFKLYLPQLIPHM 1082

  Fly  1054 LRVLQHDNSKDRMVTRRLLQALQKFGSTLGYYLPLILPPIVKLFDSPYVPQQVSMVALETINNLA 1118
            |||..||:|..|.||.:||.|:|.||:.|..||.|:|||||||||:|..|.....|||||::.|.
 Frog  1083 LRVFMHDSSVGRSVTIKLLNAIQMFGANLDDYLHLLLPPIVKLFDAPDSPMPARKVALETVDRLT 1147

  Fly  1119 CQLDFTDFSSRIIHPLVRVLDAEPELRDQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPE 1183
            ..|||||::||||||:||.||..|:||..||.||.||..||||||.:|:|||.:.|.||||:...
 Frog  1148 ESLDFTDYASRIIHPIVRTLDMSPDLRITAMDTLSSLVFQLGKKYHIFIPMVNKVLQKHRILHQR 1212

  Fly  1184 YEELLSKIKSCSTLADSYGAGESELRPSRFKNNEPFVTDRNSNN----------------KNLQV 1232
            ||.|..:|....||||              :..:|.:....:..                |.|.|
 Frog  1213 YEVLTCRILKGYTLAD--------------EEEDPLIYQHKAQRGNLSETASAPLDAGPMKKLHV 1263

  Fly  1233 TTNELRTAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISC 1297
            :|..|:.||...||||||||:|||:|||:.|||:|.|.|||:|.||||.|:.|.||||||||:||
 Frog  1264 STTNLQKAWGAARRVSKDDWLEWLRRLSVELLKDSSSPALRSCWSLAQAYNPLARDLFNAAFLSC 1328

  Fly  1298 WTELSPDLKNELTQSLIQALQVTDMPEITQTILNLAEFMEHCDRDPIPIE----TKLLGTRAMAC 1358
            |:||:.|.::||.:|:..||...|:.|:|||:|||||||||.|:.|:|:.    ..|||.||..|
 Frog  1329 WSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGVVLLGERASKC 1393

  Fly  1359 RAYAKALRYKEEEFLLREDSQVFESLILINNKLQQREAAEGLLTRYRNAANELNVQGRWYEKLHN 1423
            |||||||.|||.||.......:.||||.|||||||.|||.|:|........|:.:|..||||||.
 Frog  1394 RAYAKALHYKELEFQKGPSPAILESLISINNKLQQPEAASGVLEFAMKHYGEMEIQATWYEKLHE 1458

  Fly  1424 WDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAA 1488
            |::||..|::.::.:..|.|..||.||||||||:|.:|.......|.|...:|:::...:||.||
 Frog  1459 WEDALVAYDKKIEVNKDDSELILGRMRCLEALGEWGQLHQQCCENWTNVNEDARAKMARMAAAAA 1523

  Fly  1489 WGLQDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYER 1553
            |||:.|::|.||...||.||.||::||||||:|.|.|..||:.||:.||:||.|||:||||||.|
 Frog  1524 WGLEQWDSMEEYTCLIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDMLDAELTAMAGESYSR 1588

  Fly  1554 AYGAMVCVQMLAELEEVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDI 1618
            ||||||..|||:||||||||||:|||||.::..||.||||.||:||||::|:.|.||||.||||:
 Frog  1589 AYGAMVTCQMLSELEEVIQYKLVPERREIIRQTWWDRLQGCQRIVEDWQKILMVQSLVVSPHEDM 1653

  Fly  1619 HTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYE 1683
            .|||||||||.|||.|.|||||||||||.||.|..:||||...|||||||.|||..:.:..||::
 Frog  1654 RTWLKYASLCSKSGRLALSHKTLVMLLGVDPALESDQPLPTAHPQVTYAYMKYMWKSTRKIEAFQ 1718

  Fly  1684 QLTHFVST---YSQELSCLPPEALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKA 1745
            .:..||:.   .:|.::..|..  ||:.|:|||||:|::..||..|| .|....|...||.:..|
 Frog  1719 HMQKFVNNMQLQAQHVADDPQH--KQELQKLMARCFLKLGEWQLNLQ-GINECTIPCVLEYYSAA 1780

  Fly  1746 TSYDPNWYKAWHLWAYMNFKVV---QAQKSALDKQQ---------PPGASMGMTMGSGLDSDLMI 1798
            |.:|.|||||||.||.|||:.|   :.|....|:::         ||..|...:.|...|:..:.
 Frog  1781 TEHDHNWYKAWHAWAVMNFEAVLHFKHQNHPRDEKKVRHPSTASAPPEGSESESEGESNDNSPVS 1845

