DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment repo and ALX4

DIOPT Version :9

Sequence 1:	NP_477026.1	Gene:	repo / 47285	FlyBaseID:	FBgn0011701	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_068745.2	Gene:	ALX4 / 60529	HGNCID:	450	Length:	411	Species:	Homo sapiens

Alignment Length:	439	Identity:	127/439 - (28%)
Similarity:	174/439 - (39%)	Gaps:	136/439 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GGGGAGSGG--AGGSPNYVTKLDFVNKMGCYSPSQKYEYISAPQKLVEQQQQQQHHHQHHQHYTA 131
            |.|.|.|..  ..|..:..|.|:  :..|......|::    ||....|.|
Human    56 GFGDAKSRARYGAGQQDLATPLE--SGAGARGSFNKFQ----PQPSTPQPQ-------------- 100

  Fly   132 TPPPSHNGILLHKQSSQQQQQQQQQLVGILDYHPLNGKLDYSSSPKDQYEPQQLQHLYGGSPHHL 196
             |||             |.|.||||                     .|.:|....|||
Human   101 -PPP-------------QPQPQQQQ---------------------PQPQPPAQPHLY------- 123

  Fly   197 DHLDHGS-----DGLLQDSSPVMINGGSAG--GKLKKPDEMCSQLEAG-GAGVTPPSSSSTVVNG 253
              |..|:     ||.|:      :..||:|  ..|:.|   |...|:. |....||.|.:..::.
Human   124 --LQRGACKTPPDGSLK------LQEGSSGHSAALQVP---CYAKESSLGEPELPPDSDTVGMDS 177

  Fly   254 TTNGTGNANSSSSAGVGIQGAAGTAGG-VAAPAAKKDGSSSKKKGDPNGIKKKKTRTTFTAYQLE 317
            :......|        |::|....|.. :.:|..|.|..|:|.       ||::.|||||:||||
Human   178 SYLSVKEA--------GVKGPQDRASSDLPSPLEKADSESNKG-------KKRRNRTTFTSYQLE 227

  Fly   318 ELERAFERAPYPDVFAREELAIKLNLSESRVQVWFQNRRAKWRKHEPPRKTGYIKT--STP---P 377
            |||:.|::..||||:|||:||::.:|:|:|||||||||||||||.|...:...::|  ||.   |
Human   228 ELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELP 292

  Fly   378 TAT--------LNPGTLAPPFTSYPQTTTVTPPGSMDSWTSYQTPYELTP--------QFSLLSP 426
            ..|        .||..|.....:.|....|.|   .|...:..:|:...|        .|..:|.
Human   293 LLTRAENYAQIQNPSWLGNNGAASPVPACVVP---CDPVPACMSPHAHPPGSGASSVTDFLSVSG 354

  Fly   427 AASPYG-TYSGQ-YGAYVHESQLFP-MRHYEY-GSPTRMEMGATTGSVA 471
            |.|..| |:.|. :||    :.|.| :..||. |.|.|     .|.|:|
Human   355 AGSHVGQTHMGSLFGA----ASLSPGLNGYELNGEPDR-----KTSSIA 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	31/46 (67%)
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..145		29/139 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..219		11/49 (22%)
		Homeobox	218..270	CDD:278475	36/51 (71%)
		OAR	387..404	CDD:281777	4/13 (31%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	391..404		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010