Protein Alignment repo and ESX1

DIOPT Version :10

• Sequence 1: NP_477026.1
• Gene: repo / 47285
• FlyBaseID: FBgn0011701
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_703149.1
• Gene: ESX1 / 80712
• HGNCID: 14865
• Length: 406
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 76/290 - (26%)
• Similarity: 96/290 - (33%)
• Gaps: 134/290 - (46%)

  Fly   174 SSPKDQYEPQQLQHLYGGSPHHLDHLDHGSDGLLQDSSPVMINGGSAGGKLKKPDEMCSQ---LE 235
            |.|.|..:.:      ||..|..:.         |...|          .|.||::...:   ||
Human    66 SVPSDDQDRE------GGGGHEPEQ---------QQEEP----------PLTKPEQQQEEPPLLE 105

  Fly   236 AGGAGVTPPSSSSTVVNGTTNGTGNANSSSSAGVGIQGAAG--TAGGVAAPAAKKDGSSSKKKGD 298
            .......||   .|.|.|.                 |.|.|  ||.|...|.
Human   106 LKQEQEEPP---QTTVEGP-----------------QPAEGPQTAEGPQPPE------------- 137

  Fly   299 PNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFAREELAIKLNLSESRVQVWFQNRRAKWRKHE 363
                :|::.||.||.:||:|||..|:.:.||||.|||.||.:|||:|.|||||||||||||::::
Human   138 ----RKRRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQNRRAKWKRNQ 198

  Fly   364 ------------------------------------------------------PPRKTGYIKTS 374
                                                                  |||
Human   199 RVLMLRNTATADLAHPLDMFLGGAYYAAPALDPALCVHLVPQLPRPPVLPVPPMPPR-------- 255

  Fly   375 TPPTATLNPGTLAPPFTSYPQTTTVTPPGS 404
             ||...:.|   .||....|....| ||||
Human   256 -PPMVPMPP---RPPIAPMPPMAPV-PPGS 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeodomain	313..361	CDD:459649	32/47 (68%)
ESX1	NP_703149.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..142		26/137 (19%)
		PLN02328	45..>148	CDD:215187	29/143 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	138..143		1/4 (25%)
		Homeodomain	140..196	CDD:459649	36/55 (65%)
		15 X 9 AA tandem repeats of P-P-x-x-P-x-P-P-x	244..378		14/50 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..364