  Fly  1799 --IQR------------YAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEALLSGM 1849
              :|:            |.|||||||||||||.:||:||||||:||||||||:..:|.|||:.|:
 Frog  1846 SPVQKKPSEDISHTLLLYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGI 1910

  Fly  1850 KLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAF 1914
            |.|:|:|||||||||||||||.|.|||:||||||.|||:.|||||:|||||||||.:.||.|||.
 Frog  1911 KTIQIDTWLQVIPQLIARIDTPRALVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAAN 1975

  Fly  1915 KILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAM 1979
            |||.:|.:||.|||:||:|.|||||||||||||.||||||||||||||:|||||||.:|:|||||
 Frog  1976 KILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFAVLDPLHAM 2040

  Fly  1980 LERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLE 2044
            :||||||||||||:|||||:|.||.:|.::|..|..|.||.:|||:|||||::||:|||||||||
 Frog  2041 MERGPQTLKETSFNQAYGRDLMEAQDWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLE 2105

  Fly  2045 LPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLK 2109
            |.||||||:.|:||||||||:|:|.|.:|||..|..:|||||||||||||.:.||||.::|:|||
 Frog  2106 LQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFMFLLK 2170

  Fly  2110 GHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRD 2174
            |||||||||||||||.||||||.:||.:.|:||:||||||||||||||||||||||||||.||||
 Frog  2171 GHEDLRQDERVMQLFGLVNTLLANDPASLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRD 2235

  Fly  2175 YRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERR 2239
            ||:|||:.||.|||.||..|||||||||||||||||||:..|.||||||||||||||||:||:||
 Frog  2236 YREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRR 2300

  Fly  2240 NNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRM 2304
            .||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||
 Frog  2301 TNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRM 2365

  Fly  2305 LIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGA 2369
            |..||||||::|.||.||.:||.|||.:|||:|||||||||||||||||:|.:.|||........
 Frog  2366 LTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNIKGNKRSRTRTD 2430

  Fly  2370 PGGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVAD------ETNSKASQVIKRVKC 2428
            ....|.||   .:..:||  |.....|....|:.: .:|..:.|      ..|.||.|:|.||:.
 Frog  2431 SYSAGQSG---EIMETVE--LGETAHKKTGSTVPE-SIHTFIGDGLVQPEALNKKAIQIINRVRD 2489

  Fly  2429 KLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPFW 2471
            ||||.||..|::::..:||||||:|||::||||||||||||||
 Frog  2490 KLTGRDFSHEETLDVATQVELLIKQATSHENLCQCYIGWCPFW 2532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 1269/2269 (56%)
HEAT repeat 632..658 CDD:293787 12/25 (48%)
HEAT repeat 668..698 CDD:293787 20/29 (69%)
HEAT repeat 706..736 CDD:293787 16/29 (55%)
HEAT repeat 749..780 CDD:293787 20/30 (67%)
HEAT repeat 798..823 CDD:293787 12/24 (50%)
DUF3385 831..999 CDD:288698 104/185 (56%)
HEAT repeat 841..870 CDD:293787 20/28 (71%)
HEAT repeat 880..917 CDD:293787 17/38 (45%)
HEAT repeat 925..954 CDD:293787 18/28 (64%)
Rapamycin_bind 1937..2034 CDD:285924 72/96 (75%)
PIKKc_TOR 2075..2353 CDD:270713 229/277 (83%)
FATC 2440..2471 CDD:280430 21/30 (70%)
mtorXP_031761369.1 TEL1 346..2532 CDD:227365 1258/2220 (57%)
HEAT repeat 597..619 CDD:293787 12/21 (57%)
HEAT repeat 645..671 CDD:293787 12/25 (48%)
HEAT repeat 681..711 CDD:293787 20/29 (69%)
HEAT repeat 719..749 CDD:293787 16/29 (55%)
HEAT repeat 762..793 CDD:293787 20/30 (67%)
HEAT repeat 805..835 CDD:293787 15/29 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 646 1.000 Domainoid score I160
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H3637
Inparanoid 1 1.050 2592 1.000 Inparanoid score I30
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 1 1.000 - - FOG0003052
OrthoInspector 1 1.000 - - oto104055
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2407
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.060

Return to query results.
Submit another query.