DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEDD9 and p130CAS

DIOPT Version :9

Sequence 1:	NP_001135865.1	Gene:	NEDD9 / 4739	HGNCID:	7733	Length:	834	Species:	Homo sapiens
Sequence 2:	NP_001097456.2	Gene:	p130CAS / 38021	FlyBaseID:	FBgn0035101	Length:	831	Species:	Drosophila melanogaster

Alignment Length:	913	Identity:	233/913 - (25%)
Similarity:	384/913 - (42%)	Gaps:	257/913 - (28%)

- Green bases have known domain annotations that are detailed below.

Human     4 RNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQ 68
            :.|.|:|:|||..:.::||.|:|||||||:||:|.|.:|||||||..|||:.||||:::|
  Fly    78 QKLYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVL----- 137

Human    69 ETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTGHGTQEQ---- 129
               :|::   ||...           |:|.::|      ||         .:.....|.:.
  Fly   138 ---NSYD---SGCFS-----------PSPASSP------VP---------SLAASTATLDSSICS 170

Human   130 -EVYQ-------VPPSVQRSIGGTSG------PHVGK--------KVITPVRTGHGYVYEYPSRY 172
             |:|:       |..|...|.|.:||      ..|.:        |||||.|.|..|:|.|.
  Fly   171 AEIYENGSVISAVSSSNSNSGGASSGLGSESVSRVSRRSWHASPTKVITPQRHGDVYIYNYS--- 232

Human   173 QKDVYDIPPSHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLR 237
                   |.|.|..|. ...||:.:..::|       .|.:|.      .:|:..|..::.:|..
  Fly   233 -------PGSATGSGA-RAAPSTPQQQIYS-------NQSIYQ------NFAMMSSPRQNASGSE 276

Human   238 EKDYDFPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPNHP 302
            .:.||.|                        |||   ..|..|.|.|.:..|.|....:.|.:
  Fly   277 FETYDIP------------------------KPA---TPVPLNYDSPRSGLPKASNSTTTSSS-- 312

Human   303 PPQLG------QSVGSQ--NDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAKGSR 359
              .||      :||.:.  .::|||||                               |...||.
  Fly   313 --SLGTRFETLKSVAASIAEESYDVPR-------------------------------PLILGSN 344

Human   360 DLVDGINRLSFSSTGS---TRSNMSTSSTSSKESSLSASPAQD---------------------- 399
            .|...:::::.||:.|   |..::|.|.:||..|||:..|..|
  Fly   345 QLQQQMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANMPDYDIPRRNPLPVRRQQSGLTYDFPL 409

Human   400 --------------------KRLFLDPDTAIERLQRLQQALEMGVSSLMALVTTDWRCYGYMERH 444
                                |.|.|:..:|:|.|.:||......::.|::.|..:||....:|..
  Fly   410 PPLQEQVPRVLCTPSTVTTTKELPLELSSALETLAKLQLQTTAAINRLLSFVVPNWRTRAQLEPA 474

Human   445 INEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILHNKMKRELQRVEDSHQILSQTSHDLN-E 508
            |.:::.|..::...|.:...|.:||:.||....:..|..|::..::.:.|:::::..:|..|: :
  Fly   475 IMDLKLAALRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRDANKLIHDSSESLDAQ 539

Human   509 CSWSLNILAINKPQNKC---DDLDRFVMVAKTVPDDAKQLTTTINTNAEALFRPGPGSLHLKNGP 570
            .:||::.||.:..::.|   |.||:.::.|:|:.:|.:..|:.|..||..||:
  Fly   540 GAWSIDQLARSDEKHGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFK------------ 592

Human   571 ESIMNSTEYPHGGSQGQLLHPGDHKAQAHNKALPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQ 635
                ......|.|..|..:..|                         |.|| ..|::|||||..:
  Fly   593 ----RQLTVGHNGGSGTGVLEG-------------------------SRGS-AEWLEDYDYVAFE 627

Human   636 GKEEFERQQKELLEKENIMKQNKMQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTT---N 697
            .|:...|:.:.|  :|.|....|.|.:    :..:..|..........|.....:::.|||   :
  Fly   628 SKDAAARKNEAL--REAIPADLKTQFD----TVIRTAESSAMGAGSGSIPTTPTARTTPTTPCKS 686

Human   698 SGVSAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDT 762
            ..::.:|::|:.:|..|..||..:|:.|||:....|...|||:.|:|:.|||::|||.||.|||.
  Fly   687 PEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNLVTIGDN 751

Human   763 LTRQVTAQDIRNKVMNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRS 827
            :.|.::.:.:|.|::..:|.|.:.|||.|:.:|.||.|:||.:|:||||..|..::..|:..|..
  Fly   752 VYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVDSVVHINNLARDLKSV 816

Human   828 LLE 830
            :|:
  Fly   817 MLQ 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEDD9	NP_001135865.1	SH3_NEDD9	7..63	CDD:212935	33/55 (60%)
		Interacts strongly with spindle-regulatory protein D1M1	102..229		32/152 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..260		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..316		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..398		16/72 (22%)
		Caspase cleavage related site	360..363		1/2 (50%)
		Serine_rich_NEDD9	401..562	CDD:211404	42/164 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..623		7/62 (11%)
		DUF3513	621..828	CDD:288849	69/209 (33%)
		Divergent helix-loop-helix motif	710..760		22/49 (45%)
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	33/54 (61%)
		Serine_rich_CAS	434..596	CDD:211403	41/177 (23%)
		DUF3513	612..817	CDD:288849	70/211 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143740
Domainoid	1	1.000	122	1.000	Domainoid score	I5642
eggNOG	1	0.900	-	-		E1_28I76
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3193
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46840
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	1	1.000	-	-		FOG0004232
OrthoInspector	1	1.000	-	-		otm41781
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10654
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4915
SonicParanoid	1	1.000	-	-		X2975
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.900