DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEDD4 and Y92H12A.2

DIOPT Version :9

Sequence 1:	NP_001271267.1	Gene:	NEDD4 / 4734	HGNCID:	7727	Length:	1319	Species:	Homo sapiens
Sequence 2:	NP_001293292.1	Gene:	Y92H12A.2 / 171719	WormBaseID:	WBGene00022358	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	862	Identity:	358/862 - (41%)
Similarity:	464/862 - (53%)	Gaps:	209/862 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   485 LIKFASGNEGKVDNLSRDSNRDCTNELSNSCKT--------------------RDDFLGQVDVPL 529
            :|:..:.|...||.:..::.:...|...||..|                    :|..:|.|...|
Worm    45 MIRLENSNGDTVDEVQVETKKKTRNPTWNSVFTFRVTRACQMKILVYDENRLRKDVLMGFVSRTL 109

Human   530 YP--LPTENPRLERPYTFKDFVLHP-RSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGW 591
            ..  :.|:.|..|      ::.|.. .:.|.:..|.|.|...::|.:|    ||:..
Worm   110 NDGLITTQAPNPE------EYALQSGTASKGKSIGSLFLSFHFMPSSS----DNSPS-------- 156

Human   592 VVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQ 656
                  |:...|||..  |.:|.|||||:|..|||.||||..|.||:   ||.::::   |||:.
Worm   157 ------DSTADLQQTS--SGMPQGWEEREDGNGRTVYVNHALRTTQF---TPPESVS---NGNVD 207

Human   657 LQAQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELN 721
            .      .|.:.:.|||     |...:|:|
Worm   208 A------ITEQSVIEET-----RRRRDNYE----------------------------------- 226

Human   722 ARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYV 786

Worm   227 ----------------------------------------------------------------- 226

Human   787 DHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHA 851
             |.|:.|.....|   |:.:::||:...:    .:|:....|..|.:  |.::..||.||:::.|
Worm   227 -HRSQVTDEPSDT---TIVSNELTAIDDA----MRANFERGGGHVEE--EEDELRLPDGWDMQVA 281

Human   852 PNGRPFFIDHNTKTTTWEDPR----LKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYIN 912
            ||||.|||||.||||||.|||    .::|. ||||    |.:::|.||.|||:|.|.|||:|:|:
Worm   282 PNGRTFFIDHRTKTTTWTDPRPGAATRVPL-LRGK----TDDEIGALPAGWEQRVHADGRVFFID 341

Human   913 HNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYR 977
            ||.:||||||||.||..|.|||||||||||||.|:.|.:|.|.|....|.:|.:.|.|:.|||||
Worm   342 HNRRRTQWEDPRFENENIAGPAVPYSRDYKRKVEYLRSRLPKPNSNSGKCDMVVHRDTLFEDSYR 406

Human   978 RIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPN 1042
            .||..|..| |:.:|||||.||.|||||||.||||||:|.::||||||||||||||||||||||:
Worm   407 HIMDKKDYD-LRNKLWIEFFGETGLDYGGVTREWFFLLSHQIFNPYYGLFEYSATDNYTLQINPH 470

Human  1043 SGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWI 1107
            |..||.:|||||.||||:.|||:|||||||.|||||||||||.|.|||.||||||:||||||.::
Worm   471 SEACNPEHLSYFHFIGRIIGMAIYHGKLLDAFFIRPFYKMMLGKKITLFDMESVDNEYYNSLIYV 535

Human  1108 LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFK 1172
            .:|||.:|:|.|.:|:.:||:|...||...|:.:.||..||:|||..|
Worm   536 KDNDPADLELTFSLDDSIFGETQNIELIPNGANVPVTEDNKEEYIEAV----------------- 583

Human  1173 EGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSE 1237
                  :|.:|:::||.||||||||||..:||.||:.:|.||.||..:.||:..|||.:|..|:|
Worm   584 ------VPSNLLRLFDANELELLMCGLQKIDVKDWKANTIYKGGYGPSSQVVHNFWKCILSFDNE 642

Human  1238 KRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELW 1302
            .|.|:||||:||||||||||.|||||||.|.||:|:||:.:.||||||||||||||||.:|:||.
Worm   643 MRARVLQFVSGTSRVPMNGFRELYGSNGLQKFTIERWGSADMLPRAHTCFNRLDLPPYTTFKELK 707

Human  1303 DKLQMAIENTQGFDGVD 1319
            .||..||||::.|.|||
Worm   708 SKLLTAIENSEIFSGVD 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEDD4	NP_001271267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..229
		C2	<517..570	CDD:417471	13/75 (17%)
		Mediates interaction with TNIK. /evidence=ECO:0000250	578..981		130/406 (32%)
		WW	611..643	CDD:197736	17/31 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..780		0/24 (0%)
		WW	769..798	CDD:395320	3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..834		7/37 (19%)
		WW	842..871	CDD:395320	20/28 (71%)
		WW	893..925	CDD:197736	21/31 (68%)
		HECTc	986..1315	CDD:214523	200/328 (61%)
Y92H12A.2	NP_001293292.1	C2	20..147	CDD:301316	20/107 (19%)
		WW	170..198	CDD:278809	18/30 (60%)
		WW	272..301	CDD:278809	20/28 (71%)
		WW	323..353	CDD:197736	20/29 (69%)
		HECTc	393..721	CDD:238033	211/351 (60%)
		HECTc	415..720	CDD:214523	200/328 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I7663
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	633	1.000	Inparanoid score	I494
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D142537at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm15987
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X1682
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860