| Sequence 1: | NP_001271267.1 | Gene: | NEDD4 / 4734 | HGNCID: | 7727 | Length: | 1319 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001029358.1 | Gene: | nedd4a / 619412 | ZFINID: | ZDB-GENE-051005-2 | Length: | 910 | Species: | Danio rerio |
| Alignment Length: | 860 | Identity: | 562/860 - (65%) |
|---|---|---|---|
| Similarity: | 635/860 - (73%) | Gaps: | 86/860 - (10%) |
- Green bases have known domain annotations that are detailed below.
|
Human 502 DSNRDCTNELSNSCKTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLK 566
Human 567 MTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNH 631
Human 632 ESRRTQWKRPTPQDNLTDAE-NGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIREDEATM 695
Human 696 YSNQAFPS-PPPSSNLDVPTHLAEELNARLTIFGN---SAVSQPASSSNHSSRRGSLQAYTFEEQ 756
Human 757 PTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQ 821
Human 822 ASTS------------DSGQQVTQP-----SEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE 869
Human 870 DPRLKIPAHLRGKTSLDTSNDLGPLPPGWEE--------------------RTHTDGRIFYINHN 914
Human 915 IKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRI 979
Human 980 MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSG 1044
Human 1045 LCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILE 1109
Human 1110 NDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEG 1174
Human 1175 FFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKR 1239
Human 1240 IRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDK 1304
Human 1305 LQMAIENTQGFDGVD 1319 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| NEDD4 | NP_001271267.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 204..229 | ||
| C2 | <517..570 | CDD:417471 | 44/52 (85%) | ||
| Mediates interaction with TNIK. /evidence=ECO:0000250 | 578..981 | 213/444 (48%) | |||
| WW | 611..643 | CDD:197736 | 27/31 (87%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 755..780 | 16/24 (67%) | |||
| WW | 769..798 | CDD:395320 | 23/28 (82%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 796..834 | 13/49 (27%) | |||
| WW | 842..871 | CDD:395320 | 23/28 (82%) | ||
| WW | 893..925 | CDD:197736 | 13/51 (25%) | ||
| HECTc | 986..1315 | CDD:214523 | 289/328 (88%) | ||
| nedd4a | NP_001029358.1 | C2_NEDD4_NEDD4L | 22..153 | CDD:175999 | 47/67 (70%) |
| WW | 194..223 | CDD:366073 | 25/28 (89%) | ||
| WW | 349..378 | CDD:366073 | 23/28 (82%) | ||
| WW | 435..465 | CDD:238122 | 25/29 (86%) | ||
| HECTc | 577..906 | CDD:214523 | 289/328 (88%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C194335994 | |
| Domainoid | 1 | 1.000 | 94 | 1.000 | Domainoid score | I27154 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D142537at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000080 | |
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 1 | 0.900 | - | - | OOG6_100256 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR11254 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X1682 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| ZFIN | 1 | 1.500 | - | - | ||
| 12 | 12.350 | |||||