DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RERE and rerea

DIOPT Version :9

Sequence 1:	NP_001036146.1	Gene:	RERE / 473	HGNCID:	9965	Length:	1566	Species:	Homo sapiens
Sequence 2:	XP_005162258.1	Gene:	rerea / 569081	ZFINID:	ZDB-GENE-060718-1	Length:	1531	Species:	Danio rerio

Alignment Length:	1618	Identity:	1212/1618 - (74%)
Similarity:	1309/1618 - (80%)	Gaps:	139/1618 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDN-N 64
            |||||:|||::|:|||||||  ||||||.||||:|||||||||||||||||||:||||:||:. .
Zfish     1 MTADKEKDKERERDRDRDRD--REKRDKTRESESSRPRRSCTLEGGAKNYAESEHSEDDDNETPG 63

Human    65 SATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQD 129
            :|||||:|||:|||.||||||||||:.|||||:|||||:||||||||||||||||||||||||||
Zfish    64 AATAEEATKKSKKKLPKKKSRYERTENGEITSFITEDDIVYRPGDCVYIESRRPNTPYFICSIQD 128

Human   130 FKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVP 194
            |||                                          ||||||||||||||||||||
Zfish   129 FKL------------------------------------------SKRDHLLMNVKWYYRQSEVP 151

Human   195 DSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREF 259
            |||||||||||:|||||||||||||||:|:|||||||||||||||||||||||||||||||||||
Zfish   152 DSVYQHLVQDRNNENDSGRELVITDPVVKSRELFISDYVDTYHAAALRGKCNISHFSDIFAAREF 216

Human   260 KARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVND 324
            |||:||||||||||||||||||||||||||||||||||:|||||||.|.|||::|||||||||||
Zfish   217 KARIDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPELQPFPSPGGQTVTENEELVWMPGVND 281

Human   325 CDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVP 389
            |||||||||||||||||||||||||||||:||||||||||||||||||.||||||||||||||||
Zfish   282 CDLLMYLRAARSMAAFAGMCDGGSTEDGCLAASRDDTTLNALNTLHESSYDAGKALQRLVKKPVP 346

Human   390 KLIEKCWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHR 454
            |||||||:|||||||:|||||||||||||||||||||||||||||||||||||||||.|||||||
Zfish   347 KLIEKCWSEDEVKRFIKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASCRAHRRHR 411

Human   455 RQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWH 519
            ||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   412 RQPVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWH 476

Human   520 HGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTL 584
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||
Zfish   477 HGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRNRGSMSTL 541

Human   585 RSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKR 649
            |||||||.||||||.||.|||:|||||.|||||||||.|||.:::||.:||.||||.||:||.||
Zfish   542 RSGRKKQTASPDGRASPTNEDLRSSGRTSPSAASTSSTDSKTDSMKKPSKKTKEEAPSPMKSAKR 606

Human   650 QREKVASDTEEADRTSSKKTKTQEISRPNSPS----EGEGESSDSRSVNDEGSSDPKDIDQDNRS 710
            ||||.||||||::|.|:||:||||||.|||||    ||||||||.||||||||||||||||||||
Zfish   607 QREKGASDTEESERASAKKSKTQEISVPNSPSECEGEGEGESSDGRSVNDEGSSDPKDIDQDNRS 671

Human   711 TSPSIPSPQDNESDSDSSAQQQMLQAQ-PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVP 774
            :|||||||:|||||||||||||:||.| ||.:|..||..|            |.|.|..:|:..|
Zfish   672 SSPSIPSPRDNESDSDSSAQQQILQGQHPPVIQCQTGTLP------------PAPPPAAAASTTP 724

Human   775 PQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHP--------QRPPSPHPPPH--PSPHPPLQPL 829
            ..|:|:.|..|:....||:..|    ||.|...|        ||.||||.|..  |.|.||.|
Zfish   725 TSGAPSLSSQPSPSIPPTSMPP----QQIPPAGPLSLIQSGVQRLPSPHSPLQGMPQPPPPSQ-- 783

Human   830 TGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPL-LQHPG--PPQPFGL-----PPQASQGQAPLG 886
                   :.|...||||||..||..|.|||||. :.||.  |.|||.:     ||....|||...
Zfish   784 -------TCPQALQPPLHGPMPPMGHPLQAGPSHMPHPHALPTQPFPMAQSQVPPSPLSGQAQAA 841

Human   887 TSPAAAYPHTSLQLPASQSALQSQ---QPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHP 948
            :......|||    |.|||...||   |||||||||||||.||||||||||||||:|..|:||||
Zfish   842 SLSQQQRPHT----PPSQSQSSSQSGSQPPREQPLPPAPLPMPHIKPPPTTPIPQMPNAQSHKHP 902

