DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment repo and PDLIM7

DIOPT Version :9

Sequence 1:	NP_477026.1	Gene:	repo / 47285	FlyBaseID:	FBgn0011701	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_005442.2	Gene:	PDLIM7 / 9260	HGNCID:	22958	Length:	457	Species:	Homo sapiens

Alignment Length:	373	Identity:	84/373 - (22%)
Similarity:	120/373 - (32%)	Gaps:	96/373 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 DSSPVMINGGS------AGGKLKKPDEMCSQLEAGGAGVTPPSSSSTVVNGTTNGTGNANSSSSA 267
            ||..|::.|.:      .|||........|:|..||..    :.:...|..........|:.|..
Human     2 DSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKA----AQAGVAVGDWVLSIDGENAGSLT 62

  Fly   268 GVGIQGAAGTAG-----GV--AAPAAKKDGSSSKKKGDPNGIKKKKTRTTFT-AYQLEELERAFE 324
            .:..|......|     |:  |.|...|...:|....||       .|.||. :..|.:..|.|
Human    63 HIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADP-------PRYTFAPSVSLNKTARPF- 119

  Fly   325 RAPYPDVFAREELAIKLN--LSESRVQVWFQNRRAKWRKHEPPRKTGYIK--------TST---- 375
            .||.|...|.::....|.  :.::..|...:|.. .||   |...||..:        |.|
Human   120 GAPPPADSAPQQNGQPLRPLVPDASKQRLMENTE-DWR---PRPGTGQSRSFRILAHLTGTEFMQ 180

  Fly   376 -PPTATLN-----PGTLAP-PFTSYPQTTTVTPPGSMDSWTSYQTPYELTPQFSLLSPAASPYGT 433
             |....|.     |.|.|| |.:|.||...   ||......:.:.|:.:.|.|      |..|..
Human   181 DPDEEHLKKSSQVPRTEAPAPASSTPQEPW---PGPTAPSPTSRPPWAVDPAF------AERYAP 236

  Fly   434 YSGQYGAYVHESQLFPMRHYEYGSPTRMEMGATTGSVAGNGDESVANGGSYQTAELQTAQQQQLA 498
                     .::.....||.:..:||.::...:....|..|   |..|||              .
Human   237 ---------DKTSTVLTRHSQPATPTPLQSRTSIVQAAAGG---VPGGGS--------------N 275

  Fly   499 DGTLVTVHAHQQQQQQQQQLNGKYLSAEEAKYVHLQ---CHQSGGGLE 543
            :|.....|      |..:.:.|:||.|....| |.:   |.|.|..||
Human   276 NGKTPVCH------QCHKVIRGRYLVALGHAY-HPEEFVCSQCGKVLE 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	10/48 (21%)
PDLIM7	NP_005442.2	PDZ_signaling	5..79	CDD:238492	14/77 (18%)
		Atrophin-1	<81..254	CDD:331285	46/202 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..142		17/67 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..226		14/52 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..258		4/18 (22%)
		LIM1_Enigma	282..333	CDD:188836	13/42 (31%)
		LIM2_Enigma	341..392	CDD:188840
		LIM3_Enigma	400..454	CDD:188842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030