Protein Alignment repo and PITX3

DIOPT Version :10

• Sequence 1: NP_477026.1
• Gene: repo / 47285
• FlyBaseID: FBgn0011701
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Alignment Length: 234
• Identity: 70/234 - (29%)
• Similarity: 100/234 - (42%)
• Gaps: 45/234 - (19%)

  Fly   222 GKLKKPDEMCSQLEAGGAGVTPPSSSSTVVNGTTNGTGNANSSSSAGVGIQGAAGTAGGVAAPAA 286
            |.|.:.:.....|....||...|........|..:......|:|..|                .:
Human     4 GLLSEAEARSPALSLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPG----------------GS 52

  Fly   287 KKDGSSSKKKGDPNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFAREELAIKLNLSESRVQVW 351
            .:|||..|        |:::.||.||:.||:|||..|:|..|||:..|||:|:..||:|:||:||
Human    53 PEDGSLKK--------KQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVW 109

  Fly   352 FQNRRAKWRKHEPPRKTGYIKTS--------TPPTATLNPG---------TLAPPFT--SYPQTT 397
            |:||||||||.|..::....|.|        .||...:.||         .||||..  ::|...
Human   110 FKNRRAKWRKRERSQQAELCKGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAF 174

  Fly   398 TVTPPGSMDSWTSYQTPYELTPQFSLLSPAASPYGTYSG 436
            .....|.:.|...:..|..:..  |::..||:..||..|
Human   175 NSVNVGPLASQPVFSPPSSIAA--SMVPSAAAAPGTVPG 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeodomain	313..361	CDD:459649	28/47 (60%)
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		18/90 (20%)
		Homeodomain	63..119	CDD:459649	32/55 (58%)
		OAR	258..275	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275
		Nuclear localization signal. /evidence=ECO:0000255	268..272