Human   949 PHLSGPSPF-SMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQN 1012
            .|    .|| .|.:|||||||||||||||.||||||||||||||.|||.|...|.|||.|||||.
Zfish   903 SH----PPFPQMPSNLPPPPALKPLSSLSNHHPPSAHPPPLQLMSQSQQLQPPPVQPPVLTQSQT 963

Human  1013 LP------PPPASHPP-----TGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSA 1066
            ||      ||||  ||     :..|....||||..|.|:||..|.::|.|.|::.:  :...|..
Zfish   964 LPATGSQAPPPA--PPLPSSSSASHSAPSQPPFPPHSFMPGSSPVLSPSTVPTSVS--SSMTTLQ 1024

Human  1067 QPPCSGAAASGGSIAGGSSCP----LPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHA 1127
            |||.|.:.....|::  :.||    :|.||||||.||:.|||||||||.|||||.||:|:|||||
Zfish  1025 QPPPSISMPLPASVS--APCPGPSTVPPVQIKEEPLDETEEPESPPPPQRSPSPPPTIVNTPSHA 1087

Human  1128 SQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKER 1192
            |||||||||||||||:|||||.||.|||.||||||||||:||||||||||||||:|:|:|:||||
Zfish  1088 SQSARFYKHLDRGYNTCARTDFYFTPLASSKLAKKREEALEKAKREAEQKAREEKEKEREREKER 1152

Human  1193 EREREREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLS 1257
            |||||||:|||||||||||:||.|:.:|.::|..|||.||:|||||||.||||||||||||||||
Zfish  1153 EREREREKEAERAAKASSSSHESRMGEPPMAGSAHMRTSFDPPPTTIATVPPYIGPDTPALRTLS 1217

Human  1258 EYARPHVMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELR-E 1321
            |||||||||||||||||::.|||||||||||:|||||.||::||||||||||||||||||||| |
Zfish  1218 EYARPHVMSPTNRNHPFFVSLNPTDPLLAYHLPGLYNADPSMRERELREREIREREIRERELRME 1282

Human  1322 RMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQL 1386
            ||||||||||||||.|||:||||||||||..:.:||.||||||||||||||||||||||||||||
Zfish  1283 RMKPGFEVKPPELDSLHPSANPMEHFARHGPIGLPPMAGPHPFASFHPGLNPLERERLALAGPQL 1347

Human  1387 RPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGS--- 1448
            ||||:||:|| |||:|.||:|   :||:|||||||||||||||||||||||||||||||||.
Zfish  1348 RPEMTYPERL-AERLHVERLA---NDPMARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGGGEC 1408

Human  1449 -----AGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIP 1508
                 ....|||||||..||||||||||||.:|||||||||||||||||||||||||||||..:|
Zfish  1409 LVCPPGSGAHPLVDPLAGGPHLARFPYPPGAIPNPLLGQPPHEHEMLRHPVFGTPYPRDLPAGLP 1473

Human  1509 PPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL 1566
            ||||||||||||||||||||||||||||||||.|||||.||.|||||||||||.||||
Zfish  1474 PPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHHHMHGGPLPGQEDYYSRLKKESDKQL 1531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RERE	NP_001036146.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90		71/89 (80%)
		BAH_MTA	102..307	CDD:240060	156/204 (76%)
		ELM2	286..336	CDD:279754	44/49 (90%)
		SANT_MTA3_like	395..440	CDD:212559	42/44 (95%)
		SANT	396..441	CDD:197842	42/44 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..495		30/30 (100%)
		ZnF_GATA	503..552	CDD:214648	48/48 (100%)
		ZnF_GATA	506..560	CDD:238123	53/53 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..1133		379/632 (60%)
		Atrophin-1	568..1565	CDD:281189	720/1047 (69%)
		ICA69	627..793	CDD:282483	106/170 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1162..1246		64/83 (77%)
rerea	XP_005162258.1	BAH_MTA	101..264	CDD:240060	156/204 (76%)
		ELM2	243..293	CDD:307553	44/49 (90%)
		SANT_MTA3_like	352..397	CDD:212559	42/44 (95%)
		ZnF_GATA	460..509	CDD:214648	48/48 (100%)
		Atrophin-1	525..1530	CDD:331285	720/1047 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194330824
Domainoid	1	1.000	1388	1.000	Domainoid score	I164
eggNOG	1	0.900	-	-		E1_KOG2133
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8101
Inparanoid	1	1.050	2384	1.000	Inparanoid score	I292
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39339
OrthoDB	1	1.010	-	-		D136778at2759
OrthoFinder	1	1.000	-	-		FOG0003731
OrthoInspector	1	1.000	-	-		oto46064
orthoMCL	1	0.900	-	-		OOG6_107403
Panther	1	1.100	-	-	LDO	PTHR13859
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5144
SonicParanoid	1	1.000	-	-		X2587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300