DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment repo and Pdlim5

DIOPT Version :9

Sequence 1:	NP_477026.1	Gene:	repo / 47285	FlyBaseID:	FBgn0011701	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_006501801.1	Gene:	Pdlim5 / 56376	MGIID:	1927489	Length:	734	Species:	Mus musculus

Alignment Length:	497	Identity:	102/497 - (20%)
Similarity:	156/497 - (31%)	Gaps:	145/497 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PLMPTTTAMHPVMLGSVHELCSQQQQQQQQQRLPDCNTILPNGGGGGAGSGG----AGGSPNYVT 86
            |..||.|:           :||:..|:..:              |...||.|    ..|:|..|
Mouse   204 PRQPTVTS-----------VCSESAQELAE--------------GQRRGSQGDIKQQNGNPGTV- 242

  Fly    87 KLDFVNKMGCYSPSQKYEYISAPQKLVEQQQQQQHHHQHHQHYTATPPPSHNGILLHKQSSQQQQ 151
                  |:....|.:|:        :||:..:..|                  |..|..:|:::.
Mouse   243 ------KIPPKRPPRKH--------IVERNTEFYH------------------IPTHSDASKKRL 275

  Fly   152 QQQQQLVGILDYHPLNGKLDYSSSPKDQYEPQQLQHLYGGSPHHLDHLDHGSD------GLLQDS 210
            .:..:     |:.|..|.....|.       :.|..:.|  ..||...::.:.      ..|:|.
Mouse   276 IEDTE-----DWRPRTGTTQSRSF-------RILAQITG--TEHLTESENDNTKKAKFYSSLEDP 326

  Fly   211 SPVMING--GSAGGKLKKPDEMCSQLEAGGAGVTPPSSSSTVVNGTTNGTGNANSSSS----AGV 269
               :.||  ..|..:|.|.....:.:....|..:..|.|:..|.|...|.||..:.|.    :.|
Mouse   327 ---LKNGPHPPAAPQLLKVHSQVAIVSKEAATYSSVSRSTRTVEGALEGFGNFPAFSPPTRYSAV 388

  Fly   270 GIQGAAGTAGGVAAPAAKKDGSSSKKKGDPNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFAR 334
            .:..||.|..  ||.||                   ||| .|.....:.|..|...:..|...|
Mouse   389 VVSDAAATVS--AALAA-------------------KTR-LFGPENSQSLLDALCISTVPKPLA- 430

  Fly   335 EELAIKLNLSESRVQVWFQNRRAKWRKHEPPRKTGYIKTSTPPTAT---LNPGTLAPPFTSYPQT 396
              |:...:..||...|..:...:.....:.|..:|    ::|.:|:   .:||:..|........
Mouse   431 --LSCLQSSEESSGSVHVKKSSSTQEPSQQPASSG----ASPLSASEGPESPGSSRPSVAGLRSA 489

  Fly   397 TTVTPPGSMD----SWTSYQTPYELTPQFSLLSPAASPYGTYSGQYGAYV-------HESQLFPM 450
            ....|.||..    ||   |.|.:..|....:|..|...||     ||.|       .::.:...
Mouse   490 AAFKPVGSTSVKSPSW---QRPNQAAPSTGRISNNARSSGT-----GASVGPPQPSDQDTLVQRA 546

  Fly   451 RHYEYGSPTRMEMGATTGSVAGNGDESVANGGSYQTAELQTA 492
            .|...|.  |..|.|....|. .|...||.|.|:...|...|
Mouse   547 EHIPAGK--RTPMCAHCNQVI-RGPFLVALGKSWHPEEFNCA 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	8/46 (17%)
Pdlim5	XP_006501801.1	PDZ_signaling	10..82	CDD:238492
		PHA03307	150..>540	CDD:223039	89/447 (20%)
		DUF4749	214..315	CDD:374237	26/161 (16%)
		LIM1_ENH	558..609	CDD:188837	9/29 (31%)
		LIM2_ENH	617..668	CDD:188841
		LIM3_ENH	676..730	CDD:188843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030