DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEDD4 and Nedd4

DIOPT Version :9

Sequence 1:	NP_001271267.1	Gene:	NEDD4 / 4734	HGNCID:	7727	Length:	1319	Species:	Homo sapiens
Sequence 2:	NP_001344927.1	Gene:	Nedd4 / 17999	MGIID:	97297	Length:	1207	Species:	Mus musculus

Alignment Length:	1319	Identity:	978/1319 - (74%)
Similarity:	1065/1319 - (80%)	Gaps:	112/1319 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAQSLRLHFAARRSNTYPLSETSGDDLDSHVHMCFKRPTRISTSNVVQMKLTPRQTALAPLIKEN 65
            ||||||||||||||.||||||.|||||||||....:|..|||.::||||:|||||...||.::..
Mouse     1 MAQSLRLHFAARRSKTYPLSEPSGDDLDSHVDTHGQRRPRISVASVVQMRLTPRQAPQAPWVEHR 65

Human    66 VQSQERSSVPSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSDDASFTCILKDGIYSSAVVDN 130
                      |||:.:|||||||||||| ||.|.|.|..|:||.|..|.||..||.:.||:.:|:
Mouse    66 ----------SSESTDKKSSCLQISLQP-RYGGCLPSDTVVADRDSTSSTCASKDDVCSSSGIDS 119

Human   131 ELNAVNDGHLVSSPAICSGSLSNFSTSDNGSYSSNGSDFGSCASITSGGSYTNSVISDSSSYTFP 195
            ||:              :|||||||.||:|||||:|||.|||||:.||||.|.|.:||||.|
Mouse   120 ELD--------------NGSLSNFSASDSGSYSSSGSDCGSCASLASGGSSTGSGVSDSSGY--- 167

Human   196 PSDDTFLGGNLPSDSTSNRSVPNRNTTPCEIFSRSTSTDPFVQDDLEHGLEIMKLPVSRNTKIPL 260
               :||..||||||:.|||||| .:|||.|:...|.|..||.|:||:.|:||||||||||.|.||
Mouse   168 ---ETFFSGNLPSDNASNRSVP-VDTTPREVMCGSPSRLPFAQEDLDRGVEIMKLPVSRNAKGPL 228

Human   261 KRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSYQTSHQFIISPSEIAHNEDGTSAKGFLSTAVNG 325
            ||.:||||||||||.|.|.|||      |:|:||||||.::||:|.||:|||:..||||||||||
Mouse   229 KRCTSLVIFPRSPSNTPPASPT------SRGAYQTSHQLVVSPTETAHHEDGSGTKGFLSTAVNG 287

Human   326 LRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNTPRQTVCEKSSEGYSCVSVHFTQRKAATLDC 390
            |||||.:||||||||:||||.|||||||||:|||.|:||||||..||:||||||.||:|..|.||
Mouse   288 LRLSKMVCTPGEVRDVRPLHAKGSLQKKIVISNNRPKQTVCEKLPEGFSCVSVHLTQQKPTTSDC 352

Human   391 ETTNGDCKPEMSEIKLNSDSEYIKLMHRTSACLPSSQNVDCQININGELERPHSQMNKNHGILRR 455
            ....|.|..|..|::|.||.::..|..|.|.|||::.::...:||.||||||:|.::|.|..|:|
Mouse   353 ANPRGGCTSERLELQLQSDLDHGMLKQRASPCLPTASDMGYHLNIRGELERPNSPISKGHAALQR 417

Human   456 SISLGGAYPNISCLSSLKHNCSKGGPSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDD 520
            |:||||.||||||||||||||||||||||||||||||:||||:..|  .||.|||||:.||||||
Mouse   418 SVSLGGTYPNISCLSSLKHNCSKGGPSQLLIKFASGNDGKVDSFWR--QRDLTNELSDVCKTRDD 480

Human   521 FLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAE 585
            ||||||||||||||||||:||||||||||||||||||||||||||||||||| :||||:||:|||
Mouse   481 FLGQVDVPLYPLPTENPRMERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPK-NGSEDENADQAE 544

Human   586 ELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDA 650
            |||||||||||||||.||....||||||||||||||:|||||||||||||||||||:|.|:|||.
Mouse   545 ELEPGWVVLDQPDAATHLPHPPEPSPLPPGWEERQDVLGRTYYVNHESRRTQWKRPSPDDDLTDE 609

Human   651 ENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTH 715
            :|.::||||||||||||||||:.:..|||||.|||||:||||.|.||.||..| |||.::||.||
Mouse   610 DNDDMQLQAQRAFTTRRQISEDVDGPDNRESPENWEIVREDENTEYSGQAVQS-PPSGHIDVQTH 673

Human   716 LAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDER 780
            ||||.|.||.:.||.|.|||.:|||||||.||||...||||||||||||||||||||||||||:|
Mouse   674 LAEEFNTRLAVCGNPATSQPVTSSNHSSRGGSLQTCIFEEQPTLPVLLPTSSGLPPGWEEKQDDR 738

Human   781 GRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKG 845
            ||||||||||:||||:|||:|
Mouse   739 GRSYYVDHNSKTTTWSKPTMQ-------------------------------------------- 759

Human   846 WEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFY 910
                                   :|||.||||||||||.   ||||||||||||||||||||:|:
Mouse   760 -----------------------DDPRSKIPAHLRGKTD---SNDLGPLPPGWEERTHTDGRVFF 798

Human   911 INHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDS 975
            ||||||:||||||||:|||||||||||||||||||||||||||||.|||||||||||||.:||||
Mouse   799 INHNIKKTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFRRKLKKQTDIPNKFEMKLRRANILEDS 863

Human   976 YRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQIN 1040
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   864 YRRIMGVKRADLLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQIN 928

Human  1041 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLR 1105
            ||||||||||||||||||||||||||||||||||||||||||||.|.||||||||||||||:|||
Mouse   929 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLR 993

Human  1106 WILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAA 1170
            ||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
Mouse   994 WILENDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAA 1058

Human  1171 FKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1235
            ||||||||||||||||||||||||||||||||||||||||||||||||.|||||.||||||.|||
Mouse  1059 FKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMD 1123

Human  1236 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEE 1300
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||:|
Mouse  1124 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFDE 1188

Human  1301 LWDKLQMAIENTQGFDGVD 1319
            |||||||||||||||||||
Mouse  1189 LWDKLQMAIENTQGFDGVD 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEDD4	NP_001271267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..229		16/24 (67%)
		C2	<517..570	CDD:417471	51/52 (98%)
		Mediates interaction with TNIK. /evidence=ECO:0000250	578..981		272/402 (68%)
		WW	611..643	CDD:197736	30/31 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..780		24/24 (100%)
		WW	769..798	CDD:395320	25/28 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..834		4/37 (11%)
		WW	842..871	CDD:395320	0/28 (0%)
		WW	893..925	CDD:197736	28/31 (90%)
		HECTc	986..1315	CDD:214523	318/328 (97%)
Nedd4	NP_001344927.1	C2	<477..530	CDD:326325	51/52 (98%)
		WW	574..602	CDD:238122	26/27 (96%)
		WW	727..756	CDD:306827	25/28 (89%)
		WW	781..813	CDD:197736	28/31 (90%)
		HECTc	874..1203	CDD:214523	318/328 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83965158
Domainoid	1	1.000	616	1.000	Domainoid score	I4896
eggNOG	1	0.900	-	-		E1_COG5021
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1296	1.000	Inparanoid score	I3845
Isobase	1	0.950	-	0	Normalized mean entropy	S826
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D142537at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		oto120915
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X1682
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.240