DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment repo and ALX1

DIOPT Version :9

Sequence 1:	NP_477026.1	Gene:	repo / 47285	FlyBaseID:	FBgn0011701	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_008913.2	Gene:	ALX1 / 8092	HGNCID:	1494	Length:	326	Species:	Homo sapiens

Alignment Length:	326	Identity:	95/326 - (29%)
Similarity:	138/326 - (42%)	Gaps:	86/326 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 PQQLQHLYGGSPHHLDH----LDHGSDGLLQDSSPVMINGGSAG------GKLKKPDEMCSQLEA 236
            |.:....|.|:...|:|    ||:.|          ..:..|||      |.|.:.:... :||.
Human    14 PSKNSDFYMGAGGPLEHVMETLDNES----------FYSKASAGKCVQAFGPLPRAEHHV-RLER 67

  Fly   237 GGAGVTPPSSSSTVVNGTTNGTG------------NANSSSSAGV-GIQGAAGTAGGVAAPAAKK 288
                 |.|...|:|..|.|...|            |.||...:.| |:|           ...:.
Human    68 -----TSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNSLRMSPVKGMQ-----------EKGEL 116

  Fly   289 DGSSSKKKGDPNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFAREELAIKLNLSESRVQVWFQ 353
            |....|...:.:..||::.|||||:.||||||:.|::..||||:.||:||::..|:|:|||||||
Human   117 DELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQ 181

  Fly   354 NRRAKWRKHEPPRKTGYIKTSTPPTATLNPGTLAPPFTSYPQ----------------TTTVTPP 402
            ||||||||.|   :.|.|:.:....|.....::.|...||||                |:.:.|.
Human   182 NRRAKWRKRE---RYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCMLPR 243

  Fly   403 GSMDSWTSYQTPYELTPQFSLLSPAASPYGTYSGQYGAYVHESQLFPMRHYEYGSPTRMEMGATT 467
            .:    :|..|||..:|:      ..|.|..:|.....:.|    .|:.::...|   :..|||.
Human   244 DT----SSCMTPYSHSPR------TDSSYTGFSNHQNQFSH----VPLNNFFTDS---LLTGATN 291

  Fly   468 G 468
            |
Human   292 G 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	29/46 (63%)
ALX1	NP_008913.2	Homeobox	135..189	CDD:365835	35/53 (66%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	192..326		25/118 (21%)
		OAR	302..320	CDD:367680
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.970